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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046596
UUCD1 version UUC-HoS-00331
Ensembl Protein ID ENSP00000361596.4
UniProt Accession Q9BR09; Q3KR34; NEUL2_HUMAN
Genbank Protein ID BAB70810.1; CAC82498.1; AAH74737.1; AAI05936.1; AAI07486.1
Protein Name Neuralized-like protein 2
Genbank Nucleotide ID AK054821; AJ295985; AL008726; BC105935; BC107485
Gene Name NEURL2; C20orf163
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000124257.6 ENST00000545238.1 ENSP00000442383.1
ENSG00000124257.6 ENST00000372518.4 ENSP00000361596.4
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPA
DNA & RNA Element
UTRdbmiRTarBasemicroRNATRANSFAC
TargetScanRepTarmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexInWeb_IM
Disease-associated Information
OMIM
Protein Expression/Proteomics
THPAGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box SOCS 14960280
Classification
Family E-value Score Start End
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box 5.80e-13 50.2 243 285
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box
   S: 6    llrseprSLqhLCRlaIrrclgsqrlkaidkLPLPksLkdYLlye 50
           +l+   +SLq+LCRl+I+r++ ++    id+L+LPk+Lkd+++ye
   Q: 243  QLEYGLPSLQTLCRLVIQRSMVHRLA--IDGLHLPKELKDFCKYE 285
           5566689****************888..****************8 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Plays an important role in the process of myofiber differentiation and maturation. Probable substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex, which mediates the ubiquitination of proteins. Probably contributes to catalysis through recognition and positioning of the substrate and the ubiquitin-conjugating enzyme. During myogenesis, controls the ubiquitination and degradation of the specific pool of CTNNB1/beta-catenin located at the sarcolemma (By similarity).
 Plays an important role in the process of myofiber differentiation and maturation. Probable substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex, which mediates the ubiquitination of proteins. Probably contributes to catalysis through recognition and positioning of the substrate and the ubiquitin-conjugating enzyme. During myogenesis, controls the ubiquitination and degradation of the specific pool of CTNNB1/beta-catenin located at the sarcolemma (By similarity).
Protein Sequence
(Fasta)
MAAASEPVDS GALWGLERPE PPPTRFHRVH GANIRVDPSG TRATRVESFA HGVCFSREPL 60
APGQVFLVEI EEKELGWCGH LRLGLTALDP ASLAPVPEFS LPDLVNLGHT WVFAITRHHN 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046596|E3,SOCS|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CTTCCTCCCG CCCCTTCTTT GGTCCCTACG GACCTGGGGG GCGGTGGCGG TCAATGCCGG 60
GTCAAGGTCC GCGGGCCTCG CAGATCGTAG CCCGGGCGCA CGCGATCAGA TGATCCTGTT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046596|E3,SOCS|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway
Interpro

IPR006573--NHR_dom
IPR001496--SOCS_box
PROSITE

PS51065--NHR
PS50225--SOCS
Pfam

PF07177--Neuralized
PF07525--SOCS_box
SMART

SM00588--NEUZ
SM00969--SOCS_box
Gene Ontology

GO:0005737--C:cytoplasm
GO:0035556--P:intracellular signal transduction
GO:0016567--P:protein ubiquitination
KEGG hsa:140825
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001561 Ailuropoda melanoleuca 93.33 3.00e-154 537.00
IUUC-Aca-004460 Anolis carolinensis 74.34 3.00e-113 401.00
IUUC-Ame-011381 Astyanax mexicanus 62.69 3.00e-101 361.00
IUUC-Bta-012486 Bos taurus 93.68 1.00e-144 505.00
IUUC-Bci-013952 Botrytis cinerea 37.10 1.50e-01 31.20
IUUC-Cja-019245 Callithrix jacchus 93.03 3.00e-146 510.00
IUUC-Cfa-020571 Canis familiaris 93.33 3.00e-146 511.00
IUUC-Cpo-021996 Cavia porcellus 91.58 4.00e-143 500.00
IUUC-Csa-023472 Chlorocebus sabaeus 98.25 2.00e-148 518.00
IUUC-Cin-025368 Ciona intestinalis 35.61 4.00e-40 158.00
IUUC-Dre-028609 Danio rerio 63.02 4.00e-101 360.00
IUUC-Dno-029871 Dasypus novemcinctus 90.07 1.00e-129 455.00
IUUC-Dor-030463 Dipodomys ordii 84.91 1.00e-131 462.00
IUUC-Dme-031873 Drosophila melanogaster 37.74 4.00e-40 158.00
IUUC-Ete-032706 Echinops telfairi 88.42 2.00e-132 464.00
IUUC-Eca-034103 Equus caballus 92.25 6.00e-151 526.00
IUUC-Eeu-034855 Erinaceus europaeus 89.86 3.00e-141 494.00
IUUC-Fca-035442 Felis catus 93.68 7.00e-147 512.00
IUUC-Fal-036651 Ficedula albicollis 73.56 3.00e-110 390.00
IUUC-Gmo-038504 Gadus morhua 67.33 7.00e-34 137.00
IUUC-Gga-040928 Gallus gallus 74.16 2.00e-109 388.00
IUUC-Gac-041997 Gasterosteus aculeatus 60.70 3.00e-103 368.00
IUUC-Ggo-045554 Gorilla gorilla 98.95 4.00e-153 533.00
IUUC-Itr-048452 Ictidomys tridecemlineatus 91.29 1.00e-145 508.00
IUUC-Lch-050327 Latimeria chalumnae 68.18 7.00e-112 396.00
IUUC-Loc-052546 Lepisosteus oculatus 68.46 6.00e-102 363.00
IUUC-Laf-054489 Loxodonta africana 89.82 5.00e-140 490.00
IUUC-Meu-056619 Macropus eugenii 87.05 3.00e-104 370.00
IUUC-Mga-059826 Meleagris gallopavo 79.86 6.00e-62 229.00
IUUC-Mdo-062712 Monodelphis domestica 84.91 1.00e-134 471.00
IUUC-Mmu-064190 Mus musculus 90.53 5.00e-142 496.00
IUUC-Mpu-066287 Mustela putorius furo 92.98 3.00e-152 530.00
IUUC-Mlu-067381 Myotis lucifugus 93.33 2.00e-154 537.00
IUUC-Nle-069071 Nomascus leucogenys 97.89 5.00e-149 520.00
IUUC-Opr-071179 Ochotona princeps 92.31 8.00e-143 499.00
IUUC-Ont-072451 Oreochromis niloticus 63.12 2.00e-100 358.00
IUUC-Ocu-074047 Oryctolagus cuniculus 90.85 3.00e-145 507.00
IUUC-Ola-086786 Oryzias latipes 61.03 2.00e-93 335.00
IUUC-Oga-088222 Otolemur garnettii 89.82 9.00e-148 515.00
IUUC-Oar-089209 Ovis aries 90.88 5.00e-142 496.00
IUUC-Ptr-091394 Pan troglodytes 99.65 3.00e-152 530.00
IUUC-Pan-092410 Papio anubis 98.25 9.00e-149 519.00
IUUC-Psi-093087 Pelodiscus sinensis 80.00 8.00e-67 245.00
IUUC-Pma-094206 Petromyzon marinus 43.61 2.00e-59 221.00
IUUC-Pfo-096952 Poecilia formosa 61.51 2.00e-93 335.00
IUUC-Pab-097547 Pongo abelii 98.60 3.00e-151 527.00
IUUC-Pca-100811 Procavia capensis 89.82 8.00e-147 512.00
IUUC-Pva-102203 Pteropus vampyrus 91.93 3.00e-142 497.00
IUUC-Rno-105117 Rattus norvegicus 90.18 2.00e-146 511.00
IUUC-Sha-106495 Sarcophilus harrisii 86.69 1.00e-126 446.00
IUUC-Ssc-115387 Sus scrofa 92.28 4.00e-151 526.00
IUUC-Tgu-117336 Taeniopygia guttata 73.08 2.00e-107 382.00
IUUC-Tru-117643 Takifugu rubripes 60.89 2.00e-101 362.00
IUUC-Tni-119965 Tetraodon nigroviridis 63.46 1.00e-102 365.00
IUUC-Tbe-127810 Tupaia belangeri 93.68 6.00e-144 503.00
IUUC-Ttr-128525 Tursiops truncatus 93.33 2.00e-144 504.00
IUUC-Vpa-130813 Vicugna pacos 95.93 8.00e-109 385.00
IUUC-Xtr-132387 Xenopus tropicalis 67.42 1.00e-106 379.00
Created Date 25-Jun-2017

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