iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000071051.13	ENST00000233154.8	ENSP00000233154.4
ENSG00000071051.13	ENST00000522586.5	ENSP00000431109.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	CircNet
miRTarBase	microRNA	TRANSFAC	miRWalk
TargetScan	RepTar	SomamiR	miRcode
RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
GWASdb	GWAS Central	OMIM
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	dbPTM	HPRD
Phospho.ELM	UniProt	BioGRID
DNA Methylation
MethyCancer	TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
UBD/SH3	SH3	18539162

Classification

Family	E-value	Score	Start	End
UBD/SH3	9.10e-45	152.1	197	256

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 3    kekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
           +++vq+ly++++++++eL+++kG++++viek e+d +W+k+ k+++g+ Gl+P+n+v+ l+
   Q: 197  LHVVQTLYPFSSVTEEELNFEKGETMEVIEKPENDPEWWKC-KNARGQVGLVPKNYVVVLS 256
           689**************************************.7**************9886 PP

Organism

Homo sapiens

Functional Description
(View)

Adapter protein which associates with tyrosine-phosphorylated growth factor receptors or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in ELK1-dependent transcriptional activation in response to activated Ras signaling.

Protein Sequence
(Fasta)

MTEEVIVIAK WDYTAQQDQE LDIKKNERLW LLDDSKTWWR VRNAANRTGY VPSNYVERKN 60
SLKKGSLVKN LKDTLGLGKT RRKTSARDAS PTPSTDAEYP ANGSGADRIY DLNIPAFVKF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCCGCGGGGA TCGTCAGGCC GGAGCCGCGC GGCCGAGCGG GCGGCGGGCG GAGGGGAGGG 60
CTTGGCGGCC GGGAGGCTCG CGGCGCCCGG GCCGGCAGGG TCCGCCCGGG CCGGCAGCGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0256--Endoplasmic reticulum
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0727--SH2 domain
KW-0728--SH3 domain
KW-0810--Translation regulation

Interpro

IPR017304--NCK
IPR000980--SH2
IPR001452--SH3_domain

PROSITE

PS50001--SH2
PS50002--SH3

Pfam

PF00017--SH2
PF00018--SH3_1
PF14604--SH3_9

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN

SMART

SM00252--SH2
SM00326--SH3

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005783--C:endoplasmic reticulum
GO:0014069--C:postsynaptic density
GO:0012506--C:vesicle membrane
GO:0008093--F:cytoskeletal adaptor activity
GO:0030159--F:receptor signaling complex scaffold activity
GO:0005070--F:SH3/SH2 adaptor activity
GO:0007015--P:actin filament organization
GO:0016477--P:cell migration
GO:0060996--P:dendritic spine development
GO:0048013--P:ephrin receptor signaling pathway
GO:0007173--P:epidermal growth factor receptor signaling pathway
GO:0001771--P:immunological synapse formation
GO:0030032--P:lamellipodium assembly
GO:0008285--P:negative regulation of cell proliferation
GO:1903912--P:negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation
GO:0033137--P:negative regulation of peptidyl-serine phosphorylation
GO:1903898--P:negative regulation of PERK-mediated unfolded protein response
GO:1990441--P:negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
GO:0030838--P:positive regulation of actin filament polymerization
GO:1902237--P:positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
GO:0042102--P:positive regulation of T cell proliferation
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0036493--P:positive regulation of translation in response to endoplasmic reticulum stress
GO:0007176--P:regulation of epidermal growth factor-activated receptor activity
GO:0007172--P:signal complex assembly
GO:0007165--P:signal transduction
GO:0042110--P:T cell activation
GO:0048010--P:vascular endothelial growth factor receptor signaling pathway

KEGG

hsa:8440

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001404	Ailuropoda melanoleuca	97.63	0.00e+00	754.00
IUUC-Apl-003456	Anas platyrhynchos	92.89	0.00e+00	728.00
IUUC-Aca-005105	Anolis carolinensis	92.11	0.00e+00	723.00
IUUC-Ame-010966	Astyanax mexicanus	78.91	4.00e-177	613.00
IUUC-Bta-012424	Bos taurus	88.95	0.00e+00	652.00
IUUC-Cel-018144	Caenorhabditis elegans	42.40	8.00e-77	280.00
IUUC-Cja-019898	Callithrix jacchus	99.74	0.00e+00	764.00
IUUC-Cfa-020830	Canis familiaris	97.63	0.00e+00	753.00
IUUC-Cpo-021487	Cavia porcellus	88.95	0.00e+00	661.00
IUUC-Csa-023693	Chlorocebus sabaeus	99.74	0.00e+00	764.00
IUUC-Cin-025348	Ciona intestinalis	37.53	6.00e-67	248.00
IUUC-Dre-028334	Danio rerio	81.46	3.00e-180	624.00
IUUC-Dno-028973	Dasypus novemcinctus	94.74	0.00e+00	738.00
IUUC-Dor-031003	Dipodomys ordii	96.32	0.00e+00	711.00
IUUC-Ete-032792	Echinops telfairi	86.20	0.00e+00	662.00
IUUC-Eca-033656	Equus caballus	98.42	0.00e+00	758.00
IUUC-Fca-036347	Felis catus	97.89	0.00e+00	755.00
IUUC-Fal-037095	Ficedula albicollis	92.89	0.00e+00	729.00
IUUC-Gmo-039410	Gadus morhua	71.43	3.00e-162	564.00
IUUC-Gga-040155	Gallus gallus	92.89	0.00e+00	728.00
IUUC-Gac-041787	Gasterosteus aculeatus	73.10	4.00e-166	577.00
IUUC-Ggo-044805	Gorilla gorilla	100.00	0.00e+00	765.00
IUUC-Itr-048887	Ictidomys tridecemlineatus	96.84	0.00e+00	727.00
IUUC-Lch-049795	Latimeria chalumnae	88.68	0.00e+00	696.00
IUUC-Loc-051985	Lepisosteus oculatus	88.16	0.00e+00	671.00
IUUC-Laf-054228	Loxodonta africana	95.26	0.00e+00	739.00
IUUC-Mcc-055402	Macaca mulatta	99.74	0.00e+00	764.00
IUUC-Mga-059374	Meleagris gallopavo	92.89	0.00e+00	728.00
IUUC-Mmr-061453	Microcebus murinus	98.42	0.00e+00	758.00
IUUC-Mdo-063080	Monodelphis domestica	91.84	0.00e+00	722.00
IUUC-Mmu-063529	Mus musculus	96.05	0.00e+00	725.00
IUUC-Mpu-066815	Mustela putorius furo	97.63	0.00e+00	754.00
IUUC-Mlu-067132	Myotis lucifugus	94.43	3.00e-165	574.00
IUUC-Nle-069371	Nomascus leucogenys	100.00	0.00e+00	765.00
IUUC-Opr-070948	Ochotona princeps	97.08	0.00e+00	710.00
IUUC-Ont-071410	Oreochromis niloticus	75.06	1.00e-163	569.00
IUUC-Oan-073304	Ornithorhynchus anatinus	91.83	2.00e-165	575.00
IUUC-Ocu-074783	Oryctolagus cuniculus	97.63	0.00e+00	730.00
IUUC-Ola-086808	Oryzias latipes	73.26	6.00e-161	560.00
IUUC-Oga-088391	Otolemur garnettii	98.95	0.00e+00	740.00
IUUC-Oar-090025	Ovis aries	82.63	1.00e-169	588.00
IUUC-Ptr-090975	Pan troglodytes	100.00	0.00e+00	765.00
IUUC-Pan-092287	Papio anubis	99.74	0.00e+00	764.00
IUUC-Psi-093413	Pelodiscus sinensis	93.42	0.00e+00	730.00
IUUC-Pfo-097129	Poecilia formosa	76.71	3.00e-169	587.00
IUUC-Pab-098756	Pongo abelii	100.00	0.00e+00	765.00
IUUC-Pca-100235	Procavia capensis	82.11	0.00e+00	648.00
IUUC-Pva-102294	Pteropus vampyrus	94.47	0.00e+00	720.00
IUUC-Rno-105090	Rattus norvegicus	95.79	0.00e+00	724.00
IUUC-Sha-107521	Sarcophilus harrisii	92.37	0.00e+00	726.00
IUUC-Sar-113697	Sorex araneus	89.32	0.00e+00	671.00
IUUC-Ssc-115958	Sus scrofa	88.29	8.00e-168	582.00
IUUC-Tgu-116559	Taeniopygia guttata	90.79	0.00e+00	703.00
IUUC-Tru-117677	Takifugu rubripes	76.46	2.00e-167	582.00
IUUC-Tni-120434	Tetraodon nigroviridis	76.02	5.00e-165	573.00
IUUC-Tbe-127931	Tupaia belangeri	97.15	0.00e+00	638.00
IUUC-Ttr-128993	Tursiops truncatus	88.95	0.00e+00	655.00
IUUC-Xtr-132543	Xenopus tropicalis	83.99	0.00e+00	671.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence