iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ssc-116442

Ensembl Protein ID

ENSSSCP00000025894.1

UniProt Accession

I3LP69; I3LP69_PIG

Genbank Protein ID

ENSSSCP00000025894

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

FP236300

Gene Name

NCK1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSSSCG00000025701.1	ENSSSCT00000024187.1	ENSSSCP00000025894.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	1.10e-45	153.7	192	249

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 3    kekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvek 61
           +++vq+ly+++++nd+eL+++kGd+++viek e+d +W+k+ ++ +g  Gl+P+n+v+ 
   Q: 192  LHVVQALYPFSSSNDEELNFEKGDIMDVIEKPENDPEWWKC-RKINGMIGLVPKNYVTI 249
           689**************************************.59*************85 PP

Organism

Sus scrofa

Protein Sequence
(Fasta)

MAEEVVVVAK FDYVAQQEQE LDIKKNERLW LLDDSKSWWR VRNSMNKTGF VPSNYVERKN 60
SARKASIVKN LKDTLGIGKV KRKHSVPDSA SPADESFVDP GERLYDLNMP AYVKFNYMAE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTAGACTACT ACTAGTTAAA CTTTATCTAA ATATTTTCTA TGTGGTTACA GTGCAGAAGC 60
TGCTGAAAAA TGGCAGAAGA AGTGGTGGTA GTAGCCAAAT TTGATTATGT TGCACAACAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0728--SH3 domain

Interpro

IPR017304--NCK
IPR000980--SH2
IPR001452--SH3_domain

PROSITE

PS50001--SH2
PS50002--SH3

Pfam

PF00017--SH2
PF00018--SH3_1
PF14604--SH3_9

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN

SMART

SM00252--SH2
SM00326--SH3

Gene Ontology

GO:0005911--C:cell-cell junction
GO:0005783--C:endoplasmic reticulum
GO:0000164--C:protein phosphatase type 1 complex
GO:0005840--C:ribosome
GO:0012506--C:vesicle membrane
GO:0004860--F:protein kinase inhibitor activity
GO:0007015--P:actin filament organization
GO:0048013--P:ephrin receptor signaling pathway
GO:0030032--P:lamellipodium assembly
GO:0060548--P:negative regulation of cell death
GO:1903912--P:negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation
GO:0033137--P:negative regulation of peptidyl-serine phosphorylation
GO:1903898--P:negative regulation of PERK-mediated unfolded protein response
GO:1990441--P:negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
GO:0070262--P:peptidyl-serine dephosphorylation
GO:0030838--P:positive regulation of actin filament polymerization
GO:1903676--P:positive regulation of cap-dependent translational initiation
GO:1903679--P:positive regulation of cap-independent translational initiation
GO:1902237--P:positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
GO:0010976--P:positive regulation of neuron projection development
GO:0042102--P:positive regulation of T cell proliferation
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0036493--P:positive regulation of translation in response to endoplasmic reticulum stress
GO:0030334--P:regulation of cell migration
GO:0051707--P:response to other organism
GO:0006930--P:substrate-dependent cell migration, cell extension
GO:0042110--P:T cell activation

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002115	Ailuropoda melanoleuca	98.14	0.00e+00	738.00
IUUC-Ame-011235	Astyanax mexicanus	78.10	2.00e-180	624.00
IUUC-Bta-013039	Bos taurus	98.14	0.00e+00	736.00
IUUC-Cel-018144	Caenorhabditis elegans	41.08	7.00e-75	273.00
IUUC-Cja-019546	Callithrix jacchus	97.88	0.00e+00	729.00
IUUC-Cfa-020462	Canis familiaris	98.41	0.00e+00	739.00
IUUC-Cpo-022009	Cavia porcellus	97.35	0.00e+00	731.00
IUUC-Csa-023875	Chlorocebus sabaeus	97.61	0.00e+00	735.00
IUUC-Cho-024368	Choloepus hoffmanni	95.93	0.00e+00	647.00
IUUC-Cin-025348	Ciona intestinalis	36.79	4.00e-65	241.00
IUUC-Csv-026046	Ciona savignyi	40.35	9.00e-72	263.00
IUUC-Dre-028407	Danio rerio	76.78	8.00e-178	615.00
IUUC-Dno-029593	Dasypus novemcinctus	97.44	4.00e-174	603.00
IUUC-Dor-030730	Dipodomys ordii	96.81	0.00e+00	635.00
IUUC-Dme-031846	Drosophila melanogaster	42.36	7.00e-91	327.00
IUUC-Ete-032906	Echinops telfairi	97.35	0.00e+00	727.00
IUUC-Eca-033378	Equus caballus	97.26	0.00e+00	635.00
IUUC-Eeu-034743	Erinaceus europaeus	87.53	0.00e+00	672.00
IUUC-Fca-035745	Felis catus	98.14	0.00e+00	774.00
IUUC-Gmo-039410	Gadus morhua	60.51	7.00e-135	473.00
IUUC-Gac-042245	Gasterosteus aculeatus	75.58	6.00e-159	553.00
IUUC-Ggo-045487	Gorilla gorilla	97.61	0.00e+00	735.00
IUUC-Hsa-045902	Homo sapiens	97.61	0.00e+00	735.00
IUUC-Itr-047923	Ictidomys tridecemlineatus	97.88	0.00e+00	735.00
IUUC-Lch-050165	Latimeria chalumnae	81.96	6.00e-180	622.00
IUUC-Loc-052523	Lepisosteus oculatus	79.16	6.00e-180	622.00
IUUC-Laf-053845	Loxodonta africana	97.61	0.00e+00	733.00
IUUC-Meu-056139	Macropus eugenii	90.72	0.00e+00	667.00
IUUC-Mmr-061108	Microcebus murinus	85.94	3.00e-173	600.00
IUUC-Mdo-062258	Monodelphis domestica	94.43	0.00e+00	716.00
IUUC-Mmu-063970	Mus musculus	97.61	0.00e+00	770.00
IUUC-Mpu-066093	Mustela putorius furo	97.88	0.00e+00	737.00
IUUC-Mlu-067193	Myotis lucifugus	97.61	0.00e+00	733.00
IUUC-Nfi-068448	Neosartorya fischeri	30.25	1.00e-15	78.20
IUUC-Nle-069611	Nomascus leucogenys	97.61	0.00e+00	735.00
IUUC-Opr-070984	Ochotona princeps	96.68	1.00e-177	615.00
IUUC-Ont-072241	Oreochromis niloticus	75.64	7.00e-172	596.00
IUUC-Oan-072976	Ornithorhynchus anatinus	87.62	9.00e-165	572.00
IUUC-Ocu-073905	Oryctolagus cuniculus	98.14	0.00e+00	736.00
IUUC-Ola-086513	Oryzias latipes	74.62	2.00e-159	554.00
IUUC-Oga-088588	Otolemur garnettii	97.61	0.00e+00	734.00
IUUC-Oar-089973	Ovis aries	98.41	0.00e+00	737.00
IUUC-Ptr-090968	Pan troglodytes	97.61	0.00e+00	735.00
IUUC-Pan-092840	Papio anubis	97.76	6.00e-175	605.00
IUUC-Pfo-096057	Poecilia formosa	73.98	4.00e-169	587.00
IUUC-Pab-097807	Pongo abelii	97.88	0.00e+00	736.00
IUUC-Pca-100522	Procavia capensis	96.81	4.00e-173	599.00
IUUC-Pva-103083	Pteropus vampyrus	97.88	0.00e+00	735.00
IUUC-Rno-104839	Rattus norvegicus	94.69	0.00e+00	733.00
IUUC-Sha-107294	Sarcophilus harrisii	92.84	0.00e+00	705.00
IUUC-Sar-113675	Sorex araneus	96.02	0.00e+00	719.00
IUUC-Tru-118058	Takifugu rubripes	74.30	1.00e-168	585.00
IUUC-Tsy-119184	Tarsius syrichta	90.00	0.00e+00	627.00
IUUC-Tni-119974	Tetraodon nigroviridis	73.98	8.00e-157	546.00
IUUC-Ttr-129155	Tursiops truncatus	95.76	0.00e+00	729.00
IUUC-Vpa-130344	Vicugna pacos	98.14	0.00e+00	736.00
IUUC-Xtr-132372	Xenopus tropicalis	86.70	0.00e+00	654.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence