iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
microRNA	RAID2
Post-translational Modifications (PTMs)
dbPAF	PHOSIDA
Protein Expression/Proteomics

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	8.70e-12	44.9	967	1022

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 5    kvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
           +v++ly  ++++++eL+++   +++ +  ++++ gWl+g  +l+gk Gl+Pen+ve+l+
   Q: 967  RVRTLYACMGESEGELSFEPNQIITNV-RYSHEPGWLQG--TLNGKTGLIPENYVEHLK 1022
           799************************.***********..8**************986 PP

Organism

Drosophila melanogaster

Protein Sequence
(Fasta)

MGGGKNVRRG LEPLEFEECI VDSPDFRENL NRHEKELDHT SHQIKRIIKE VKDLMSAAKI 60
LSTRMKQLAI LLNDFNFECI GTAQTDDENV ICESLKRFGA IIGNIEDERE KMLTLADKHI 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGTTAATATA CTTAACAGCA CGTTCAGATA ACTTGTGTAT TTTTATCAGA CCTACATTAA 60
TTTTTTTTTC TAATCGGAGA TTTAACAGTC AAAGTAATAT ATATATATTG TGGTGCATTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0343--GTPase activation
KW-1267--Proteomics identification
KW-1185--Reference proteome

Interpro

IPR027267--AH/BAR-dom
IPR011993--PH_dom-like
IPR001849--PH_domain
IPR008936--Rho_GTPase_activation_prot
IPR000198--RhoGAP_dom
IPR001452--SH3_domain

PROSITE

PS50003--PH_DOMAIN
PS50238--RHOGAP
PS50002--SH3

Pfam

PF00169--PH
PF00620--RhoGAP
PF14604--SH3_9

SMART

SM00324--RhoGAP
SM00326--SH3

Gene Ontology

GO:0005622--C:intracellular
GO:0005096--F:GTPase activator activity
GO:0005543--F:phospholipid binding
GO:0007266--P:Rho protein signal transduction

KEGG

dme:Dmel_CG8948

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001613	Ailuropoda melanoleuca	46.00	1.00e-138	486.00
IUUC-Apl-003297	Anas platyrhynchos	42.56	2.00e-127	449.00
IUUC-Aca-004570	Anolis carolinensis	44.80	1.00e-137	482.00
IUUC-Ame-011422	Astyanax mexicanus	39.37	1.00e-113	402.00
IUUC-Bta-012379	Bos taurus	42.91	4.00e-131	461.00
IUUC-Cel-018542	Caenorhabditis elegans	41.11	1.00e-121	430.00
IUUC-Cja-019208	Callithrix jacchus	45.81	1.00e-138	486.00
IUUC-Cfa-020928	Canis familiaris	45.47	5.00e-138	484.00
IUUC-Cpo-021338	Cavia porcellus	45.64	3.00e-138	485.00
IUUC-Csa-023570	Chlorocebus sabaeus	45.64	4.00e-138	484.00
IUUC-Cin-025725	Ciona intestinalis	38.66	1.00e-103	369.00
IUUC-Cme-027204	Cyanidioschyzon merolae	33.33	2.00e-01	28.10
IUUC-Dre-027525	Danio rerio	41.94	1.00e-121	429.00
IUUC-Dno-029143	Dasypus novemcinctus	45.85	9.00e-139	486.00
IUUC-Dor-030697	Dipodomys ordii	45.97	4.00e-139	488.00
IUUC-Ete-032645	Echinops telfairi	42.61	6.00e-118	417.00
IUUC-Eca-033791	Equus caballus	45.83	7.00e-138	483.00
IUUC-Eeu-035202	Erinaceus europaeus	44.33	8.00e-43	168.00
IUUC-Fca-036131	Felis catus	45.36	7.00e-133	467.00
IUUC-Fal-037129	Ficedula albicollis	45.84	9.00e-139	486.00
IUUC-Gga-041023	Gallus gallus	43.62	6.00e-136	477.00
IUUC-Gac-041728	Gasterosteus aculeatus	39.70	7.00e-112	397.00
IUUC-Ggo-044863	Gorilla gorilla	45.82	9.00e-138	483.00
IUUC-Hsa-046471	Homo sapiens	45.64	6.00e-138	484.00
IUUC-Itr-049060	Ictidomys tridecemlineatus	45.10	4.00e-139	488.00
IUUC-Lch-050300	Latimeria chalumnae	43.31	2.00e-115	409.00
IUUC-Loc-052782	Lepisosteus oculatus	41.59	3.00e-138	484.00
IUUC-Laf-053585	Loxodonta africana	45.84	1.00e-134	473.00
IUUC-Mcc-055458	Macaca mulatta	45.64	2.00e-138	485.00
IUUC-Meu-056107	Macropus eugenii	39.05	8.00e-107	380.00
IUUC-Mga-059914	Meleagris gallopavo	41.65	7.00e-115	407.00
IUUC-Mmr-060728	Microcebus murinus	44.81	1.00e-123	436.00
IUUC-Mdo-062387	Monodelphis domestica	44.77	2.00e-139	489.00
IUUC-Mmu-063756	Mus musculus	45.64	1.00e-140	493.00
IUUC-Mlu-067375	Myotis lucifugus	38.08	1.00e-117	416.00
IUUC-Nle-069043	Nomascus leucogenys	41.21	7.00e-95	340.00
IUUC-Opr-071168	Ochotona princeps	39.58	2.00e-64	239.00
IUUC-Ont-071443	Oreochromis niloticus	42.53	2.00e-130	459.00
IUUC-Oan-073441	Ornithorhynchus anatinus	44.12	2.00e-106	379.00
IUUC-Ocu-073915	Oryctolagus cuniculus	46.01	1.00e-138	486.00
IUUC-Ola-086319	Oryzias latipes	43.68	5.00e-123	434.00
IUUC-Oga-088922	Otolemur garnettii	47.29	2.00e-49	188.00
IUUC-Oar-089349	Ovis aries	45.76	2.00e-137	482.00
IUUC-Ptr-091027	Pan troglodytes	45.64	8.00e-138	483.00
IUUC-Pan-092791	Papio anubis	45.64	3.00e-138	484.00
IUUC-Psi-093144	Pelodiscus sinensis	43.94	1.00e-138	486.00
IUUC-Pma-094731	Petromyzon marinus	30.98	4.00e-17	83.60
IUUC-Pfo-097265	Poecilia formosa	40.16	1.00e-124	439.00
IUUC-Pab-097783	Pongo abelii	45.81	1.00e-138	486.00
IUUC-Pva-102980	Pteropus vampyrus	44.93	3.00e-139	488.00
IUUC-Rno-105142	Rattus norvegicus	45.47	3.00e-140	491.00
IUUC-Sha-107213	Sarcophilus harrisii	43.92	1.00e-124	439.00
IUUC-Ssc-115511	Sus scrofa	45.59	3.00e-65	241.00
IUUC-Tgu-117458	Taeniopygia guttata	42.72	2.00e-131	462.00
IUUC-Tru-117767	Takifugu rubripes	40.32	6.00e-131	461.00
IUUC-Tsy-119150	Tarsius syrichta	43.95	9.00e-128	450.00
IUUC-Tni-119893	Tetraodon nigroviridis	40.74	7.00e-88	317.00
IUUC-Tbe-128126	Tupaia belangeri	26.92	4.00e-06	45.80
IUUC-Ttr-129045	Tursiops truncatus	40.28	3.00e-111	395.00
IUUC-Xtr-131767	Xenopus tropicalis	44.41	5.00e-129	454.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence