iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Apl-003489

Ensembl Protein ID

ENSAPLP00000003937.1

UniProt Accession

U3I9L6; U3I9L6_ANAPL

Genbank Protein ID

ENSAPLP00000003937

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

ADON01038620

Gene Name

FBXW7

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSAPLG00000004403.1	ENSAPLT00000004544.1	ENSAPLP00000003937.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	5.90e-61	199.4	611	644
UBD/Beta-Prp	2.80e-102	341.6	362	644

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    HtdsvtclafsdtllvsGsdDgtikvWDlrtgvl 35
           H++ vtcl+f+ ++++++sdDgt+k+WDl+tg  
   Q: 611  HQSAVTCLQFNKNFVITSSDDGTVKLWDLKTGEF 644
           9*********449******************976 PP

UBD/Beta-Prp

   S: 3    ktlkghhksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlk 91
           k+lkgh+++vitc++f   ++ +++gs+d+t+kvw++ tgk+lr+l gh+++v++ ++ ++  i+++gs+Drt+kvw+ +tg+c+htl 
   Q: 362  KVLKGHDDHVITCLQF--CGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDN--IIISGSTDRTLKVWNAETGECIHTLY 446
           6799************..*******************************************..************************** PP
   S: 92   ghedsvlslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgght 180
           gh+++v+++++++  +++vsGs+d t+rvwd+etgqcl+ +l gh ++v+cv++++  + +vsG++D +v++Wd +t+++l+tl+g ht
   Q: 447  GHTSTVRCMHLHE--KRVVSGSRDATLRVWDIETGQCLH-VLMGHVAAVRCVQYDG--RRVVSGAYDFMVKVWDPETETCLHTLQG-HT 529
           *************..************************.****************..***************************9.** PP
   S: 181  dsvyslsfdsngkelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriWdlrsgdllktlqlhnssvis 269
           ++vysl+fd    ++vsgsld+++++wd++tg+c++tl+gh++ ++ +++   d++lvsg++D +++iWd+++g++l+tlq++n++ ++
   Q: 530  NRVYSLQFDG--IHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELK--DNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSA 614
           *********9..9**************************************..************************************ PP
   S: 270  vavlsfgdnvlvlgsedskvniwklkknep 299
           v++l+f++n +++ s+d++v++w+lk+ e+
   Q: 615  VTCLQFNKNFVITSSDDGTVKLWDLKTGEF 644
           *************************98776 PP

Organism

Anas platyrhynchos

Protein Sequence
(Fasta)

MNQELLSVGS KRRRTGGSLR GNASSSQVDE EQMNRVVEEE EQQQRRQQEE QHIGRNGEIG 60
GEEPGFDDRH ESQQEQLEEN NNRLITVDEE STCNQEEDDD EHAGDQMDQE SDDFDQSDDS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGAATCAGG AACTGCTCTC TGTGGGCAGC AAGAGGCGAC GAACTGGTGG ATCTCTTCGA 60
GGTAATGCTT CCTCAAGCCA AGTAGATGAG GAGCAGATGA ATCGGGTTGT AGAAGAGGAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR001810--F-box_dom
IPR020472--G-protein_beta_WD-40_rep
IPR002469--Peptidase_S9B_N
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50181--FBOX
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF12937--F-box-like
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00256--FBOX
SM00320--WD40

Gene Ontology

GO:0005737--C:cytoplasm
GO:1990452--C:Parkin-FBXW7-Cul1 ubiquitin ligase complex
GO:0019005--C:SCF ubiquitin ligase complex
GO:0097027--F:ubiquitin-protein transferase activator activity
GO:0032876--P:negative regulation of DNA endoreduplication
GO:0045741--P:positive regulation of epidermal growth factor-activated receptor activity
GO:0070374--P:positive regulation of ERK1 and ERK2 cascade
GO:1903378--P:positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
GO:1901800--P:positive regulation of proteasomal protein catabolic process
GO:1903955--P:positive regulation of protein targeting to mitochondrion
GO:2000060--P:positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0051443--P:positive regulation of ubiquitin-protein transferase activity
GO:0050821--P:protein stabilization
GO:0016567--P:protein ubiquitination
GO:1903146--P:regulation of mitophagy
GO:0031146--P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0007062--P:sister chromatid cohesion

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002406	Ailuropoda melanoleuca	98.57	0.00e+00	1129.00
IUUC-Aca-005318	Anolis carolinensis	97.82	0.00e+00	1098.00
IUUC-Ago-007794	Ashbya gossypii	31.07	6.00e-62	231.00
IUUC-Acl-008123	Aspergillus clavatus	32.20	1.00e-74	274.00
IUUC-Afu-009014	Aspergillus fumigatus	32.13	3.00e-75	275.00
IUUC-Ani-009332	Aspergillus nidulans	33.27	5.00e-80	291.00
IUUC-Ang-009529	Aspergillus niger	33.77	3.00e-75	276.00
IUUC-Aor-010215	Aspergillus oryzae	30.51	1.00e-74	273.00
IUUC-Ate-010535	Aspergillus terreus	31.89	5.00e-76	278.00
IUUC-Ame-010898	Astyanax mexicanus	93.31	0.00e+00	1047.00
IUUC-Bta-012391	Bos taurus	98.55	0.00e+00	1107.00
IUUC-Cel-018495	Caenorhabditis elegans	48.73	2.00e-131	462.00
IUUC-Cja-018902	Callithrix jacchus	99.28	0.00e+00	1129.00
IUUC-Cfa-020237	Canis familiaris	98.93	0.00e+00	1129.00
IUUC-Cpo-022234	Cavia porcellus	98.55	0.00e+00	1104.00
IUUC-Csa-023532	Chlorocebus sabaeus	99.46	0.00e+00	1130.00
IUUC-Cho-025026	Choloepus hoffmanni	82.77	0.00e+00	761.00
IUUC-Cin-025516	Ciona intestinalis	70.34	3.00e-141	494.00
IUUC-Csv-026312	Ciona savignyi	74.13	0.00e+00	756.00
IUUC-Cne-027018	Cryptococcus neoformans	32.89	7.00e-73	268.00
IUUC-Cme-027168	Cyanidioschyzon merolae	31.10	3.00e-31	129.00
IUUC-Dre-028303	Danio rerio	93.90	0.00e+00	1048.00
IUUC-Dno-029576	Dasypus novemcinctus	96.96	0.00e+00	1112.00
IUUC-Dor-030196	Dipodomys ordii	88.70	0.00e+00	1176.00
IUUC-Ete-032791	Echinops telfairi	90.74	0.00e+00	1002.00
IUUC-Eca-033424	Equus caballus	98.55	0.00e+00	1103.00
IUUC-Eeu-034996	Erinaceus europaeus	95.87	0.00e+00	1090.00
IUUC-Fca-036422	Felis catus	98.93	0.00e+00	1132.00
IUUC-Fal-037267	Ficedula albicollis	97.83	0.00e+00	1099.00
IUUC-Gmo-039119	Gadus morhua	83.12	0.00e+00	901.00
IUUC-Ggr-039781	Gaeumannomyces graminis	34.46	6.00e-85	308.00
IUUC-Gga-040667	Gallus gallus	94.18	0.00e+00	1229.00
IUUC-Gac-042423	Gasterosteus aculeatus	74.45	0.00e+00	804.00
IUUC-Ggo-044422	Gorilla gorilla	98.93	0.00e+00	1132.00
IUUC-Hsa-045898	Homo sapiens	99.11	0.00e+00	1132.00
IUUC-Itr-048241	Ictidomys tridecemlineatus	99.57	0.00e+00	973.00
IUUC-Kpa-049097	Komagataella pastoris	32.25	6.00e-77	281.00
IUUC-Lch-050414	Latimeria chalumnae	96.56	0.00e+00	1087.00
IUUC-Loc-052348	Lepisosteus oculatus	95.83	0.00e+00	1072.00
IUUC-Laf-054054	Loxodonta africana	99.10	0.00e+00	1133.00
IUUC-Mcc-055056	Macaca mulatta	99.46	0.00e+00	1130.00
IUUC-Meu-056778	Macropus eugenii	88.37	0.00e+00	713.00
IUUC-Mor-057133	Magnaporthe oryzae	39.13	6.00e-74	272.00
IUUC-Mpo-057542	Magnaporthe poae	39.13	4.00e-74	273.00
IUUC-Mla-059081	Melampsora laricipopulina	32.38	3.00e-76	279.00
IUUC-Mga-059255	Meleagris gallopavo	95.03	0.00e+00	1224.00
IUUC-Mvi-060490	Microbotryum violaceum	38.75	3.00e-67	250.00
IUUC-Mmr-061292	Microcebus murinus	99.28	0.00e+00	1129.00
IUUC-Mdo-062304	Monodelphis domestica	87.98	0.00e+00	1176.00
IUUC-Mmu-063610	Mus musculus	88.31	0.00e+00	1214.00
IUUC-Mpu-065931	Mustela putorius furo	99.11	0.00e+00	1132.00
IUUC-Mlu-066976	Myotis lucifugus	89.55	0.00e+00	1196.00
IUUC-Nfi-068428	Neosartorya fischeri	31.73	5.00e-75	275.00
IUUC-Nle-070174	Nomascus leucogenys	99.11	0.00e+00	1133.00
IUUC-Opr-070851	Ochotona princeps	86.32	0.00e+00	652.00
IUUC-Ont-071997	Oreochromis niloticus	93.10	0.00e+00	1070.00
IUUC-Oan-072936	Ornithorhynchus anatinus	90.68	0.00e+00	1228.00
IUUC-Ocu-074742	Oryctolagus cuniculus	99.10	0.00e+00	1129.00
IUUC-Obr-076806	Oryza brachyantha	31.52	9.00e-30	125.00
IUUC-Oin-079809	Oryza indica	31.52	6.00e-30	126.00
IUUC-Ola-087098	Oryzias latipes	93.90	0.00e+00	1058.00
IUUC-Olu-087837	Ostreococcus lucimarinus	34.47	4.00e-38	150.00
IUUC-Oga-088884	Otolemur garnettii	100.00	0.00e+00	785.00
IUUC-Oar-090220	Ovis aries	97.87	0.00e+00	1122.00
IUUC-Ptr-090492	Pan troglodytes	99.11	0.00e+00	1132.00
IUUC-Pan-091770	Papio anubis	99.46	0.00e+00	1130.00
IUUC-Psi-093207	Pelodiscus sinensis	98.55	0.00e+00	1104.00
IUUC-Pma-094749	Petromyzon marinus	82.88	0.00e+00	946.00
IUUC-Pno-095026	Phaeosphaeria nodorum	38.83	7.00e-71	261.00
IUUC-Pfo-096493	Poecilia formosa	94.19	0.00e+00	1060.00
IUUC-Pab-098141	Pongo abelii	98.55	0.00e+00	1103.00
IUUC-Pca-100571	Procavia capensis	98.49	0.00e+00	810.00
IUUC-Pva-102988	Pteropus vampyrus	99.28	0.00e+00	1126.00
IUUC-Pgr-103612	Puccinia graminis	35.41	4.00e-62	233.00
IUUC-Rno-105706	Rattus norvegicus	98.03	0.00e+00	1125.00
IUUC-Sce-106314	Saccharomyces cerevisiae	29.39	9.00e-61	228.00
IUUC-Sha-107653	Sarcophilus harrisii	92.23	0.00e+00	1224.00
IUUC-Sja-107840	Schizosaccharomyces japonicus	33.83	5.00e-79	288.00
IUUC-Spo-108115	Schizosaccharomyces pombe	32.35	4.00e-63	235.00
IUUC-Sar-113600	Sorex araneus	93.18	0.00e+00	1038.00
IUUC-Sre-114901	Sporisorium reilianum	48.13	1.00e-67	251.00
IUUC-Ssc-115787	Sus scrofa	97.49	0.00e+00	1102.00
IUUC-Tgu-117510	Taeniopygia guttata	95.60	0.00e+00	1236.00
IUUC-Tru-117819	Takifugu rubripes	92.11	0.00e+00	1080.00
IUUC-Tsy-118828	Tarsius syrichta	99.28	0.00e+00	1130.00
IUUC-Tni-120468	Tetraodon nigroviridis	93.47	0.00e+00	1072.00
IUUC-Tme-127021	Tuber melanosporum	34.34	2.00e-83	303.00
IUUC-Tbe-127925	Tupaia belangeri	99.81	0.00e+00	1102.00
IUUC-Ttr-128899	Tursiops truncatus	98.92	0.00e+00	1128.00
IUUC-Uma-129449	Ustilago maydis	46.89	1.00e-66	248.00
IUUC-Vda-129802	Verticillium dahliae	35.99	2.00e-87	316.00
IUUC-Vpa-130082	Vicugna pacos	99.15	0.00e+00	951.00
IUUC-Xtr-132213	Xenopus tropicalis	87.20	0.00e+00	1162.00
IUUC-Xma-133646	Xiphophorus maculatus	94.02	0.00e+00	1053.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence