iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ggo-044460

UUCD1 version

UUC-GoG-00491

Ensembl Protein ID

ENSGGOP00000016866.1

UniProt Accession

G3RM52; G3RM52_GORGO

Protein Name

Uncharacterized protein

Gene Name

VAV3

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSGGOG00000001895.2	ENSGGOT00000023725.1	ENSGGOP00000016866.1
ENSGGOG00000001895.2	ENSGGOT00000001908.2	ENSGGOP00000001867.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	4.50e-15	55.8	709	760

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 7    qvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvek 61
           ++ yd+ a +  eL+l kGdvv++   +   +gW++g  e +g+ G fP+ +ve+
   Q: 709  IARYDFCARDMRELSLLKGDVVKIY-TKMSANGWWRG--EVNGRVGWFPSTYVEE 760
           688*********************9.999999*****..9*************86 PP

Organism

Gorilla gorilla

Protein Sequence
(Fasta)

FWKKKSYIFR TTYLISIFLF SQVIETLSRL SRTPIALATG IRPFPTEESI NDEDIYKGLP 60
DLIDETLVED EEDLYDCVYG EDEGGEVYED LMKAEEAHQP KCPENDIRSC CLAEIKQTEE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTTTGGAAAA AGAAATCTTA TATTTTCCGA ACTACATATC TAATTAGTAT TTTCCTCTTT 60
TCTCAGGTTA TAGAAACATT ATCACGACTT TCTCGAACAC CTATAGCATT GGCCACAGGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0344--Guanine-nucleotide releasing factor
KW-0472--Membrane
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0727--SH2 domain
KW-0728--SH3 domain
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0862--Zinc

Interpro

IPR001715--CH-domain
IPR000219--DH-domain
IPR001331--GDS_CDC24_CS
IPR002219--PE/DAG-bd
IPR011993--PH_dom-like
IPR001849--PH_domain
IPR000980--SH2
IPR011511--SH3_2
IPR001452--SH3_domain

PROSITE

PS00741--DH_1
PS50010--DH_2
PS50003--PH_DOMAIN
PS50001--SH2
PS50002--SH3
PS00479--ZF_DAG_PE_1
PS50081--ZF_DAG_PE_2

Pfam

PF00130--C1_1
PF00169--PH
PF00621--RhoGEF
PF00017--SH2
PF07653--SH3_2

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN

SMART

SM00109--C1
SM00233--PH
SM00325--RhoGEF
SM00252--SH2
SM00326--SH3

Gene Ontology

GO:0005737--C:cytoplasm
GO:0070062--C:extracellular exosome
GO:0016021--C:integral component of membrane
GO:0005886--C:plasma membrane
GO:0030676--F:Rac guanyl-nucleotide exchange factor activity
GO:0050853--P:B cell receptor signaling pathway
GO:0006974--P:cellular response to DNA damage stimulus
GO:0007229--P:integrin-mediated signaling pathway
GO:0030032--P:lamellipodium assembly
GO:0030593--P:neutrophil chemotaxis
GO:0030890--P:positive regulation of B cell proliferation
GO:0045785--P:positive regulation of cell adhesion
GO:0043552--P:positive regulation of phosphatidylinositol 3-kinase activity
GO:0008361--P:regulation of cell size
GO:0035023--P:regulation of Rho protein signal transduction
GO:0042493--P:response to drug
GO:0007264--P:small GTPase mediated signal transduction
GO:0006906--P:vesicle fusion

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001362	Ailuropoda melanoleuca	94.23	0.00e+00	1390.00
IUUC-Apl-003734	Anas platyrhynchos	84.65	0.00e+00	1284.00
IUUC-Aca-004477	Anolis carolinensis	80.38	0.00e+00	1208.00
IUUC-Ame-011279	Astyanax mexicanus	62.30	0.00e+00	922.00
IUUC-Bta-012722	Bos taurus	93.57	0.00e+00	1379.00
IUUC-Cja-018941	Callithrix jacchus	96.85	0.00e+00	1429.00
IUUC-Cfa-020266	Canis familiaris	94.86	0.00e+00	1398.00
IUUC-Cpo-021966	Cavia porcellus	95.86	0.00e+00	1394.00
IUUC-Csa-023892	Chlorocebus sabaeus	96.59	0.00e+00	1429.00
IUUC-Dre-028199	Danio rerio	62.55	0.00e+00	926.00
IUUC-Dno-029474	Dasypus novemcinctus	94.23	0.00e+00	1390.00
IUUC-Eca-033961	Equus caballus	94.86	0.00e+00	1429.00
IUUC-Eeu-034719	Erinaceus europaeus	75.19	0.00e+00	785.00
IUUC-Fca-036572	Felis catus	93.96	0.00e+00	1384.00
IUUC-Fal-036802	Ficedula albicollis	82.41	0.00e+00	1279.00
IUUC-Gmo-039409	Gadus morhua	65.93	0.00e+00	966.00
IUUC-Gga-040884	Gallus gallus	83.46	0.00e+00	1266.00
IUUC-Gac-041395	Gasterosteus aculeatus	68.02	0.00e+00	1053.00
IUUC-Hsa-046099	Homo sapiens	93.92	0.00e+00	1419.00
IUUC-Itr-048144	Ictidomys tridecemlineatus	93.26	0.00e+00	1412.00
IUUC-Lch-049650	Latimeria chalumnae	81.69	5.00e-109	386.00
IUUC-Loc-052487	Lepisosteus oculatus	69.92	0.00e+00	1043.00
IUUC-Laf-054564	Loxodonta africana	93.44	0.00e+00	1385.00
IUUC-Mcc-054622	Macaca mulatta	93.16	0.00e+00	1411.00
IUUC-Meu-056680	Macropus eugenii	82.41	0.00e+00	1207.00
IUUC-Mga-060013	Meleagris gallopavo	79.71	0.00e+00	1195.00
IUUC-Mmr-061251	Microcebus murinus	89.99	0.00e+00	1410.00
IUUC-Mdo-061875	Monodelphis domestica	91.08	0.00e+00	1362.00
IUUC-Mmu-063735	Mus musculus	93.04	0.00e+00	1400.00
IUUC-Mpu-065856	Mustela putorius furo	94.62	0.00e+00	1394.00
IUUC-Mlu-068108	Myotis lucifugus	88.48	0.00e+00	1309.00
IUUC-Nle-069863	Nomascus leucogenys	93.16	0.00e+00	1404.00
IUUC-Opr-070372	Ochotona princeps	79.57	0.00e+00	834.00
IUUC-Ont-072286	Oreochromis niloticus	68.59	0.00e+00	1036.00
IUUC-Ocu-074194	Oryctolagus cuniculus	95.01	0.00e+00	1399.00
IUUC-Ola-086336	Oryzias latipes	67.58	0.00e+00	1036.00
IUUC-Oga-089104	Otolemur garnettii	56.01	0.00e+00	820.00
IUUC-Oar-089272	Ovis aries	93.31	0.00e+00	1416.00
IUUC-Ptr-090652	Pan troglodytes	94.62	0.00e+00	1412.00
IUUC-Pan-092550	Papio anubis	93.39	0.00e+00	1410.00
IUUC-Psi-093784	Pelodiscus sinensis	79.27	0.00e+00	1202.00
IUUC-Ppa-095161	Physcomitrella patens	43.64	3.00e-09	56.20
IUUC-Pfo-097308	Poecilia formosa	66.41	0.00e+00	1037.00
IUUC-Pab-098698	Pongo abelii	94.49	0.00e+00	1416.00
IUUC-Pva-102262	Pteropus vampyrus	93.72	0.00e+00	1324.00
IUUC-Rno-105421	Rattus norvegicus	92.52	0.00e+00	1404.00
IUUC-Sha-107325	Sarcophilus harrisii	90.94	0.00e+00	1376.00
IUUC-Sar-113456	Sorex araneus	88.06	0.00e+00	1313.00
IUUC-Ssc-115338	Sus scrofa	55.63	0.00e+00	825.00
IUUC-Tgu-116595	Taeniopygia guttata	80.65	0.00e+00	1199.00
IUUC-Tru-118577	Takifugu rubripes	64.09	0.00e+00	1010.00
IUUC-Tsy-119429	Tarsius syrichta	86.35	0.00e+00	1264.00
IUUC-Tni-119951	Tetraodon nigroviridis	68.05	0.00e+00	1009.00
IUUC-Tbe-127995	Tupaia belangeri	68.50	2.00e-137	483.00
IUUC-Ttr-128281	Tursiops truncatus	93.96	0.00e+00	1384.00
IUUC-Vpa-130066	Vicugna pacos	47.95	1.00e-34	141.00
IUUC-Xtr-132427	Xenopus tropicalis	72.02	0.00e+00	1119.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence