iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
TargetScan	RepTar	SomamiR	miRcode
RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	Mentha
InWeb_IM
Protein 3D Structure
PDB	MMDB	SCOP
Disease-associated Information
GWASdb	GWAS Central	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosSNP	PhosphositePlus
dbPTM	HPRD	Phospho.ELM	UniProt
BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
DUB/JAMM	JAMM	19615732

Organism

Homo sapiens

Functional Description
(View)

Metalloprotease that specifically deubiquitinates monoubiquitinated histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Preferentially deubiquitinates monoubiquitinated H2A in hyperacetylated nucleosomes. Deubiquitination of histone H2A leads to facilitate the phosphorylation and dissociation of histone H1 from the nucleosome. Acts as a coactivator by participating in the initiation and elongation steps of androgen receptor (AR)-induced gene activation.

Protein Sequence
(Fasta)

MAAEEADVDI EGDVVAAAGA QPGSGENTAS VLQKDHYLDS SWRTENGLIP WTLDNTISEE 60
NRAVIEKMLL EEEYYLSKKS QPEKVWLDQK EDDKKYMKSL QKTAKIMVHS PTKPASYSVK 120

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Nucleotide Sequence
(Fasta)

GCGGGATCTC TCGGGAGGAC GGACGGGGTC AGGTCCCATC ATGGCGGCTG AAGAGGCGGA 60
TGTGGATATC GAAGGGGACG TGGTAGCGGC GGCGGGGGCA CAGCCAGGGT GAGGCTTAGA 120

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Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0010--Activator
KW-0025--Alternative splicing
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0238--DNA-binding
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0482--Metalloprotease
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-0645--Protease
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc

Interpro

IPR009057--Homeobox-like
IPR000555--JAMM/MPN+_dom
IPR033497--MYSM1
IPR001005--SANT/Myb
IPR017884--SANT_dom
IPR007526--SWIRM
IPR011991--WHTH_DNA-bd_dom

PROSITE

PS51293--SANT
PS50934--SWIRM

Pfam

PF01398--JAB
PF00249--Myb_DNA-binding
PF04433--SWIRM

SMART

SM00232--JAB_MPN
SM00717--SANT

Gene Ontology

GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0003677--F:DNA binding
GO:0042393--F:histone binding
GO:0046872--F:metal ion binding
GO:0008237--F:metallopeptidase activity
GO:0032403--F:protein complex binding
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0003713--F:transcription coactivator activity
GO:0006338--P:chromatin remodeling
GO:0035522--P:monoubiquitinated histone H2A deubiquitination
GO:0043473--P:pigmentation
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0016579--P:protein deubiquitination
GO:0030334--P:regulation of cell migration
GO:0051797--P:regulation of hair follicle development
GO:0006351--P:transcription, DNA-templated

KEGG

hsa:114803

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001270	Ailuropoda melanoleuca	88.75	0.00e+00	1442.00
IUUC-Apl-003363	Anas platyrhynchos	73.29	0.00e+00	1043.00
IUUC-Aca-005139	Anolis carolinensis	68.28	0.00e+00	1079.00
IUUC-Aly-005879	Arabidopsis lyrata	44.00	2.00e-07	49.70
IUUC-Ath-006818	Arabidopsis thaliana	44.00	3.00e-07	49.70
IUUC-Ame-011693	Astyanax mexicanus	55.22	0.00e+00	694.00
IUUC-Bta-013079	Bos taurus	86.83	0.00e+00	1354.00
IUUC-Bol-015375	Brassica oleracea	46.00	2.00e-08	53.10
IUUC-Bra-017353	Brassica rapa	44.00	2.00e-07	49.70
IUUC-Cja-019242	Callithrix jacchus	95.77	0.00e+00	1533.00
IUUC-Cfa-020562	Canis familiaris	87.27	0.00e+00	1358.00
IUUC-Cpo-021656	Cavia porcellus	80.48	0.00e+00	1241.00
IUUC-Cre-022774	Chlamydomonas reinhardtii	38.00	5.00e-15	75.50
IUUC-Csa-023482	Chlorocebus sabaeus	97.35	0.00e+00	1537.00
IUUC-Cho-024724	Choloepus hoffmanni	69.45	4.00e-87	316.00
IUUC-Cme-027237	Cyanidioschyzon merolae	40.49	2.00e-31	130.00
IUUC-Dre-028234	Danio rerio	69.14	7.00e-177	614.00
IUUC-Dno-029985	Dasypus novemcinctus	80.49	0.00e+00	1172.00
IUUC-Dor-030957	Dipodomys ordii	76.75	0.00e+00	1127.00
IUUC-Ete-032831	Echinops telfairi	75.30	0.00e+00	1140.00
IUUC-Eca-033285	Equus caballus	85.27	0.00e+00	1362.00
IUUC-Eeu-035164	Erinaceus europaeus	68.86	0.00e+00	981.00
IUUC-Fca-036480	Felis catus	85.68	0.00e+00	1316.00
IUUC-Fal-037081	Ficedula albicollis	69.60	0.00e+00	1003.00
IUUC-Gmo-039445	Gadus morhua	62.36	5.00e-164	571.00
IUUC-Gga-040639	Gallus gallus	73.08	0.00e+00	1078.00
IUUC-Gac-042370	Gasterosteus aculeatus	65.55	7.00e-155	541.00
IUUC-Gma-043648	Glycine max	44.00	2.00e-07	50.10
IUUC-Ggo-044894	Gorilla gorilla	99.28	0.00e+00	1584.00
IUUC-Itr-047908	Ictidomys tridecemlineatus	88.43	0.00e+00	1202.00
IUUC-Lch-049854	Latimeria chalumnae	61.04	0.00e+00	895.00
IUUC-Loc-052310	Lepisosteus oculatus	72.21	0.00e+00	650.00
IUUC-Laf-053369	Loxodonta africana	87.11	0.00e+00	1379.00
IUUC-Mcc-055385	Macaca mulatta	97.10	0.00e+00	1539.00
IUUC-Meu-056008	Macropus eugenii	61.56	0.00e+00	889.00
IUUC-Mga-059526	Meleagris gallopavo	68.81	0.00e+00	972.00
IUUC-Mmr-060949	Microcebus murinus	91.70	0.00e+00	1461.00
IUUC-Mdo-061821	Monodelphis domestica	72.60	0.00e+00	1160.00
IUUC-Mmu-064166	Mus musculus	79.14	0.00e+00	1241.00
IUUC-Mpu-065701	Mustela putorius furo	87.19	0.00e+00	1409.00
IUUC-Mlu-067089	Myotis lucifugus	87.26	0.00e+00	1412.00
IUUC-Nle-069917	Nomascus leucogenys	98.67	0.00e+00	1579.00
IUUC-Opr-070449	Ochotona princeps	75.63	0.00e+00	831.00
IUUC-Ont-071468	Oreochromis niloticus	66.51	2.00e-159	556.00
IUUC-Ocu-073867	Oryctolagus cuniculus	84.80	0.00e+00	798.00
IUUC-Ola-087430	Oryzias latipes	48.78	0.00e+00	635.00
IUUC-Olu-087581	Ostreococcus lucimarinus	40.13	7.00e-31	128.00
IUUC-Oga-088967	Otolemur garnettii	89.89	0.00e+00	1379.00
IUUC-Oar-089773	Ovis aries	86.11	0.00e+00	1338.00
IUUC-Ptr-091260	Pan troglodytes	99.52	0.00e+00	1591.00
IUUC-Pan-092564	Papio anubis	96.86	0.00e+00	1533.00
IUUC-Psi-094097	Pelodiscus sinensis	74.29	0.00e+00	1005.00
IUUC-Pma-094538	Petromyzon marinus	65.00	6.00e-38	151.00
IUUC-Pfo-097392	Poecilia formosa	64.37	2.00e-172	600.00
IUUC-Pab-098496	Pongo abelii	98.43	0.00e+00	1572.00
IUUC-Pop-099207	Populus trichocarpa	37.88	2.00e-08	53.10
IUUC-Pca-100438	Procavia capensis	56.70	2.00e-156	546.00
IUUC-Ppe-101933	Prunus persica	44.00	5.00e-08	51.20
IUUC-Pva-103082	Pteropus vampyrus	87.19	0.00e+00	1392.00
IUUC-Rno-105976	Rattus norvegicus	78.15	0.00e+00	1203.00
IUUC-Sha-106498	Sarcophilus harrisii	68.25	0.00e+00	1016.00
IUUC-Sly-111876	Solanum lycopersicum	32.50	8.00e-08	51.20
IUUC-Stu-112613	Solanum tuberosum	44.00	1.00e-07	50.40
IUUC-Sar-113274	Sorex araneus	77.99	0.00e+00	1183.00
IUUC-Sre-115088	Sporisorium reilianum	32.67	2.00e-08	55.50
IUUC-Ssc-115653	Sus scrofa	85.42	0.00e+00	1364.00
IUUC-Tgu-117140	Taeniopygia guttata	70.26	0.00e+00	1012.00
IUUC-Tru-117818	Takifugu rubripes	65.01	2.00e-152	533.00
IUUC-Tsy-118897	Tarsius syrichta	86.97	0.00e+00	1314.00
IUUC-Tni-119769	Tetraodon nigroviridis	51.59	0.00e+00	691.00
IUUC-Tbe-127944	Tupaia belangeri	95.10	0.00e+00	808.00
IUUC-Ttr-129252	Tursiops truncatus	94.07	0.00e+00	770.00
IUUC-Vpa-130289	Vicugna pacos	87.39	0.00e+00	1328.00
IUUC-Vvi-131499	Vitis vinifera	40.00	9.00e-08	51.20
IUUC-Xtr-131964	Xenopus tropicalis	56.39	0.00e+00	824.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence