iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ame-011138

Ensembl Protein ID

ENSAMXP00000021679.1

UniProt Accession

W5LPB0; W5LPB0_ASTMX

Genbank Protein ID

ENSAMXP00000021679

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

APWO01094374

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSAMXG00000021055.1	ENSAMXT00000021679.1	ENSAMXP00000021679.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	4.20e-134	447.4	609	939

Active Site

Position(s)	Description	Evidence
909	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 3    sdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldlp 91
           + lk+rl+ ef+gE+gld+gGv+re+++l+ske++np++glf+ys++d++tlq+np+sgl+n++hl++F+f+Gr+ g+a+++g+lld++
   Q: 609  DLLKARLWLEFAGEKGLDYGGVAREWFFLISKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFKFIGRVAGMAVYHGKLLDAF 697
           66899************************************************************************************ PP
   S: 92   lsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvvey 180
           + ++fyk++l+k+++l+d+e+vd+e+++slk+i+en   d    +ldl+f+++ee++g+t+++eLkpgG +i V+ +Nk+eY++lv+++
   Q: 698  FIRPFYKMMLQKPITLQDMESVDSEYFNSLKWILEN---DPA--DLDLRFTIDEELFGQTHQHELKPGGTDIVVNDSNKKEYIHLVMQW 781
           **********************************99...555..57999999************************************* PP
   S: 181  rlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFvT 269
           r+ ++i++q+++f+eGf+e+ip++l+++F+e+elell+cG  ++dv+d++++tkyk+gy +++p+iqwFw+++  +++e+r ++LqFvT
   Q: 782  RFVNRIQKQMTSFKEGFYELIPQDLIKIFDENELELLMCGLGDVDVNDWRENTKYKNGYGPNQPVIQWFWKTVLLMDAEKRIRLLQFVT 870
           ***************************************************************************************** PP
   S: 270  gssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFe 334
           g+sr+P++Gfael     p+lf+i+++++ d+lP+++TCfn+L+LP+Y+s e+l+ekL +Aie+++gF+
   Q: 871  GTSRVPMNGFAELYgsngPQLFTIEQWGTRDKLPRAHTCFNRLDLPPYESFEELREKLNIAIENAQGFD 939
           ********************************************************************8 PP

Organism

Astyanax mexicanus

Protein Sequence
(Fasta)

MNNNNNMAAV VVPEVRGLHA EEDEARILRV KVISGIGLAK KDILGASDPY TRLSLYDPVN 60
GELTSLQTKT IKKTLDPKWN EEFFFRVHPR KHRLLLEVFD ENRLTRDDFL GQVDVPLHQI 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TACACTCTGG TGGGCGGGGC GTTGCTGTGT GTGGGCGTGG CTTGTACCAG GGGCGTGTGC 60
TGTAAGCGGA AGGAAAGAGA CGGTAAGATG GCCAGCGCTG ATGCTACGAC ACGTTTGAGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001201	Ailuropoda melanoleuca	69.03	0.00e+00	1130.00
IUUC-Apl-003886	Anas platyrhynchos	66.67	0.00e+00	1212.00
IUUC-Bta-012453	Bos taurus	83.51	0.00e+00	844.00
IUUC-Cel-018564	Caenorhabditis elegans	51.64	8.00e-179	620.00
IUUC-Cja-019034	Callithrix jacchus	85.00	0.00e+00	885.00
IUUC-Cfa-020258	Canis familiaris	62.65	0.00e+00	979.00
IUUC-Cpo-021648	Cavia porcellus	64.18	0.00e+00	1115.00
IUUC-Csa-023334	Chlorocebus sabaeus	85.21	0.00e+00	875.00
IUUC-Cin-025157	Ciona intestinalis	54.48	0.00e+00	953.00
IUUC-Csv-026098	Ciona savignyi	57.72	0.00e+00	644.00
IUUC-Dse-031241	Dothistroma septosporum	46.42	9.00e-156	543.00
IUUC-Dme-032166	Drosophila melanogaster	65.30	0.00e+00	720.00
IUUC-Ete-032409	Echinops telfairi	77.20	0.00e+00	776.00
IUUC-Eca-033441	Equus caballus	69.08	0.00e+00	1207.00
IUUC-Fca-036384	Felis catus	68.69	0.00e+00	1120.00
IUUC-Fal-037547	Ficedula albicollis	84.34	0.00e+00	850.00
IUUC-Gmo-039679	Gadus morhua	74.06	0.00e+00	1329.00
IUUC-Gga-040524	Gallus gallus	69.08	0.00e+00	1247.00
IUUC-Gac-042607	Gasterosteus aculeatus	73.33	0.00e+00	1336.00
IUUC-Hsa-046479	Homo sapiens	85.21	0.00e+00	886.00
IUUC-Itr-048383	Ictidomys tridecemlineatus	67.24	0.00e+00	841.00
IUUC-Lch-050445	Latimeria chalumnae	69.75	0.00e+00	1178.00
IUUC-Loc-052645	Lepisosteus oculatus	77.35	0.00e+00	1395.00
IUUC-Laf-053638	Loxodonta africana	84.31	0.00e+00	865.00
IUUC-Mcc-055585	Macaca mulatta	85.21	0.00e+00	885.00
IUUC-Meu-056897	Macropus eugenii	87.80	2.00e-157	550.00
IUUC-Mga-059362	Meleagris gallopavo	66.53	0.00e+00	1233.00
IUUC-Mmr-061061	Microcebus murinus	69.42	0.00e+00	1150.00
IUUC-Mdo-062178	Monodelphis domestica	61.10	0.00e+00	1038.00
IUUC-Mpu-066567	Mustela putorius furo	70.04	0.00e+00	1269.00
IUUC-Mlu-068148	Myotis lucifugus	63.36	0.00e+00	992.00
IUUC-Nle-069225	Nomascus leucogenys	85.00	0.00e+00	884.00
IUUC-Ont-071664	Oreochromis niloticus	72.77	0.00e+00	1319.00
IUUC-Oan-073019	Ornithorhynchus anatinus	84.97	0.00e+00	857.00
IUUC-Ocu-074409	Oryctolagus cuniculus	84.79	0.00e+00	883.00
IUUC-Oar-089797	Ovis aries	84.38	0.00e+00	847.00
IUUC-Ptr-091629	Pan troglodytes	85.21	0.00e+00	886.00
IUUC-Psi-093618	Pelodiscus sinensis	83.92	0.00e+00	857.00
IUUC-Pfo-097145	Poecilia formosa	87.50	0.00e+00	877.00
IUUC-Pab-098394	Pongo abelii	69.75	0.00e+00	1241.00
IUUC-Pca-100568	Procavia capensis	62.22	0.00e+00	907.00
IUUC-Tgu-117474	Taeniopygia guttata	64.31	0.00e+00	1155.00
IUUC-Tru-117675	Takifugu rubripes	71.38	0.00e+00	1292.00
IUUC-Tni-119993	Tetraodon nigroviridis	71.76	0.00e+00	1271.00
IUUC-Tbe-127408	Tupaia belangeri	79.65	0.00e+00	779.00
IUUC-Uma-129332	Ustilago maydis	52.58	1.00e-140	493.00
IUUC-Vpa-130503	Vicugna pacos	84.21	0.00e+00	834.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence