iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Dre-028027

Ensembl Protein ID

ENSDARP00000072319.3

UniProt Accession

Q70ZY9; Q70ZY9_DANRE

Genbank Protein ID

AAI62587.1; CAD22320.1

Protein Name

HIC1 protein; Hypermethylated in cancer 1

Genbank Nucleotide ID

CT027805; AJ429491

Gene Name

hic1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSDARG00000055493.5	ENSDART00000077853.3	ENSDARP00000072319.3
ENSDARG00000055493.5	ENSDART00000148190.1	ENSDARP00000116361.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/BCR/BTB_Other: BTB	5.00e-13	50.1	28	89

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/BCR/BTB_Other: BTB

   S: 1    aDvilvvggeeffahkivLaasSsvFyalflmeleesksklmveik.d.vqpevfrallkFlYtgklde 67
           +Dvi+vv++  f+ahk +LaasS ++++l  +        + ++++ + v+p+vfr++l+++Ytg+l+e
   Q: 28   CDVIIVVQNALFRAHKNILAASSLYLKSLVVH-------DNLINLDhEmVSPGVFRVILDYIYTGRLSE 89
           9*****************************66.......5789999549*****************987 PP

Organism

Danio rerio

Protein Sequence
(Fasta)

MLDAMEVPSH ARHLLLQLNT QRTKGFLCDV IIVVQNALFR AHKNILAASS LYLKSLVVHD 60
NLINLDHEMV SPGVFRVILD YIYTGRLSEC DPTSPNEPNI GAVLAAASYL QLLDLVTLCK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CAAACACGAG CAGAGCGGGA CACAAGCGGA GCAGGCTAAA GGACAAGGGA CAACGCGGAA 60
GAAGCTGGAA ACACCGGGGA AAGTTTACGT TTTAAAAAGG GATTTGGACG ACTGGGGATT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR000210--BTB/POZ_dom
IPR028424--HIC1
IPR011333--SKP1/BTB/POZ
IPR013087--Znf_C2H2_type
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50097--BTB
PS00028--ZINC_FINGER_C2H2_1
PS50157--ZINC_FINGER_C2H2_2

Pfam

PF00651--BTB

SMART

SM00225--BTB
SM00355--ZnF_C2H2

Gene Ontology

GO:0005622--C:intracellular
GO:0003677--F:DNA binding
GO:0046872--F:metal ion binding
GO:0003700--F:transcription factor activity, sequence-specific DNA binding
GO:0008630--P:intrinsic apoptotic signaling pathway in response to DNA damage
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter

KEGG

dre:436585

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001347	Ailuropoda melanoleuca	61.49	6.00e-88	318.00
IUUC-Aca-004680	Anolis carolinensis	83.33	2.00e-65	244.00
IUUC-Ame-010967	Astyanax mexicanus	74.93	0.00e+00	929.00
IUUC-Bta-013567	Bos taurus	57.54	1.00e-88	321.00
IUUC-Cja-019621	Callithrix jacchus	82.02	1.00e-36	145.00
IUUC-Cfa-020731	Canis familiaris	58.10	3.00e-91	329.00
IUUC-Cpo-021326	Cavia porcellus	57.82	9.00e-95	341.00
IUUC-Csa-023645	Chlorocebus sabaeus	57.82	4.00e-91	329.00
IUUC-Dno-028900	Dasypus novemcinctus	57.82	8.00e-93	335.00
IUUC-Fal-036980	Ficedula albicollis	52.51	1.00e-111	397.00
IUUC-Gga-040708	Gallus gallus	63.19	3.00e-109	389.00
IUUC-Gac-041742	Gasterosteus aculeatus	63.57	0.00e+00	673.00
IUUC-Ggo-044591	Gorilla gorilla	57.54	1.00e-89	324.00
IUUC-Hsa-046769	Homo sapiens	57.54	2.00e-89	323.00
IUUC-Itr-048627	Ictidomys tridecemlineatus	58.71	1.00e-90	328.00
IUUC-Lch-049412	Latimeria chalumnae	52.39	1.00e-180	626.00
IUUC-Loc-051883	Lepisosteus oculatus	73.67	7.00e-127	447.00
IUUC-Laf-053358	Loxodonta africana	58.43	3.00e-91	329.00
IUUC-Mcc-054981	Macaca mulatta	57.82	4.00e-91	329.00
IUUC-Meu-056181	Macropus eugenii	52.48	5.00e-46	178.00
IUUC-Mga-059592	Meleagris gallopavo	66.67	2.00e-108	386.00
IUUC-Mmr-061560	Microcebus murinus	56.42	9.00e-92	331.00
IUUC-Mmu-064258	Mus musculus	57.57	3.00e-92	333.00
IUUC-Mpu-065911	Mustela putorius furo	58.10	6.00e-91	328.00
IUUC-Mlu-067575	Myotis lucifugus	60.87	2.00e-85	310.00
IUUC-Nfi-068445	Neosartorya fischeri	33.33	4.50e-02	31.60
IUUC-Ont-072493	Oreochromis niloticus	64.29	0.00e+00	752.00
IUUC-Ola-086584	Oryzias latipes	61.45	0.00e+00	708.00
IUUC-Ptr-090491	Pan troglodytes	61.69	8.00e-80	291.00
IUUC-Pma-094179	Petromyzon marinus	73.08	2.00e-32	129.00
IUUC-Pfo-096282	Poecilia formosa	65.78	0.00e+00	777.00
IUUC-Pab-098488	Pongo abelii	57.54	1.00e-89	323.00
IUUC-Pca-100667	Procavia capensis	54.47	2.00e-91	330.00
IUUC-Pva-102421	Pteropus vampyrus	58.38	4.00e-95	342.00
IUUC-Rno-105528	Rattus norvegicus	65.52	6.00e-75	275.00
IUUC-Sar-113478	Sorex araneus	64.73	6.00e-79	288.00
IUUC-Ssc-115420	Sus scrofa	58.10	2.00e-95	343.00
IUUC-Tgu-116642	Taeniopygia guttata	63.19	2.00e-109	390.00
IUUC-Tru-118583	Takifugu rubripes	75.88	2.00e-117	416.00
IUUC-Xtr-132210	Xenopus tropicalis	51.48	7.00e-172	597.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence