iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Dre-027612

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

SHANK-associated RH domain-interacting protein

Genbank Nucleotide ID

CU693494

Gene Name

sharpin

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSDARG00000076995.4	ENSDART00000155651.1	ENSDARP00000128247.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/ZnF/NZF	4.40e-11	43.0	349	376
ULD/UDP/UBQ/UBQ_Other	6.30e-10	39.7	191	260

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/ZnF/NZF

   S: 2    eaqWaCsaCTflNePeavkCemCsrpRg 29
           +++W C++CTf+N++ +++Ce+Cs+ R+
   Q: 349  QSGWPCPSCTFINKSTRPGCEICSTDRP 376
           799**********************998 PP

ULD/UDP/UBQ/UBQ_Other

   S: 3    vtvksldgs.eltlkvnpsdtVaeLKekiekklgippeqqrLiykGkiL.eddktLady.glkdgstihll 70
           v+v+++ +s   t+k++p+ tVa LK++++ + g++p+ qr+i+  ++L  d +++++y   +dg+t++l+
   Q: 191  VIVEDASSScCVTVKIHPHVTVASLKQQMFVEYGFHPRVQRWII-SQCLcSDSRSVSSYgVCRDGDTAFLY 260
           7899999999*********************************9.66777*********556999999997 PP

Organism

Danio rerio

Protein Sequence
(Fasta)

MSTSTGCSTV LMSVRVSVRP LPVGSDSLRL QLSMNPNRAG LFTLTLRHTD RGGRSVSLAE 60
FDLRSVQYEL KSPRCHELRL LKPPHDCLSF SFRSEQEAQE WATVVMSSLR ESHRVASICQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCTTAATATA ATACAATTAA TGGGTAATTT AATAAATAAT ATTACAAATT CTGTCCGCTG 60
TATCCTTTCC AGCACCCACT GTCGGAACCA CACGTTTGTG TCAGGAGAAA GTGGCGGTAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome

Interpro

IPR011993--PH_dom-like
IPR031912--Sharpin_PH
IPR029071--Ubiquitin-rel_dom
IPR001876--Znf_RanBP2

PROSITE

PS01358--ZF_RANBP2_1
PS50199--ZF_RANBP2_2

Pfam

PF16764--Sharpin_PH
PF00641--zf-RanBP

SMART

SM00547--ZnF_RBZ

Gene Ontology

GO:0071797--C:LUBAC complex
GO:0043130--F:ubiquitin binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0048701--P:embryonic cranial skeleton morphogenesis
GO:0048592--P:eye morphogenesis
GO:0071600--P:otic vesicle morphogenesis
GO:0043123--P:positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0097039--P:protein linear polyubiquitination

KEGG

dre:793673

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001223	Ailuropoda melanoleuca	36.75	7.00e-44	171.00
IUUC-Acl-008308	Aspergillus clavatus	39.47	1.30e-02	34.30
IUUC-Afu-008913	Aspergillus fumigatus	40.74	3.30e-02	33.10
IUUC-Cja-019031	Callithrix jacchus	40.31	1.00e-31	130.00
IUUC-Cfa-020863	Canis familiaris	34.61	1.00e-38	154.00
IUUC-Cpo-022499	Cavia porcellus	35.52	3.00e-39	155.00
IUUC-Dor-030914	Dipodomys ordii	36.10	4.00e-32	132.00
IUUC-Ete-032940	Echinops telfairi	38.71	8.00e-38	151.00
IUUC-Eca-033537	Equus caballus	36.04	1.00e-47	184.00
IUUC-Eeu-035176	Erinaceus europaeus	52.71	3.00e-32	132.00
IUUC-Mcc-055686	Macaca mulatta	35.58	9.00e-42	164.00
IUUC-Mmr-060584	Microcebus murinus	36.34	2.00e-43	169.00
IUUC-Mmu-063740	Mus musculus	37.80	5.00e-34	138.00
IUUC-Mlu-067878	Myotis lucifugus	37.95	6.00e-50	191.00
IUUC-Nfi-068513	Neosartorya fischeri	40.74	3.70e-02	32.70
IUUC-Oga-088300	Otolemur garnettii	36.63	1.00e-46	180.00
IUUC-Oar-089549	Ovis aries	35.86	5.00e-42	165.00
IUUC-Pva-102595	Pteropus vampyrus	40.23	3.00e-39	156.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence