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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046989
Ensembl Protein ID ENSP00000346300.3
UniProt Accession P46109; A8KA44; D3DX35; CRKL_HUMAN
Genbank Protein ID CAA42199.1; CAG30309.1; BAF85598.1; EAX02932.1; EAX02933.1; EAX02934.1; AAH43500.1
Protein Name Crk-like protein
Genbank Nucleotide ID X59656; CR456423; AK292909; CH471176; CH471176; CH471176; BC043500
Gene Name CRKL
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000099942.12 ENST00000354336.7 ENSP00000346300.3
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
miRWalkTargetScanmiRecordsRepTar
miRNAMapSomamiRmiRcodeRAID2
LncRNADisease
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Variation
GWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMUniProtPHOSIDA
BioGRIDmUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
UBD/SH3 1.00e-18 68.7 124 181
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/SH3
   S: 2    skekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekl 62
           ++e+v++lyd+ +++ ++L +kkG+++ +i  e+ +e W+++ ++  g+ G++P  +vekl
   Q: 124  NLEYVRTLYDFPGNDAEDLPFKKGEILVII--EKPEEQWWSA-RNKDGRVGMIPVPYVEKL 181
           5789**************************..88999***99.6**************997 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Interacts with tyrosine-phosphorylated EPOR and INPP5D/SHIP1 (PubMed:11443118). Interacts with DOCK2 and DOCK5 via its first SH3 domain (PubMed:12393632, PubMed:19004829). Interacts with phosphorylated CBLB and IRS4 (PubMed:10022120, PubMed:9614078).
 Interacts with tyrosine-phosphorylated EPOR and INPP5D/SHIP1 (PubMed:11443118). Interacts with DOCK2 and DOCK5 via its first SH3 domain (PubMed:12393632, PubMed:19004829). Interacts with phosphorylated CBLB and IRS4 (PubMed:10022120, PubMed:9614078).
Protein Sequence
(Fasta)
MSSARFDSSD RSAWYMGPVS RQEAQTRLQG QRHGMFLVRD SSTCPGDYVL SVSENSRVSH 60
YIINSLPNRR FKIGDQEFDH LPALLEFYKI HYLDTTTLIE PAPRYPSPPM GSVSAPNLPT 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046989|UBD,SH3|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CGGAGGGGGA GGTGGCTGCC GCTTCTCCCG CGTCCGCCAT TTTGTTGCTG TGGCTATTGG 60
GAACAAGCTG GGCAAAAGCA CCCCGGAGGC GCGACGCTCC TTCGAGTTCG GTGCCTCGTG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046989|UBD,SH3|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0181--Complete proteome
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0727--SH2 domain
KW-0728--SH3 domain
Interpro

IPR000980--SH2
IPR011511--SH3_2
IPR001452--SH3_domain
PROSITE

PS50001--SH2
PS50002--SH3
Pfam

PF00017--SH2
PF00018--SH3_1
PF07653--SH3_2
PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN
SMART

SM00252--SH2
SM00326--SH3
Gene Ontology

GO:0005829--C:cytosol
GO:0005768--C:endosome
GO:0070062--C:extracellular exosome
GO:0045296--F:cadherin binding
GO:0003723--F:RNA binding
GO:0005070--F:SH3/SH2 adaptor activity
GO:0004871--F:signal transducer activity
GO:0000186--P:activation of MAPKK activity
GO:0009887--P:animal organ morphogenesis
GO:0009952--P:anterior/posterior pattern specification
GO:0001568--P:blood vessel development
GO:0007507--P:heart development
GO:0035556--P:intracellular signal transduction
GO:0007254--P:JNK cascade
GO:0060017--P:parathyroid gland development
GO:0008284--P:positive regulation of cell proliferation
GO:1900026--P:positive regulation of substrate adhesion-dependent cell spreading
GO:0007265--P:Ras protein signal transduction
GO:0048538--P:thymus development
KEGG hsa:1399
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002025 Ailuropoda melanoleuca 97.93 8.00e-172 595.00
IUUC-Apl-004166 Anas platyrhynchos 89.07 5.00e-158 550.00
IUUC-Aca-004695 Anolis carolinensis 54.24 5.00e-84 303.00
IUUC-Ame-011285 Astyanax mexicanus 80.13 1.00e-138 485.00
IUUC-Bta-013076 Bos taurus 76.69 3.00e-112 398.00
IUUC-Cja-019850 Callithrix jacchus 99.31 1.00e-173 602.00
IUUC-Cfa-020428 Canis familiaris 97.24 2.00e-170 590.00
IUUC-Cpo-022079 Cavia porcellus 96.55 2.00e-169 587.00
IUUC-Csa-023877 Chlorocebus sabaeus 99.66 3.00e-174 603.00
IUUC-Cin-025128 Ciona intestinalis 50.78 6.00e-80 290.00
IUUC-Csv-026340 Ciona savignyi 47.93 7.00e-70 257.00
IUUC-Dre-027833 Danio rerio 80.68 5.00e-134 470.00
IUUC-Dno-029510 Dasypus novemcinctus 95.52 8.00e-169 585.00
IUUC-Dor-030297 Dipodomys ordii 97.03 1.00e-175 608.00
IUUC-Dme-031600 Drosophila melanogaster 44.08 2.00e-69 255.00
IUUC-Eca-033810 Equus caballus 97.93 3.00e-171 593.00
IUUC-Fca-036412 Felis catus 97.93 8.00e-172 595.00
IUUC-Fal-037170 Ficedula albicollis 90.69 2.00e-152 531.00
IUUC-Gga-040733 Gallus gallus 91.72 2.00e-141 494.00
IUUC-Gac-042398 Gasterosteus aculeatus 80.77 1.00e-144 505.00
IUUC-Ggo-044447 Gorilla gorilla 100.00 5.00e-117 412.00
IUUC-Itr-048092 Ictidomys tridecemlineatus 97.93 4.00e-171 593.00
IUUC-Kpa-049154 Komagataella pastoris 40.91 2.00e-10 60.10
IUUC-Lch-050385 Latimeria chalumnae 60.20 1.00e-99 356.00
IUUC-Loc-052916 Lepisosteus oculatus 84.92 9.00e-148 516.00
IUUC-Laf-053545 Loxodonta africana 97.00 8.00e-114 402.00
IUUC-Mga-059586 Meleagris gallopavo 93.10 6.00e-155 540.00
IUUC-Mvi-060518 Microbotryum violaceum 37.70 7.00e-11 61.20
IUUC-Mdo-061868 Monodelphis domestica 89.66 1.00e-158 552.00
IUUC-Mmu-063179 Mus musculus 96.55 4.00e-170 590.00
IUUC-Mpu-065863 Mustela putorius furo 97.93 1.00e-171 595.00
IUUC-Mlu-067290 Myotis lucifugus 96.90 3.00e-170 590.00
IUUC-Nle-069118 Nomascus leucogenys 100.00 2.00e-174 604.00
IUUC-Opr-070565 Ochotona princeps 95.38 5.00e-173 600.00
IUUC-Ont-071608 Oreochromis niloticus 81.47 9.00e-148 516.00
IUUC-Oan-072801 Ornithorhynchus anatinus 90.10 4.00e-164 570.00
IUUC-Ocu-073759 Oryctolagus cuniculus 97.24 3.00e-170 590.00
IUUC-Ola-086748 Oryzias latipes 76.32 4.00e-125 441.00
IUUC-Oga-088248 Otolemur garnettii 97.93 2.00e-171 594.00
IUUC-Oar-089525 Ovis aries 76.45 4.00e-122 430.00
IUUC-Ptr-091553 Pan troglodytes 100.00 2.00e-174 604.00
IUUC-Pan-092639 Papio anubis 100.00 2.00e-174 604.00
IUUC-Psi-093546 Pelodiscus sinensis 86.36 1.00e-100 358.00
IUUC-Pma-094340 Petromyzon marinus 59.68 2.00e-103 369.00
IUUC-Pfo-096090 Poecilia formosa 81.70 7.00e-148 516.00
IUUC-Pab-097876 Pongo abelii 99.57 3.00e-138 483.00
IUUC-Pca-100447 Procavia capensis 97.93 1.00e-171 595.00
IUUC-Pva-102346 Pteropus vampyrus 97.23 2.00e-169 587.00
IUUC-Rno-106017 Rattus norvegicus 96.55 5.00e-170 589.00
IUUC-Sha-106511 Sarcophilus harrisii 89.69 4.00e-103 367.00
IUUC-Sar-113583 Sorex araneus 96.90 1.00e-169 588.00
IUUC-Sre-115190 Sporisorium reilianum 30.00 2.00e-09 58.50
IUUC-Ssc-115339 Sus scrofa 95.52 3.00e-167 580.00
IUUC-Tgu-116454 Taeniopygia guttata 90.11 5.00e-97 346.00
IUUC-Tru-118580 Takifugu rubripes 78.14 2.00e-138 484.00
IUUC-Tsy-119327 Tarsius syrichta 95.53 3.00e-166 577.00
IUUC-Tni-120626 Tetraodon nigroviridis 77.88 8.00e-139 486.00
IUUC-Ttr-128248 Tursiops truncatus 96.90 2.00e-170 590.00
IUUC-Xtr-132626 Xenopus tropicalis 86.14 1.00e-151 529.00
Created Date 25-Jun-2017

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