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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Hsa-046535
UUCD1 version UUC-HoS-00771
Ensembl Protein ID ENSP00000311899.2
UniProt Accession Q8N136; Q6ZRY1; Q8N776; DAW1_HUMAN
Genbank Protein ID BAC05039.1; BAC05425.1; BAC87175.1; AAX93215.1; AAH36377.1
Protein Name Dynein assembly factor with WDR repeat domains 1; Outer row dynein assembly protein 16 homolog; WD repeat-containing protein 69
Genbank Nucleotide ID AK097409; AK098821; AK127882; AC073065; BC036377
Gene Name DAW1; WDR69
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000123977.9 ENST00000373666.6 ENSP00000362770.2
ENSG00000123977.9 ENST00000309931.2 ENSP00000311899.2
ENSG00000123977.9 ENST00000454999.5 ENSP00000403670.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsiteCircNetmicroRNA
TRANSFACTargetScanRepTarmiRcode
RAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Disease-associated Variation
GWASdbGWAS Central
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusdbPTMBioGRID
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 1.40e-60 200.1 132 171
UBD/Beta-Prp 9.90e-124 414.0 47 269
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 1    gHtdsvtclaf..sd.tllvsGsdDgtikvWDlrtgvllk 37
           gH + v+++af  +  + +++Gs D+t+k+W++ tg++ +
   Q: 132  GHRNVVYAIAFnnPYgDKIATGSFDKTCKLWSVETGKCYH 171
           8**********8755788*******************976 PP
   

   UBD/Beta-Prp
   S: 18   fspdksllatgsrdgtikvwdvttgkl...........lrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvl 98
            +++ + l+t+sr++ +k+   + + +           ++ l+ h  + t v ++++g+ ++tgs Drt k+wd  +g+ + tl+gh + v+
   Q: 47   EIQKAEPLLTASRTEQVKLLIQRLQEKlgqnsnhtfylFKVLKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVY 138
           46677778888888888887777666646666666666666677777799999999999999999999999999999999999999999999 PP
   S: 99   slsfsp.sgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvyslsfd 189
           +++f+  +gdk+++Gs d+t ++w +etg+c++ t++gh++ + c++++p++ l+++Gs D+t +lWd+++g+ ++tl+g h   + slsf+
   Q: 139  AIAFNNpYGDKIATGSFDKTCKLWSVETGKCYH-TFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLRG-HSAEIISLSFN 228
           999988899999999999999999999999999.9999999999999999999999999999999999999999999998.99999999999 PP
   S: 190  sngkelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrf 230
            +g ++++gs d tv +wd  tg+ v++l+gh + ++s  f
   Q: 229  TSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAEISSASF 269
           99999999999999999999999999999999988888776 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     May play a role in axonemal outer row dynein assembly.
 May play a role in axonemal outer row dynein assembly.
Protein Sequence
(Fasta)
MKLKSLLLRY YPPGIMLEYE KHGELKTKSI DLLDLGPSTD VSALVEEIQK AEPLLTASRT 60
EQVKLLIQRL QEKLGQNSNH TFYLFKVLKA HILPLTNVAL NKSGSCFITG SYDRTCKLWD 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046535|E3,WD_repeat;UBD,Beta-Prp|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
AGGCTTTCTG GTGTAGGTTC CGACGCACCT GCCTTCCATT CCCGCCTATC CATTTAGGCT 60
GCGACCTCTG GTAGTTCTCC ACTTTCTCTA ATTCTGAGTT ACTTCATCCT TAAGAAGTGG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046535|E3,WD_repeat;UBD,Beta-Prp|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0966--Cell projection
KW-0969--Cilium
KW-0181--Complete proteome
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat
Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF00400--WD40
PRINTS

PR00320--GPROTEINBRPT
SMART

SM00320--WD40
Gene Ontology

GO:0005929--C:cilium
GO:0005737--C:cytoplasm
GO:0007368--P:determination of left/right symmetry
GO:0007507--P:heart development
KEGG hsa:164781
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002244 Ailuropoda melanoleuca 92.77 0.00e+00 763.00
IUUC-Apl-003764 Anas platyrhynchos 77.80 0.00e+00 653.00
IUUC-Aca-005354 Anolis carolinensis 81.20 0.00e+00 716.00
IUUC-Afl-008745 Aspergillus flavus 34.85 3.00e-60 226.00
IUUC-Afu-008962 Aspergillus fumigatus 38.05 2.00e-61 230.00
IUUC-Aor-010048 Aspergillus oryzae 38.96 3.00e-62 232.00
IUUC-Ame-010648 Astyanax mexicanus 67.87 2.00e-172 598.00
IUUC-Bta-013294 Bos taurus 91.81 0.00e+00 786.00
IUUC-Bci-013681 Botrytis cinerea 36.09 8.00e-59 223.00
IUUC-Cja-018728 Callithrix jacchus 94.22 0.00e+00 817.00
IUUC-Cfa-021122 Canis familiaris 92.53 0.00e+00 808.00
IUUC-Cpo-021472 Cavia porcellus 86.57 0.00e+00 728.00
IUUC-Cre-022946 Chlamydomonas reinhardtii 42.04 8.00e-63 234.00
IUUC-Csa-023349 Chlorocebus sabaeus 97.83 0.00e+00 839.00
IUUC-Cho-024337 Choloepus hoffmanni 72.31 2.00e-158 551.00
IUUC-Cin-025447 Ciona intestinalis 67.71 0.00e+00 626.00
IUUC-Csv-026024 Ciona savignyi 67.47 7.00e-180 623.00
IUUC-Cgl-026771 Colletotrichum gloeosporioides 31.34 7.00e-50 193.00
IUUC-Dre-028787 Danio rerio 70.96 0.00e+00 645.00
IUUC-Dno-029788 Dasypus novemcinctus 84.82 0.00e+00 720.00
IUUC-Dor-030679 Dipodomys ordii 88.34 2.00e-84 306.00
IUUC-Dme-031913 Drosophila melanogaster 37.69 9.00e-89 320.00
IUUC-Ete-032844 Echinops telfairi 88.38 6.00e-104 370.00
IUUC-Eca-034088 Equus caballus 92.05 0.00e+00 796.00
IUUC-Eeu-034898 Erinaceus europaeus 79.01 3.00e-148 518.00
IUUC-Fca-036058 Felis catus 83.05 0.00e+00 670.00
IUUC-Fal-036638 Ficedula albicollis 78.64 2.00e-158 551.00
IUUC-Fox-037826 Fusarium oxysporum 36.57 3.00e-47 185.00
IUUC-Fso-038216 Fusarium solani 35.35 1.00e-54 208.00
IUUC-Gmo-039010 Gadus morhua 68.28 9.00e-151 526.00
IUUC-Ggr-039928 Gaeumannomyces graminis 37.58 1.00e-61 231.00
IUUC-Gga-040984 Gallus gallus 79.71 0.00e+00 697.00
IUUC-Gac-042552 Gasterosteus aculeatus 71.74 0.00e+00 640.00
IUUC-Ggo-044596 Gorilla gorilla 86.83 0.00e+00 708.00
IUUC-Itr-048672 Ictidomys tridecemlineatus 91.79 3.00e-146 510.00
IUUC-Lch-049902 Latimeria chalumnae 82.41 0.00e+00 727.00
IUUC-Loc-051919 Lepisosteus oculatus 82.17 0.00e+00 730.00
IUUC-Laf-053877 Loxodonta africana 89.88 0.00e+00 779.00
IUUC-Mcc-055010 Macaca mulatta 97.83 0.00e+00 839.00
IUUC-Meu-055980 Macropus eugenii 71.28 2.00e-157 548.00
IUUC-Mga-059883 Meleagris gallopavo 73.52 3.00e-180 624.00
IUUC-Mmr-061645 Microcebus murinus 93.61 0.00e+00 794.00
IUUC-Mdo-062166 Monodelphis domestica 88.81 0.00e+00 746.00
IUUC-Mmu-063653 Mus musculus 89.88 0.00e+00 782.00
IUUC-Mpu-066807 Mustela putorius furo 92.38 0.00e+00 790.00
IUUC-Mlu-067792 Myotis lucifugus 91.06 0.00e+00 784.00
IUUC-Nfi-068459 Neosartorya fischeri 34.35 2.00e-58 222.00
IUUC-Nle-069067 Nomascus leucogenys 96.87 0.00e+00 826.00
IUUC-Opr-070841 Ochotona princeps 76.73 6.00e-176 610.00
IUUC-Ont-072191 Oreochromis niloticus 72.95 0.00e+00 653.00
IUUC-Oan-073649 Ornithorhynchus anatinus 83.87 3.00e-105 374.00
IUUC-Ocu-074966 Oryctolagus cuniculus 78.28 0.00e+00 636.00
IUUC-Ola-087021 Oryzias latipes 60.38 5.00e-155 540.00
IUUC-Oga-088193 Otolemur garnettii 92.81 0.00e+00 795.00
IUUC-Oar-089207 Ovis aries 93.01 0.00e+00 805.00
IUUC-Ptr-091298 Pan troglodytes 99.52 0.00e+00 854.00
IUUC-Pan-092620 Papio anubis 97.67 0.00e+00 691.00
IUUC-Psi-093232 Pelodiscus sinensis 83.13 0.00e+00 726.00
IUUC-Ppa-095852 Physcomitrella patens 34.63 1.00e-52 201.00
IUUC-Pfo-096971 Poecilia formosa 71.26 0.00e+00 638.00
IUUC-Pab-098360 Pongo abelii 98.79 0.00e+00 845.00
IUUC-Pca-100384 Procavia capensis 86.27 0.00e+00 752.00
IUUC-Pva-102206 Pteropus vampyrus 90.10 0.00e+00 761.00
IUUC-Pyt-104470 Pyrenophora triticirepentis 36.70 2.00e-64 241.00
IUUC-Rno-105944 Rattus norvegicus 89.88 0.00e+00 781.00
IUUC-Sha-106970 Sarcophilus harrisii 88.81 0.00e+00 747.00
IUUC-Ssl-108470 Sclerotinia sclerotiorum 42.42 2.00e-77 284.00
IUUC-Smo-109147 Selaginella moellendorffii 34.97 2.00e-51 196.00
IUUC-Ssc-115618 Sus scrofa 90.14 0.00e+00 767.00
IUUC-Tgu-117237 Taeniopygia guttata 77.70 0.00e+00 660.00
IUUC-Tsy-119604 Tarsius syrichta 92.47 2.00e-76 279.00
IUUC-Tbe-127358 Tupaia belangeri 76.14 0.00e+00 631.00
IUUC-Ttr-129197 Tursiops truncatus 90.60 0.00e+00 780.00
IUUC-Vpa-130692 Vicugna pacos 85.54 0.00e+00 722.00
IUUC-Xtr-132612 Xenopus tropicalis 79.62 0.00e+00 708.00
Created Date 25-Jun-2017

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