iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
microRNA	TRANSFAC	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/ZnF/NZF	2.90e-12	46.3	343	371
ULD/UDP/UBQ/UBQ_Other	1.50e-11	44.4	232	287

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/ZnF/NZF

   S: 2    eaqWaCsaCTflNePeavkCemCsrpRgc 30
           +++W+C++CTf+N++++++CemCs++R+c
   Q: 343  QPGWSCPSCTFINASNRPGCEMCSTQRPC 371
           789*************************9 PP

ULD/UDP/UBQ/UBQ_Other

   S: 9    dgs.eltlkvnpsdtVaeLKekiekklgippeqqrLiykGkiL.eddktLadyglkd 63
            +s + +l+++p++++a L+e++++++g+pp+ qr+++ G++L  + ++La+yg+ +
   Q: 232  SSSaHVSLQIHPHCSIAALQEQVFSEFGFPPAVQRWVI-GRCLcMPERSLASYGVSQ 287
           2333666779****************************.**************8843 PP

Organism

Rattus norvegicus

Functional Description
(View)

Component of the LUBAC complex which conjugates linear polyubiquitin chains in a head-to-tail manner to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation. LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways. Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation. LUBAC is proposed to be recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex. Together with FAM105B/otulin, the LUBAC complex regulates the canonical Wnt signaling during angiogenesis (By similarity).

Protein Sequence
(Fasta)

MSPPAGGAAA AADPASPVVL LAVQAAVRLL GAGHEDEAQL RKLQLKADPE RPGRFRLGLL 60
GIEPGAVSLE WPLESICYTI RGPNQHELQP PPGGPGTFSV HFLNSEEAQQ WAALVRDATA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTGGTTTTGG CTTATGTCGG GCAGCAGCTA TCGTTCGTTC GAACTTTTAA GAAAAGTCCA 60
TCCTTGCCTC CTTTTTGTGA ACGGTGATCG GTCTGTGACA CTGTCCCCAG GTCCTGCAGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0965--Cell junction
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0770--Synapse
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR031912--Sharpin_PH
IPR029071--Ubiquitin-rel_dom
IPR001876--Znf_RanBP2

PROSITE

PS01358--ZF_RANBP2_1
PS50199--ZF_RANBP2_2

Pfam

PF16764--Sharpin_PH

SMART

SM00547--ZnF_RBZ

Gene Ontology

GO:0030054--C:cell junction
GO:0005829--C:cytosol
GO:0030425--C:dendrite
GO:0071797--C:LUBAC complex
GO:0014069--C:postsynaptic density
GO:0042802--F:identical protein binding
GO:0031593--F:polyubiquitin binding
GO:0032403--F:protein complex binding
GO:0043130--F:ubiquitin binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0030262--P:apoptotic nuclear changes
GO:0007420--P:brain development
GO:0031424--P:keratinization
GO:0007005--P:mitochondrion organization
GO:0050728--P:negative regulation of inflammatory response
GO:0043123--P:positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0051260--P:protein homooligomerization
GO:0097039--P:protein linear polyubiquitination
GO:2000348--P:regulation of CD40 signaling pathway
GO:0010803--P:regulation of tumor necrosis factor-mediated signaling pathway

KEGG

rno:81859

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001223	Ailuropoda melanoleuca	69.38	2.00e-111	395.00
IUUC-Apl-004151	Anas platyrhynchos	63.83	3.00e-16	76.30
IUUC-Afu-008913	Aspergillus fumigatus	44.00	3.00e-02	33.10
IUUC-Ang-009713	Aspergillus niger	31.67	3.10e-01	29.60
IUUC-Bta-012948	Bos taurus	71.83	6.00e-119	420.00
IUUC-Cja-019031	Callithrix jacchus	67.59	9.00e-107	380.00
IUUC-Cfa-020863	Canis familiaris	66.12	3.00e-93	335.00
IUUC-Cpo-022499	Cavia porcellus	69.48	2.00e-111	395.00
IUUC-Csa-023641	Chlorocebus sabaeus	71.63	2.00e-112	398.00
IUUC-Dno-029459	Dasypus novemcinctus	68.94	1.00e-47	182.00
IUUC-Dor-030914	Dipodomys ordii	62.58	1.00e-79	290.00
IUUC-Ete-032940	Echinops telfairi	61.86	7.00e-80	290.00
IUUC-Eca-033537	Equus caballus	71.02	6.00e-116	410.00
IUUC-Eeu-035176	Erinaceus europaeus	62.78	3.00e-49	188.00
IUUC-Fca-035971	Felis catus	69.55	1.00e-103	369.00
IUUC-Gmo-039219	Gadus morhua	35.26	9.00e-43	167.00
IUUC-Gac-041562	Gasterosteus aculeatus	37.90	9.00e-33	134.00
IUUC-Ggo-044678	Gorilla gorilla	70.60	9.00e-111	393.00
IUUC-Hsa-046578	Homo sapiens	72.70	6.00e-117	414.00
IUUC-Itr-047913	Ictidomys tridecemlineatus	69.51	3.00e-113	401.00
IUUC-Mcc-055686	Macaca mulatta	66.57	3.00e-115	407.00
IUUC-Meu-055912	Macropus eugenii	48.41	1.00e-49	189.00
IUUC-Mmr-060584	Microcebus murinus	71.23	4.00e-119	421.00
IUUC-Mdo-062191	Monodelphis domestica	49.41	1.00e-68	253.00
IUUC-Mmu-063740	Mus musculus	88.52	5.00e-144	503.00
IUUC-Mpu-066878	Mustela putorius furo	67.46	1.00e-94	340.00
IUUC-Mlu-067878	Myotis lucifugus	70.41	3.00e-115	407.00
IUUC-Nfi-068513	Neosartorya fischeri	44.00	3.10e-02	33.10
IUUC-Nle-069748	Nomascus leucogenys	72.55	1.00e-106	379.00
IUUC-Ont-072270	Oreochromis niloticus	34.19	6.00e-40	158.00
IUUC-Oga-088300	Otolemur garnettii	72.28	1.00e-122	432.00
IUUC-Oar-089549	Ovis aries	71.91	8.00e-123	433.00
IUUC-Ptr-090961	Pan troglodytes	72.58	3.00e-105	375.00
IUUC-Pan-092687	Papio anubis	71.51	1.00e-113	403.00
IUUC-Pfo-096865	Poecilia formosa	31.51	6.00e-32	131.00
IUUC-Pab-097872	Pongo abelii	72.61	2.00e-103	369.00
IUUC-Pca-100363	Procavia capensis	63.13	5.00e-53	201.00
IUUC-Pva-102595	Pteropus vampyrus	67.91	4.00e-96	344.00
IUUC-Sha-106838	Sarcophilus harrisii	48.12	7.00e-56	211.00
IUUC-Sar-113611	Sorex araneus	73.17	2.00e-25	109.00
IUUC-Ssc-116263	Sus scrofa	69.57	9.00e-111	393.00
IUUC-Tru-118089	Takifugu rubripes	35.95	2.00e-46	179.00
IUUC-Tni-120004	Tetraodon nigroviridis	34.91	3.00e-37	149.00
IUUC-Tbe-127471	Tupaia belangeri	64.40	3.00e-89	322.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence