iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Bta-012481

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Kelch-like protein 13

Genbank Nucleotide ID

BC150039

Gene Name

KLHL13

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSBTAG00000000501.5	ENSBTAT00000000639.4	ENSBTAP00000000639.4

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB	2.20e-15	56.9	92	160
E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box	7.40e-08	31.7	193	224

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB

   S: 1    aDvilvvg..geeffahkivLaasSsvFyalflmeleesksklmveikdvqpevfrallkFlYtgklden 68
           +Dv+l  g  +  f++h++++a++S++F+a+f+++++e++   ++++++v+   +r +++F+Yt kl++n
   Q: 92   CDVTLMPGdtDDAFPVHRVMMASASDYFKAMFTGGMKEQD-LMCIKLHGVSKVGLRKIIDFIYTAKLSLN 160
           8*******99*****************************9.**************************987 PP

E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box

   S: 1    leNclgilrfAdlydcpdLkdaaldfilkhFk 32
           l+Nc+++ r+A++y+++++ +++++f+lk+F+
   Q: 193  LDNCVEVGRIANTYNLTEVDKYVNSFVLKNFP 224
           69*****************************6 PP

Organism

Bos taurus

Functional Description
(View)

Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes and thereby coordinates faithful mitotic progression and completion of cytokinesis (By similarity).

Protein Sequence
(Fasta)

MPLKWKTSSP AIWKFPVPVL KTSRSTPLSP AYISLVEEED QHMKLSLGSS EMGLSSHLQS 60
SKAGTTRIFT SNTHSSVVLQ GFDQLRLEGL LCDVTLMPGD TDDAFPVHRV MMASASDYFK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGAATCATCA TATGGCTTTA GGGGACAGGA GGATTTAAAG GAGGTGCCTT GCAGCCCTAT 60
TTTACAGATT GGAAGCATCG GTTTCAGGGC ACTGGCAGGA TCGTTGGCTT GTTCTCCGCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0131--Cell cycle
KW-0132--Cell division
KW-0181--Complete proteome
KW-0880--Kelch repeat
KW-0498--Mitosis
KW-1185--Reference proteome
KW-0677--Repeat
KW-0833--Ubl conjugation pathway

Interpro

IPR011705--BACK
IPR017096--BTB-kelch_protein
IPR000210--BTB/POZ_dom
IPR015915--Kelch-typ_b-propeller
IPR006652--Kelch_1
IPR011333--SKP1/BTB/POZ

PROSITE

PS50097--BTB

Pfam

PF07707--BACK
PF00651--BTB
PF01344--Kelch_1

SMART

SM00875--BACK
SM00225--BTB
SM00612--Kelch

Gene Ontology

GO:0031463--C:Cul3-RING ubiquitin ligase complex
GO:0030496--C:midbody
GO:0000910--P:cytokinesis
GO:0007067--P:mitotic nuclear division
GO:0016567--P:protein ubiquitination

KEGG

bta:528138

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001184	Ailuropoda melanoleuca	99.85	0.00e+00	1277.00
IUUC-Aca-005013	Anolis carolinensis	92.98	0.00e+00	1263.00
IUUC-Ame-011461	Astyanax mexicanus	85.90	0.00e+00	1209.00
IUUC-Cja-019972	Callithrix jacchus	99.54	0.00e+00	1273.00
IUUC-Cfa-021230	Canis familiaris	100.00	0.00e+00	1209.00
IUUC-Cpo-022428	Cavia porcellus	99.39	0.00e+00	1271.00
IUUC-Csa-023027	Chlorocebus sabaeus	99.69	0.00e+00	1274.00
IUUC-Cin-025654	Ciona intestinalis	64.98	0.00e+00	806.00
IUUC-Csv-026204	Ciona savignyi	66.55	0.00e+00	798.00
IUUC-Dre-028137	Danio rerio	86.66	0.00e+00	1212.00
IUUC-Dno-029077	Dasypus novemcinctus	98.96	0.00e+00	1176.00
IUUC-Dor-030975	Dipodomys ordii	99.24	0.00e+00	1300.00
IUUC-Ete-032431	Echinops telfairi	98.59	0.00e+00	1293.00
IUUC-Eca-033771	Equus caballus	99.85	0.00e+00	1276.00
IUUC-Fca-036060	Felis catus	98.27	0.00e+00	1214.00
IUUC-Fal-037167	Ficedula albicollis	88.57	0.00e+00	1007.00
IUUC-Gmo-039422	Gadus morhua	82.66	0.00e+00	1050.00
IUUC-Gac-042629	Gasterosteus aculeatus	89.26	0.00e+00	1162.00
IUUC-Ggo-045388	Gorilla gorilla	99.69	0.00e+00	1274.00
IUUC-Hsa-046694	Homo sapiens	99.69	0.00e+00	1274.00
IUUC-Lch-050402	Latimeria chalumnae	91.60	0.00e+00	1255.00
IUUC-Loc-052719	Lepisosteus oculatus	90.35	0.00e+00	1211.00
IUUC-Laf-054306	Loxodonta africana	98.93	0.00e+00	1267.00
IUUC-Mcc-055150	Macaca mulatta	99.68	0.00e+00	1207.00
IUUC-Mga-060174	Meleagris gallopavo	93.28	0.00e+00	1273.00
IUUC-Mmr-061476	Microcebus murinus	100.00	0.00e+00	1211.00
IUUC-Mdo-061869	Monodelphis domestica	89.01	0.00e+00	1173.00
IUUC-Mmu-063669	Mus musculus	95.42	0.00e+00	1316.00
IUUC-Mpu-066379	Mustela putorius furo	99.68	0.00e+00	1240.00
IUUC-Mlu-067214	Myotis lucifugus	99.69	0.00e+00	1273.00
IUUC-Nle-069858	Nomascus leucogenys	99.68	0.00e+00	1207.00
IUUC-Ont-071620	Oreochromis niloticus	89.39	0.00e+00	1168.00
IUUC-Ocu-074431	Oryctolagus cuniculus	99.69	0.00e+00	1276.00
IUUC-Ola-086565	Oryzias latipes	89.87	0.00e+00	1170.00
IUUC-Oga-089132	Otolemur garnettii	99.85	0.00e+00	1276.00
IUUC-Oar-090227	Ovis aries	100.00	0.00e+00	1277.00
IUUC-Pan-092417	Papio anubis	99.69	0.00e+00	1274.00
IUUC-Pma-094341	Petromyzon marinus	73.37	0.00e+00	810.00
IUUC-Pfo-096698	Poecilia formosa	86.01	0.00e+00	1135.00
IUUC-Pca-100332	Procavia capensis	92.82	0.00e+00	1202.00
IUUC-Pva-102590	Pteropus vampyrus	99.24	0.00e+00	1258.00
IUUC-Rno-105802	Rattus norvegicus	95.66	0.00e+00	1255.00
IUUC-Sha-107055	Sarcophilus harrisii	89.16	0.00e+00	1219.00
IUUC-Sar-113034	Sorex araneus	94.50	0.00e+00	1221.00
IUUC-Tgu-117014	Taeniopygia guttata	93.28	0.00e+00	1274.00
IUUC-Tru-117586	Takifugu rubripes	89.10	0.00e+00	1166.00
IUUC-Tsy-119600	Tarsius syrichta	92.52	0.00e+00	1191.00
IUUC-Tni-119722	Tetraodon nigroviridis	86.75	0.00e+00	1134.00
IUUC-Tbe-127718	Tupaia belangeri	84.44	0.00e+00	959.00
IUUC-Ttr-128975	Tursiops truncatus	100.00	0.00e+00	1277.00
IUUC-Vpa-130756	Vicugna pacos	95.57	0.00e+00	1197.00
IUUC-Xtr-132681	Xenopus tropicalis	91.30	0.00e+00	1249.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence