iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Apl-003912

Ensembl Protein ID

ENSAPLP00000008146.1

UniProt Accession

U3ILM4; U3ILM4_ANAPL

Genbank Protein ID

ENSAPLP00000008146

Protein Name

E3 ubiquitin-protein ligase

Genbank Nucleotide ID

ADON01113355

Gene Name

WWP2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSAPLG00000008423.1	ENSAPLT00000008818.1	ENSAPLP00000008146.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	4.20e-136	453.5	496	828

Active Site

Position(s)	Description	Evidence
797	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dl++rl++ ++gEegld+gG++re+++lls+e+ np+++lf+y  +++++lq+np+s + np+hl +F+f+Gr++++al++g+++d+
   Q: 496  PYDLRRRLYIIMRGEEGLDYGGIAREWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASSI-NPDHLTYFRFIGRFIAMALYHGKFIDT 583
           6799********************************************************9.89************************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
            ++ +fyk++l+k+ +l+dle++dpe+y+s+ + ken   ++ee+gl+l f ++ eilg+++++eLk+gGe+i+Vt+eNkeeY+ l+++
   Q: 584  GFTLPFYKRMLNKRPTLKDLESIDPEFYNSIVWTKEN---SLEECGLELYFIQDMEILGKVTTHELKEGGESIRVTEENKEEYIMLLTD 669
           ***********************************99...9************************************************ PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +r+++g++eq++af +Gfnev+ple+l++F+e+elel++cG++eid++d++k+t y++ yt++s++iqwFw+v++e+++e+r ++LqFv
   Q: 670  WRFTRGVEEQTKAFLDGFNEVVPLEWLRYFDEKELELMLCGMQEIDMNDWQKNTIYRH-YTKNSKQIQWFWQVVKEMDNEKRIRLLQFV 757
           ********************************************************99.****************************** PP
   S: 269  TgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           Tg++rlP+gGfael     p++f+i k +++++lP+s+TCfn+L+LP+Y+s+e+lkekLlyAieet+gF++
   Q: 758  TGTCRLPVGGFAELIgsngPQKFCIDKVGKETWLPRSHTCFNRLDLPPYKSYEQLKEKLLYAIEETEGFGQ 828
           *********************************************************************96 PP

Organism

Anas platyrhynchos

Protein Sequence
(Fasta)

ETKKTGKQMG SSELLWNEIL VLNLLKSANE SGSVWAAVPA RGSQIFLAPC GRADVALGSG 60
AVGVENRQLT LNLQTENKGS VVSGGELTIF LDGPAVDLGS LPNGSAVTDG SQVPGRDPSS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GAGACCAAGA AGACGGGGAA GCAGATGGGG AGCTCGGAGC TGCTCTGGAA CGAGATCCTC 60
GTCCTGTAAG TCCCTGCGAA CCCCCNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR024928--E3_ub_ligase_SMURF1
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00632--HECT
PF00397--WW

SMART

SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0005737--C:cytoplasm
GO:0070062--C:extracellular exosome
GO:0016020--C:membrane
GO:0005634--C:nucleus
GO:0001190--F:transcriptional activator activity, RNA polymerase II transcription factor binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0051224--P:negative regulation of protein transport
GO:0043433--P:negative regulation of sequence-specific DNA binding transcription factor activity
GO:0032410--P:negative regulation of transporter activity
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0051865--P:protein autoubiquitination
GO:0070534--P:protein K63-linked ubiquitination
GO:0042391--P:regulation of membrane potential
GO:1901016--P:regulation of potassium ion transmembrane transporter activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001575	Ailuropoda melanoleuca	76.80	0.00e+00	1236.00
IUUC-Aca-004291	Anolis carolinensis	74.97	0.00e+00	1224.00
IUUC-Bta-013231	Bos taurus	76.75	0.00e+00	1236.00
IUUC-Cja-019455	Callithrix jacchus	76.87	0.00e+00	1260.00
IUUC-Cfa-021017	Canis familiaris	76.99	0.00e+00	1249.00
IUUC-Cpo-021988	Cavia porcellus	76.14	0.00e+00	1238.00
IUUC-Csa-023549	Chlorocebus sabaeus	76.87	0.00e+00	1265.00
IUUC-Dre-028513	Danio rerio	88.00	0.00e+00	1074.00
IUUC-Dno-028976	Dasypus novemcinctus	76.77	0.00e+00	1253.00
IUUC-Dor-030176	Dipodomys ordii	91.45	0.00e+00	1100.00
IUUC-Eca-033949	Equus caballus	76.99	0.00e+00	1246.00
IUUC-Eeu-034529	Erinaceus europaeus	67.88	0.00e+00	953.00
IUUC-Fca-036236	Felis catus	76.99	0.00e+00	1263.00
IUUC-Fal-036948	Ficedula albicollis	94.24	0.00e+00	1128.00
IUUC-Gmo-038842	Gadus morhua	85.37	0.00e+00	1013.00
IUUC-Gga-040617	Gallus gallus	74.52	0.00e+00	1272.00
IUUC-Ggo-045278	Gorilla gorilla	77.23	0.00e+00	1271.00
IUUC-Hsa-046148	Homo sapiens	77.23	0.00e+00	1271.00
IUUC-Itr-047945	Ictidomys tridecemlineatus	90.61	0.00e+00	1027.00
IUUC-Lch-050663	Latimeria chalumnae	90.61	0.00e+00	1105.00
IUUC-Loc-052604	Lepisosteus oculatus	69.52	0.00e+00	1132.00
IUUC-Laf-053944	Loxodonta africana	75.78	0.00e+00	1239.00
IUUC-Mcc-055655	Macaca mulatta	76.75	0.00e+00	1263.00
IUUC-Meu-055953	Macropus eugenii	76.18	0.00e+00	949.00
IUUC-Mga-060190	Meleagris gallopavo	75.00	0.00e+00	1272.00
IUUC-Mmr-060896	Microcebus murinus	76.75	0.00e+00	1250.00
IUUC-Mdo-062536	Monodelphis domestica	76.87	0.00e+00	1268.00
IUUC-Mmu-064017	Mus musculus	76.75	0.00e+00	1256.00
IUUC-Mpu-066608	Mustela putorius furo	74.16	0.00e+00	1193.00
IUUC-Mlu-067623	Myotis lucifugus	75.09	0.00e+00	1202.00
IUUC-Nle-069496	Nomascus leucogenys	75.09	0.00e+00	1221.00
IUUC-Opr-071054	Ochotona princeps	90.75	0.00e+00	1096.00
IUUC-Ont-071279	Oreochromis niloticus	68.76	0.00e+00	1099.00
IUUC-Oan-073512	Ornithorhynchus anatinus	74.70	0.00e+00	1204.00
IUUC-Ocu-074271	Oryctolagus cuniculus	73.94	0.00e+00	1227.00
IUUC-Oga-088164	Otolemur garnettii	76.87	0.00e+00	1253.00
IUUC-Oar-089698	Ovis aries	76.87	0.00e+00	1238.00
IUUC-Ptr-091306	Pan troglodytes	75.78	0.00e+00	1239.00
IUUC-Pan-092814	Papio anubis	73.20	0.00e+00	1174.00
IUUC-Pfo-096709	Poecilia formosa	85.57	0.00e+00	1018.00
IUUC-Pab-098494	Pongo abelii	75.87	0.00e+00	1230.00
IUUC-Pca-100596	Procavia capensis	80.90	0.00e+00	956.00
IUUC-Pva-103154	Pteropus vampyrus	72.78	0.00e+00	1139.00
IUUC-Rno-104954	Rattus norvegicus	79.66	0.00e+00	1204.00
IUUC-Sha-106781	Sarcophilus harrisii	77.10	0.00e+00	1279.00
IUUC-Ssc-116307	Sus scrofa	68.32	0.00e+00	1106.00
IUUC-Tgu-116530	Taeniopygia guttata	88.13	0.00e+00	1033.00
IUUC-Tbe-127793	Tupaia belangeri	65.90	0.00e+00	1037.00
IUUC-Ttr-128275	Tursiops truncatus	91.27	0.00e+00	1107.00
IUUC-Xtr-132866	Xenopus tropicalis	86.06	0.00e+00	1050.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence