iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
circBase	microRNA	RAID2
Protein-protein Interaction
IID
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	7.00e-111	371.1	413	584

Active Site

Position(s)	Description	Evidence
691	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldlplsksfykll 100
           ++dl+++l++ef gE gld+gGvtre+++lls++++np++glf+ys++d++tlq+np+s  +npehl++F+f+Gr++g+a+++g+lld+++ ++fyk++
   Q: 413  DYDLRNKLWIEFFGETGLDYGGVTREWFFLLSHQIFNPYYGLFEYSATDNYTLQINPHSEACNPEHLSYFHFIGRIIGMAIYHGKLLDAFFIRPFYKMM 511
           5799*********************************************************************************************** PP
   S: 101  lgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvv 178
           lgkk++l d+e+vd+e+y+sl ++k+n   d   ++l+ltfs +++i+get++ eL+p+G+n+pVt++NkeeY+++vv
   Q: 512  LGKKITLFDMESVDNEYYNSLIYVKDN---D--PADLELTFSLDDSIFGETQNIELIPNGANVPVTEDNKEEYIEAVV 584
           *************************88...4..555899***********************************9985 PP

Organism

Caenorhabditis elegans

Protein Sequence
(Fasta)

MVVQTVVHGY PPNTDNETEL LRVRLLRGTK LGKRDLLGVC SPYCMIRLEN SNGDTVDEVQ 60
VETKKKTRNP TWNSVFTFRV TRACQMKILV YDENRLRKDV LMGFVSRTLN DGLITTQAPN 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTCCACCCCC GCCACGTCCC CATTCCACGT GGAACCGTTT CCCCCCATAT GTTCTGATTT 60
CCACGTTGCC ATTGCATTTT TGCTCATTTC TAACATTTTA CACACACGAT GGTTGTGCAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0436--Ligase
KW-1267--Proteomics identification
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0016874--F:ligase activity
GO:0004842--F:ubiquitin-protein transferase activity

KEGG

cel:CELE_Y92H12A.2

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001314	Ailuropoda melanoleuca	52.53	1.00e-178	619.00
IUUC-Apl-003886	Anas platyrhynchos	53.19	5.00e-178	617.00
IUUC-Aca-004744	Anolis carolinensis	53.01	2.00e-174	605.00
IUUC-Ame-011138	Astyanax mexicanus	59.75	3.00e-170	591.00
IUUC-Bta-012679	Bos taurus	52.53	7.00e-179	619.00
IUUC-Cja-018732	Callithrix jacchus	52.51	2.00e-179	621.00
IUUC-Cfa-021226	Canis familiaris	52.69	4.00e-179	620.00
IUUC-Cpo-021671	Cavia porcellus	52.53	6.00e-179	619.00
IUUC-Csa-023334	Chlorocebus sabaeus	53.38	8.00e-178	616.00
IUUC-Cin-025157	Ciona intestinalis	50.85	1.00e-169	589.00
IUUC-Csv-026098	Ciona savignyi	51.69	6.00e-134	469.00
IUUC-Dre-027770	Danio rerio	58.91	1.00e-169	589.00
IUUC-Dno-029466	Dasypus novemcinctus	52.61	4.00e-179	620.00
IUUC-Dor-030138	Dipodomys ordii	51.68	5.00e-173	600.00
IUUC-Dme-032166	Drosophila melanogaster	58.64	3.00e-179	620.00
IUUC-Ete-033145	Echinops telfairi	49.16	3.00e-164	570.00
IUUC-Eca-033445	Equus caballus	52.53	1.00e-178	619.00
IUUC-Eeu-035247	Erinaceus europaeus	52.19	2.00e-177	615.00
IUUC-Fca-036384	Felis catus	54.04	0.00e+00	626.00
IUUC-Fal-037604	Ficedula albicollis	51.06	5.00e-174	603.00
IUUC-Gmo-039679	Gadus morhua	52.24	1.00e-171	595.00
IUUC-Gga-041276	Gallus gallus	52.86	3.00e-177	614.00
IUUC-Gac-042020	Gasterosteus aculeatus	50.75	4.00e-170	590.00
IUUC-Ggo-045332	Gorilla gorilla	52.34	1.00e-178	619.00
IUUC-Hsa-045968	Homo sapiens	52.34	8.00e-179	619.00
IUUC-Itr-048383	Ictidomys tridecemlineatus	49.53	8.00e-169	585.00
IUUC-Lch-050443	Latimeria chalumnae	52.19	1.00e-176	612.00
IUUC-Loc-052645	Lepisosteus oculatus	53.25	7.00e-175	606.00
IUUC-Lma-052980	Leptosphaeria maculans	42.93	1.00e-84	305.00
IUUC-Laf-053850	Loxodonta africana	52.53	1.00e-178	619.00
IUUC-Mcc-055821	Macaca mulatta	52.34	7.00e-179	619.00
IUUC-Mga-059362	Meleagris gallopavo	52.49	4.00e-177	613.00
IUUC-Mmr-061061	Microcebus murinus	53.21	3.00e-180	624.00
IUUC-Mdo-062173	Monodelphis domestica	50.49	1.00e-173	602.00
IUUC-Mmu-064136	Mus musculus	52.36	1.00e-178	619.00
IUUC-Mpu-066765	Mustela putorius furo	52.53	1.00e-178	619.00
IUUC-Mlu-067565	Myotis lucifugus	52.86	2.00e-179	621.00
IUUC-Nle-069225	Nomascus leucogenys	53.89	0.00e+00	629.00
IUUC-Opr-071044	Ochotona princeps	52.36	3.00e-177	614.00
IUUC-Ont-071664	Oreochromis niloticus	51.73	1.00e-163	568.00
IUUC-Oan-073019	Ornithorhynchus anatinus	51.95	1.00e-172	598.00
IUUC-Ocu-074160	Oryctolagus cuniculus	52.44	1.00e-178	619.00
IUUC-Ola-087467	Oryzias latipes	57.65	5.00e-163	566.00
IUUC-Oga-088460	Otolemur garnettii	52.53	2.00e-178	618.00
IUUC-Oar-090198	Ovis aries	52.69	2.00e-179	621.00
IUUC-Ptr-090939	Pan troglodytes	52.34	8.00e-179	619.00
IUUC-Pan-092284	Papio anubis	52.34	6.00e-179	620.00
IUUC-Psi-093645	Pelodiscus sinensis	53.03	1.00e-178	619.00
IUUC-Pma-094364	Petromyzon marinus	57.83	9.00e-163	565.00
IUUC-Ppa-095250	Physcomitrella patens	45.58	1.00e-78	285.00
IUUC-Pfo-097145	Poecilia formosa	51.12	8.00e-168	583.00
IUUC-Pab-098088	Pongo abelii	52.34	6.00e-179	620.00
IUUC-Pca-100568	Procavia capensis	48.72	6.00e-160	557.00
IUUC-Pva-102354	Pteropus vampyrus	52.36	6.00e-178	616.00
IUUC-Rno-106095	Rattus norvegicus	57.97	6.00e-166	577.00
IUUC-Sha-107482	Sarcophilus harrisii	51.76	4.00e-175	607.00
IUUC-Ssc-115950	Sus scrofa	55.56	7.00e-156	543.00
IUUC-Tgu-117130	Taeniopygia guttata	52.86	8.00e-178	616.00
IUUC-Tru-117675	Takifugu rubripes	57.71	2.00e-166	578.00
IUUC-Tsy-119492	Tarsius syrichta	52.19	4.00e-175	607.00
IUUC-Tni-119993	Tetraodon nigroviridis	51.77	2.00e-170	591.00
IUUC-Tme-126897	Tuber melanosporum	43.22	2.00e-132	465.00
IUUC-Tbe-127408	Tupaia belangeri	49.30	4.00e-149	521.00
IUUC-Ttr-128235	Tursiops truncatus	58.70	7.00e-169	586.00
IUUC-Vpa-130503	Vicugna pacos	51.61	3.00e-170	591.00
IUUC-Xtr-132859	Xenopus tropicalis	52.53	2.00e-178	618.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence