iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Pab-098782

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Tripartite motif-containing protein 5

Genbank Nucleotide ID

ABGA01014872

Gene Name

TRIM5

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPPYG00000003564.2	ENSPPYT00000004249.2	ENSPPYP00000004088.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	3.90e-09	37.0	15	59
E3 activity/RING/U-box	2.00e-06	27.9	9	79

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C+iCle + + pl+l+CgH f++ Cl + + ++ + ++e +CP+Cr
   Q: 15   CPICLELLTQ-PLSLDCGHSFCQACLTANHKKSTLDKGERSCPVCR 59
           ********99.***************555568999**********8 PP

E3 activity/RING/U-box

   S: 2    vpeeflCpIslelMrdPvvlpsGitydrssIekwl.....asggktcPvtrqplteedlvPnltlrrliqa 67
           v ee  CpI lel ++P  l +G+++ ++++         ++g+++cPv+r + +++++ Pn  + +++++
   Q: 9    VKEEVTCPICLELLTQPLSLDCGHSFCQACLTANHkkstlDKGERSCPVCRVSYQPKNIRPNRHVANIVEK 79
           78999*************************976432333377888*****************998887776 PP

Organism

Pongo abelii

Protein Sequence
(Fasta)

MASGILVNVK EEVTCPICLE LLTQPLSLDC GHSFCQACLT ANHKKSTLDK GERSCPVCRV 60
SYQPKNIRPN RHVANIVEKL REVKLSPEGQ KVDHCARHGE KLLLFCKEDG KVICWLCERS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGAATTTCGA AAAAGGGCAC CTTTTCTAAT TTTTAATACT GGCTGGGTTA ATCTGAAACT 60
ATGTCAGAAG AAGTGGCATG ATAACAAGAT CTTGAGACTC AAGAGAAAAG GGAGATTGAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001870--B30.2/SPRY
IPR003879--Butyrophylin
IPR013320--ConA-like_dom
IPR010908--Longin_dom
IPR003877--SPRY_dom
IPR032917--TRIM5
IPR027370--Znf-RING_LisH
IPR000315--Znf_B-box
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50188--B302_SPRY
PS50119--ZF_BBOX
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF00622--SPRY
PF00643--zf-B_box
PF13445--zf-RING_UBOX

PRINTS

PR01407--BUTYPHLNCDUF

SMART

SM00336--BBOX
SM00184--RING
SM00449--SPRY

Gene Ontology

GO:1990462--C:omegasome
GO:0000932--C:P-body
GO:0008329--F:signaling pattern recognition receptor activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0006914--P:autophagy
GO:0051607--P:defense response to virus
GO:0045087--P:innate immune response
GO:0046597--P:negative regulation of viral entry into host cell
GO:1902187--P:negative regulation of viral release from host cell
GO:0043123--P:positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043410--P:positive regulation of MAPK cascade
GO:0051092--P:positive regulation of NF-kappaB transcription factor activity
GO:0070534--P:protein K63-linked ubiquitination
GO:0031664--P:regulation of lipopolysaccharide-mediated signaling pathway
GO:0032880--P:regulation of protein localization

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Bta-013110	Bos taurus	57.79	3.00e-157	548.00
IUUC-Cja-019944	Callithrix jacchus	68.02	0.00e+00	652.00
IUUC-Csa-023609	Chlorocebus sabaeus	82.33	0.00e+00	872.00
IUUC-Cho-024416	Choloepus hoffmanni	64.84	3.00e-95	342.00
IUUC-Dor-030700	Dipodomys ordii	52.02	7.00e-146	510.00
IUUC-Ete-033021	Echinops telfairi	54.73	2.00e-127	449.00
IUUC-Eeu-034968	Erinaceus europaeus	50.43	9.00e-117	413.00
IUUC-Ggo-044783	Gorilla gorilla	90.69	0.00e+00	888.00
IUUC-Hsa-046573	Homo sapiens	93.51	0.00e+00	936.00
IUUC-Mcc-055525	Macaca mulatta	85.92	0.00e+00	889.00
IUUC-Mmr-061336	Microcebus murinus	63.45	2.00e-153	535.00
IUUC-Mlu-067695	Myotis lucifugus	60.79	1.00e-156	546.00
IUUC-Nle-069081	Nomascus leucogenys	89.68	0.00e+00	885.00
IUUC-Opr-071057	Ochotona princeps	52.95	9.00e-133	466.00
IUUC-Oar-090073	Ovis aries	56.50	1.00e-142	499.00
IUUC-Ptr-090927	Pan troglodytes	92.90	0.00e+00	922.00
IUUC-Pan-092730	Papio anubis	85.71	0.00e+00	885.00
IUUC-Pca-100502	Procavia capensis	51.40	4.00e-132	464.00
IUUC-Sar-113094	Sorex araneus	49.09	1.00e-112	400.00
IUUC-Ssc-115715	Sus scrofa	57.09	4.00e-143	501.00
IUUC-Tsy-119055	Tarsius syrichta	60.40	4.00e-164	570.00
IUUC-Tbe-127426	Tupaia belangeri	54.02	3.00e-134	471.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence