• HOME
  • BROWSE
  • SEARCH
  • LINK
  • DOWNLOAD
  • USER GUIDE
  • Protein
  • Gene
  • Annotation
  • Classification
  • Domain Profile
  • Function
  • Protein Sequence
  • Nucleotide Sequence
  • Keyword
  • GO
  • Orthology
  • TOP

Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Hsa-045916
UUCD1 version UUC-HoS-01023
Ensembl Protein ID ENSP00000369716.4
UniProt Accession Q12873; D3DTQ9; E9PG89; Q9Y4I0; CHD3_HUMAN
Genbank Protein ID AAC39923.1; EAW90114.1; EAW90116.1; AAB87383.1; AAC50228.1
Protein Name Chromodomain-helicase-DNA-binding protein 3; ATP-dependent helicase CHD3; Mi-2 autoantigen 240 kDa protein; Mi2-alpha; Zinc finger helicase
Genbank Nucleotide ID U91543; AC104581; CH471108; AF006515; U08379
Gene Name CHD3
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000170004.16 ENST00000380358.8 ENSP00000369716.4
ENSG00000170004.16 ENST00000358181.8 ENSP00000350907.4
ENSG00000170004.16 ENST00000330494.11 ENSP00000332628.7
ENSG00000170004.16 ENST00000452447.1 ENSP00000405861.1
ENSG00000170004.16 ENST00000571249.1 ENSP00000458861.1
ENSG00000170004.16 ENST00000470531.5 ENSP00000467547.1
ENSG00000170004.16 ENST00000439235.5 ENSP00000395252.1
ENSG00000170004.16 ENST00000573936.5 ENSP00000459321.1
ENSG00000170004.16 ENST00000449744.1 ENSP00000411959.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbcircBaseCircNetmiRTarBase
microRNATRANSFACTargetScanRepTar
miRNAMapSomamiRmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Disease-associated Variation
GWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMUniProtPHOSIDA
BioGRID
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/RING/PHD 2.00e-15 58.4 439 484
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/PHD
   S: 2    kvClvCgeggedekslveCekCrewfHpaClklsveeelpnsekwiCpkCrs 53
           ++C vC++gge    ++ C+ C +++H  Cl ++  +  p+ + w Cp C++
   Q: 439  DYCEVCQQGGE----IILCDTCPRAYHLVCLDPE-LDRAPEGK-WSCPHCEK 484
           79*********....9******************.*******7.******86 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Required for anchoring centrosomal pericentrin in both interphase and mitosis, for spindle organization and centrosome integrity.
 Component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Required for anchoring centrosomal pericentrin in both interphase and mitosis, for spindle organization and centrosome integrity.
Protein Sequence
(Fasta)
MASPLRDEEE EEEEMVVSEE EEEEEEEGDE EEEEEVEAAD EDDEEDDDEG VLGRGPGHDR 60
GRDRHSPPGC HLFPPPPPPP PPLPPPPPPP PPDKDDIRLL PSALGVKKRK RGPKKQKENK 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-045916|E3,PHD|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GATGGCTTCC CCTCTGAGGG ACGAGGAGGA GGAGGAGGAG GAGATGGTGG TGTCGGAGGA 60
GGAAGAAGAG GAGGAAGAAG AGGGCGACGA GGAGGAGGAG GAGGAGGTGG AGGCGGCCGA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-045916|E3,PHD|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0067--ATP-binding
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0238--DNA-binding
KW-0347--Helicase
KW-0378--Hydrolase
KW-1017--Isopeptide bond
KW-0479--Metal-binding
KW-0547--Nucleotide-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0832--Ubl conjugation
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR028722--CHD3
IPR012957--CHD_C2
IPR012958--CHD_N
IPR000953--Chromo/chromo_shadow_dom
IPR023780--Chromo_domain
IPR016197--Chromodomain-like
IPR023779--Chromodomain_CS
IPR002464--DNA/RNA_helicase_DEAH_CS
IPR009462--DUF1086
IPR009463--DUF1087
IPR014001--Helicase_ATP-bd
IPR001650--Helicase_C
IPR009071--HMG_box_dom
IPR027417--P-loop_NTPase
IPR000330--SNF2_N
IPR019786--Zinc_finger_PHD-type_CS
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS00598--CHROMO_1
PS50013--CHROMO_2
PS00690--DEAH_ATP_HELICASE
PS51192--HELICASE_ATP_BIND_1
PS51194--HELICASE_CTER
PS01359--ZF_PHD_1
PS50016--ZF_PHD_2
Pfam

PF08074--CHDCT2
PF08073--CHDNT
PF00385--Chromo
PF06461--DUF1086
PF06465--DUF1087
PF00271--Helicase_C
PF00628--PHD
PF00176--SNF2_N
SMART

SM00298--CHROMO
SM00487--DEXDc
SM01146--DUF1086
SM01147--DUF1087
SM00490--HELICc
SM00249--PHD
Gene Ontology

GO:0005813--C:centrosome
GO:0005737--C:cytoplasm
GO:0005815--C:microtubule organizing center
GO:0005730--C:nucleolus
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0016581--C:NuRD complex
GO:0005524--F:ATP binding
GO:0004003--F:ATP-dependent DNA helicase activity
GO:0003677--F:DNA binding
GO:0004386--F:helicase activity
GO:0004407--F:histone deacetylase activity
GO:0003723--F:RNA binding
GO:0008270--F:zinc ion binding
GO:0051297--P:centrosome organization
GO:0006333--P:chromatin assembly or disassembly
GO:1901796--P:regulation of signal transduction by p53 class mediator
GO:0006357--P:regulation of transcription from RNA polymerase II promoter
GO:0006355--P:regulation of transcription, DNA-templated
GO:0007051--P:spindle organization
GO:0006351--P:transcription, DNA-templated
KEGG hsa:1107
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aca-004560 Anolis carolinensis 82.31 0.00e+00 2729.00
IUUC-Bta-012868 Bos taurus 98.63 0.00e+00 3235.00
IUUC-Cja-019018 Callithrix jacchus 91.35 0.00e+00 3101.00
IUUC-Cfa-021055 Canis familiaris 98.32 0.00e+00 3192.00
IUUC-Cpo-021523 Cavia porcellus 98.22 0.00e+00 3274.00
IUUC-Csa-024136 Chlorocebus sabaeus 99.44 0.00e+00 3211.00
IUUC-Csv-025847 Ciona savignyi 54.49 0.00e+00 1416.00
IUUC-Dor-030167 Dipodomys ordii 96.87 0.00e+00 2613.00
IUUC-Ete-032757 Echinops telfairi 92.16 0.00e+00 2910.00
IUUC-Eeu-034777 Erinaceus europaeus 88.61 0.00e+00 2623.00
IUUC-Fca-036043 Felis catus 98.22 0.00e+00 3233.00
IUUC-Gmo-038957 Gadus morhua 80.00 0.00e+00 1459.00
IUUC-Gac-041375 Gasterosteus aculeatus 70.96 0.00e+00 2549.00
IUUC-Gma-043999 Glycine max 43.10 0.00e+00 738.00
IUUC-Ggo-045538 Gorilla gorilla 99.75 0.00e+00 3205.00
IUUC-Itr-048463 Ictidomys tridecemlineatus 99.01 0.00e+00 3133.00
IUUC-Lch-050343 Latimeria chalumnae 79.78 0.00e+00 2095.00
IUUC-Loc-052383 Lepisosteus oculatus 81.47 0.00e+00 2071.00
IUUC-Laf-053870 Loxodonta africana 98.46 0.00e+00 2852.00
IUUC-Mcc-055499 Macaca mulatta 93.18 0.00e+00 3089.00
IUUC-Meu-056292 Macropus eugenii 90.50 0.00e+00 1261.00
IUUC-Mmr-061223 Microcebus murinus 97.69 0.00e+00 3204.00
IUUC-Mdo-062971 Monodelphis domestica 91.10 0.00e+00 2840.00
IUUC-Mmu-063920 Mus musculus 96.22 0.00e+00 3165.00
IUUC-Mpu-065809 Mustela putorius furo 98.23 0.00e+00 2945.00
IUUC-Mlu-067355 Myotis lucifugus 97.71 0.00e+00 3233.00
IUUC-Nle-069842 Nomascus leucogenys 98.81 0.00e+00 3067.00
IUUC-Opr-070960 Ochotona princeps 96.79 0.00e+00 3088.00
IUUC-Oan-072885 Ornithorhynchus anatinus 59.94 0.00e+00 1918.00
IUUC-Ocu-074438 Oryctolagus cuniculus 93.50 0.00e+00 3050.00
IUUC-Oga-088374 Otolemur garnettii 98.58 0.00e+00 3210.00
IUUC-Oar-089784 Ovis aries 95.59 0.00e+00 3169.00
IUUC-Ptr-090799 Pan troglodytes 99.95 0.00e+00 3229.00
IUUC-Pab-098174 Pongo abelii 96.73 0.00e+00 3061.00
IUUC-Pca-100829 Procavia capensis 96.69 0.00e+00 2354.00
IUUC-Rno-104884 Rattus norvegicus 96.30 0.00e+00 2990.00
IUUC-Sha-107233 Sarcophilus harrisii 92.96 0.00e+00 3044.00
IUUC-Sly-110976 Solanum lycopersicum 43.76 0.00e+00 741.00
IUUC-Ssc-115751 Sus scrofa 98.68 0.00e+00 3186.00
IUUC-Tru-118648 Takifugu rubripes 76.04 0.00e+00 2134.00
IUUC-Tni-120039 Tetraodon nigroviridis 75.64 0.00e+00 2097.00
IUUC-Tbe-128117 Tupaia belangeri 93.01 0.00e+00 1333.00
IUUC-Vpa-130209 Vicugna pacos 88.27 0.00e+00 645.00
IUUC-Vvi-130849 Vitis vinifera 43.83 0.00e+00 736.00
IUUC-Xtr-132833 Xenopus tropicalis 72.72 0.00e+00 2420.00
Created Date 25-Jun-2017

https://dev.news.makassarkota.go.id/public/pgsoft-demo/ https://jdih.sumbawabaratkab.go.id/lato/pg-soft-demo/ https://dev.news.makassarkota.go.id/public/slot-gacor/ http://pbb.tanahbumbukab.go.id/-/slot-gacor/ slot gacor https://siakad.unipra.ac.id/sass/slot-gacor-x500/ http://kpm.dinus.ac.id/assets/images/berita/slot/
Copyright © 2004-2017.The CUCKOO Workgroup. All Rights Reserved