iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Oar-090043

Ensembl Protein ID

ENSOARP00000001508.1

UniProt Accession

W5NTL6; W5NTL6_SHEEP

Genbank Protein ID

ENSOARP00000001508

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AMGL01001186

Gene Name

HECTD3

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOARG00000001446.1	ENSOART00000001551.1	ENSOARP00000001508.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	2.10e-75	254.4	489	813

Active Site

Position(s)	Description	Evidence
783	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 8    rlevefvgEegldlgGvtreflallskelqnpd......lglflysendketlqpnpdsglknp..ehlklFeflGrllgkalqdgrll 88
            +e++f  E  +d+gG +r+ la +s+el+ ++      l++f++++n+ + +  ++d+++ np  + +  +e++G+l+g al+ +++l
   Q: 489  WWECKFIAEGIIDQGGGFRDSLADMSEELCPSSadtpvpLPFFVRTANQGNGTGEARDMYVPNPscRDFAKYEWIGQLMGAALRGKEFL 577
           355*****************************9999*99**********************9999999********************* PP
   S: 89   dlplsksfyklllgkklsl.edleevdpelykslkeikenaesdieelgldltfsvseei...lgetkeeeLkpgGenipVtneNkeeY 173
            l l+ +++k+l g+++s+ +d+++vd+ l+k l+ ++      +++++++++f ++ +    l++++++eL+pgG+ i V +e+++++
   Q: 578  VLALPGFVWKQLSGEEVSWsKDFPAVDSVLVKLLEVMEG-----MDKETFEFKFGKELTFttvLSDQQVVELIPGGSGIVVGYEDRSRF 661
           **************************************5.....56666777777443334449************************* PP
   S: 174  vklvveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerk 262
           ++lv ++rl+e  keqv+a+++G+ +v+p+ +l+l+t++ele  +cG++e++v++l+k t++++ +++++  +q+Fwe+l++f++e+r+
   Q: 662  IQLVQKARLEE-SKEQVAAMQAGLLKVVPQAVLDLLTWQELEKKVCGDPEVTVDALRKLTRFED-FEPSDTRVQYFWEALNNFTNEDRS 748
           **********9.9*************************************************76.************************ PP
   S: 263  afLqFvTgssrlPlgGfaelkprlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFe 334
           +fL+FvTg sr P    a + p +     ++++d lP+s+TC ++L LP+Y s ++++ekL+yA  ++ +++
   Q: 749  RFLRFVTGPSRPP----AHIYPDKLG---YETTDALPESSTCSSTLFLPHYASAKVCEEKLRYAAYNCVAID 813
           *************....566666554...5669*********************************998776 PP

Organism

Ovis aries

Protein Sequence
(Fasta)

MAGPGPGAAL ESPRQLLGRV RFLAEAAKSL RAGRPLPAAL AFVPREVLYK LYKDPAGPSR 60
VLLPVXAGRA AGSSLTAVVV WCSRQEQLAE HLGDCGLDEG WLLVCRPAEG GARLVPIDTP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCTGGCC CGGGTCCGGG CGCGGCGCTA GAGTCCCCGC GACAGCTGCT GGGCCGTGTA 60
CGCTTTCTGG CGGAGGCAGC GAAGAGCCTC CGTGCCGGGC GGCCGCTGCC GGCGGCGCTA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR004939--APC_su10/DOC_dom
IPR008979--Galactose-bd-like
IPR000569--HECT_dom

PROSITE

PS51284--DOC
PS50237--HECT

Pfam

PF03256--ANAPC10
PF00632--HECT

SMART

SM01337--APC10
SM00119--HECTc

Gene Ontology

GO:0048471--C:perinuclear region of cytoplasm
GO:0004842--F:ubiquitin-protein transferase activity
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001229	Ailuropoda melanoleuca	91.87	0.00e+00	1572.00
IUUC-Apl-003715	Anas platyrhynchos	85.25	0.00e+00	1308.00
IUUC-Aca-004377	Anolis carolinensis	76.16	0.00e+00	1323.00
IUUC-Ame-011918	Astyanax mexicanus	62.88	0.00e+00	1056.00
IUUC-Bta-012736	Bos taurus	93.38	0.00e+00	1590.00
IUUC-Cja-019926	Callithrix jacchus	92.22	0.00e+00	1565.00
IUUC-Cfa-020753	Canis familiaris	97.92	0.00e+00	1162.00
IUUC-Cpo-021415	Cavia porcellus	91.17	0.00e+00	1554.00
IUUC-Csa-023096	Chlorocebus sabaeus	91.99	0.00e+00	1561.00
IUUC-Dre-028746	Danio rerio	67.02	0.00e+00	1132.00
IUUC-Dno-029293	Dasypus novemcinctus	97.18	0.00e+00	1057.00
IUUC-Dor-031113	Dipodomys ordii	97.70	0.00e+00	1222.00
IUUC-Ete-032601	Echinops telfairi	89.25	0.00e+00	1334.00
IUUC-Eca-034198	Equus caballus	90.24	0.00e+00	1553.00
IUUC-Eeu-034708	Erinaceus europaeus	96.88	0.00e+00	890.00
IUUC-Fca-035478	Felis catus	92.02	0.00e+00	1542.00
IUUC-Fal-037366	Ficedula albicollis	77.33	0.00e+00	1332.00
IUUC-Gmo-039020	Gadus morhua	75.15	0.00e+00	1036.00
IUUC-Gga-040332	Gallus gallus	78.41	0.00e+00	1339.00
IUUC-Gac-042336	Gasterosteus aculeatus	67.76	0.00e+00	1175.00
IUUC-Ggo-045382	Gorilla gorilla	92.22	0.00e+00	1565.00
IUUC-Hsa-046562	Homo sapiens	92.22	0.00e+00	1565.00
IUUC-Itr-048208	Ictidomys tridecemlineatus	92.22	0.00e+00	1567.00
IUUC-Lch-049606	Latimeria chalumnae	65.42	0.00e+00	839.00
IUUC-Loc-052448	Lepisosteus oculatus	60.65	0.00e+00	1008.00
IUUC-Laf-054507	Loxodonta africana	90.95	0.00e+00	1582.00
IUUC-Mcc-055690	Macaca mulatta	91.99	0.00e+00	1562.00
IUUC-Meu-055970	Macropus eugenii	82.67	0.00e+00	1369.00
IUUC-Mga-059654	Meleagris gallopavo	85.32	0.00e+00	1292.00
IUUC-Mmr-061069	Microcebus murinus	92.45	0.00e+00	1569.00
IUUC-Mdo-062547	Monodelphis domestica	91.25	0.00e+00	777.00
IUUC-Mmu-063096	Mus musculus	91.75	0.00e+00	1558.00
IUUC-Mpu-065846	Mustela putorius furo	92.10	0.00e+00	1577.00
IUUC-Mlu-067992	Myotis lucifugus	91.23	0.00e+00	1490.00
IUUC-Nle-069565	Nomascus leucogenys	91.73	0.00e+00	1457.00
IUUC-Opr-070853	Ochotona princeps	83.80	0.00e+00	1006.00
IUUC-Ont-071628	Oreochromis niloticus	67.49	0.00e+00	1146.00
IUUC-Ocu-074094	Oryctolagus cuniculus	92.45	0.00e+00	1570.00
IUUC-Ola-087384	Oryzias latipes	67.63	0.00e+00	1189.00
IUUC-Oga-088224	Otolemur garnettii	92.07	0.00e+00	1566.00
IUUC-Ptr-090852	Pan troglodytes	92.33	0.00e+00	1563.00
IUUC-Pan-092787	Papio anubis	91.99	0.00e+00	1564.00
IUUC-Psi-092986	Pelodiscus sinensis	72.86	0.00e+00	979.00
IUUC-Pma-094416	Petromyzon marinus	38.28	1.00e-161	563.00
IUUC-Pfo-096720	Poecilia formosa	67.80	0.00e+00	1187.00
IUUC-Pab-098325	Pongo abelii	90.77	0.00e+00	1196.00
IUUC-Pca-100885	Procavia capensis	82.32	0.00e+00	1179.00
IUUC-Pva-102829	Pteropus vampyrus	78.76	0.00e+00	967.00
IUUC-Rno-104882	Rattus norvegicus	91.75	0.00e+00	1561.00
IUUC-Sha-106811	Sarcophilus harrisii	90.57	2.00e-115	408.00
IUUC-Sar-113020	Sorex araneus	81.95	0.00e+00	690.00
IUUC-Ssc-115436	Sus scrofa	98.52	5.00e-159	553.00
IUUC-Tgu-117042	Taeniopygia guttata	78.15	0.00e+00	1333.00
IUUC-Tru-118419	Takifugu rubripes	66.35	0.00e+00	1115.00
IUUC-Tsy-118829	Tarsius syrichta	97.79	0.00e+00	926.00
IUUC-Tni-120410	Tetraodon nigroviridis	54.59	0.00e+00	864.00
IUUC-Tbe-128113	Tupaia belangeri	97.39	0.00e+00	764.00
IUUC-Ttr-128167	Tursiops truncatus	89.42	0.00e+00	1498.00
IUUC-Xtr-132910	Xenopus tropicalis	62.82	0.00e+00	1015.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence