iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ont-071345

Ensembl Protein ID

ENSONIP00000004751.1

UniProt Accession

I3J7B1; I3J7B1_ORENI

Genbank Protein ID

ENSONIP00000004751

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AERX01034983

Gene Name

HECW2 (1 of many)

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSONIG00000003777.1	ENSONIT00000004754.1	ENSONIP00000004751.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	7.30e-121	404.0	1205	1537

Active Site

Position(s)	Description	Evidence
1505	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 3    sdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlld 89
           + ++++l+v+fvgEegld++G++ref++l+s+el+np++glf+ys+nd++t+q++p s +   +h ++F+f Gr+lg+al ++ lld
   Q: 1205 DLQRSKLYVSFVGEEGLDYSGPSREFFFLVSRELFNPYYGLFEYSANDTYTVQISPMSAFV-DNHHEWFRFSGRILGMALIHQYLLD 1290
           456689****************************************************985.5************************ PP
   S: 90   lplsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvkl 176
           ++++++fyk ll+ +++l+dle +d+e+++sl+++k+n   di+++ ldl+f+v+ee++g+++e+eLkpgG+nipV ++Nk+eY+++
   Q: 1291 AFFTRPFYKGLLRISCDLSDLEYLDEEFHQSLQWMKDN---DIDDM-LDLSFTVNEEVFGQITERELKPGGANIPVSEKNKKEYIER 1373
           ************************************99...9***9.**************************************** PP
   S: 177  vveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerka 263
           +v++r+++g+  q+e++ +Gf+ev++ +l+s+F+++elel+i G++eid+ d++++t+y+ggy++++ +i+wFw ++e+f++e+r +
   Q: 1374 MVKWRIERGVVHQTESLVRGFYEVVDARLVSVFDARELELVIAGTAEIDLTDWRNNTEYRGGYHDNHIVIRWFWAAVERFNNEQRLR 1460
           *************************************************************************************** PP
   S: 264  fLqFvTgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFels 336
           +LqFvTg+s++P +Gfa+l+    pr+f+++k+++ ++lP+++TCfn+L+LP+Y+s ++l+ekLl+A+eet+ F+l+
   Q: 1461 LLQFVTGTSSIPYEGFASLRgsngPRRFCVEKWGKVTSLPRAHTCFNRLDLPPYPSFSVLYEKLLTAVEETSTFGLE 1537
           **************************************************************************985 PP

Organism

Oreochromis niloticus

Protein Sequence
(Fasta)

PSGSAREHLL AVRRRTPHTR PYTIGPDEPI GASTSASSTM SSGNQPETAG LGLQRANSDT 60
DLVTSESRSS LTASTYQVTL GHSQLVISWD IKEEVDAADW IGLYHIDETC VANVWESKNR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCCAGTGGCA GTGCCAGGGA ACACCTGCTG GCGGTGCGTC GGCGCACTCC ACATACCCGA 60
CCCTACACGA TTGGGCCTGA CGTCTGCAGC TTGTCAGTGC AGGAACCAAT TGGAGCCTCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR032348--HECW_N
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF16562--HECW_N
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Apl-003935	Anas platyrhynchos	87.47	0.00e+00	1457.00
IUUC-Ame-010893	Astyanax mexicanus	89.59	0.00e+00	1317.00
IUUC-Bta-013093	Bos taurus	86.57	0.00e+00	1419.00
IUUC-Cja-019651	Callithrix jacchus	86.71	0.00e+00	1443.00
IUUC-Cfa-021232	Canis familiaris	87.91	0.00e+00	1444.00
IUUC-Cpo-021770	Cavia porcellus	88.23	0.00e+00	1474.00
IUUC-Csa-023970	Chlorocebus sabaeus	88.04	0.00e+00	1453.00
IUUC-Cho-024512	Choloepus hoffmanni	78.30	0.00e+00	1231.00
IUUC-Csv-026127	Ciona savignyi	71.99	8.00e-155	540.00
IUUC-Dre-028275	Danio rerio	87.39	0.00e+00	1486.00
IUUC-Dme-032217	Drosophila melanogaster	70.08	0.00e+00	642.00
IUUC-Ete-033132	Echinops telfairi	73.51	0.00e+00	1113.00
IUUC-Eca-033978	Equus caballus	88.02	0.00e+00	1446.00
IUUC-Fal-037110	Ficedula albicollis	87.02	0.00e+00	1448.00
IUUC-Gga-040821	Gallus gallus	88.73	0.00e+00	1461.00
IUUC-Gac-042181	Gasterosteus aculeatus	79.14	0.00e+00	1531.00
IUUC-Ggo-044862	Gorilla gorilla	75.08	0.00e+00	1454.00
IUUC-Hsa-046219	Homo sapiens	74.97	0.00e+00	1481.00
IUUC-Lch-050526	Latimeria chalumnae	86.87	0.00e+00	1443.00
IUUC-Loc-052648	Lepisosteus oculatus	89.67	0.00e+00	1467.00
IUUC-Laf-054005	Loxodonta africana	78.07	0.00e+00	1461.00
IUUC-Mcc-055314	Macaca mulatta	87.91	0.00e+00	1451.00
IUUC-Meu-056356	Macropus eugenii	76.22	0.00e+00	755.00
IUUC-Mga-060074	Meleagris gallopavo	87.96	0.00e+00	1381.00
IUUC-Mmr-061526	Microcebus murinus	88.16	0.00e+00	1453.00
IUUC-Mmu-064165	Mus musculus	87.89	0.00e+00	1450.00
IUUC-Mpu-065835	Mustela putorius furo	88.40	0.00e+00	1389.00
IUUC-Mlu-067709	Myotis lucifugus	86.38	0.00e+00	1414.00
IUUC-Opr-070330	Ochotona princeps	76.29	0.00e+00	1214.00
IUUC-Ocu-074775	Oryctolagus cuniculus	88.04	0.00e+00	1454.00
IUUC-Oga-088177	Otolemur garnettii	88.24	0.00e+00	1450.00
IUUC-Oar-089452	Ovis aries	87.44	0.00e+00	1453.00
IUUC-Pan-091838	Papio anubis	87.80	0.00e+00	1446.00
IUUC-Psi-094090	Pelodiscus sinensis	87.83	0.00e+00	1419.00
IUUC-Pfo-096520	Poecilia formosa	72.31	0.00e+00	2158.00
IUUC-Pab-098405	Pongo abelii	75.08	0.00e+00	1456.00
IUUC-Pva-102324	Pteropus vampyrus	87.44	0.00e+00	1436.00
IUUC-Sha-106985	Sarcophilus harrisii	85.71	0.00e+00	1375.00
IUUC-Sar-113505	Sorex araneus	84.99	0.00e+00	1369.00
IUUC-Ssc-115534	Sus scrofa	96.13	0.00e+00	736.00
IUUC-Tgu-117078	Taeniopygia guttata	86.70	0.00e+00	1447.00
IUUC-Tru-118671	Takifugu rubripes	82.97	0.00e+00	1504.00
IUUC-Tsy-119379	Tarsius syrichta	70.12	0.00e+00	673.00
IUUC-Tni-120619	Tetraodon nigroviridis	91.69	0.00e+00	1498.00
IUUC-Ttr-128469	Tursiops truncatus	77.81	0.00e+00	1226.00
IUUC-Vpa-130498	Vicugna pacos	70.81	0.00e+00	1046.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence