iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mdo-062246

UUCD1 version

UUC-MoD-00200

Ensembl Protein ID

ENSMODP00000021548.2

UniProt Accession

F6T4A1; F6T4A1_MONDO

Protein Name

Uncharacterized protein

Gene Name

HERC4

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMODG00000017265.3	ENSMODT00000021924.2	ENSMODP00000021548.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.30e-102	343.8	719	1042

Active Site

Position(s)	Description	Evidence
1011	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 4    dlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           d kk l+v fvgE+++d+gGv +ef+ l+++el +p++g+f+y e+++  ++ +++      e  +lF+++G+++g+a+++  ++dl
   Q: 719  DYKKPLKVIFVGEDAVDAGGVRKEFFLLIMRELLDPKYGMFRYYEDSRLIWFSDKTF-----EDSDLFHLIGVICGLAIYNFTIVDL 800
           78999***********************************************88877.....689********************** PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklv 177
           +++ ++yk+ll+kk +l+dl+e++p++ +s+++++++ e+die++ ++l+f+++ e++g+t+++eL+p+G+ + V+++N+ e+v+ +
   Q: 801  HFPLALYKKLLKKKPTLDDLKELMPDVGRSMQQLLDYPEDDIEDT-FCLNFTITVENFGTTEVKELIPNGAVTVVNKQNRMEFVDSY 886
           ********************************************8.***************************************** PP
   S: 178  veyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkaf 264
           v+y++++++++ ++af+eGf++v+  ++l+lF+++el+ ++ G++++d+++l+k+t+ykg+y +d+p+i+ Fwev++e+  e++k+f
   Q: 887  VDYIFNKSVASLFDAFHEGFHKVCGGKVLQLFHPNELQAMVIGNTNYDWKELEKNTEYKGEYWADHPTIKIFWEVFHELPLEKKKQF 973
           *************************************************************************************** PP
   S: 265  LqFvTgssrlPlgGfaelkprlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           L F+Tgs+r+P+ G+++lk    vi+   + ++ lP s+TCfn+L+LP+Y++keil++kL+ Ai++++gF+l
   Q: 974  LLFLTGSDRIPILGMKSLK---LVIQStGGGETYLPVSHTCFNLLDLPKYTEKEILRSKLIQAIDHNEGFSL 1042
           *******************...7777758888**************************************86 PP

Organism

Monodelphis domestica

Protein Sequence
(Fasta)

MMEQYILVAV MISDSWVMKN PGRSQDTTSE EFQEHYQLTH GSLQNACDTS SKNFPYLRGY 60
IYGEMETQIE QVVALDAQNI VAVSCGEAHT LALNDKGQVY AWGLDTDGQL GLPGTEEYIK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGCAACTACC TTGTTCAACT TTCATCTGGA TGATTGTAAT AGACACCTAA TTGGTTTTCC 60
TGCTTCCTGT CTATTTCCTC TCCAAAGCAT CCTTCGTGCT GCTTCCAAGG CAATCTTCAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000569--HECT_dom
IPR009091--RCC1/BLIP-II
IPR000408--Reg_chr_condens

PROSITE

PS50237--HECT
PS00626--RCC1_2
PS50012--RCC1_3

Pfam

PF00632--HECT
PF00415--RCC1

PRINTS

PR00633--RCCNDNSATION

SMART

SM00119--HECTc

Gene Ontology

GO:0005829--C:cytosol
GO:0001650--C:fibrillar center
GO:0004842--F:ubiquitin-protein transferase activity
GO:0007283--P:spermatogenesis

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001666	Ailuropoda melanoleuca	92.46	0.00e+00	1751.00
IUUC-Apl-003295	Anas platyrhynchos	85.66	0.00e+00	1684.00
IUUC-Aca-004336	Anolis carolinensis	85.36	0.00e+00	1676.00
IUUC-Ame-010768	Astyanax mexicanus	71.69	0.00e+00	1431.00
IUUC-Bta-013279	Bos taurus	91.75	0.00e+00	1740.00
IUUC-Cja-019023	Callithrix jacchus	92.26	0.00e+00	1742.00
IUUC-Cfa-021074	Canis familiaris	92.67	0.00e+00	1757.00
IUUC-Cpo-021461	Cavia porcellus	89.94	0.00e+00	1692.00
IUUC-Csa-024261	Chlorocebus sabaeus	92.46	0.00e+00	1752.00
IUUC-Cho-024513	Choloepus hoffmanni	71.84	0.00e+00	677.00
IUUC-Cin-025232	Ciona intestinalis	44.62	0.00e+00	793.00
IUUC-Dre-028829	Danio rerio	73.49	0.00e+00	1418.00
IUUC-Dno-029445	Dasypus novemcinctus	89.98	0.00e+00	1539.00
IUUC-Dor-030158	Dipodomys ordii	92.31	0.00e+00	833.00
IUUC-Ete-033072	Echinops telfairi	82.03	0.00e+00	1506.00
IUUC-Eca-033317	Equus caballus	90.84	0.00e+00	1719.00
IUUC-Fca-035682	Felis catus	93.53	0.00e+00	1765.00
IUUC-Fal-036969	Ficedula albicollis	84.52	0.00e+00	1660.00
IUUC-Gmo-038671	Gadus morhua	72.26	0.00e+00	1424.00
IUUC-Gga-041174	Gallus gallus	85.34	0.00e+00	1681.00
IUUC-Gac-042600	Gasterosteus aculeatus	72.41	0.00e+00	1366.00
IUUC-Ggo-044589	Gorilla gorilla	92.26	0.00e+00	1774.00
IUUC-Hsa-046772	Homo sapiens	92.16	0.00e+00	1772.00
IUUC-Lch-050147	Latimeria chalumnae	79.95	0.00e+00	1292.00
IUUC-Loc-052684	Lepisosteus oculatus	78.59	0.00e+00	1538.00
IUUC-Laf-053844	Loxodonta africana	91.55	0.00e+00	1731.00
IUUC-Mcc-055531	Macaca mulatta	90.16	0.00e+00	1739.00
IUUC-Mga-060151	Meleagris gallopavo	84.46	0.00e+00	1368.00
IUUC-Mmr-060954	Microcebus murinus	92.46	0.00e+00	1749.00
IUUC-Mmu-063369	Mus musculus	92.40	0.00e+00	1765.00
IUUC-Mpu-065936	Mustela putorius furo	91.79	0.00e+00	1759.00
IUUC-Mlu-067326	Myotis lucifugus	91.75	0.00e+00	1709.00
IUUC-Nle-069453	Nomascus leucogenys	93.12	0.00e+00	1758.00
IUUC-Ont-071720	Oreochromis niloticus	73.69	0.00e+00	1431.00
IUUC-Oan-073464	Ornithorhynchus anatinus	90.64	0.00e+00	1761.00
IUUC-Ocu-074207	Oryctolagus cuniculus	89.68	0.00e+00	1745.00
IUUC-Ola-086762	Oryzias latipes	72.55	0.00e+00	1377.00
IUUC-Oga-088435	Otolemur garnettii	92.67	0.00e+00	1752.00
IUUC-Oar-089233	Ovis aries	91.85	0.00e+00	1741.00
IUUC-Ptr-091368	Pan troglodytes	92.46	0.00e+00	1776.00
IUUC-Pan-092300	Papio anubis	92.46	0.00e+00	1752.00
IUUC-Psi-093406	Pelodiscus sinensis	87.47	0.00e+00	1712.00
IUUC-Pma-094113	Petromyzon marinus	70.33	0.00e+00	1114.00
IUUC-Pfo-097021	Poecilia formosa	72.67	0.00e+00	1444.00
IUUC-Pab-098327	Pongo abelii	92.46	0.00e+00	1777.00
IUUC-Pca-101075	Procavia capensis	92.07	0.00e+00	796.00
IUUC-Pva-102909	Pteropus vampyrus	80.24	0.00e+00	1440.00
IUUC-Rno-105457	Rattus norvegicus	91.96	0.00e+00	1758.00
IUUC-Sha-106632	Sarcophilus harrisii	96.61	0.00e+00	1849.00
IUUC-Sar-113679	Sorex araneus	84.50	0.00e+00	1096.00
IUUC-Tgu-116849	Taeniopygia guttata	80.35	0.00e+00	1555.00
IUUC-Tru-118206	Takifugu rubripes	71.46	0.00e+00	1327.00
IUUC-Tsy-119521	Tarsius syrichta	77.29	0.00e+00	1362.00
IUUC-Tni-120233	Tetraodon nigroviridis	70.86	0.00e+00	1313.00
IUUC-Tbe-127941	Tupaia belangeri	77.93	0.00e+00	1319.00
IUUC-Ttr-128926	Tursiops truncatus	90.46	0.00e+00	1055.00
IUUC-Vpa-130448	Vicugna pacos	91.55	0.00e+00	1734.00
IUUC-Xtr-132719	Xenopus tropicalis	72.72	0.00e+00	1325.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence