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Tag Content
UUCD2 ID IUUC-Gga-040911
UUCD1 version UUC-GaG-00730
Ensembl Protein ID ENSGALP00000054982.1
UniProt Accession Q5ZJ41; MARH5_CHICK
Genbank Protein ID CAG32252.1
Protein Name E3 ubiquitin-protein ligase MARCH5; Membrane-associated RING finger protein 5; Membrane-associated RING-CH protein V; RING-type E3 ubiquitin transferase MARCH5
Genbank Nucleotide ID AJ720593
Gene Name MARCH5; RCJMB04_20o22
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSGALG00000032234.2 ENSGALT00000054118.1 ENSGALP00000054982.1
ENSGALG00000032234.2 ENSGALT00000090068.1 ENSGALP00000059007.1
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/RING/PHD 9.40e-12 45.3 15 73
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/PHD
   S: 2    kvClvCgeggedek...slveCek..CrewfHpaClklsveeelpnsek..wiCpkCrs 53
           ++C+vC++++ed++   ++  C++  +++w+H++Cl+++v+e+++++++  ++Cp+C++
   Q: 15   RSCWVCFATDEDDRtaeWVRPCRCrgSTKWVHQTCLQRWVDEKQRGNSTarVACPQCNA 73
           68***********7778******999*********************9999******97 PP
   
Organism Gallus gallus
Functional Description
(View)

Functional Description


     Mitochondrial E3 ubiquitin-protein ligase that plays a crucial role in the control of mitochondrial morphology by acting as a positive regulator of mitochondrial fission. May play a role in the prevention of cell senescence acting as a regulator of mitochondrial quality control.
 Mitochondrial E3 ubiquitin-protein ligase that plays a crucial role in the control of mitochondrial morphology by acting as a positive regulator of mitochondrial fission. May play a role in the prevention of cell senescence acting as a regulator of mitochondrial quality control.
Protein Sequence
(Fasta)
MSEQTGLALP QTMDRSCWVC FATDEDDRTA EWVRPCRCRG STKWVHQTCL QRWVDEKQRG 60
NSTARVACPQ CNAEYLIVFP KLGPVVYVLD LADRLISKAC PFAAAGIMVG SIYWTAVTYG 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Gga-040911|E3,PHD|Gallus gallus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CCTCACAGAG GCACCGCCGC CTTTCATCTC GGCGCCGCGG CGGCTGAGGC CGCGCCGTGC 60
GTGCGTAGCG CCCTCCGCGC GCCGCGTCCC GCCCGCCGAG GGAGGCGCGT GGCGGGGGGC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Gga-040911|E3,PHD|Gallus gallus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0256--Endoplasmic reticulum
KW-0472--Membrane
KW-0479--Metal-binding
KW-0496--Mitochondrion
KW-1000--Mitochondrion outer membrane
KW-1185--Reference proteome
KW-0808--Transferase
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR033275--MARCH-like
IPR011016--Znf_RING-CH
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS51292--ZF_RING_CH
Pfam

PF12906--RINGv
SMART

SM00744--RINGv
Gene Ontology

GO:0005783--C:endoplasmic reticulum
GO:0005789--C:endoplasmic reticulum membrane
GO:0016021--C:integral component of membrane
GO:0005741--C:mitochondrial outer membrane
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0090344--P:negative regulation of cell aging
GO:0090141--P:positive regulation of mitochondrial fission
GO:0051865--P:protein autoubiquitination
GO:0070585--P:protein localization to mitochondrion
GO:0000209--P:protein polyubiquitination
GO:0090140--P:regulation of mitochondrial fission
KEGG gga:423815
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002055 Ailuropoda melanoleuca 99.25 2.00e-158 550.00
IUUC-Apl-004106 Anas platyrhynchos 100.00 3.00e-159 553.00
IUUC-Aca-004615 Anolis carolinensis 98.17 3.00e-160 556.00
IUUC-Acl-008017 Aspergillus clavatus 25.74 5.00e-10 58.90
IUUC-Afl-008538 Aspergillus flavus 21.43 4.00e-05 42.70
IUUC-Afu-008855 Aspergillus fumigatus 24.06 3.00e-10 59.70
IUUC-Ang-009850 Aspergillus niger 23.48 6.00e-09 55.10
IUUC-Ate-010339 Aspergillus terreus 25.62 3.00e-11 62.80
IUUC-Ame-011363 Astyanax mexicanus 94.66 7.00e-161 558.00
IUUC-Bgr-012038 Blumeria graminis 30.99 9.00e-09 55.10
IUUC-Bta-013194 Bos taurus 99.25 2.00e-158 550.00
IUUC-Bci-013963 Botrytis cinerea 24.06 1.00e-08 54.30
IUUC-Bdi-014566 Brachypodium distachyon 43.06 1.00e-08 53.10
IUUC-Cel-018634 Caenorhabditis elegans 40.91 3.00e-10 57.80
IUUC-Cja-019097 Callithrix jacchus 97.38 5.00e-156 543.00
IUUC-Cfa-020404 Canis familiaris 97.45 3.00e-159 553.00
IUUC-Cpo-022094 Cavia porcellus 98.18 8.00e-161 558.00
IUUC-Csa-023955 Chlorocebus sabaeus 98.18 8.00e-161 558.00
IUUC-Cho-024819 Choloepus hoffmanni 94.52 5.00e-118 416.00
IUUC-Cin-025730 Ciona intestinalis 59.57 4.00e-99 353.00
IUUC-Csv-025975 Ciona savignyi 59.85 2.00e-97 348.00
IUUC-Cgl-026746 Colletotrichum gloeosporioides 31.30 2.00e-06 45.10
IUUC-Cne-027028 Cryptococcus neoformans 35.82 6.00e-08 51.60
IUUC-Dre-027676 Danio rerio 94.66 3.00e-160 556.00
IUUC-Dno-029876 Dasypus novemcinctus 97.81 2.00e-160 558.00
IUUC-Dor-030204 Dipodomys ordii 95.45 2.00e-105 374.00
IUUC-Dse-031226 Dothistroma septosporum 26.52 1.00e-10 60.80
IUUC-Dme-031751 Drosophila melanogaster 53.48 3.00e-83 301.00
IUUC-Ete-032941 Echinops telfairi 98.18 8.00e-161 558.00
IUUC-Eca-033559 Equus caballus 98.18 8.00e-161 558.00
IUUC-Eeu-034761 Erinaceus europaeus 96.62 2.00e-152 531.00
IUUC-Fca-035951 Felis catus 98.18 8.00e-161 558.00
IUUC-Fal-036756 Ficedula albicollis 99.29 1.00e-167 581.00
IUUC-Fox-037934 Fusarium oxysporum 28.46 9.00e-08 51.60
IUUC-Fso-038122 Fusarium solani 28.80 1.00e-09 57.40
IUUC-Gmo-038695 Gadus morhua 92.16 7.00e-147 512.00
IUUC-Gac-042449 Gasterosteus aculeatus 94.49 8.00e-154 535.00
IUUC-Ggo-045555 Gorilla gorilla 98.18 8.00e-161 558.00
IUUC-Hsa-046302 Homo sapiens 98.18 8.00e-161 558.00
IUUC-Itr-048942 Ictidomys tridecemlineatus 98.18 8.00e-161 558.00
IUUC-Kpa-049406 Komagataella pastoris 22.22 4.00e-03 35.80
IUUC-Lch-050077 Latimeria chalumnae 95.00 5.00e-161 559.00
IUUC-Loc-052045 Lepisosteus oculatus 95.37 3.00e-161 560.00
IUUC-Lma-053141 Leptosphaeria maculans 25.71 2.00e-08 54.30
IUUC-Laf-053982 Loxodonta africana 97.81 8.00e-159 552.00
IUUC-Mcc-055278 Macaca mulatta 98.18 8.00e-161 558.00
IUUC-Meu-056185 Macropus eugenii 98.50 3.00e-156 543.00
IUUC-Mor-057070 Magnaporthe oryzae 26.04 1.00e-07 51.20
IUUC-Mpo-057293 Magnaporthe poae 23.97 2.00e-05 44.30
IUUC-Mla-059023 Melampsora laricipopulina 25.19 9.00e-07 48.50
IUUC-Mga-060064 Meleagris gallopavo 97.79 4.00e-157 546.00
IUUC-Mvi-060427 Microbotryum violaceum 28.21 6.00e-07 49.30
IUUC-Mmr-060872 Microcebus murinus 98.18 8.00e-161 558.00
IUUC-Mdo-062907 Monodelphis domestica 98.18 8.00e-161 558.00
IUUC-Mmu-063792 Mus musculus 98.18 8.00e-161 558.00
IUUC-Mpu-065948 Mustela putorius furo 98.18 9.00e-161 558.00
IUUC-Mlu-067399 Myotis lucifugus 96.77 2.00e-159 554.00
IUUC-Nfi-068312 Neosartorya fischeri 24.24 3.00e-10 59.70
IUUC-Ncr-068837 Neurospora crassa 31.67 7.00e-13 68.90
IUUC-Nle-069197 Nomascus leucogenys 98.18 8.00e-161 558.00
IUUC-Opr-070474 Ochotona princeps 91.24 3.00e-146 510.00
IUUC-Ont-071896 Oreochromis niloticus 47.25 4.00e-73 267.00
IUUC-Oan-073425 Ornithorhynchus anatinus 97.08 4.00e-159 553.00
IUUC-Ocu-074127 Oryctolagus cuniculus 98.18 8.00e-161 558.00
IUUC-Ola-086561 Oryzias latipes 97.75 2.00e-155 541.00
IUUC-Oga-089004 Otolemur garnettii 95.05 2.00e-159 554.00
IUUC-Oar-089485 Ovis aries 96.76 6.00e-159 552.00
IUUC-Ptr-091645 Pan troglodytes 98.18 8.00e-161 558.00
IUUC-Pan-092408 Papio anubis 98.18 8.00e-161 558.00
IUUC-Psi-093325 Pelodiscus sinensis 92.83 1.00e-153 534.00
IUUC-Pma-094495 Petromyzon marinus 85.43 8.00e-87 312.00
IUUC-Pno-094820 Phaeosphaeria nodorum 26.40 1.00e-08 54.30
IUUC-Pfo-097381 Poecilia formosa 93.59 5.00e-157 546.00
IUUC-Pab-097888 Pongo abelii 98.18 8.00e-161 558.00
IUUC-Pva-102265 Pteropus vampyrus 98.18 8.00e-161 558.00
IUUC-Pgr-103326 Puccinia graminis 24.49 1.00e-02 35.40
IUUC-Pte-104347 Pyrenophora teres 27.53 2.00e-10 60.80
IUUC-Pyt-104598 Pyrenophora triticirepentis 36.00 1.00e-06 46.60
IUUC-Rno-105983 Rattus norvegicus 98.18 8.00e-161 558.00
IUUC-Sha-106483 Sarcophilus harrisii 98.51 1.00e-158 551.00
IUUC-Sja-107897 Schizosaccharomyces japonicus 28.07 6.00e-06 44.70
IUUC-Spo-108227 Schizosaccharomyces pombe 27.38 3.00e-05 42.40
IUUC-Sar-113087 Sorex araneus 95.49 5.00e-151 526.00
IUUC-Sre-114892 Sporisorium reilianum 26.67 4.00e-14 72.80
IUUC-Ssc-115964 Sus scrofa 96.74 1.00e-159 555.00
IUUC-Tgu-117325 Taeniopygia guttata 100.00 7.00e-160 555.00
IUUC-Tru-118291 Takifugu rubripes 94.79 1.00e-108 384.00
IUUC-Tsy-119454 Tarsius syrichta 82.33 4.00e-126 443.00
IUUC-Tni-119754 Tetraodon nigroviridis 96.23 4.00e-149 519.00
IUUC-Tre-122138 Trichoderma reesei 32.03 5.00e-09 55.80
IUUC-Tvi-122629 Trichoderma virens 31.50 1.00e-09 57.80
IUUC-Tae-124283 Triticum aestivum 45.45 8.00e-06 43.50
IUUC-Tbe-127988 Tupaia belangeri 98.31 1.00e-137 481.00
IUUC-Ttr-128413 Tursiops truncatus 99.57 7.00e-135 472.00
IUUC-Uma-129544 Ustilago maydis 26.90 4.00e-16 79.30
IUUC-Vda-129998 Verticillium dahliae 29.57 1.00e-07 50.80
IUUC-Vpa-130036 Vicugna pacos 94.89 1.00e-154 538.00
IUUC-Xtr-131932 Xenopus tropicalis 92.81 1.00e-153 535.00
IUUC-Xma-134072 Xiphophorus maculatus 93.24 1.00e-156 545.00
IUUC-Zma-135012 Zea mays 46.51 1.00e-08 50.80
Created Date 25-Jun-2017

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