iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ssc-116307

UUCD1 version

UUC-SuS-00398

Ensembl Protein ID

ENSSSCP00000023077.1

UniProt Accession

I3LG84; I3LG84_PIG

Protein Name

Uncharacterized protein

Gene Name

WWP2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSSSCG00000022609.1	ENSSSCT00000025575.1	ENSSSCP00000023077.1
ENSSSCG00000022609.1	ENSSSCT00000032019.1	ENSSSCP00000019876.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	3.30e-115	385.3	592	919

Active Site

Position(s)	Description	Evidence
888	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dl++rl++ ++gEegld+gG++re+++lls+e+ np+++lf+y  +++++lq+np+s + np+hl +F+f+ ++l+kal++g+++d+
   Q: 592  PYDLRRRLYIIMRGEEGLDYGGIAREWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASSI-NPDHLTYFRFVWKFLAKALYHGKFIDT 679
           6799********************************************************9.89************************* PP
   S: 91   plsksfyklllgkklsl.edleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvv 178
            ++ +fyk++l+k+ +  +++++  ++++             ++ +gl+l f ++ eilg+++++eLk+gGe+i+Vt+eNkeeY+ l++
   Q: 680  GFTLPFYKRMLNKRPTAaQEVSSASRDFFPL----------GLSXCGLELYFIQDMEILGKVTTHELKEGGESIRVTEENKEEYIMLLT 758
           *************877668888888887754..........568899****************************************** PP
   S: 179  eyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevl.eefsseerkafLq 266
           ++r+++g++eq++af +Gfnev ple+l++F+e+elel++cG++eid++d++k+t y++ yt++s++iqwFw+    ++++e+r ++Lq
   Q: 759  DWRFTRGVEEQTKAFLDGFNEVAPLEWLRYFDEKELELMLCGMQEIDMSDWQKNTIYRH-YTKNSKQIQWFWQESaVAMDNEKRIRLLQ 846
           *********************************************************99.************87659************ PP
   S: 267  FvTgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           FvTg++rlP+gGf el     p++f+i k +++++lP+s+TCfn+L+LP+Y+s+e+lkekLlyAieet+gF++
   Q: 847  FVTGTCRLPVGGFVELIgsngPQKFCIDKVGKETWLPRSHTCFNRLDLPPYKSYEQLKEKLLYAIEETEGFGQ 919
           ***********************************************************************96 PP

Organism

Sus scrofa

Protein Sequence
(Fasta)

KREDSCHRGA PGSPLTHPGL FLSFPPVVSA KPKVHSRQPR INSFVEVAVD GLPSETKKTG 60
KRIGSSELLW NEIIILNVTA QSHLDLKVWS CHTLRNELLG TTSLSLWDHN SGPLENTQLT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AAGAGGGAAG ACAGCTGCCA CAGGGGGGCA CCTGGGAGCC CTCTGACTCA TCCCGGGCTC 60
TTTCTGTCTT TCCCTCCAGT GGTGTCAGCA AAGCCCAAGG TGCATAGTCG TCAACCTCGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1267--Proteomics identification
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00632--HECT
PF00397--WW

SMART

SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0005737--C:cytoplasm
GO:0070062--C:extracellular exosome
GO:0016020--C:membrane
GO:0005634--C:nucleus
GO:0001190--F:transcriptional activator activity, RNA polymerase II transcription factor binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0051224--P:negative regulation of protein transport
GO:0043433--P:negative regulation of sequence-specific DNA binding transcription factor activity
GO:0032410--P:negative regulation of transporter activity
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0051865--P:protein autoubiquitination
GO:0070534--P:protein K63-linked ubiquitination
GO:0042391--P:regulation of membrane potential
GO:1901016--P:regulation of potassium ion transmembrane transporter activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001575	Ailuropoda melanoleuca	84.99	0.00e+00	1455.00
IUUC-Apl-003912	Anas platyrhynchos	68.32	0.00e+00	1123.00
IUUC-Aca-004291	Anolis carolinensis	72.09	0.00e+00	1284.00
IUUC-Bta-013231	Bos taurus	84.13	0.00e+00	1426.00
IUUC-Cja-019455	Callithrix jacchus	83.96	0.00e+00	1470.00
IUUC-Cfa-021017	Canis familiaris	84.36	0.00e+00	1443.00
IUUC-Cpo-021988	Cavia porcellus	82.74	0.00e+00	1466.00
IUUC-Csa-023549	Chlorocebus sabaeus	84.29	0.00e+00	1476.00
IUUC-Dre-028513	Danio rerio	86.91	0.00e+00	1062.00
IUUC-Dno-028976	Dasypus novemcinctus	84.53	0.00e+00	1474.00
IUUC-Dor-030176	Dipodomys ordii	79.62	0.00e+00	1308.00
IUUC-Eca-033949	Equus caballus	85.51	0.00e+00	1462.00
IUUC-Eeu-034529	Erinaceus europaeus	88.18	0.00e+00	1093.00
IUUC-Fca-036236	Felis catus	84.85	0.00e+00	1486.00
IUUC-Fal-036948	Ficedula albicollis	74.97	0.00e+00	1266.00
IUUC-Gmo-038842	Gadus morhua	84.01	0.00e+00	991.00
IUUC-Gga-040617	Gallus gallus	78.12	0.00e+00	1372.00
IUUC-Gac-041338	Gasterosteus aculeatus	65.69	0.00e+00	1145.00
IUUC-Ggo-045278	Gorilla gorilla	84.18	0.00e+00	1476.00
IUUC-Hsa-046148	Homo sapiens	84.18	0.00e+00	1477.00
IUUC-Itr-047945	Ictidomys tridecemlineatus	92.18	0.00e+00	1042.00
IUUC-Lch-050663	Latimeria chalumnae	69.83	0.00e+00	1228.00
IUUC-Loc-052604	Lepisosteus oculatus	68.02	0.00e+00	1187.00
IUUC-Laf-053944	Loxodonta africana	84.85	0.00e+00	1484.00
IUUC-Mcc-055655	Macaca mulatta	84.18	0.00e+00	1474.00
IUUC-Meu-055953	Macropus eugenii	69.50	0.00e+00	1217.00
IUUC-Mga-060190	Meleagris gallopavo	78.12	0.00e+00	1375.00
IUUC-Mmr-060896	Microcebus murinus	84.40	0.00e+00	1441.00
IUUC-Mdo-062536	Monodelphis domestica	78.99	0.00e+00	1414.00
IUUC-Mmu-064017	Mus musculus	83.63	0.00e+00	1442.00
IUUC-Mpu-066608	Mustela putorius furo	85.07	0.00e+00	1442.00
IUUC-Mlu-067623	Myotis lucifugus	85.08	0.00e+00	1466.00
IUUC-Nle-069496	Nomascus leucogenys	82.30	0.00e+00	1432.00
IUUC-Opr-071054	Ochotona princeps	83.03	0.00e+00	1184.00
IUUC-Ont-071279	Oreochromis niloticus	82.59	0.00e+00	1019.00
IUUC-Oan-073512	Ornithorhynchus anatinus	76.85	0.00e+00	1315.00
IUUC-Ocu-074271	Oryctolagus cuniculus	83.74	0.00e+00	1440.00
IUUC-Ola-087237	Oryzias latipes	66.08	0.00e+00	1115.00
IUUC-Oga-088164	Otolemur garnettii	84.96	0.00e+00	1485.00
IUUC-Oar-089698	Ovis aries	84.13	0.00e+00	1434.00
IUUC-Ptr-091306	Pan troglodytes	82.96	0.00e+00	1446.00
IUUC-Pan-092814	Papio anubis	81.13	0.00e+00	1392.00
IUUC-Pfo-096709	Poecilia formosa	68.01	0.00e+00	1149.00
IUUC-Pab-098494	Pongo abelii	79.33	0.00e+00	1414.00
IUUC-Pca-100596	Procavia capensis	80.88	0.00e+00	1063.00
IUUC-Pva-103154	Pteropus vampyrus	88.72	0.00e+00	1197.00
IUUC-Rno-104954	Rattus norvegicus	83.78	0.00e+00	1278.00
IUUC-Sha-106781	Sarcophilus harrisii	78.77	0.00e+00	1449.00
IUUC-Tgu-116530	Taeniopygia guttata	72.86	0.00e+00	1106.00
IUUC-Tru-118287	Takifugu rubripes	84.59	0.00e+00	988.00
IUUC-Tsy-119097	Tarsius syrichta	77.48	0.00e+00	843.00
IUUC-Tni-120801	Tetraodon nigroviridis	66.70	0.00e+00	1119.00
IUUC-Tbe-127793	Tupaia belangeri	80.73	0.00e+00	1106.00
IUUC-Ttr-128275	Tursiops truncatus	89.78	0.00e+00	1166.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence