iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Yli-134537

Ensembl Protein ID

CAG79486

UniProt Accession

Q6C619; NPL4_YARLI

Genbank Protein ID

CAG79486.2

Protein Name

Nuclear protein localization protein 4

Genbank Nucleotide ID

CR382131

Gene Name

NPL4; YALI0E13233g

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
YALI0_E13233g	CAG79486	CAG79486

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
UBD/ZnF/NZF	35.11	2.00e-87	321.00	IUUC-Hsa-046334
UBD/ZnF/NZF	35.10	4.00e-88	323.00	IUUC-Mmu-063916
UBD/ZnF/NZF	35.27	2.00e-89	326.00	IUUC-Rno-105582
UBD/ZnF/Other	48.89	8.00e-152	531.00	IUUC-Sce-106145

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Yarrowia lipolytica

Functional Description
(View)

Involved in the import of nuclear-targeted proteins into the nucleus and the export of poly(A) RNA out of the nucleus. Has a role in the endoplasmic reticulum-associated degradation (ERAD) pathway (By similarity).

Protein Sequence
(Fasta)

MILRFRSKKG TLRAEAQPTD LFDVAFKKLT EDLPDIDPAT ITLATSPTGK QEPASRLLGK 60
TVQKLGLNHG DMLFVSYTDS APRAAVEAVT AETAPQMTAA HIRDATKQLP VDDYLEKQDG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGTGAGTA CTGCAGACAC AAACAGCTGT GGAATTGTGC CCAGACTAAC TCAGATCCTG 60
CGATTCCGGT CCAAAAAGGG CACTCTTCGA GCGGAGGCCC AGCCCACAGA TCTCTTCGAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0256--Endoplasmic reticulum
KW-0472--Membrane
KW-0509--mRNA transport
KW-0539--Nucleus
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0811--Translocation
KW-0813--Transport

Interpro

IPR016563--Npl4
IPR007717--NPL4_C
IPR007716--NPL4_Zn-bd_put

Pfam

PF05021--NPL4
PF05020--zf-NPL4

Gene Ontology

GO:0036266--C:Cdc48p-Npl4p-Vms1p AAA ATPase complex
GO:0005829--C:cytosol
GO:0000837--C:Doa10p ubiquitin ligase complex
GO:0000839--C:Hrd1p ubiquitin ligase ERAD-L complex
GO:0031965--C:nuclear membrane
GO:0005634--C:nucleus
GO:0048471--C:perinuclear region of cytoplasm
GO:1990112--C:RQC complex
GO:0034098--C:VCP-NPL4-UFD1 AAA ATPase complex
GO:0043130--F:ubiquitin binding
GO:0031625--F:ubiquitin protein ligase binding
GO:0071712--P:ER-associated misfolded protein catabolic process
GO:0072671--P:mitochondria-associated ubiquitin-dependent protein catabolic process
GO:0051228--P:mitotic spindle disassembly
GO:0051028--P:mRNA transport
GO:0051974--P:negative regulation of telomerase activity
GO:0070651--P:nonfunctional rRNA decay
GO:1900182--P:positive regulation of protein localization to nucleus
GO:0030970--P:retrograde protein transport, ER to cytosol
GO:1990116--P:ribosome-associated ubiquitin-dependent protein catabolic process
GO:0071629--P:ubiquitin-dependent catabolism of misfolded proteins by cytoplasm-associated proteasome
GO:0030433--P:ubiquitin-dependent ERAD pathway
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

yli:YALI0E13233g

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000460	Aegilops tauschii	21.15	6.00e-06	43.50
IUUC-Aml-002268	Ailuropoda melanoleuca	37.83	3.00e-89	320.00
IUUC-Atr-002939	Amborella trichopoda	23.95	4.00e-06	43.90
IUUC-Apl-003496	Anas platyrhynchos	37.30	4.00e-90	323.00
IUUC-Aca-005230	Anolis carolinensis	34.28	5.00e-89	319.00
IUUC-Aly-006056	Arabidopsis lyrata	22.10	2.00e-03	34.70
IUUC-Ath-006993	Arabidopsis thaliana	31.03	2.30e-01	28.10
IUUC-Ago-007954	Ashbya gossypii	43.60	2.00e-125	440.00
IUUC-Acl-008208	Aspergillus clavatus	42.54	7.00e-138	482.00
IUUC-Afl-008574	Aspergillus flavus	44.19	6.00e-141	492.00
IUUC-Afu-008825	Aspergillus fumigatus	45.09	3.00e-147	513.00
IUUC-Ani-009495	Aspergillus nidulans	43.71	4.00e-140	489.00
IUUC-Ang-009762	Aspergillus niger	45.62	7.00e-144	502.00
IUUC-Aor-010199	Aspergillus oryzae	44.02	2.00e-140	490.00
IUUC-Ate-010592	Aspergillus terreus	46.74	3.00e-143	499.00
IUUC-Ame-011438	Astyanax mexicanus	38.65	4.00e-28	114.00
IUUC-Bgr-012124	Blumeria graminis	42.55	4.00e-141	493.00
IUUC-Bta-013312	Bos taurus	35.46	5.00e-92	329.00
IUUC-Bci-013648	Botrytis cinerea	42.93	6.00e-144	502.00
IUUC-Bdi-014326	Brachypodium distachyon	22.71	7.00e-06	43.10
IUUC-Bol-016294	Brassica oleracea	22.83	1.00e-06	45.80
IUUC-Bra-017023	Brassica rapa	23.19	4.00e-07	47.00
IUUC-Cel-018713	Caenorhabditis elegans	36.91	1.00e-77	281.00
IUUC-Cja-018869	Callithrix jacchus	35.11	1.00e-90	325.00
IUUC-Cfa-020757	Canis familiaris	37.63	4.00e-89	320.00
IUUC-Cpo-022390	Cavia porcellus	38.94	6.00e-88	316.00
IUUC-Csa-023366	Chlorocebus sabaeus	35.28	9.00e-91	325.00
IUUC-Cho-024455	Choloepus hoffmanni	36.84	3.00e-64	237.00
IUUC-Cin-025638	Ciona intestinalis	30.63	5.00e-64	236.00
IUUC-Csv-026310	Ciona savignyi	30.47	4.00e-62	230.00
IUUC-Cgl-026685	Colletotrichum gloeosporioides	42.81	2.00e-135	474.00
IUUC-Cne-026794	Cryptococcus neoformans	37.28	2.00e-109	387.00
IUUC-Cme-027248	Cyanidioschyzon merolae	24.43	8.00e-08	49.70
IUUC-Dre-027689	Danio rerio	36.54	1.00e-86	311.00
IUUC-Dno-030004	Dasypus novemcinctus	34.64	2.00e-90	324.00
IUUC-Dor-030585	Dipodomys ordii	37.25	1.00e-86	311.00
IUUC-Dse-031202	Dothistroma septosporum	41.83	2.00e-129	454.00
IUUC-Dme-032092	Drosophila melanogaster	33.91	4.00e-78	283.00
IUUC-Ete-033009	Echinops telfairi	44.74	7.00e-31	125.00
IUUC-Eca-034001	Equus caballus	35.46	6.00e-92	329.00
IUUC-Eeu-034485	Erinaceus europaeus	27.82	6.00e-51	193.00
IUUC-Fca-036128	Felis catus	38.94	4.00e-88	317.00
IUUC-Fal-037523	Ficedula albicollis	35.51	3.00e-91	327.00
IUUC-Fox-037802	Fusarium oxysporum	44.80	9.00e-149	518.00
IUUC-Fso-038152	Fusarium solani	44.54	3.00e-147	513.00
IUUC-Gmo-038486	Gadus morhua	38.02	9.00e-81	292.00
IUUC-Ggr-039916	Gaeumannomyces graminis	43.44	7.00e-141	492.00
IUUC-Gga-041208	Gallus gallus	35.15	6.00e-91	326.00
IUUC-Gac-042304	Gasterosteus aculeatus	34.82	3.00e-77	280.00
IUUC-Gma-044007	Glycine max	24.30	4.00e-03	33.90
IUUC-Ggo-045236	Gorilla gorilla	34.28	3.00e-84	303.00
IUUC-Hsa-046334	Homo sapiens	35.11	9.00e-91	325.00
IUUC-Hvu-047323	Hordeum vulgare	23.08	5.00e-03	32.00
IUUC-Itr-047878	Ictidomys tridecemlineatus	39.94	1.00e-58	218.00
IUUC-Lch-050302	Latimeria chalumnae	34.45	2.00e-88	317.00
IUUC-Lpe-051362	Leersia perrieri	24.26	1.00e-06	45.80
IUUC-Loc-052548	Lepisosteus oculatus	37.50	1.00e-87	315.00
IUUC-Lma-053092	Leptosphaeria maculans	44.26	6.00e-141	492.00
IUUC-Laf-053911	Loxodonta africana	34.99	3.00e-91	327.00
IUUC-Mcc-055830	Macaca mulatta	35.35	1.00e-90	325.00
IUUC-Meu-056460	Macropus eugenii	30.58	5.00e-13	67.00
IUUC-Mor-057189	Magnaporthe oryzae	45.75	5.00e-150	522.00
IUUC-Mpo-057366	Magnaporthe poae	44.74	5.00e-144	502.00
IUUC-Mtr-057834	Medicago truncatula	30.12	3.00e-01	27.70
IUUC-Mla-059190	Melampsora laricipopulina	37.26	3.00e-114	404.00
IUUC-Mga-060036	Meleagris gallopavo	35.04	4.00e-90	323.00
IUUC-Mvi-060275	Microbotryum violaceum	36.09	1.00e-113	402.00
IUUC-Mmr-061300	Microcebus murinus	35.59	5.00e-91	326.00
IUUC-Mdo-062911	Monodelphis domestica	35.58	1.00e-89	321.00
IUUC-Mmu-063916	Mus musculus	37.45	2.00e-88	318.00
IUUC-Mac-065601	Musa acuminata	24.22	2.50e-02	31.20
IUUC-Mpu-065912	Mustela putorius furo	37.60	3.00e-89	320.00
IUUC-Mlu-067965	Myotis lucifugus	34.46	7.00e-90	322.00
IUUC-Nfi-068465	Neosartorya fischeri	45.09	3.00e-148	516.00
IUUC-Ncr-068936	Neurospora crassa	44.63	7.00e-145	505.00
IUUC-Nle-069570	Nomascus leucogenys	35.28	4.00e-91	326.00
IUUC-Opr-071097	Ochotona princeps	35.43	2.00e-79	287.00
IUUC-Ont-071430	Oreochromis niloticus	34.32	4.00e-85	306.00
IUUC-Oan-073709	Ornithorhynchus anatinus	33.14	9.00e-62	228.00
IUUC-Ocu-074875	Oryctolagus cuniculus	34.75	4.00e-86	310.00
IUUC-Oba-075214	Oryza barthii	24.05	2.00e-07	48.10
IUUC-Obr-076758	Oryza brachyantha	22.88	9.00e-07	45.40
IUUC-Ogl-077665	Oryza glaberrima	24.05	2.00e-07	48.10
IUUC-Ogu-078899	Oryza glumaepatula	24.05	2.00e-07	48.10
IUUC-Oin-079167	Oryza indica	24.05	2.00e-07	48.10
IUUC-Olo-080451	Oryza longistaminata	24.37	1.00e-07	48.10
IUUC-Ome-081836	Oryza meridionalis	23.53	2.00e-07	48.10
IUUC-Oni-083019	Oryza nivara	24.05	2.00e-07	48.10
IUUC-Opu-083122	Oryza punctata	24.26	8.00e-08	49.30
IUUC-Oru-084900	Oryza rufipogon	24.05	2.00e-07	48.10
IUUC-Osa-086054	Oryza sativa	24.05	2.00e-07	48.10
IUUC-Ola-087077	Oryzias latipes	32.93	6.00e-68	249.00
IUUC-Oga-088049	Otolemur garnettii	34.26	4.00e-70	256.00
IUUC-Oar-089678	Ovis aries	35.46	3.00e-92	330.00
IUUC-Ptr-091380	Pan troglodytes	35.11	1.00e-90	325.00
IUUC-Pan-092821	Papio anubis	35.17	2.00e-88	317.00
IUUC-Psi-093074	Pelodiscus sinensis	34.86	2.00e-90	324.00
IUUC-Pma-094102	Petromyzon marinus	33.33	3.00e-86	310.00
IUUC-Pno-094987	Phaeosphaeria nodorum	43.26	4.00e-140	490.00
IUUC-Ppa-095368	Physcomitrella patens	22.09	1.00e-05	41.60
IUUC-Pfo-097245	Poecilia formosa	35.71	7.00e-84	302.00
IUUC-Pab-098763	Pongo abelii	35.35	2.00e-90	324.00
IUUC-Pva-102308	Pteropus vampyrus	32.28	2.00e-71	261.00
IUUC-Pgr-103553	Puccinia graminis	39.17	1.00e-112	398.00
IUUC-Pte-104100	Pyrenophora teres	43.59	5.00e-136	476.00
IUUC-Pyt-104482	Pyrenophora triticirepentis	43.12	3.00e-137	479.00
IUUC-Rno-105582	Rattus norvegicus	37.65	2.00e-89	321.00
IUUC-Sce-106145	Saccharomyces cerevisiae	49.15	8.00e-147	511.00
IUUC-Sha-106647	Sarcophilus harrisii	35.17	2.00e-91	327.00
IUUC-Sja-107972	Schizosaccharomyces japonicus	44.08	9.00e-135	471.00
IUUC-Spo-108281	Schizosaccharomyces pombe	43.75	1.00e-136	478.00
IUUC-Ssl-108617	Sclerotinia sclerotiorum	42.76	5.00e-141	492.00
IUUC-Smo-108933	Selaginella moellendorffii	25.18	1.00e-06	45.40
IUUC-Sit-110083	Setaria italica	24.50	3.00e-08	50.80
IUUC-Stu-112422	Solanum tuberosum	20.08	3.00e-03	34.30
IUUC-Sbi-113987	Sorghum bicolor	21.96	2.00e-05	41.20
IUUC-Sre-115095	Sporisorium reilianum	38.40	1.00e-114	405.00
IUUC-Ssc-116141	Sus scrofa	37.55	1.00e-88	318.00
IUUC-Tgu-117492	Taeniopygia guttata	36.46	2.00e-77	281.00
IUUC-Tru-118463	Takifugu rubripes	35.94	4.00e-84	303.00
IUUC-Tsy-118993	Tarsius syrichta	29.91	2.00e-67	248.00
IUUC-Tni-119896	Tetraodon nigroviridis	36.69	1.00e-83	301.00
IUUC-Tca-121169	Theobroma cacao	24.03	3.80e-02	30.40
IUUC-Tre-122046	Trichoderma reesei	43.69	2.00e-142	497.00
IUUC-Tvi-122415	Trichoderma virens	43.52	1.00e-141	494.00
IUUC-Tae-125503	Triticum aestivum	21.94	7.00e-06	42.70
IUUC-Tme-127123	Tuber melanosporum	45.29	2.00e-148	517.00
IUUC-Tbe-127629	Tupaia belangeri	37.18	1.00e-38	152.00
IUUC-Ttr-128476	Tursiops truncatus	29.77	2.00e-63	234.00
IUUC-Uma-129492	Ustilago maydis	38.33	5.00e-117	413.00
IUUC-Vda-129702	Verticillium dahliae	43.12	9.00e-136	475.00
IUUC-Vvi-131090	Vitis vinifera	22.35	3.00e-03	34.30
IUUC-Xtr-131786	Xenopus tropicalis	36.51	1.00e-87	315.00
IUUC-Xma-133997	Xiphophorus maculatus	38.05	4.00e-83	300.00
IUUC-Zma-134847	Zea mays	23.83	6.00e-06	43.10

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence