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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-064196
UUCD1 version UUC-MuM-00912
Ensembl Protein ID ENSMUSP00000029740.9
UniProt Accession Q9D0C1; Q8R5A1; Q9D885; RN115_MOUSE
Genbank Protein ID BAB25607.1; BAB27716.1; AAH23113.1
Protein Name E3 ubiquitin-protein ligase RNF115; RING finger protein 115; RING-type E3 ubiquitin transferase RNF115; Rabring 7; Zinc finger protein 364
Genbank Nucleotide ID AK008329; AK011584; BC023113
Gene Name Rnf115; Zfp364; Znf364
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000028098.13 ENSMUST00000029740.13 ENSMUSP00000029740.9
ENSMUSG00000028098.13 ENSMUST00000199051.4 ENSMUSP00000143321.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemicroRNATRANSFACRepTar
RAID2
Protein-protein Interaction
IIDiRefIndexHINTMentha
Post-translational Modifications (PTMs)
CPLMPhosphositePlusmUbiSiDa
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/RING/RING 1.00e-08 36.7 229 270
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/RING
   S: 1    CaiCledf..kdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C++C+ed+  ++ ++ lpC+H+fh +C+  w         +++CP+Cr
   Q: 229  CPVCKEDYtvEEKVRQLPCNHFFHSSCIVPW------LELHDTCPVCR 270
           ********99566******************......**********8 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     E3 ubiquitin-protein ligase that mediates E2-dependent, 'Lys-48'- and/or 'Lys-63'-linked polyubiquitination of substrates and may play a role in diverse biological processes. Through their polyubiquitination, may play a role in the endosomal trafficking and degradation of membrane receptors including EGFR, FLT3, MET and CXCR4.
 E3 ubiquitin-protein ligase that mediates E2-dependent, 'Lys-48'- and/or 'Lys-63'-linked polyubiquitination of substrates and may play a role in diverse biological processes. Through their polyubiquitination, may play a role in the endosomal trafficking and degradation of membrane receptors including EGFR, FLT3, MET and CXCR4.
Protein Sequence
(Fasta)
MAEASAAGAD AGSAVAAHRF FCHFCKGEVN PKLPEYICPR CDSGFIEEVT DDSSFLGGGG 60
SRTDNSTATH FAELWDHLDH TMFLQDFRPF LSSNPLDQDN RANERGHQTH TDFWGPSRPP 120
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Protein Fasta Sequence


>IUUC-Mmu-064196|E3,RING|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GCGGACTCAC GTGACCCTTG CGGGCCTCGG AGCGGCGGGC CGCCCAGAGG AGGCGGCGAC 60
GGCGGTGGCG ACCGCAGCAC GGGAGGTAGC GGCCTGGGGA GGGACCGCCG GCCGCCCTTT 120
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Nucleotide Fasta Sequence


>IUUC-Mmu-064196|E3,RING|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS50089--ZF_RING_2
Pfam

PF13639--zf-RING_2
SMART

SM00184--RING
Gene Ontology

GO:0005829--C:cytosol
GO:0061630--F:ubiquitin protein ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0042059--P:negative regulation of epidermal growth factor receptor signaling pathway
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0051865--P:protein autoubiquitination
GO:0070936--P:protein K48-linked ubiquitination
GO:0070534--P:protein K63-linked ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0043162--P:ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
KEGG mmu:67845
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000079 Aegilops tauschii 29.96 6.00e-26 111.00
IUUC-Aml-002035 Ailuropoda melanoleuca 95.14 6.00e-158 549.00
IUUC-Apl-003694 Anas platyrhynchos 69.90 3.00e-90 324.00
IUUC-Aca-004365 Anolis carolinensis 77.98 1.00e-43 167.00
IUUC-Aly-006495 Arabidopsis lyrata 29.89 2.00e-21 96.30
IUUC-Ath-006961 Arabidopsis thaliana 30.50 1.00e-22 100.00
IUUC-Ate-010398 Aspergillus terreus 38.66 4.00e-18 86.30
IUUC-Ame-011898 Astyanax mexicanus 53.52 3.00e-76 278.00
IUUC-Bta-013190 Bos taurus 82.64 9.00e-131 459.00
IUUC-Bci-013958 Botrytis cinerea 36.19 3.00e-17 83.60
IUUC-Bdi-014806 Brachypodium distachyon 26.60 5.00e-24 105.00
IUUC-Bol-016085 Brassica oleracea 32.27 2.00e-29 123.00
IUUC-Bra-016939 Brassica rapa 31.67 4.00e-29 121.00
IUUC-Cja-020001 Callithrix jacchus 90.97 6.00e-151 526.00
IUUC-Cfa-020882 Canis familiaris 95.12 4.00e-157 547.00
IUUC-Cpo-021690 Cavia porcellus 87.18 6.00e-117 413.00
IUUC-Csa-024004 Chlorocebus sabaeus 93.75 6.00e-148 516.00
IUUC-Cho-024643 Choloepus hoffmanni 92.55 6.00e-80 290.00
IUUC-Cin-025452 Ciona intestinalis 41.18 3.00e-19 87.40
IUUC-Csv-025892 Ciona savignyi 38.10 7.00e-22 96.30
IUUC-Dre-027515 Danio rerio 58.68 7.00e-85 306.00
IUUC-Dno-029010 Dasypus novemcinctus 94.79 2.00e-157 548.00
IUUC-Dor-030147 Dipodomys ordii 85.24 1.00e-135 475.00
IUUC-Dse-031376 Dothistroma septosporum 34.53 2.00e-17 84.30
IUUC-Dme-031601 Drosophila melanogaster 55.56 2.00e-35 142.00
IUUC-Ete-032392 Echinops telfairi 91.30 7.00e-79 286.00
IUUC-Eca-033803 Equus caballus 95.57 2.00e-146 511.00
IUUC-Eeu-034831 Erinaceus europaeus 76.79 2.00e-99 355.00
IUUC-Fca-036192 Felis catus 94.10 7.00e-165 572.00
IUUC-Gmo-039513 Gadus morhua 59.12 8.00e-92 330.00
IUUC-Gga-040282 Gallus gallus 77.35 9.00e-78 282.00
IUUC-Gac-041784 Gasterosteus aculeatus 59.43 2.00e-91 328.00
IUUC-Ggo-044873 Gorilla gorilla 93.40 3.00e-147 514.00
IUUC-Hsa-045780 Homo sapiens 93.06 3.00e-147 514.00
IUUC-Hvu-047180 Hordeum vulgare 47.17 2.00e-21 96.70
IUUC-Itr-048142 Ictidomys tridecemlineatus 93.36 7.00e-141 492.00
IUUC-Lch-050673 Latimeria chalumnae 77.85 4.00e-133 467.00
IUUC-Laf-054384 Loxodonta africana 92.71 5.00e-142 496.00
IUUC-Mcc-055137 Macaca mulatta 93.75 6.00e-148 516.00
IUUC-Meu-056635 Macropus eugenii 88.19 4.00e-118 417.00
IUUC-Mtr-058295 Medicago truncatula 41.94 2.00e-21 96.30
IUUC-Mla-058832 Melampsora laricipopulina 45.57 2.00e-14 72.00
IUUC-Mmr-060631 Microcebus murinus 96.88 3.00e-169 587.00
IUUC-Mdo-062489 Monodelphis domestica 89.24 8.00e-133 466.00
IUUC-Mpu-066575 Mustela putorius furo 95.14 5.00e-166 576.00
IUUC-Mlu-067024 Myotis lucifugus 88.93 1.00e-145 508.00
IUUC-Ncr-068908 Neurospora crassa 31.51 5.00e-18 85.90
IUUC-Nle-069348 Nomascus leucogenys 92.01 1.00e-143 502.00
IUUC-Opr-070812 Ochotona princeps 87.15 3.00e-150 524.00
IUUC-Ont-072555 Oreochromis niloticus 61.01 1.00e-87 316.00
IUUC-Ocu-074691 Oryctolagus cuniculus 95.49 7.00e-155 539.00
IUUC-Ola-087047 Oryzias latipes 62.41 1.00e-99 355.00
IUUC-Oga-089111 Otolemur garnettii 94.81 2.00e-150 524.00
IUUC-Oar-089999 Ovis aries 82.99 2.00e-131 462.00
IUUC-Ptr-091473 Pan troglodytes 93.06 6.00e-147 513.00
IUUC-Pan-092618 Papio anubis 81.25 8.00e-120 422.00
IUUC-Psi-093930 Pelodiscus sinensis 82.76 1.00e-118 419.00
IUUC-Pma-094530 Petromyzon marinus 50.94 9.00e-65 239.00
IUUC-Pno-094903 Phaeosphaeria nodorum 41.03 7.00e-18 85.10
IUUC-Pfo-096461 Poecilia formosa 69.70 3.00e-65 241.00
IUUC-Pab-098466 Pongo abelii 93.75 3.00e-148 517.00
IUUC-Pop-100026 Populus trichocarpa 30.23 2.00e-25 109.00
IUUC-Pca-100550 Procavia capensis 76.39 5.00e-117 413.00
IUUC-Pva-102881 Pteropus vampyrus 92.36 3.00e-153 534.00
IUUC-Rno-104914 Rattus norvegicus 99.65 3.00e-174 603.00
IUUC-Sha-107616 Sarcophilus harrisii 89.30 3.00e-120 424.00
IUUC-Sja-107922 Schizosaccharomyces japonicus 45.19 5.00e-23 102.00
IUUC-Spo-108354 Schizosaccharomyces pombe 34.18 8.00e-25 108.00
IUUC-Smo-109522 Selaginella moellendorffii 51.43 5.00e-20 88.60
IUUC-Sly-111262 Solanum lycopersicum 29.84 2.00e-25 109.00
IUUC-Stu-112897 Solanum tuberosum 30.23 1.00e-24 106.00
IUUC-Sar-113319 Sorex araneus 72.22 1.00e-62 233.00
IUUC-Sre-115230 Sporisorium reilianum 38.79 5.00e-18 85.90
IUUC-Ssc-115917 Sus scrofa 84.38 5.00e-137 480.00
IUUC-Tgu-117105 Taeniopygia guttata 90.55 2.00e-67 246.00
IUUC-Tsy-119630 Tarsius syrichta 85.26 1.00e-141 495.00
IUUC-Tni-120265 Tetraodon nigroviridis 64.48 8.00e-105 373.00
IUUC-Tca-120938 Theobroma cacao 40.65 7.00e-21 94.70
IUUC-Tae-122764 Triticum aestivum 46.23 5.00e-21 95.10
IUUC-Tur-125986 Triticum urartu 29.57 2.00e-24 107.00
IUUC-Tme-127143 Tuber melanosporum 46.85 4.00e-28 118.00
IUUC-Tbe-127794 Tupaia belangeri 73.71 4.00e-104 370.00
IUUC-Ttr-129117 Tursiops truncatus 82.64 1.00e-125 442.00
IUUC-Uma-129414 Ustilago maydis 35.83 2.00e-17 84.30
IUUC-Vpa-130755 Vicugna pacos 80.81 4.00e-118 417.00
IUUC-Xtr-132520 Xenopus tropicalis 75.18 1.00e-100 358.00
IUUC-Xma-133074 Xiphophorus maculatus 69.09 8.00e-65 240.00
Created Date 25-Jun-2017

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