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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Mmu-063569
UUCD1 version UUC-MuM-00032
Ensembl Protein ID ENSMUSP00000124710.1
UniProt Accession Q7TPH6; Q6PCM8; MYCB2_MOUSE
Genbank Protein ID AAP88591.1; AAH59257.1
Protein Name E3 ubiquitin-protein ligase MYCBP2; Myc-binding protein 2; Pam/highwire/rpm-1 protein; Protein associated with Myc; RING-type E3 ubiquitin transferase MYCBP2
Genbank Nucleotide ID AY325887; BC059257
Gene Name Mycbp2; Pam; Phr1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000033004.14 ENSMUST00000159855.7 ENSMUSP00000124710.1
ENSMUSG00000033004.14 ENSMUST00000161278.1 ENSMUSP00000125189.1
ENSMUSG00000033004.14 ENSMUST00000161008.7 ENSMUSP00000124443.1
ENSMUSG00000033004.14 ENSMUST00000160758.7 ENSMUSP00000124601.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemiRTarBasemicroRNATRANSFAC
RepTarRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
Mentha
Protein 3D Structure
PDBMMDB
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusdbPTMPhospho.ELM
UniProtPHOSIDAmUbiSiDa
Protein Expression/Proteomics
GPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/RING/RING RING 20534529; 20203175; 20592256
Reviewed
Classification
Family Identity E-value Score Source Orthology
E3 activity/RING/RING 62.76 0.00e+00 727.00 IUUC-Dme-031777
Organism Mus musculus
Functional Description
(View)

Functional Description


     E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of TSC2/tuberin. Interacts with the E2 enzymes UBE2D1, UBE2D3 and UBE2L3 (By similarity). May have a role during synaptogenesis; candidate for respiratory distress and ventilatory disorders that arise from defective neuronal control of breathing. May function as a facilitator or regulator of transcriptional activation by MYC.
 E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of TSC2/tuberin. Interacts with the E2 enzymes UBE2D1, UBE2D3 and UBE2L3 (By similarity). May have a role during synaptogenesis; candidate for respiratory distress and ventilatory disorders that arise from defective neuronal control of breathing. May function as a facilitator or regulator of transcriptional activation by MYC.
Protein Sequence
(Fasta)
MMMCAATASP AAASSGPGGD GFFAAATISS SPAPGALFMP VPDGSVAAAG LGLGLPTTDS 60
RGHYQLLLSG RALADRYRRI YTTALSDRDQ AGSSTGHPAS RNKKILNKKK LKRKQKSKSK 120
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Protein Fasta Sequence


>IUUC-Mmu-063569|E3,RING|Mus musculus
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Nucleotide Sequence
(Fasta)
TCCCATTGCG GGCAACTCCG GTGGTGGCAG CAGCAGCGGC GGCGGCGGCA CCGCCTCCTC 60
CTCACACTCC GCGGGTGGCG GGGTTAGATG AGCGGCCCCA ACAGCGGCGA GGGCGGCGCA 120
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Nucleotide Fasta Sequence


>IUUC-Mmu-063569|E3,RING|Mus musculus
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Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0903--Direct protein sequencing
KW-1015--Disulfide bond
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR004939--APC_su10/DOC_dom
IPR017868--Filamin/ABP280_repeat-like
IPR008979--Galactose-bd-like
IPR013783--Ig-like_fold
IPR014756--Ig_E-set
IPR012983--PHR
IPR009091--RCC1/BLIP-II
IPR000408--Reg_chr_condens
IPR003646--SH3-like_bac-type
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS51284--DOC
PS50194--FILAMIN_REPEAT
PS00626--RCC1_2
PS50012--RCC1_3
PS50089--ZF_RING_2
Pfam

PF03256--ANAPC10
PF00630--Filamin
PF08005--PHR
PF00415--RCC1
PF08239--SH3_3
PF13639--zf-RING_2
PRINTS

PR00633--RCCNDNSATION
SMART

SM01337--APC10
SM00184--RING
Gene Ontology

GO:0030424--C:axon
GO:0016020--C:membrane
GO:0015630--C:microtubule cytoskeleton
GO:0005634--C:nucleus
GO:0042803--F:protein homodimerization activity
GO:0016740--F:transferase activity
GO:0008270--F:zinc ion binding
GO:0021785--P:branchiomotor neuron axon guidance
GO:0048667--P:cell morphogenesis involved in neuron differentiation
GO:0021952--P:central nervous system projection neuron axonogenesis
GO:0008045--P:motor neuron axon guidance
GO:0042177--P:negative regulation of protein catabolic process
GO:0016567--P:protein ubiquitination
GO:0051493--P:regulation of cytoskeleton organization
GO:0032880--P:regulation of protein localization
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated
KEGG mmu:105689
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001951 Ailuropoda melanoleuca 97.24 0.00e+00 8628.00
IUUC-Apl-003625 Anas platyrhynchos 91.84 0.00e+00 8114.00
IUUC-Aca-005207 Anolis carolinensis 91.35 0.00e+00 8043.00
IUUC-Ame-010649 Astyanax mexicanus 85.04 0.00e+00 7691.00
IUUC-Bta-012670 Bos taurus 95.64 0.00e+00 8533.00
IUUC-Cel-018686 Caenorhabditis elegans 32.47 0.00e+00 660.00
IUUC-Cja-019910 Callithrix jacchus 95.48 0.00e+00 8569.00
IUUC-Cfa-020184 Canis familiaris 96.82 0.00e+00 8685.00
IUUC-Cpo-021334 Cavia porcellus 94.73 0.00e+00 8424.00
IUUC-Csa-023291 Chlorocebus sabaeus 97.20 0.00e+00 8777.00
IUUC-Cho-024927 Choloepus hoffmanni 89.86 0.00e+00 856.00
IUUC-Cin-025345 Ciona intestinalis 53.78 0.00e+00 942.00
IUUC-Csv-026264 Ciona savignyi 50.38 0.00e+00 1095.00
IUUC-Dre-028645 Danio rerio 84.14 0.00e+00 7616.00
IUUC-Dno-029670 Dasypus novemcinctus 94.35 0.00e+00 8416.00
IUUC-Dor-030993 Dipodomys ordii 90.96 0.00e+00 2398.00
IUUC-Dme-031777 Drosophila melanogaster 62.57 0.00e+00 725.00
IUUC-Ete-032613 Echinops telfairi 90.33 0.00e+00 8023.00
IUUC-Eca-034364 Equus caballus 97.07 0.00e+00 8735.00
IUUC-Eeu-035200 Erinaceus europaeus 79.12 0.00e+00 2510.00
IUUC-Fca-036054 Felis catus 94.32 0.00e+00 8488.00
IUUC-Fal-036991 Ficedula albicollis 93.24 0.00e+00 8255.00
IUUC-Gmo-038487 Gadus morhua 85.25 0.00e+00 4133.00
IUUC-Gga-041035 Gallus gallus 92.45 0.00e+00 8260.00
IUUC-Gac-041637 Gasterosteus aculeatus 84.79 0.00e+00 4082.00
IUUC-Ggo-045091 Gorilla gorilla 94.36 0.00e+00 7307.00
IUUC-Hsa-046977 Homo sapiens 95.42 0.00e+00 8557.00
IUUC-Itr-048995 Ictidomys tridecemlineatus 94.00 0.00e+00 2503.00
IUUC-Lch-050171 Latimeria chalumnae 73.46 0.00e+00 1243.00
IUUC-Loc-052822 Lepisosteus oculatus 86.81 0.00e+00 7799.00
IUUC-Laf-054065 Loxodonta africana 96.86 0.00e+00 8711.00
IUUC-Mcc-054947 Macaca mulatta 97.24 0.00e+00 8786.00
IUUC-Meu-056600 Macropus eugenii 89.58 0.00e+00 1516.00
IUUC-Mga-059559 Meleagris gallopavo 91.23 0.00e+00 7438.00
IUUC-Mmr-060973 Microcebus murinus 96.69 0.00e+00 7176.00
IUUC-Mdo-061938 Monodelphis domestica 91.80 0.00e+00 5031.00
IUUC-Mpu-066457 Mustela putorius furo 97.31 0.00e+00 8661.00
IUUC-Mlu-067165 Myotis lucifugus 95.29 0.00e+00 8103.00
IUUC-Nle-069042 Nomascus leucogenys 95.14 0.00e+00 8589.00
IUUC-Opr-070201 Ochotona princeps 82.31 0.00e+00 2817.00
IUUC-Ont-072263 Oreochromis niloticus 83.55 0.00e+00 7418.00
IUUC-Oan-073108 Ornithorhynchus anatinus 91.56 0.00e+00 6917.00
IUUC-Ocu-074359 Oryctolagus cuniculus 95.67 0.00e+00 6999.00
IUUC-Ola-087074 Oryzias latipes 81.29 0.00e+00 5023.00
IUUC-Oga-088322 Otolemur garnettii 95.42 0.00e+00 8569.00
IUUC-Oar-089244 Ovis aries 96.70 0.00e+00 8630.00
IUUC-Ptr-091449 Pan troglodytes 95.00 0.00e+00 8560.00
IUUC-Pan-091756 Papio anubis 96.47 0.00e+00 5074.00
IUUC-Psi-093387 Pelodiscus sinensis 91.33 0.00e+00 6182.00
IUUC-Pma-094327 Petromyzon marinus 71.05 4.00e-119 421.00
IUUC-Ppa-095276 Physcomitrella patens 40.38 7.00e-56 211.00
IUUC-Pfo-097372 Poecilia formosa 84.19 0.00e+00 7524.00
IUUC-Pab-097572 Pongo abelii 96.05 0.00e+00 7200.00
IUUC-Pca-101007 Procavia capensis 91.93 0.00e+00 4009.00
IUUC-Pva-102217 Pteropus vampyrus 89.99 0.00e+00 4274.00
IUUC-Rno-105422 Rattus norvegicus 96.12 0.00e+00 8409.00
IUUC-Sha-107119 Sarcophilus harrisii 86.14 0.00e+00 3929.00
IUUC-Smo-108712 Selaginella moellendorffii 39.60 5.00e-57 214.00
IUUC-Sar-113595 Sorex araneus 94.50 0.00e+00 2315.00
IUUC-Ssc-115690 Sus scrofa 95.37 0.00e+00 8229.00
IUUC-Tgu-116555 Taeniopygia guttata 91.49 0.00e+00 7670.00
IUUC-Tru-117796 Takifugu rubripes 83.22 0.00e+00 7535.00
IUUC-Tsy-118924 Tarsius syrichta 91.96 0.00e+00 5579.00
IUUC-Tni-120759 Tetraodon nigroviridis 82.85 0.00e+00 7452.00
IUUC-Ttr-128814 Tursiops truncatus 93.68 0.00e+00 3643.00
IUUC-Vpa-130430 Vicugna pacos 92.22 0.00e+00 8097.00
IUUC-Xtr-131898 Xenopus tropicalis 86.69 0.00e+00 1567.00
Created Date 25-Jun-2017

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