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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-064391
UUCD1 version UUC-MuM-00312
Ensembl Protein ID ENSMUSP00000111048.3
UniProt Accession P51944; Q3TF73; Q60797; Q60799; Q8BSX9; Q8C4D9; Q8CI26; CCNF_MOUSE
Genbank Protein ID CAA87695.1; AAA62317.1; AAA63152.1; BAC26886.1; BAC38507.1; BAE35214.1; BAE41025.1; AAH37662.1
Protein Name Cyclin-F
Genbank Nucleotide ID Z47766; U20612; U20636; AK030298; AK082485; AK159594; AK169263; AC117577
Gene Name Ccnf
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000072082.6 ENSMUST00000115390.3 ENSMUSP00000111048.3
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
miRTarBasemicroRNATRANSFACRepTar
RAID2
Protein-protein Interaction
IIDiRefIndex
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusdbPTM
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
E3 adaptor/Cullin RING/SCF/F-box 83.89 0.00e+00 1193.00 IUUC-Hsa-046867
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Mus musculus
Functional Description
(View)

Functional Description


     Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of CP110 during G2 phase, thereby acting as an inhibitor of centrosome reduplication.
 Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of CP110 during G2 phase, thereby acting as an inhibitor of centrosome reduplication.
Protein Sequence
(Fasta)
MGSGGVIHCR CAKCFCYPTK RRIKRRPRNL TILSLPEDVL FHILKWLSVG DILAVRAVHS 60
HLKYLVDNHA SVWASASFQE LWPSPQNLKL FERAAEKGNF EAAVKLGIAY LYNEGLSVSD 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-064391|E3,F-box|Mus musculus
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Nucleotide Sequence
(Fasta)
GGGGGTGGGG CCCGCGCCTG CGTGAGGCGC TCCGTGCACT TGCCCCAGGC GCGGGCGCGC 60
TTGAGAGCGG TCTAAAGCGG CAGTGGAGGG AGCTCGGCGA TGGGGAGCGG CGGTGGTGAG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-064391|E3,F-box|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0131--Cell cycle
KW-0132--Cell division
KW-0181--Complete proteome
KW-0195--Cyclin
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0498--Mitosis
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway
Interpro

IPR028857--CCNF_metazoan
IPR013763--Cyclin-like
IPR004367--Cyclin_C-dom
IPR006671--Cyclin_N
IPR001810--F-box_dom
IPR013780--Glyco_hydro_b
PROSITE

PS00292--CYCLINS
PS50181--FBOX
Pfam

PF02984--Cyclin_C
PF00134--Cyclin_N
PF00646--F-box
SMART

SM00385--CYCLIN
SM01332--Cyclin_C
SM00256--FBOX
Gene Ontology

GO:0030054--C:cell junction
GO:0005814--C:centriole
GO:0005813--C:centrosome
GO:0005634--C:nucleus
GO:0019005--C:SCF ubiquitin ligase complex
GO:0004842--F:ubiquitin-protein transferase activity
GO:0051301--P:cell division
GO:0007067--P:mitotic nuclear division
GO:0010826--P:negative regulation of centrosome duplication
GO:0001890--P:placenta development
GO:0016567--P:protein ubiquitination
GO:0000320--P:re-entry into mitotic cell cycle
GO:0031146--P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
KEGG mmu:12449
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001520 Ailuropoda melanoleuca 81.47 0.00e+00 1149.00
IUUC-Apl-003215 Anas platyrhynchos 67.65 0.00e+00 1030.00
IUUC-Ame-011700 Astyanax mexicanus 58.44 0.00e+00 694.00
IUUC-Bta-013230 Bos taurus 81.83 0.00e+00 1170.00
IUUC-Cja-019256 Callithrix jacchus 82.88 0.00e+00 1193.00
IUUC-Cfa-020123 Canis familiaris 82.63 0.00e+00 1164.00
IUUC-Cpo-021599 Cavia porcellus 85.31 0.00e+00 1269.00
IUUC-Csa-023518 Chlorocebus sabaeus 78.12 0.00e+00 1085.00
IUUC-Cgl-026734 Colletotrichum gloeosporioides 35.90 1.40e-02 33.50
IUUC-Cne-026925 Cryptococcus neoformans 30.26 4.40e+00 26.90
IUUC-Dre-028186 Danio rerio 57.10 0.00e+00 691.00
IUUC-Dno-029401 Dasypus novemcinctus 79.87 0.00e+00 1115.00
IUUC-Dor-031087 Dipodomys ordii 78.74 0.00e+00 1124.00
IUUC-Ete-032869 Echinops telfairi 95.04 6.00e-78 285.00
IUUC-Eca-033473 Equus caballus 83.31 0.00e+00 1176.00
IUUC-Eeu-034533 Erinaceus europaeus 66.41 1.00e-157 550.00
IUUC-Fca-035961 Felis catus 80.88 0.00e+00 1134.00
IUUC-Fal-036659 Ficedula albicollis 65.00 0.00e+00 967.00
IUUC-Gmo-039557 Gadus morhua 57.28 0.00e+00 647.00
IUUC-Gga-040389 Gallus gallus 65.10 0.00e+00 818.00
IUUC-Gac-042059 Gasterosteus aculeatus 59.25 0.00e+00 666.00
IUUC-Ggo-044497 Gorilla gorilla 83.63 0.00e+00 1182.00
IUUC-Hsa-046867 Homo sapiens 83.89 0.00e+00 1177.00
IUUC-Itr-047922 Ictidomys tridecemlineatus 86.58 0.00e+00 1295.00
IUUC-Lch-050143 Latimeria chalumnae 64.77 0.00e+00 852.00
IUUC-Loc-052538 Lepisosteus oculatus 66.67 7.00e-45 172.00
IUUC-Laf-054481 Loxodonta africana 77.62 0.00e+00 1090.00
IUUC-Mcc-055426 Macaca mulatta 83.40 0.00e+00 1185.00
IUUC-Meu-056150 Macropus eugenii 69.37 0.00e+00 889.00
IUUC-Mga-059822 Meleagris gallopavo 63.87 0.00e+00 756.00
IUUC-Mmr-061785 Microcebus murinus 82.97 0.00e+00 1192.00
IUUC-Mdo-062763 Monodelphis domestica 72.63 0.00e+00 1051.00
IUUC-Mpu-065756 Mustela putorius furo 82.68 0.00e+00 1167.00
IUUC-Mlu-067607 Myotis lucifugus 82.50 0.00e+00 1162.00
IUUC-Nle-069147 Nomascus leucogenys 83.76 0.00e+00 1155.00
IUUC-Opr-071129 Ochotona princeps 82.21 0.00e+00 1198.00
IUUC-Ont-072031 Oreochromis niloticus 60.26 0.00e+00 708.00
IUUC-Oan-073514 Ornithorhynchus anatinus 64.29 8.00e-162 563.00
IUUC-Ocu-074914 Oryctolagus cuniculus 81.63 0.00e+00 1123.00
IUUC-Ola-086606 Oryzias latipes 57.66 0.00e+00 655.00
IUUC-Oga-088632 Otolemur garnettii 83.57 0.00e+00 1200.00
IUUC-Oar-090320 Ovis aries 77.92 0.00e+00 1118.00
IUUC-Ptr-091175 Pan troglodytes 83.76 0.00e+00 1176.00
IUUC-Pan-092003 Papio anubis 83.40 0.00e+00 1171.00
IUUC-Psi-093719 Pelodiscus sinensis 66.97 0.00e+00 985.00
IUUC-Pma-094390 Petromyzon marinus 54.62 6.00e-124 437.00
IUUC-Pfo-096911 Poecilia formosa 58.75 0.00e+00 717.00
IUUC-Pab-097562 Pongo abelii 83.63 0.00e+00 1207.00
IUUC-Pca-100748 Procavia capensis 67.00 6.00e-115 408.00
IUUC-Pva-102168 Pteropus vampyrus 79.15 0.00e+00 1122.00
IUUC-Rno-105157 Rattus norvegicus 95.62 0.00e+00 1388.00
IUUC-Sha-107184 Sarcophilus harrisii 71.35 0.00e+00 1060.00
IUUC-Sar-113086 Sorex araneus 68.27 7.00e-85 308.00
IUUC-Ssc-116347 Sus scrofa 81.40 0.00e+00 1139.00
IUUC-Tgu-117463 Taeniopygia guttata 64.64 0.00e+00 962.00
IUUC-Tru-118348 Takifugu rubripes 59.19 0.00e+00 719.00
IUUC-Tsy-119459 Tarsius syrichta 80.69 2.00e-94 340.00
IUUC-Tni-120853 Tetraodon nigroviridis 60.42 0.00e+00 665.00
IUUC-Tbe-127361 Tupaia belangeri 73.68 0.00e+00 686.00
IUUC-Ttr-128214 Tursiops truncatus 72.74 0.00e+00 984.00
IUUC-Xtr-132479 Xenopus tropicalis 66.82 0.00e+00 792.00
Created Date 25-Jun-2017

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