iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Oar-089315

Ensembl Protein ID

ENSOARP00000018720.1

UniProt Accession

W5Q7M8; W5Q7M8_SHEEP

Genbank Protein ID

ENSOARP00000018720

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AMGL01027720

Gene Name

NOD2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOARG00000017441.1	ENSOART00000018984.1	ENSOARP00000018720.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/CARD	2.90e-13	50.3	141	198

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/CARD

   S: 2    deeyrlllstlqdrvrklLdvtdvldkylseflleeekelilaaaetkgnmqaaelLLk 60
           ++e+r++++t ++r+r+lLd++ v++++l++fll+  +el+++ a + ++++++ + ++
   Q: 141  TDEIRRPIFTSSQRARRLLDLAAVKANGLAAFLLQCIQELPVPLALPFEDAACK-KYMS 198
           59***************************************************9.5555 PP

Organism

Ovis aries

Protein Sequence
(Fasta)

MCAQDAFQTQ RSQLVELLVS GSLEGFESIV DRLLSREVLS WEDYEGLSLV GQPISHLARR 60
LLDTIWNKGA WGCEQLTAAV QEAQADSQPP ELPSSWDPHS PHPARDLQSH RPAIVRRPYG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGTGCGCGC AAGATGCTTT TCAGACACAG AGAAGCCAGC TGGTGGAGTT GCTGGTCTCG 60
GGGTCCCTGG AGGGCTTTGA GAGTATTGTG GACCGGCTGC TTTCCCGGGA AGTCCTCTCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0547--Nucleotide-binding
KW-1185--Reference proteome

Interpro

IPR007109--Brix
IPR001315--CARD
IPR011029--DEATH-like_dom
IPR001611--Leu-rich_rpt
IPR007111--NACHT_NTPase
IPR027417--P-loop_NTPase

PROSITE

PS50209--CARD
PS51450--LRR
PS50837--NACHT

Pfam

PF00619--CARD
PF13516--LRR_6

Gene Ontology

GO:0016323--C:basolateral plasma membrane
GO:0009986--C:cell surface
GO:0008180--C:COP9 signalosome
GO:0005856--C:cytoskeleton
GO:0005829--C:cytosol
GO:0005794--C:Golgi apparatus
GO:0031982--C:vesicle
GO:0005524--F:ATP binding
GO:0032500--F:muramyl dipeptide binding
GO:0042834--F:peptidoglycan binding
GO:0071225--P:cellular response to muramyl dipeptide
GO:0002374--P:cytokine secretion involved in immune response
GO:0042742--P:defense response to bacterium
GO:0016045--P:detection of bacterium
GO:0032498--P:detection of muramyl dipeptide
GO:0045087--P:innate immune response
GO:0030277--P:maintenance of gastrointestinal epithelium
GO:0070431--P:nucleotide-binding oligomerization domain containing 2 signaling pathway
GO:0050871--P:positive regulation of B cell activation
GO:1900017--P:positive regulation of cytokine production involved in inflammatory response
GO:0043123--P:positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0050718--P:positive regulation of interleukin-1 beta secretion
GO:0032740--P:positive regulation of interleukin-17 production
GO:0032755--P:positive regulation of interleukin-6 production
GO:0032757--P:positive regulation of interleukin-8 production
GO:0046330--P:positive regulation of JNK cascade
GO:0051092--P:positive regulation of NF-kappaB transcription factor activity
GO:1901224--P:positive regulation of NIK/NF-kappaB signaling
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0032760--P:positive regulation of tumor necrosis factor production
GO:0002830--P:positive regulation of type 2 immune response
GO:0042981--P:regulation of apoptotic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000642	Aegilops tauschii	31.48	2.50e-01	29.30
IUUC-Aml-001822	Ailuropoda melanoleuca	79.59	0.00e+00	1397.00
IUUC-Ame-011021	Astyanax mexicanus	44.46	0.00e+00	821.00
IUUC-Bta-013241	Bos taurus	96.06	0.00e+00	1873.00
IUUC-Cja-019633	Callithrix jacchus	77.26	0.00e+00	1134.00
IUUC-Cfa-020039	Canis familiaris	81.85	0.00e+00	1540.00
IUUC-Cpo-022337	Cavia porcellus	75.56	0.00e+00	1400.00
IUUC-Csa-023906	Chlorocebus sabaeus	80.77	0.00e+00	1529.00
IUUC-Dre-027568	Danio rerio	45.92	0.00e+00	788.00
IUUC-Dno-029098	Dasypus novemcinctus	78.82	0.00e+00	1382.00
IUUC-Dor-031102	Dipodomys ordii	70.79	0.00e+00	636.00
IUUC-Ete-032943	Echinops telfairi	75.24	0.00e+00	1051.00
IUUC-Eca-034310	Equus caballus	83.04	0.00e+00	1545.00
IUUC-Eeu-034589	Erinaceus europaeus	82.58	2.00e-152	533.00
IUUC-Fca-036252	Felis catus	80.04	0.00e+00	782.00
IUUC-Gac-041442	Gasterosteus aculeatus	44.95	0.00e+00	791.00
IUUC-Ggo-044861	Gorilla gorilla	81.07	0.00e+00	1485.00
IUUC-Hsa-046093	Homo sapiens	80.57	0.00e+00	1474.00
IUUC-Itr-048543	Ictidomys tridecemlineatus	78.51	0.00e+00	1377.00
IUUC-Lch-049454	Latimeria chalumnae	54.27	0.00e+00	903.00
IUUC-Laf-053553	Loxodonta africana	80.28	0.00e+00	1396.00
IUUC-Mcc-055772	Macaca mulatta	80.77	0.00e+00	1504.00
IUUC-Meu-056785	Macropus eugenii	67.84	1.00e-109	391.00
IUUC-Mmr-060596	Microcebus murinus	79.98	0.00e+00	1458.00
IUUC-Mdo-062983	Monodelphis domestica	67.67	0.00e+00	1080.00
IUUC-Mmu-063951	Mus musculus	73.65	0.00e+00	1410.00
IUUC-Mpu-066412	Mustela putorius furo	80.57	0.00e+00	1514.00
IUUC-Mlu-067601	Myotis lucifugus	79.07	0.00e+00	1380.00
IUUC-Nle-069913	Nomascus leucogenys	81.46	0.00e+00	1256.00
IUUC-Opr-070999	Ochotona princeps	77.73	0.00e+00	888.00
IUUC-Ont-072512	Oreochromis niloticus	46.01	0.00e+00	837.00
IUUC-Oan-073564	Ornithorhynchus anatinus	60.39	0.00e+00	1040.00
IUUC-Ocu-074837	Oryctolagus cuniculus	80.97	0.00e+00	1481.00
IUUC-Ola-086555	Oryzias latipes	45.68	0.00e+00	793.00
IUUC-Oga-088909	Otolemur garnettii	79.49	0.00e+00	1464.00
IUUC-Ptr-090542	Pan troglodytes	81.16	0.00e+00	1484.00
IUUC-Pan-092545	Papio anubis	80.97	0.00e+00	1503.00
IUUC-Pma-094167	Petromyzon marinus	31.46	3.00e-60	226.00
IUUC-Pfo-096976	Poecilia formosa	44.36	0.00e+00	782.00
IUUC-Pab-098481	Pongo abelii	80.67	0.00e+00	1474.00
IUUC-Pca-100135	Procavia capensis	74.34	0.00e+00	1236.00
IUUC-Pva-102127	Pteropus vampyrus	79.19	0.00e+00	1379.00
IUUC-Pgr-103397	Puccinia graminis	44.00	8.30e-01	27.70
IUUC-Ptt-103832	Puccinia triticina	29.17	1.70e+00	27.70
IUUC-Rno-105783	Rattus norvegicus	75.76	0.00e+00	1394.00
IUUC-Sar-113448	Sorex araneus	73.32	0.00e+00	894.00
IUUC-Tru-118708	Takifugu rubripes	44.37	0.00e+00	759.00
IUUC-Tni-120172	Tetraodon nigroviridis	37.09	6.00e-33	134.00
IUUC-Tbe-127661	Tupaia belangeri	82.04	0.00e+00	776.00
IUUC-Ttr-128318	Tursiops truncatus	81.07	0.00e+00	1446.00
IUUC-Vpa-130502	Vicugna pacos	77.31	2.00e-160	560.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence