iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Fal-036948

Ensembl Protein ID

ENSFALP00000002852.1

UniProt Accession

U3JJ98; U3JJ98_FICAL

Genbank Protein ID

ENSFALP00000002852

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AGTO01001491

Gene Name

WWP2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSFALG00000002719.1	ENSFALT00000002864.1	ENSFALP00000002852.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	5.10e-136	453.2	591	923

Active Site

Position(s)	Description	Evidence
892	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dl++rl++ ++gEegld+gG++re+++lls+e+ np+++lf+y  +++++lq+np+s + np+hl +F+f+Gr++++al++g+++d+
   Q: 591  PYDLRRRLYIIMRGEEGLDYGGIAREWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASSI-NPDHLTYFRFIGRFIAMALYHGKFIDT 678
           6799********************************************************9.89************************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
            ++ +fyk++l+k+ +l+dle++dpe+y+s+ + ken   ++ee+gl+l f ++ eilg+++++eLk+gGe+i+Vt+eNkeeY+ l+++
   Q: 679  GFTLPFYKRMLNKRPTLKDLESIDPEFYNSIVWTKEN---SLEECGLELYFIQDMEILGKVTTHELKEGGESIRVTEENKEEYIMLLTD 764
           ***********************************99...9************************************************ PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +r+++g++eq++af +Gfnev+ple+l++F+e+elel++cG++eid++d++k+t y++ yt++s++iqwFw+v++e+++e+r ++LqFv
   Q: 765  WRFTRGVEEQTKAFLDGFNEVVPLEWLRYFDEKELELMLCGMQEIDMNDWQKNTIYRH-YTKNSKQIQWFWQVVKEMDNEKRIRLLQFV 852
           ********************************************************99.****************************** PP
   S: 269  TgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           Tg++rlP+gGfael     p++f+i k +++++lP+s+TCfn+L+LP+Y+s+e+lkekLlyAieet+gF++
   Q: 853  TGTCRLPVGGFAELIgsngPQKFCIDKVGKETWLPRSHTCFNRLDLPPYKSYEQLKEKLLYAIEETEGFGQ 923
           *********************************************************************96 PP

Organism

Ficedula albicollis

Protein Sequence
(Fasta)

MAAASSSRAR AGPPCEKSPL SVKVVSVKPK AQSRPARMNC FVEVAGDGLP SETKKTGKQM 60
GVSELLWNEI LTLNVTAQSH LELKVWICHT LRNELLGAAS VSLGSLLKGG GKLENRQLTL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCCGCTG CCAGCTCCAG CAGGGCCAGG GCCGGGCCGC CCTGCGAGAA ATCCCCGCTC 60
TCCGTGAAAG GTGGGTGCTG CTGCCTCGCT GGGATTGCCC CTGCCAGGAG TGTGTGCTGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00632--HECT
PF00397--WW

SMART

SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0005737--C:cytoplasm
GO:0070062--C:extracellular exosome
GO:0016020--C:membrane
GO:0005634--C:nucleus
GO:0001190--F:transcriptional activator activity, RNA polymerase II transcription factor binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0051224--P:negative regulation of protein transport
GO:0043433--P:negative regulation of sequence-specific DNA binding transcription factor activity
GO:0032410--P:negative regulation of transporter activity
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0051865--P:protein autoubiquitination
GO:0070534--P:protein K63-linked ubiquitination
GO:0042391--P:regulation of membrane potential
GO:1901016--P:regulation of potassium ion transmembrane transporter activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001575	Ailuropoda melanoleuca	78.56	0.00e+00	1409.00
IUUC-Apl-003912	Anas platyrhynchos	72.40	0.00e+00	1220.00
IUUC-Aca-004291	Anolis carolinensis	76.15	0.00e+00	1375.00
IUUC-Bta-013231	Bos taurus	78.07	0.00e+00	1389.00
IUUC-Cja-019455	Callithrix jacchus	77.96	0.00e+00	1416.00
IUUC-Cfa-021017	Canis familiaris	78.40	0.00e+00	1397.00
IUUC-Cpo-021988	Cavia porcellus	77.74	0.00e+00	1400.00
IUUC-Csa-023549	Chlorocebus sabaeus	78.18	0.00e+00	1423.00
IUUC-Dre-028513	Danio rerio	92.99	0.00e+00	1145.00
IUUC-Dno-028976	Dasypus novemcinctus	78.84	0.00e+00	1420.00
IUUC-Dor-030176	Dipodomys ordii	76.66	0.00e+00	1337.00
IUUC-Eca-033949	Equus caballus	78.51	0.00e+00	1407.00
IUUC-Eeu-034529	Erinaceus europaeus	83.81	0.00e+00	1055.00
IUUC-Fca-036236	Felis catus	78.95	0.00e+00	1424.00
IUUC-Gmo-038842	Gadus morhua	89.95	0.00e+00	1073.00
IUUC-Gga-040617	Gallus gallus	86.35	0.00e+00	1514.00
IUUC-Gac-041338	Gasterosteus aculeatus	70.31	0.00e+00	1236.00
IUUC-Ggo-045278	Gorilla gorilla	78.40	0.00e+00	1429.00
IUUC-Hsa-046148	Homo sapiens	78.40	0.00e+00	1429.00
IUUC-Itr-047945	Ictidomys tridecemlineatus	95.52	0.00e+00	1087.00
IUUC-Lch-050663	Latimeria chalumnae	72.51	0.00e+00	1329.00
IUUC-Loc-052604	Lepisosteus oculatus	70.90	0.00e+00	1266.00
IUUC-Laf-053944	Loxodonta africana	78.73	0.00e+00	1419.00
IUUC-Mcc-055655	Macaca mulatta	77.96	0.00e+00	1421.00
IUUC-Meu-055953	Macropus eugenii	69.26	0.00e+00	1234.00
IUUC-Mga-060190	Meleagris gallopavo	86.01	0.00e+00	1527.00
IUUC-Mmr-060896	Microcebus murinus	78.67	0.00e+00	1414.00
IUUC-Mdo-062536	Monodelphis domestica	80.09	0.00e+00	1461.00
IUUC-Mmu-064017	Mus musculus	78.51	0.00e+00	1409.00
IUUC-Mpu-066608	Mustela putorius furo	76.56	0.00e+00	1355.00
IUUC-Mlu-067623	Myotis lucifugus	76.01	0.00e+00	1359.00
IUUC-Nle-069496	Nomascus leucogenys	76.32	0.00e+00	1378.00
IUUC-Opr-071054	Ochotona princeps	80.67	0.00e+00	1169.00
IUUC-Ont-071279	Oreochromis niloticus	89.11	0.00e+00	1103.00
IUUC-Oan-073512	Ornithorhynchus anatinus	76.78	0.00e+00	1364.00
IUUC-Ocu-074271	Oryctolagus cuniculus	78.49	0.00e+00	1403.00
IUUC-Ola-087237	Oryzias latipes	68.31	0.00e+00	1197.00
IUUC-Oga-088164	Otolemur garnettii	78.07	0.00e+00	1413.00
IUUC-Oar-089698	Ovis aries	77.96	0.00e+00	1387.00
IUUC-Ptr-091306	Pan troglodytes	77.08	0.00e+00	1397.00
IUUC-Pan-092814	Papio anubis	75.44	0.00e+00	1346.00
IUUC-Pfo-096709	Poecilia formosa	90.91	0.00e+00	1085.00
IUUC-Pab-098494	Pongo abelii	77.49	0.00e+00	1387.00
IUUC-Pca-100596	Procavia capensis	78.39	0.00e+00	1061.00
IUUC-Pva-103154	Pteropus vampyrus	85.52	0.00e+00	1155.00
IUUC-Rno-104954	Rattus norvegicus	78.08	0.00e+00	1241.00
IUUC-Sha-106781	Sarcophilus harrisii	78.99	0.00e+00	1467.00
IUUC-Ssc-116307	Sus scrofa	75.05	0.00e+00	1295.00
IUUC-Tgu-116530	Taeniopygia guttata	84.19	0.00e+00	1278.00
IUUC-Tru-118287	Takifugu rubripes	90.86	0.00e+00	1079.00
IUUC-Tni-120801	Tetraodon nigroviridis	70.04	0.00e+00	1192.00
IUUC-Tbe-127793	Tupaia belangeri	76.54	0.00e+00	1077.00
IUUC-Ttr-128275	Tursiops truncatus	85.11	0.00e+00	1173.00
IUUC-Uma-129332	Ustilago maydis	46.28	8.00e-143	500.00
IUUC-Xtr-132866	Xenopus tropicalis	82.94	0.00e+00	1129.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence