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Tag Content
iUUCD ID IUUC-Dre-028444
Ensembl Protein ID ENSDARP00000005309.7
UniProt Accession Q90XF2; Q7ZU17; KPCI_DANRE
Genbank Protein ID AAK91291.1; AAH47164.1
Protein Name Protein kinase C iota type; Atypical protein kinase C-lambda/iota; Heart and soul protein; nPKC-iota
Genbank Nucleotide ID AF390109; BC047164
Gene Name prkci; hal
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSDARG00000021225.8 ENSDART00000015723.7 ENSDARP00000005309.7
Status Unreviewed
Classification
Family E-Value Score Start End
ULD/UDP/UFD/PB1 3.50e-21 76.1 18 99
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   ULD/UDP/UFD/PB1
   S: 1    tvrvkvsykgeirsfaldlekpgkfedLlkavrtltelkn.sevalkYeDedGDlvtlksDedldkavslla.skksllrlliq 82
           +vrvk++y+g+i  + +++e+++++e L+++vr++++++n + +++k+ De+GD +t++s+ +l++a++l++ +k+s l ++++
   Q: 18   QVRVKAYYRGDI--MITHFEPSISYEGLCNEVRDMCSMDNdQLFTMKWIDEEGDPCTVSSQLELEEALRLYElNKDSELIIHVF 99
           69**********..88******************************************************************98 PP
   
Organism Danio rerio
Functional Description
(View)

Functional Description


     Calcium- and diacylglycerol-independent serine/ threonine-protein kinase that plays a general protective role against apoptotic stimuli, is involved in NF-kappa-B activation, cell survival, differentiation and polarity, and contributes to the regulation of microtubule dynamics in the early secretory pathway (By similarity). Is required for the formation and maintenance of the zonula adherens during early epithelial development and plays a critical role in organ morphogenesis and in regulating the orientation of cell division.
 Calcium- and diacylglycerol-independent serine/ threonine-protein kinase that plays a general protective role against apoptotic stimuli, is involved in NF-kappa-B activation, cell survival, differentiation and polarity, and contributes to the regulation of microtubule dynamics in the early secretory pathway (By similarity). Is required for the formation and maintenance of the zonula adherens during early epithelial development and plays a critical role in organ morphogenesis and in regulating the orientation of cell division.
Protein Sequence
(Fasta)
MPTLRDSTMS HPGENPHQVR VKAYYRGDIM ITHFEPSISY EGLCNEVRDM CSMDNDQLFT 60
MKWIDEEGDP CTVSSQLELE EALRLYELNK DSELIIHVFP CVPEKPGMPC PGEDKSIYRR 120
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Protein Fasta Sequence


>IUUC-Dre-028444|ULD,PB1|Danio rerio
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Nucleotide Sequence
(Fasta)
CCCCCTCCAC ATTCCGCTGT TTGGATCAGT CCGTCTCGAG GCCTGCGCGA CAGAAGAAGG 60
GAGTGTTTCC CCGTCTGACA GAACTTCTAG TAGTCCGATT AATTTCCGTC TGAACTTCAC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Dre-028444|ULD,PB1|Danio rerio
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0217--Developmental protein
KW-0418--Kinase
KW-0479--Metal-binding
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0723--Serine/threonine-protein kinase
KW-0808--Transferase
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR000961--AGC-kinase_C
IPR034661--aPKC_iota
IPR020454--DAG/PE-bd
IPR011009--Kinase-like_dom
IPR000270--PB1_dom
IPR002219--PE/DAG-bd
IPR012233--PKC
IPR017892--Pkinase_C
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR008271--Ser/Thr_kinase_AS
PROSITE

PS51285--AGC_KINASE_CTER
PS51745--PB1
PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00108--PROTEIN_KINASE_ST
PS00479--ZF_DAG_PE_1
PS50081--ZF_DAG_PE_2
Pfam

PF00130--C1_1
PF00564--PB1
PF00069--Pkinase
PF00433--Pkinase_C
PRINTS

PR00008--DAGPEDOMAIN
SMART

SM00109--C1
SM00666--PB1
SM00133--S_TK_X
SM00220--S_TKc
Gene Ontology

GO:0005829--C:cytosol
GO:0005622--C:intracellular
GO:0031226--C:intrinsic component of plasma membrane
GO:0005634--C:nucleus
GO:0005915--C:zonula adherens
GO:0005524--F:ATP binding
GO:0046872--F:metal ion binding
GO:0005543--F:phospholipid binding
GO:0004697--F:protein kinase C activity
GO:0004674--F:protein serine/threonine kinase activity
GO:0034334--P:adherens junction maintenance
GO:0034332--P:adherens junction organization
GO:0007420--P:brain development
GO:0045217--P:cell-cell junction maintenance
GO:0045216--P:cell-cell junction organization
GO:0007502--P:digestive tract mesoderm development
GO:0048546--P:digestive tract morphogenesis
GO:0021744--P:dorsal motor nucleus of vagus nerve development
GO:0035050--P:embryonic heart tube development
GO:0000132--P:establishment of mitotic spindle orientation
GO:0016332--P:establishment or maintenance of polarity of embryonic epithelium
GO:0048699--P:generation of neurons
GO:0007507--P:heart development
GO:0035556--P:intracellular signal transduction
GO:0045199--P:maintenance of epithelial cell apical/basal polarity
GO:0008078--P:mesodermal cell migration
GO:0001738--P:morphogenesis of a polarized epithelium
GO:0001841--P:neural tube formation
GO:0007405--P:neuroblast proliferation
GO:0007097--P:nuclear migration
GO:0042476--P:odontogenesis
GO:0018105--P:peptidyl-serine phosphorylation
GO:0035845--P:photoreceptor cell outer segment organization
GO:0035778--P:pronephric nephron tubule epithelial cell differentiation
GO:0060041--P:retina development in camera-type eye
GO:0060042--P:retina morphogenesis in camera-type eye
GO:0021591--P:ventricular system development
KEGG dre:117507
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001764 Ailuropoda melanoleuca 89.31 0.00e+00 934.00
IUUC-Apl-003711 Anas platyrhynchos 90.07 0.00e+00 1023.00
IUUC-Aca-005142 Anolis carolinensis 89.70 0.00e+00 1035.00
IUUC-Ame-010977 Astyanax mexicanus 91.50 0.00e+00 1058.00
IUUC-Bta-013414 Bos taurus 88.59 0.00e+00 1060.00
IUUC-Cel-018340 Caenorhabditis elegans 58.26 0.00e+00 699.00
IUUC-Cja-019802 Callithrix jacchus 89.70 0.00e+00 1019.00
IUUC-Cfa-021236 Canis familiaris 87.92 0.00e+00 1044.00
IUUC-Cpo-022127 Cavia porcellus 87.48 0.00e+00 987.00
IUUC-Csa-023332 Chlorocebus sabaeus 89.42 0.00e+00 866.00
IUUC-Cho-025054 Choloepus hoffmanni 91.06 1.00e-64 241.00
IUUC-Cin-025740 Ciona intestinalis 58.85 0.00e+00 691.00
IUUC-Csv-026145 Ciona savignyi 61.01 0.00e+00 695.00
IUUC-Dno-029228 Dasypus novemcinctus 96.77 0.00e+00 632.00
IUUC-Dme-031630 Drosophila melanogaster 67.01 0.00e+00 798.00
IUUC-Ete-032633 Echinops telfairi 67.41 5.00e-174 604.00
IUUC-Eca-033572 Equus caballus 89.68 0.00e+00 1021.00
IUUC-Eeu-035110 Erinaceus europaeus 88.74 0.00e+00 1052.00
IUUC-Fca-035559 Felis catus 88.26 0.00e+00 1059.00
IUUC-Fal-036953 Ficedula albicollis 90.21 0.00e+00 1021.00
IUUC-Gmo-039334 Gadus morhua 92.18 0.00e+00 1096.00
IUUC-Gga-040223 Gallus gallus 87.98 0.00e+00 1053.00
IUUC-Gac-042113 Gasterosteus aculeatus 91.23 0.00e+00 1089.00
IUUC-Ggo-044520 Gorilla gorilla 84.31 0.00e+00 957.00
IUUC-Hsa-046991 Homo sapiens 88.42 0.00e+00 1061.00
IUUC-Lch-050263 Latimeria chalumnae 87.46 0.00e+00 1040.00
IUUC-Loc-052221 Lepisosteus oculatus 91.85 0.00e+00 1052.00
IUUC-Laf-053591 Loxodonta africana 88.59 0.00e+00 1059.00
IUUC-Mcc-055118 Macaca mulatta 88.24 0.00e+00 1047.00
IUUC-Mga-059886 Meleagris gallopavo 90.07 0.00e+00 1021.00
IUUC-Mmr-060926 Microcebus murinus 88.59 0.00e+00 1061.00
IUUC-Mdo-062698 Monodelphis domestica 85.26 0.00e+00 1015.00
IUUC-Mmu-063689 Mus musculus 88.09 0.00e+00 1049.00
IUUC-Mpu-066630 Mustela putorius furo 89.43 0.00e+00 1046.00
IUUC-Mlu-067416 Myotis lucifugus 86.10 0.00e+00 1007.00
IUUC-Nle-069811 Nomascus leucogenys 88.42 0.00e+00 1059.00
IUUC-Opr-070466 Ochotona princeps 79.60 0.00e+00 679.00
IUUC-Ont-072278 Oreochromis niloticus 88.93 0.00e+00 1008.00
IUUC-Oan-073651 Ornithorhynchus anatinus 96.13 0.00e+00 726.00
IUUC-Ocu-074383 Oryctolagus cuniculus 88.42 0.00e+00 1060.00
IUUC-Ola-087283 Oryzias latipes 84.50 0.00e+00 836.00
IUUC-Oga-088337 Otolemur garnettii 81.20 0.00e+00 951.00
IUUC-Oar-089954 Ovis aries 89.88 0.00e+00 1028.00
IUUC-Ptr-091673 Pan troglodytes 88.42 0.00e+00 1061.00
IUUC-Pan-092494 Papio anubis 88.42 0.00e+00 1057.00
IUUC-Psi-094044 Pelodiscus sinensis 86.49 0.00e+00 1041.00
IUUC-Pfo-096661 Poecilia formosa 88.94 0.00e+00 1040.00
IUUC-Pab-097659 Pongo abelii 88.09 0.00e+00 1053.00
IUUC-Pca-101107 Procavia capensis 89.53 0.00e+00 726.00
IUUC-Rno-105790 Rattus norvegicus 88.26 0.00e+00 1055.00
IUUC-Sha-106895 Sarcophilus harrisii 89.58 0.00e+00 1004.00
IUUC-Sar-113513 Sorex araneus 85.05 4.00e-153 535.00
IUUC-Ssc-115835 Sus scrofa 89.08 0.00e+00 936.00
IUUC-Tgu-116874 Taeniopygia guttata 87.85 0.00e+00 1048.00
IUUC-Tru-117823 Takifugu rubripes 91.00 0.00e+00 1048.00
IUUC-Tsy-119154 Tarsius syrichta 89.88 0.00e+00 1020.00
IUUC-Tni-119968 Tetraodon nigroviridis 90.64 0.00e+00 1044.00
IUUC-Tbe-127238 Tupaia belangeri 71.05 0.00e+00 669.00
IUUC-Ttr-129208 Tursiops truncatus 88.27 0.00e+00 1059.00
IUUC-Vpa-130363 Vicugna pacos 79.70 0.00e+00 920.00
IUUC-Xtr-132652 Xenopus tropicalis 83.90 0.00e+00 1002.00
Created Date 25-Jun-2017

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