iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Eca-033458

Ensembl Protein ID

ENSECAP00000002280.1

UniProt Accession

F6X0W1; F6X0W1_HORSE

Protein Name

Phosphoinositide phospholipase C

Gene Name

PLCG2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSECAG00000000291.1	ENSECAT00000003199.1	ENSECAP00000002280.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	2.10e-10	40.5	772	828

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 4    ekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
           ++v++lydy+a+ +deL++ +G  ++ +   ++ +gW+kg    +  +  fP+n+ve ++
   Q: 772  RTVKALYDYKAKRSDELSFCRGALIHNV--SKEPGGWWKGD-YGTRIQQYFPSNYVEDIS 828
           789************************9..77889*****6.55556679******9985 PP

Organism

Equus caballus

Protein Sequence
(Fasta)

MNTMVNVNAL PEYEKSQIKR ALELGTVMTV FSFRKSTPER RTVQVIMETR QVAWSKTADK 60
IEGFLDIMEI KEIRPGKSSK DFERAKAVRQ KEDCCFTILY GTQFVLSTLS LAADSREDAT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGAACACCA TGGTCAATGT GAACGCCCTT CCGGAATACG AGAAGAGTCA GATCAAGAGG 60
GCCCTGGAGC TGGGCACAGT GATGACCGTG TTCAGCTTCC GCAAGTCCAC GCCGGAGCGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0442--Lipid degradation
KW-0443--Lipid metabolism
KW-1185--Reference proteome
KW-0727--SH2 domain
KW-0728--SH3 domain
KW-0807--Transducer

Interpro

IPR000008--C2_dom
IPR011992--EF-hand-dom_pair
IPR011993--PH_dom-like
IPR001849--PH_domain
IPR001192--PI-PLC_fam
IPR016279--PLC-gamma
IPR028381--PLC-gamma2
IPR017946--PLC-like_Pdiesterase_TIM-brl
IPR000909--PLipase_C_PInositol-sp_X_dom
IPR001711--PLipase_C_Pinositol-sp_Y
IPR000980--SH2
IPR001452--SH3_domain

PROSITE

PS50004--C2
PS50003--PH_DOMAIN
PS50007--PIPLC_X_DOMAIN
PS50008--PIPLC_Y_DOMAIN
PS50001--SH2
PS50002--SH3

Pfam

PF00168--C2
PF00388--PI-PLC-X
PF00387--PI-PLC-Y
PF00017--SH2
PF00018--SH3_1

PRINTS

PR00390--PHPHLIPASEC
PR00401--SH2DOMAIN
PR00452--SH3DOMAIN

SMART

SM00239--C2
SM00233--PH
SM00148--PLCXc
SM00149--PLCYc
SM00252--SH2
SM00326--SH3

Gene Ontology

GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0005886--C:plasma membrane
GO:0004435--F:phosphatidylinositol phospholipase C activity
GO:0004871--F:signal transducer activity
GO:0032237--P:activation of store-operated calcium channel activity
GO:0050853--P:B cell receptor signaling pathway
GO:0002316--P:follicular B cell differentiation
GO:0032959--P:inositol trisphosphate biosynthetic process
GO:0035556--P:intracellular signal transduction
GO:0043069--P:negative regulation of programmed cell death
GO:0006661--P:phosphatidylinositol biosynthetic process
GO:0009395--P:phospholipid catabolic process
GO:0002092--P:positive regulation of receptor internalization
GO:0032481--P:positive regulation of type I interferon production
GO:0010468--P:regulation of gene expression
GO:0051209--P:release of sequestered calcium ion into cytosol
GO:0032496--P:response to lipopolysaccharide
GO:0050852--P:T cell receptor signaling pathway

KEGG

ecb:100055670

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Apl-003345	Anas platyrhynchos	83.22	0.00e+00	2040.00
IUUC-Aca-004266	Anolis carolinensis	80.35	0.00e+00	2125.00
IUUC-Ame-011540	Astyanax mexicanus	59.00	0.00e+00	1440.00
IUUC-Bta-013196	Bos taurus	95.09	0.00e+00	2408.00
IUUC-Cpo-021890	Cavia porcellus	92.99	0.00e+00	2479.00
IUUC-Csa-024233	Chlorocebus sabaeus	95.65	0.00e+00	2536.00
IUUC-Dre-028650	Danio rerio	59.46	0.00e+00	1457.00
IUUC-Dno-028871	Dasypus novemcinctus	95.49	0.00e+00	2455.00
IUUC-Eeu-035329	Erinaceus europaeus	91.79	0.00e+00	2424.00
IUUC-Fal-037390	Ficedula albicollis	82.96	0.00e+00	2199.00
IUUC-Gga-040918	Gallus gallus	83.44	0.00e+00	2185.00
IUUC-Ggo-045625	Gorilla gorilla	94.78	0.00e+00	2525.00
IUUC-Hsa-046129	Homo sapiens	96.05	0.00e+00	2569.00
IUUC-Loc-052025	Lepisosteus oculatus	61.83	0.00e+00	1585.00
IUUC-Mcc-054831	Macaca mulatta	95.79	0.00e+00	2471.00
IUUC-Mga-059368	Meleagris gallopavo	83.60	0.00e+00	2171.00
IUUC-Mmr-060898	Microcebus murinus	91.90	0.00e+00	2286.00
IUUC-Mmu-064334	Mus musculus	94.23	0.00e+00	2480.00
IUUC-Mlu-067230	Myotis lucifugus	96.37	0.00e+00	2558.00
IUUC-Nle-069318	Nomascus leucogenys	90.36	0.00e+00	2345.00
IUUC-Opr-070718	Ochotona princeps	82.02	0.00e+00	1115.00
IUUC-Ocu-073814	Oryctolagus cuniculus	94.55	0.00e+00	2500.00
IUUC-Ola-086501	Oryzias latipes	57.39	0.00e+00	1449.00
IUUC-Oga-088036	Otolemur garnettii	95.52	0.00e+00	1838.00
IUUC-Oar-089556	Ovis aries	95.02	0.00e+00	2408.00
IUUC-Ptr-091001	Pan troglodytes	96.05	0.00e+00	2567.00
IUUC-Pan-092744	Papio anubis	95.97	0.00e+00	2543.00
IUUC-Psi-093987	Pelodiscus sinensis	83.44	0.00e+00	2193.00
IUUC-Pfo-096249	Poecilia formosa	58.24	0.00e+00	1492.00
IUUC-Pab-098268	Pongo abelii	93.44	0.00e+00	2477.00
IUUC-Pva-102939	Pteropus vampyrus	94.08	0.00e+00	2353.00
IUUC-Sre-115229	Sporisorium reilianum	43.33	1.00e-09	59.70
IUUC-Ssc-115308	Sus scrofa	90.83	0.00e+00	2217.00
IUUC-Tgu-116811	Taeniopygia guttata	82.88	0.00e+00	2196.00
IUUC-Tru-117536	Takifugu rubripes	57.11	0.00e+00	1432.00
IUUC-Tsy-119139	Tarsius syrichta	86.14	0.00e+00	989.00
IUUC-Ttr-128392	Tursiops truncatus	92.57	0.00e+00	2414.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence