iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Pfo-096734

Ensembl Protein ID

ENSPFOP00000026047.1

UniProt Accession

A0A087XT08; A0A087XT08_POEFO

Genbank Protein ID

ENSPFOP00000008911

Protein Name

Ubiquitin thioesterase

Genbank Nucleotide ID

AYCK01006332

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPFOG00000008913.2	ENSPFOT00000008923.2	ENSPFOP00000008911.2
ENSPFOG00000008913.2	ENSPFOT00000030041.1	ENSPFOP00000026047.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/OTU	6.00e-44	150.4	81	271

Active Site

Position(s)	Description	Evidence
83	N/A	{ECO:0000256\|PIRSR:PIRSR013503-1}
86	Nucleophile	{ECO:0000256\|PIRSR:PIRSR013503-1}
260		{ECO:0000256\|PIRSR:PIRSR013503-1}

Domain Profile

DUB/OTU

   S: 2    lilktkgDGnCLlrAvsqs..........................................................llgvfdddslsd 32
           +i+kt++DGnC++rA++++                                                          ll++f+d+ +sd
   Q: 81   YIRKTRPDGNCFYRAFGFAhlesllddskelqkfkavaakskldlvnegfteftiedfhntfmdlielcekhprlqeLLNFFNDQNMSD 169
           89*************************************************************************************** PP
   S: 33   alveaLreltseylqkesdffsefieekedekefcqklvepeak.geeihifaLaqiLsrpiivvdvdsleskvggillpllfpeeklk 120
           ++v++Lr+lts ylq+e+ ff++fie+++++kefcq++vep++k +++ihi+aLa++L+++i v+++d++e   gg ++ ++fpe   +
   Q: 170  YVVVYLRLLTSGYLQREHGFFEHFIEGGRTIKEFCQQEVEPMSKeSDHIHIIALAKALNVSILVEYMDRGE---GGSVNNHIFPEGG-D 254
           **********************************************************************9...9************.* PP
   S: 121  kpivLlYrsgHYdaLva 137
           ++i LlYr+gHYd+L++
   Q: 255  PRIFLLYRPGHYDILYK 271
           ***************96 PP

Organism

Poecilia formosa

Protein Sequence
(Fasta)

IAKMAEEQQE SSQGEMEAGG VNCLAYDEAI IAQQDRIQQE IANTNPLVSD RQDLSVLQKE 60
YAEDDTVYQL KLKDLYKKYA YIRKTRPDGN CFYRAFGFAH LESLLDDSKE LQKFKAVAAK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TGAATCAAGC ACTTTTTCCT CTCTCCTCTT TTCGGAAGTA TATAATGCAT GAGGTCATGA 60
AGAAGGAGGA AACAGATCTC GATAGCTAAG ATGGCGGAGG AACAGCAGGA ATCCTCGCAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR003323--OTU_dom
IPR030298--OTUB1
IPR016615--Otubain
IPR019400--Peptidase_C65_otubain

PROSITE

PS50802--OTU

Pfam

PF10275--Peptidase_C65

Gene Ontology

GO:0005634--C:nucleus
GO:0019784--F:NEDD8-specific protease activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0071108--P:protein K48-linked deubiquitination

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001871	Ailuropoda melanoleuca	78.23	8.00e-126	442.00
IUUC-Apl-003233	Anas platyrhynchos	56.92	3.00e-15	73.20
IUUC-Aca-004648	Anolis carolinensis	77.34	3.00e-116	410.00
IUUC-Aly-005710	Arabidopsis lyrata	41.11	2.00e-50	192.00
IUUC-Ath-007112	Arabidopsis thaliana	41.60	1.00e-49	189.00
IUUC-Afl-008439	Aspergillus flavus	31.65	3.00e-07	48.90
IUUC-Ame-010662	Astyanax mexicanus	88.06	1.00e-142	498.00
IUUC-Bta-013533	Bos taurus	79.61	2.00e-122	431.00
IUUC-Bol-016100	Brassica oleracea	40.53	7.00e-49	187.00
IUUC-Bra-017705	Brassica rapa	37.12	2.00e-43	169.00
IUUC-Cel-018295	Caenorhabditis elegans	34.55	4.00e-40	158.00
IUUC-Cja-019190	Callithrix jacchus	80.95	8.00e-123	432.00
IUUC-Cfa-020430	Canis familiaris	80.95	2.00e-122	432.00
IUUC-Cpo-022355	Cavia porcellus	79.61	7.00e-123	432.00
IUUC-Cre-022997	Chlamydomonas reinhardtii	37.04	4.00e-42	165.00
IUUC-Csa-023286	Chlorocebus sabaeus	77.27	2.00e-120	425.00
IUUC-Cho-024411	Choloepus hoffmanni	44.19	3.00e-27	114.00
IUUC-Cin-025507	Ciona intestinalis	44.44	3.00e-43	168.00
IUUC-Csv-026273	Ciona savignyi	47.76	1.00e-64	239.00
IUUC-Dre-028315	Danio rerio	84.13	9.00e-129	452.00
IUUC-Dno-029165	Dasypus novemcinctus	81.00	9.00e-98	348.00
IUUC-Dor-030943	Dipodomys ordii	79.61	7.00e-123	432.00
IUUC-Dme-031922	Drosophila melanogaster	55.20	3.00e-75	275.00
IUUC-Ete-032296	Echinops telfairi	76.10	1.00e-71	263.00
IUUC-Eca-033695	Equus caballus	80.56	4.00e-122	430.00
IUUC-Eeu-034775	Erinaceus europaeus	44.64	7.00e-55	206.00
IUUC-Fca-036441	Felis catus	80.31	1.00e-122	432.00
IUUC-Gmo-038908	Gadus morhua	86.67	7.00e-141	492.00
IUUC-Ggr-040020	Gaeumannomyces graminis	32.85	4.00e-30	126.00
IUUC-Gga-040460	Gallus gallus	71.59	9.00e-114	402.00
IUUC-Gac-042417	Gasterosteus aculeatus	90.40	4.00e-138	483.00
IUUC-Gma-043712	Glycine max	41.64	1.00e-49	189.00
IUUC-Ggo-044552	Gorilla gorilla	79.25	4.00e-74	271.00
IUUC-Hsa-046766	Homo sapiens	80.00	6.00e-123	433.00
IUUC-Itr-048312	Ictidomys tridecemlineatus	79.61	7.00e-123	432.00
IUUC-Lch-050602	Latimeria chalumnae	75.49	1.00e-111	395.00
IUUC-Laf-053705	Loxodonta africana	79.61	7.00e-123	432.00
IUUC-Mcc-055745	Macaca mulatta	74.73	1.00e-119	422.00
IUUC-Meu-056569	Macropus eugenii	67.53	2.00e-106	378.00
IUUC-Mtr-057712	Medicago truncatula	40.64	2.00e-45	176.00
IUUC-Mvi-060358	Microbotryum violaceum	32.73	1.00e-15	77.40
IUUC-Mmr-061123	Microcebus murinus	80.93	6.00e-102	363.00
IUUC-Mdo-062613	Monodelphis domestica	72.06	8.00e-100	356.00
IUUC-Mmu-063658	Mus musculus	79.61	7.00e-123	432.00
IUUC-Mac-065274	Musa acuminata	35.60	2.00e-35	143.00
IUUC-Mpu-066172	Mustela putorius furo	80.00	6.00e-123	433.00
IUUC-Mlu-066966	Myotis lucifugus	80.78	1.00e-123	435.00
IUUC-Nle-069519	Nomascus leucogenys	70.43	7.00e-75	273.00
IUUC-Opr-070761	Ochotona princeps	36.71	6.00e-26	110.00
IUUC-Ont-071901	Oreochromis niloticus	92.43	1.00e-140	492.00
IUUC-Oan-072922	Ornithorhynchus anatinus	43.75	2.00e-56	211.00
IUUC-Ocu-074643	Oryctolagus cuniculus	44.20	4.00e-55	207.00
IUUC-Oni-082026	Oryza nivara	27.64	1.00e-11	64.30
IUUC-Oru-084761	Oryza rufipogon	27.64	1.00e-11	64.30
IUUC-Ola-087331	Oryzias latipes	86.84	3.00e-96	344.00
IUUC-Oga-088064	Otolemur garnettii	80.00	6.00e-123	433.00
IUUC-Oar-089251	Ovis aries	80.48	3.00e-121	427.00
IUUC-Ptr-091430	Pan troglodytes	80.95	7.00e-123	433.00
IUUC-Pan-091969	Papio anubis	44.20	2.00e-55	208.00
IUUC-Psi-093823	Pelodiscus sinensis	77.25	1.00e-115	409.00
IUUC-Pma-094366	Petromyzon marinus	68.52	5.00e-98	350.00
IUUC-Pab-097919	Pongo abelii	81.60	2.00e-100	358.00
IUUC-Pop-099401	Populus trichocarpa	40.51	3.00e-47	181.00
IUUC-Ppe-101977	Prunus persica	41.26	3.00e-49	189.00
IUUC-Pva-102499	Pteropus vampyrus	80.88	4.00e-122	430.00
IUUC-Rno-105233	Rattus norvegicus	79.61	7.00e-123	432.00
IUUC-Sha-107081	Sarcophilus harrisii	79.76	1.00e-121	429.00
IUUC-Sly-111640	Solanum lycopersicum	40.15	3.00e-46	178.00
IUUC-Sar-113295	Sorex araneus	45.09	2.00e-54	205.00
IUUC-Ssc-116202	Sus scrofa	80.00	6.00e-123	433.00
IUUC-Tru-117664	Takifugu rubripes	88.32	6.00e-144	503.00
IUUC-Tca-121467	Theobroma cacao	40.44	6.00e-48	184.00
IUUC-Tbe-128116	Tupaia belangeri	78.26	1.00e-74	273.00
IUUC-Ttr-128622	Tursiops truncatus	79.22	2.00e-120	424.00
IUUC-Uma-129443	Ustilago maydis	32.42	3.00e-24	105.00
IUUC-Vvi-131389	Vitis vinifera	40.81	1.00e-48	186.00
IUUC-Xtr-131951	Xenopus tropicalis	43.42	3.00e-52	198.00
IUUC-Xma-134191	Xiphophorus maculatus	98.41	2.00e-137	481.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence