iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
RAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
CPLM	PhosphositePlus
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/Alpha-Helix/UBA	2.30e-10	40.7	596	633
ULD/UDP/UBQ/UBQ_PIM	1.80e-23	82.7	33	106

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/Alpha-Helix/UBA

   S: 3    dedkleqlveMGF.dreealqaLraannnleaAveyLl 39
           ++++leql +MGF +re++lqaL a++++++aA+e+Ll
   Q: 596  FQQQLEQLNAMGFlNREANLQALIATGGDINAAIERLL 633
           799**********************************9 PP

ULD/UDP/UBQ/UBQ_PIM

   S: 1    mkltvktlkgkefelevseddtveelKekiakesgvppeqqkLIyaGkiLkDdttLselgikdgsvvhlvvkksk 75
           +k+tvkt+k+ke e+ v e++tv+++Ke+i+k+++ + +q+ LI+aGkiLkD++tL ++gi+dg +vhlv+k ++
   Q: 33   IKVTVKTPKEKE-EFAVPENSTVQQFKEAISKRFKSQTDQLVLIFAGKILKDQDTLIQHGIHDGLTVHLVIKSQN 106
           69**********.***********************************************************986 PP

Organism

Rattus norvegicus

Protein Sequence
(Fasta)

MAENGESSGP PRPSRGPAAA PGAANPPAEP KIIKVTVKTP KEKEEFAVPE NSTVQQFKEA 60
ISKRFKSQTD QLVLIFAGKI LKDQDTLIQH GIHDGLTVHL VIKSQNRPQG QATTQPSTTA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGCGCGGGCG CCGCAGCTGC AGGAGTCGCT GGGAGTGCGC GCGGGCAGAT CACAAGGCGG 60
CGGCGGCAGA GACGGCCTGC AGGACCTGCT CTCTCAGCCC TTAGCCGAGG CCTACGCCGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1267--Proteomics identification
KW-1185--Reference proteome

Interpro

IPR016024--ARM-type_fold
IPR006636--STI1_HS-bd
IPR015940--UBA
IPR009060--UBA-like
IPR015496--Ubiquilin
IPR029071--Ubiquitin-rel_dom
IPR000626--Ubiquitin_dom

PROSITE

PS50030--UBA
PS50053--UBIQUITIN_2

Pfam

PF00627--UBA
PF00240--ubiquitin

SMART

SM00727--STI1
SM00165--UBA
SM00213--UBQ

Gene Ontology

GO:0005829--C:cytosol
GO:0005886--C:plasma membrane
GO:1900186--P:negative regulation of clathrin-dependent endocytosis
GO:1904021--P:negative regulation of G-protein coupled receptor internalization
GO:1903071--P:positive regulation of ER-associated ubiquitin-dependent protein catabolic process
GO:2000785--P:regulation of autophagosome assembly
GO:0030433--P:ubiquitin-dependent ERAD pathway

KEGG

rno:317396

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Bta-013571	Bos taurus	89.89	3.00e-170	592.00
IUUC-Cre-022634	Chlamydomonas reinhardtii	48.15	3.00e-11	62.80
IUUC-Csa-023627	Chlorocebus sabaeus	88.82	5.00e-171	594.00
IUUC-Ete-033071	Echinops telfairi	85.91	2.00e-163	569.00
IUUC-Eeu-034727	Erinaceus europaeus	88.17	7.00e-169	587.00
IUUC-Fso-038204	Fusarium solani	43.28	2.00e-08	53.50
IUUC-Mor-057194	Magnaporthe oryzae	49.02	8.00e-08	51.60
IUUC-Mmu-064179	Mus musculus	95.70	2.00e-179	622.00
IUUC-Mlu-067252	Myotis lucifugus	84.36	1.00e-130	459.00
IUUC-Ncr-068732	Neurospora crassa	48.00	1.00e-07	50.80
IUUC-Pca-100227	Procavia capensis	87.03	1.00e-88	320.00
IUUC-Pgr-103261	Puccinia graminis	53.33	2.00e-07	50.40
IUUC-Sar-113652	Sorex araneus	93.08	6.00e-65	241.00
IUUC-Vda-129991	Verticillium dahliae	46.30	3.00e-07	50.10

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence