iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	microRNA	TRANSFAC
TargetScan	RepTar	miRcode	RAID2
Protein-protein Interaction
IID	InWeb_IM
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus
DNA Methylation
MethyCancer	TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	1.00e-08	37.2	16	57

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadCl.qkwpglknssskefrCPlCr 46
           C+iCle +kd p++ +CgH f+++Cl   w    +    +f CP+Cr
   Q: 16   CPICLEYLKD-PVTINCGHNFCRSCLsVSW----KDLDDTFPCPVCR 57
           **********.999************999*....8899********8 PP

Organism

Homo sapiens

Protein Sequence
(Fasta)

MEFVTALVNL QEESSCPICL EYLKDPVTIN CGHNFCRSCL SVSWKDLDDT FPCPVCRFCF 60
PYKSFRRNPQ LRNLTEIAKQ LQIRRSKRKR QKENAMCEKH NQFLTLFCVK DLEILCTQCS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ACTTCCGGTG GAGCAGCCAA CCACCGCGCT GGTCAATTGT ATGCCTAAAA CTCGAAAACC 60
AAGGCGCCCA GGGTTGTGTG AGGGTTTCCG CTCTGCGCCC CGCGGGGTTC CATGGGTCCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001870--B30.2/SPRY
IPR003879--Butyrophylin
IPR013320--ConA-like_dom
IPR006574--PRY
IPR003877--SPRY_dom
IPR000315--Znf_B-box
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50188--B302_SPRY
PS50119--ZF_BBOX
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF13765--PRY
PF00622--SPRY
PF00643--zf-B_box

PRINTS

PR01407--BUTYPHLNCDUF

SMART

SM00336--BBOX
SM00589--PRY
SM00184--RING
SM00449--SPRY

Gene Ontology

GO:0005622--C:intracellular
GO:0008270--F:zinc ion binding

KEGG

hsa:166655

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002232	Ailuropoda melanoleuca	74.51	0.00e+00	712.00
IUUC-Cja-019789	Callithrix jacchus	90.00	0.00e+00	881.00
IUUC-Cpo-021902	Cavia porcellus	58.82	1.00e-149	523.00
IUUC-Csa-023531	Chlorocebus sabaeus	93.84	0.00e+00	924.00
IUUC-Dno-028914	Dasypus novemcinctus	48.28	1.00e-127	449.00
IUUC-Eca-034104	Equus caballus	63.85	3.00e-170	591.00
IUUC-Fca-036334	Felis catus	76.01	0.00e+00	757.00
IUUC-Ggo-045579	Gorilla gorilla	98.09	0.00e+00	959.00
IUUC-Itr-048645	Ictidomys tridecemlineatus	69.98	0.00e+00	693.00
IUUC-Laf-054199	Loxodonta africana	49.26	1.00e-120	426.00
IUUC-Mcc-055021	Macaca mulatta	93.84	0.00e+00	922.00
IUUC-Mmr-061504	Microcebus murinus	78.34	0.00e+00	779.00
IUUC-Mmu-063283	Mus musculus	53.38	1.00e-138	486.00
IUUC-Mpu-066667	Mustela putorius furo	74.30	0.00e+00	718.00
IUUC-Mlu-068022	Myotis lucifugus	44.59	1.00e-116	413.00
IUUC-Nle-069929	Nomascus leucogenys	46.45	3.00e-117	415.00
IUUC-Ocu-073791	Oryctolagus cuniculus	73.05	0.00e+00	626.00
IUUC-Oga-088888	Otolemur garnettii	78.98	0.00e+00	788.00
IUUC-Ptr-091466	Pan troglodytes	97.66	0.00e+00	955.00
IUUC-Pan-091784	Papio anubis	93.40	0.00e+00	920.00
IUUC-Pab-097844	Pongo abelii	46.24	7.00e-115	407.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence