iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Xma-134195

Ensembl Protein ID

ENSXMAP00000007337.1

UniProt Accession

M3ZYP3; M3ZYP3_XIPMA

Genbank Protein ID

ENSXMAP00000007337

Protein Name

Ubiquitin carboxyl-terminal hydrolase 16; Deubiquitinating enzyme 16; Ubiquitin thioesterase 16; Ubiquitin-specific-processing protease 16

Genbank Nucleotide ID

AGAJ01003691

Gene Name

usp16; USP16

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSXMAG00000007314.1	ENSXMAT00000007345.1	ENSXMAP00000007337.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	6.20e-82	275.5	218	835

Active Site

Position(s)	Description	Evidence
227	Nucleophile	ECO:0000256\|HAMAP-Rule:MF_03062}
777	Proton acceptor	ECO:0000256\|HAMAP-Rule:MF_03062}

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenp.............kepkgellkslqklfeelwkskkkavsprellka 76
           +Gl+NlgNtC++N+vLQ Ls+++ lr+ l++ ++ek++ + +              ++ g+l+ ++ kl++e+++sk+++v+prel+++
   Q: 218  KGLSNLGNTCFFNAVLQNLSQTQLLRQILNKVTEEKMSLDIKpdaslnlepilvqLDQPGSLTLAMCKLLNEIQESKRGVVTPRELFTQ 306
           5******************************66666655544557777777888888888***************************** PP
   S: 77   lkkeaeefsgyeqqDaqEflaflldqleeelkk.......eknkpkeeeeeedkselsde......aeekkkkknkslisdlFqgqlks 152
           ++k+a +f+g++qqD+qE+l++lld+++ e  k       e       + +++++ +++e      +e++k+   k+++++lF+g+++s
   Q: 307  VCKKAARFKGFQQQDSQELLRYLLDGMRAEELKrvsmgitE-------SLKQSSKVTDEEkikaavKEYEKNGVPKNFVDQLFGGEMTS 388
           ***************************97764524444332.......2222222222223455557889999999************* PP
   S: 153  qikclecdnvssreepfldlslpvpgkeetkke........................................................ 185
           +i+c+ec++vs+ +e fldlslpv+++  +kk+                                                        
   Q: 389  TIMCQECKTVSVVTEMFLDLSLPVSDEAYRKKNpkkvfprtsessqderngsdlisrnddsttgasskyqqkkakkqakkqakhqkrqh 477
           ****************************998889******************************************************* PP
   S: 186  ......................................................................................... 185
                                                                                                    
   Q: 478  kletritlgnstfpsnaegdqidvtkdaedtentdhmpheedslnehdpkpvceseqdqnveqeneddkdsptddgslaessvsnrftv 566
           ***************************************************************************************** PP
   S: 186  ......................................................................................slq 188
                                                                                                 s+q
   Q: 567  lseeqhshdsascnktpntdlegeldtqlanqleqvtlndafiedlesmdpavesedeveytiinqdpefafntlstrtspekqecSVQ 655
           ***************************************************************************************** PP
   S: 189  dcLesftkeeelegenkyycekckkkqe...............aekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdls 262
           +cL +ft+ e+l+++n + c +c+k+ +               a k++ +++ P vL+lh+kRf  +++++s  k+n++v+fpl Ldl+
   Q: 656  SCLFQFTEVETLTQNNSLLCVSCTKRHKkgektggskkniytdALKQMLISSPPSVLTLHMKRF--QQNGYSICKVNRHVQFPLILDLA 742
           ************************9888999999999999999*********************..88889999*************** PP
   S: 263  pfctspeekqke...kkkYeLiavvvHsGslssGHYvayvkn..................ekgkWllfdDskVtevkeeevleetgsta 330
           p+c+ ++++  e   +  Y+L++vv HsG+++sGHY+ayvk                    +g+W++++D++V++v+e++v++   ++a
   Q: 743  PYCAAKCKNIYEggtQILYSLYGVVEHSGTMRSGHYTAYVKArpdslksssngkqgdtdlPRGSWFHISDTSVQPVSESKVQS---CQA 828
           *****999887788899*************************9999999988877766666777*******************...*** PP
   S: 331  YvlfYkr 337
           Y+lfY+r
   Q: 829  YLLFYER 835
           *****98 PP

Organism

Xiphophorus maculatus

Functional Description
(View)

Specifically deubiquitinates 'Lys-120' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A is a prerequisite for subsequent phosphorylation at 'Ser-11' of histone H3 (H3S10ph), and is required for chromosome segregation when cells enter into mitosis. Regulates Hox gene expression via histone H2A deubiquitination. Prefers nucleosomal substrates. Does not deubiquitinate histone H2B.

Protein Sequence
(Fasta)

MGKKRGKDRS FREDEDVEFT GPSCRHIRKG TDQTLIKKLS AVSDWTRCQE CKHEDNKENI 60
STTKSEESEE ETVPLWMCLK CGHRGCGRDS ENQHAIKHYE TPRSDPHCLV VGLDNWSVWC 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTGTATGCGT TCCTCAGTAA AAAATGCCAC TCACAATATG GGGGGCGTCA TTCACGTACG 60
ATCCCGGAAG TTCATGTGGT GGTTCGTGTG GTTTCTATAA CACACATCAC ATTTTTGTTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0010--Activator
KW-0131--Cell cycle
KW-0132--Cell division
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0498--Mitosis
KW-0539--Nucleus
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR030849--UBP16
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00443--UCH
PF02148--zf-UBP

SMART

SM00290--ZnF_UBP

Gene Ontology

GO:0005634--C:nucleus
GO:0004197--F:cysteine-type endopeptidase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0003713--F:transcription coactivator activity
GO:0008270--F:zinc ion binding
GO:0051301--P:cell division
GO:0016578--P:histone deubiquitination
GO:0007067--P:mitotic nuclear division
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0051289--P:protein homotetramerization
GO:0051726--P:regulation of cell cycle
GO:0006351--P:transcription, DNA-templated
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

xma:102229313

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000997	Aegilops tauschii	35.86	2.00e-25	112.00
IUUC-Aml-001931	Ailuropoda melanoleuca	52.37	9.00e-113	401.00
IUUC-Atr-003015	Amborella trichopoda	28.20	1.00e-34	142.00
IUUC-Apl-004145	Anas platyrhynchos	54.36	8.00e-109	388.00
IUUC-Aca-004314	Anolis carolinensis	43.92	5.00e-175	608.00
IUUC-Ame-011659	Astyanax mexicanus	55.92	8.00e-135	474.00
IUUC-Bta-013362	Bos taurus	46.01	0.00e+00	629.00
IUUC-Bdi-014624	Brachypodium distachyon	37.82	8.00e-25	109.00
IUUC-Bol-015853	Brassica oleracea	40.97	5.00e-25	110.00
IUUC-Cja-019177	Callithrix jacchus	44.86	0.00e+00	632.00
IUUC-Cfa-020051	Canis familiaris	52.73	5.00e-112	399.00
IUUC-Cpo-021886	Cavia porcellus	44.47	8.00e-178	617.00
IUUC-Csa-024103	Chlorocebus sabaeus	44.68	0.00e+00	630.00
IUUC-Cho-024315	Choloepus hoffmanni	47.17	3.00e-47	183.00
IUUC-Cin-025775	Ciona intestinalis	43.97	5.00e-35	139.00
IUUC-Csv-026075	Ciona savignyi	46.04	9.00e-48	184.00
IUUC-Dre-028388	Danio rerio	55.57	0.00e+00	809.00
IUUC-Dno-029409	Dasypus novemcinctus	46.89	0.00e+00	635.00
IUUC-Dor-030443	Dipodomys ordii	46.48	1.00e-82	301.00
IUUC-Ete-032807	Echinops telfairi	46.00	8.00e-92	331.00
IUUC-Eca-033479	Equus caballus	44.91	0.00e+00	636.00
IUUC-Eeu-034835	Erinaceus europaeus	57.53	4.00e-68	253.00
IUUC-Fca-036320	Felis catus	44.37	0.00e+00	634.00
IUUC-Fal-037029	Ficedula albicollis	47.53	4.00e-106	379.00
IUUC-Gmo-039480	Gadus morhua	60.45	3.00e-149	522.00
IUUC-Gga-040527	Gallus gallus	51.42	1.00e-110	394.00
IUUC-Gac-042343	Gasterosteus aculeatus	66.31	0.00e+00	1038.00
IUUC-Gma-044402	Glycine max	28.57	6.00e-32	132.00
IUUC-Ggo-045598	Gorilla gorilla	44.62	1.00e-179	623.00
IUUC-Hsa-046598	Homo sapiens	44.95	0.00e+00	627.00
IUUC-Hvu-047146	Hordeum vulgare	36.82	1.00e-25	112.00
IUUC-Itr-047951	Ictidomys tridecemlineatus	45.42	0.00e+00	634.00
IUUC-Lch-050536	Latimeria chalumnae	50.59	8.00e-107	381.00
IUUC-Lpe-050703	Leersia perrieri	36.22	4.00e-25	110.00
IUUC-Loc-051814	Lepisosteus oculatus	61.34	4.00e-147	515.00
IUUC-Laf-053732	Loxodonta africana	43.45	3.00e-179	622.00
IUUC-Mcc-054661	Macaca mulatta	44.73	0.00e+00	629.00
IUUC-Meu-055967	Macropus eugenii	49.64	9.00e-98	351.00
IUUC-Mtr-057945	Medicago truncatula	31.21	7.00e-32	133.00
IUUC-Mga-059551	Meleagris gallopavo	53.44	2.00e-114	407.00
IUUC-Mmr-061747	Microcebus murinus	45.96	5.00e-180	624.00
IUUC-Mdo-062220	Monodelphis domestica	52.64	8.00e-116	411.00
IUUC-Mmu-063582	Mus musculus	45.64	3.00e-170	592.00
IUUC-Mac-064941	Musa acuminata	39.20	4.00e-31	129.00
IUUC-Mpu-066339	Mustela putorius furo	45.15	0.00e+00	629.00
IUUC-Mlu-067511	Myotis lucifugus	50.12	1.00e-110	394.00
IUUC-Nle-069252	Nomascus leucogenys	44.56	0.00e+00	629.00
IUUC-Opr-070969	Ochotona princeps	46.55	4.00e-178	618.00
IUUC-Ont-071786	Oreochromis niloticus	70.08	0.00e+00	1049.00
IUUC-Ocu-074704	Oryctolagus cuniculus	45.25	4.00e-179	622.00
IUUC-Oba-075094	Oryza barthii	34.83	1.00e-24	108.00
IUUC-Obr-076743	Oryza brachyantha	34.69	1.00e-25	112.00
IUUC-Ogl-077739	Oryza glaberrima	34.83	9.00e-25	109.00
IUUC-Ogu-078851	Oryza glumaepatula	34.33	7.00e-25	109.00
IUUC-Oin-079402	Oryza indica	34.33	6.00e-25	109.00
IUUC-Olo-080431	Oryza longistaminata	34.33	6.00e-25	109.00
IUUC-Ome-081580	Oryza meridionalis	34.33	8.00e-25	109.00
IUUC-Oni-082644	Oryza nivara	34.33	6.00e-25	109.00
IUUC-Opu-083452	Oryza punctata	34.83	4.00e-25	110.00
IUUC-Oru-084546	Oryza rufipogon	34.33	7.00e-25	109.00
IUUC-Osa-085858	Oryza sativa	34.33	6.00e-25	109.00
IUUC-Ola-086795	Oryzias latipes	63.70	0.00e+00	942.00
IUUC-Oga-088713	Otolemur garnettii	44.02	8.00e-177	614.00
IUUC-Oar-089887	Ovis aries	45.90	0.00e+00	630.00
IUUC-Ptr-091670	Pan troglodytes	44.62	2.00e-180	625.00
IUUC-Pan-092293	Papio anubis	44.73	0.00e+00	629.00
IUUC-Psi-093101	Pelodiscus sinensis	50.00	8.00e-108	384.00
IUUC-Ppa-095584	Physcomitrella patens	29.91	3.00e-37	150.00
IUUC-Pfo-097202	Poecilia formosa	91.76	0.00e+00	1513.00
IUUC-Pop-099136	Populus trichocarpa	28.92	9.00e-36	145.00
IUUC-Pca-101069	Procavia capensis	50.57	1.00e-66	248.00
IUUC-Ppe-101794	Prunus persica	33.24	2.00e-36	147.00
IUUC-Rno-105237	Rattus norvegicus	45.60	4.00e-174	605.00
IUUC-Sha-106889	Sarcophilus harrisii	54.20	3.00e-114	405.00
IUUC-Sit-110283	Setaria italica	29.39	3.00e-25	110.00
IUUC-Sly-111491	Solanum lycopersicum	28.98	2.00e-33	137.00
IUUC-Stu-112820	Solanum tuberosum	30.38	1.00e-37	152.00
IUUC-Sar-113530	Sorex araneus	51.43	2.00e-112	400.00
IUUC-Sbi-113785	Sorghum bicolor	37.76	3.00e-22	101.00
IUUC-Ssc-116091	Sus scrofa	43.64	7.00e-180	624.00
IUUC-Tgu-117478	Taeniopygia guttata	49.16	4.00e-106	379.00
IUUC-Tru-118640	Takifugu rubripes	62.31	0.00e+00	942.00
IUUC-Tsy-119042	Tarsius syrichta	38.25	1.00e-103	370.00
IUUC-Tni-120015	Tetraodon nigroviridis	60.28	0.00e+00	916.00
IUUC-Tae-125785	Triticum aestivum	36.32	2.00e-24	108.00
IUUC-Tur-126788	Triticum urartu	36.32	2.00e-24	108.00
IUUC-Tbe-127309	Tupaia belangeri	43.77	2.00e-67	250.00
IUUC-Ttr-128271	Tursiops truncatus	44.26	4.00e-179	622.00
IUUC-Vpa-130674	Vicugna pacos	43.79	5.00e-166	578.00
IUUC-Xtr-131869	Xenopus tropicalis	49.23	7.00e-113	401.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence