iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Kpa-049351

Ensembl Protein ID

CAY71159

UniProt Accession

C4R6H3; LIS1_KOMPG

Genbank Protein ID

CAY71159.1

Protein Name

Nuclear distribution protein PAC1; Lissencephaly-1 homolog; nudF homolog

Genbank Nucleotide ID

FN392321

Gene Name

PAC1; LIS1; PAS_chr3_1092

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
PAS_chr3_1092	CAY71159	CAY71159

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.40e-35	117.9	225	262
UBD/Beta-Prp	7.60e-49	164.5	121	492

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf..sd.tllvsGsdDgtikvWDlrtgvl 35
           gH++ ++cl+f  ++   lvs+s D+t kvWD+rtg  
   Q: 225  GHENIISCLCFhpTEpSKLVSCSKDKTTKVWDTRTGSI 262
           8***********644788*****************976 PP

UBD/Beta-Prp

   S: 4    tlkghhksvitcvkfspdksllatgsrdgtikvwdvttgkllrsl..sgheaevtavkfspdgk...........ilvtgseDrtikvwdls...tgkcvh 88
           +l+ h+ +++t+++++p+++++at+s+dgti +w++ + +  +++    h+  ++++kf +++            +l+tgs+D +ik+wd++   + k ++
   Q: 121  KLNMHNGHPVTAIDIHPFQPIMATASQDGTIVIWNLLNLTEPQQIirNAHTRSINTIKFMNQEVmdghstkknrlLLATGSSDLLIKIWDIEdsaNLKALR 221
           688999*****************************9997774444466777777777777765556666667778**************888777999*** PP
   S: 89   tlkghedsvlslsfspsg.dklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvyslsf 188
           tl+ghe+ + +l f+p+  +klvs s+d+t +vwd++tg+ +   + gh+ +v++v ++ +g    ++s+D  +rl +l tg+ +  + g h++ v++++f
   Q: 222  TLTGHENIISCLCFHPTEpSKLVSCSKDKTTKVWDTRTGSIVL-SFVGHSNWVRSVDINRTGEFTLTSSNDHSIRLSSLLTGTGIGLMIG-HEQVVEKVKF 320
           ****************888************************.*********************************************9.*********6 PP
   S: 189  dsng.............................kelvsgsldgtvklwdlq................tgecvrtlnghtdnvksvrfspnderlvsgssDg 244
            +                               k+++sg++d++v +w l                 +g+ + +l++h+++vk+++ +pn+ +++s+++D+
   Q: 321  LPMAcnkyldhiagvkfqnelkinddnynkvdyKYCISGGRDNSVCIWLLPlplirsdgtmhpstnpEGKLILKLTEHKSWVKDIAIHPNSRFIISVGDDR 421
           6655666777777777777779999999*****************************99999999999999****************************** PP
   S: 245  siriWdlrsgdllktlqlhn...ssvisvavlsfgdnvl...................vlgsedskvniwkl 294
            i+iWdl      + lq  +   ++  +++ l++ ++v+                   + g +d++v +wk 
   Q: 422  KINIWDLGLLLESNLLQPFRsisTQGFPST-LCMAKPVIkdqesddlillneamrcylAVGHSDGTVTLWKK 492
           *****9876555555555552213333333.68888888888888888999999988777777999999994 PP

Organism

Komagataella pastoris

Functional Description
(View)

Positively regulates the activity of the minus-end directed microtubule motor protein dynein. Plays a central role in positioning the mitotic spindle at the bud neck during cell division. Targets cytoplasmic dynein to microtubule plus ends, thereby promoting dynein-mediated microtubule sliding along the bud cortex and consequently the movement of the mitotic spindle to the bud neck.

Protein Sequence
(Fasta)

MSDILTKKQD IELRRAVIQY LRYFVPEFAQ DTAVNTISRL LLDADLNKFD NEIQRMIPKQ 60
YLEKKWTAVL RLHRKVEELE RTIGYQSNKV EIELQSQPHS DITSNSLDRI NWVPGIEPFQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGAGTGATA TACTGACAAA AAAGCAAGAT ATCGAATTAC GAAGAGCAGT CATCCAATAT 60
TTGCGTTACT TTGTTCCTGA GTTTGCTCAG GATACGGCGG TCAACACTAT TTCAAGATTA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0131--Cell cycle
KW-0132--Cell division
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0493--Microtubule
KW-0498--Mitosis
KW-1185--Reference proteome
KW-0677--Repeat
KW-0813--Transport
KW-0853--WD repeat

Interpro

IPR017252--Dynein_regulator_LIS1
IPR020472--G-protein_beta_WD-40_rep
IPR002469--Peptidase_S9B_N
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005874--C:microtubule
GO:0000922--C:spindle pole
GO:0051301--P:cell division
GO:0007067--P:mitotic nuclear division
GO:0006810--P:transport

KEGG

ppa:PAS_chr3_1092

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001589	Ailuropoda melanoleuca	29.19	5.00e-42	162.00
IUUC-Apl-004024	Anas platyrhynchos	29.37	3.00e-44	170.00
IUUC-Aca-004564	Anolis carolinensis	29.37	6.00e-43	166.00
IUUC-Ago-007862	Ashbya gossypii	32.04	6.00e-55	206.00
IUUC-Acl-008360	Aspergillus clavatus	30.11	8.00e-47	179.00
IUUC-Afl-008502	Aspergillus flavus	30.90	5.00e-44	169.00
IUUC-Afu-008848	Aspergillus fumigatus	31.37	8.00e-49	185.00
IUUC-Ani-009173	Aspergillus nidulans	28.41	5.00e-44	169.00
IUUC-Ang-009873	Aspergillus niger	29.14	2.00e-43	167.00
IUUC-Aor-009973	Aspergillus oryzae	29.30	2.00e-42	164.00
IUUC-Ate-010523	Aspergillus terreus	28.54	1.00e-43	168.00
IUUC-Ame-010969	Astyanax mexicanus	29.14	3.00e-44	170.00
IUUC-Bgr-011972	Blumeria graminis	29.66	7.00e-49	186.00
IUUC-Bta-013106	Bos taurus	29.37	2.00e-44	171.00
IUUC-Bci-013615	Botrytis cinerea	29.59	5.00e-47	179.00
IUUC-Cel-018459	Caenorhabditis elegans	29.41	3.00e-43	166.00
IUUC-Cja-018755	Callithrix jacchus	28.67	1.00e-42	165.00
IUUC-Cfa-020749	Canis familiaris	29.37	2.00e-44	171.00
IUUC-Cpo-022371	Cavia porcellus	29.37	2.00e-44	171.00
IUUC-Cho-024764	Choloepus hoffmanni	32.36	3.00e-31	127.00
IUUC-Cin-025753	Ciona intestinalis	27.87	4.00e-40	156.00
IUUC-Csv-025817	Ciona savignyi	28.50	4.00e-40	156.00
IUUC-Cgl-026529	Colletotrichum gloeosporioides	29.45	7.00e-41	159.00
IUUC-Cne-027087	Cryptococcus neoformans	28.14	6.00e-37	145.00
IUUC-Dre-028314	Danio rerio	29.11	2.00e-45	174.00
IUUC-Dno-029050	Dasypus novemcinctus	29.37	2.00e-44	171.00
IUUC-Dor-030222	Dipodomys ordii	31.85	5.00e-36	142.00
IUUC-Dse-031164	Dothistroma septosporum	29.93	3.00e-47	180.00
IUUC-Dme-031745	Drosophila melanogaster	28.44	2.00e-37	147.00
IUUC-Eca-034288	Equus caballus	29.19	1.00e-41	161.00
IUUC-Eeu-034984	Erinaceus europaeus	31.85	6.00e-36	142.00
IUUC-Fca-036498	Felis catus	29.37	2.00e-44	171.00
IUUC-Fal-036920	Ficedula albicollis	29.37	3.00e-44	170.00
IUUC-Fox-037996	Fusarium oxysporum	30.46	2.00e-50	191.00
IUUC-Fso-038160	Fusarium solani	27.27	4.00e-45	173.00
IUUC-Gmo-039166	Gadus morhua	29.04	1.00e-45	175.00
IUUC-Ggr-040051	Gaeumannomyces graminis	28.57	4.00e-43	166.00
IUUC-Gga-040623	Gallus gallus	29.37	3.00e-44	170.00
IUUC-Gac-041363	Gasterosteus aculeatus	28.81	3.00e-46	177.00
IUUC-Hsa-046358	Homo sapiens	29.60	1.00e-44	171.00
IUUC-Itr-047890	Ictidomys tridecemlineatus	29.37	2.00e-44	171.00
IUUC-Lch-049936	Latimeria chalumnae	29.07	7.00e-44	169.00
IUUC-Loc-052476	Lepisosteus oculatus	29.19	5.00e-42	162.00
IUUC-Lma-053170	Leptosphaeria maculans	29.26	1.00e-45	175.00
IUUC-Laf-053713	Loxodonta africana	29.29	2.00e-42	164.00
IUUC-Mcc-054628	Macaca mulatta	29.37	3.00e-44	170.00
IUUC-Mor-056962	Magnaporthe oryzae	30.28	2.00e-46	177.00
IUUC-Mpo-057583	Magnaporthe poae	28.11	8.00e-39	152.00
IUUC-Mla-058819	Melampsora laricipopulina	28.34	9.00e-43	165.00
IUUC-Mga-059945	Meleagris gallopavo	29.14	5.00e-44	169.00
IUUC-Mvi-060403	Microbotryum violaceum	28.10	2.00e-41	160.00
IUUC-Mmr-061289	Microcebus murinus	29.19	4.00e-42	163.00
IUUC-Mdo-061912	Monodelphis domestica	29.37	1.00e-43	168.00
IUUC-Mmu-063253	Mus musculus	29.37	2.00e-44	171.00
IUUC-Mpu-066638	Mustela putorius furo	29.37	2.00e-44	171.00
IUUC-Mlu-067267	Myotis lucifugus	29.23	3.00e-42	163.00
IUUC-Nfi-068571	Neosartorya fischeri	29.54	2.00e-43	167.00
IUUC-Ncr-068895	Neurospora crassa	30.54	6.00e-46	176.00
IUUC-Nle-069087	Nomascus leucogenys	30.54	1.00e-37	147.00
IUUC-Opr-070579	Ochotona princeps	29.37	2.00e-44	171.00
IUUC-Ont-071905	Oreochromis niloticus	29.27	3.00e-46	176.00
IUUC-Oan-073072	Ornithorhynchus anatinus	29.37	2.00e-44	171.00
IUUC-Ocu-074180	Oryctolagus cuniculus	29.37	2.00e-44	171.00
IUUC-Ola-086815	Oryzias latipes	29.34	5.00e-46	176.00
IUUC-Oga-088219	Otolemur garnettii	28.84	2.00e-42	164.00
IUUC-Oar-090394	Ovis aries	29.37	2.00e-44	171.00
IUUC-Ptr-091517	Pan troglodytes	29.37	2.00e-44	171.00
IUUC-Pan-092421	Papio anubis	29.37	3.00e-44	170.00
IUUC-Psi-093370	Pelodiscus sinensis	29.60	2.00e-44	171.00
IUUC-Pma-094319	Petromyzon marinus	29.50	1.00e-36	144.00
IUUC-Pno-094815	Phaeosphaeria nodorum	30.88	1.00e-49	188.00
IUUC-Pfo-096228	Poecilia formosa	29.04	1.00e-45	174.00
IUUC-Pab-098421	Pongo abelii	29.37	2.00e-44	171.00
IUUC-Pva-102960	Pteropus vampyrus	29.37	7.00e-45	172.00
IUUC-Pgr-103538	Puccinia graminis	27.97	1.00e-41	161.00
IUUC-Pte-104261	Pyrenophora teres	31.57	7.00e-51	192.00
IUUC-Pyt-104780	Pyrenophora triticirepentis	31.57	5.00e-51	192.00
IUUC-Rno-105123	Rattus norvegicus	29.37	2.00e-44	171.00
IUUC-Sce-106208	Saccharomyces cerevisiae	29.27	3.00e-51	193.00
IUUC-Sha-107010	Sarcophilus harrisii	29.37	7.00e-44	169.00
IUUC-Sja-107899	Schizosaccharomyces japonicus	29.03	7.00e-43	166.00
IUUC-Ssl-108571	Sclerotinia sclerotiorum	29.36	6.00e-47	179.00
IUUC-Sar-113309	Sorex araneus	28.71	3.00e-40	157.00
IUUC-Sre-115003	Sporisorium reilianum	27.46	2.00e-41	161.00
IUUC-Ssc-116148	Sus scrofa	29.37	2.00e-44	171.00
IUUC-Tgu-117299	Taeniopygia guttata	29.37	4.00e-44	169.00
IUUC-Tru-118179	Takifugu rubripes	28.81	8.00e-46	175.00
IUUC-Tsy-119493	Tarsius syrichta	29.84	2.00e-43	167.00
IUUC-Tni-120288	Tetraodon nigroviridis	29.04	3.00e-44	170.00
IUUC-Tre-121977	Trichoderma reesei	27.58	4.00e-41	160.00
IUUC-Tvi-122661	Trichoderma virens	28.08	6.00e-43	166.00
IUUC-Tme-127031	Tuber melanosporum	29.14	2.00e-44	171.00
IUUC-Ttr-128929	Tursiops truncatus	29.37	2.00e-44	171.00
IUUC-Uma-129347	Ustilago maydis	27.83	2.00e-42	164.00
IUUC-Vda-129837	Verticillium dahliae	29.75	5.00e-43	166.00
IUUC-Vpa-130532	Vicugna pacos	28.87	3.00e-27	113.00
IUUC-Xtr-131985	Xenopus tropicalis	30.30	1.00e-46	178.00
IUUC-Xma-133469	Xiphophorus maculatus	29.04	1.00e-45	174.00
IUUC-Yli-134403	Yarrowia lipolytica	29.44	2.00e-43	167.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence