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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046694
UUCD1 version UUC-HoS-00415
Ensembl Protein ID ENSP00000262820.3
UniProt Accession Q9P2N7; B3KV78; B3KWM7; B7Z3S9; B7Z5P2; B7Z802; D3DWH6; Q6P2E3; Q96QI7; Q9UDN9; KLH13_HUMAN
Genbank Protein ID BAA92547.1; CAC41335.1; BAG53690.1; BAG54189.1; BAH12315.1; BAH12978.1; BAH13788.1; AAF03529.1; EAW89898.1; EAW89900.1; AAH64576.2
Protein Name Kelch-like protein 13; BTB and kelch domain-containing protein 2
Genbank Nucleotide ID AB037730; AL591986; AK122724; AK125356; AK296324; AK299257; AK302713; AC006968; CH471161; CH471161; BC064576
Gene Name KLHL13; BKLHD2; KIAA1309
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000003096.13 ENST00000539496.5 ENSP00000443191.1
ENSG00000003096.13 ENST00000262820.7 ENSP00000262820.3
ENSG00000003096.13 ENST00000540167.5 ENSP00000441029.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBaseCircNet
miRTarBasemicroRNATRANSFACmiRWalk
RepTarmiRNAMapSomamiRmiRcode
RAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Disease-associated Information
ClinVarGWASdbGWAS CentralOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusBioGRID
mUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 adaptor/Cullin RING/BCR/BTB_3-box BTB_3-box 17543862; 15772280
Classification
Family E-value Score Start End
E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB 6.60e-15 56.9 92 160
E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box 7.40e-08 31.7 193 224
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB
   S: 1    aDvilvvg..geeffahkivLaasSsvFyalflmeleesksklmveikdvqpevfrallkFlYtgklden 68
           +Dv+l  g  +  f++h++++a++S++F+a+f+++++e++   ++++++v+   +r +++F+Yt kl++n
   Q: 92   CDVTLMPGdtDDAFPVHRVMMASASDYFKAMFTGGMKEQD-LMCIKLHGVSKVGLRKIIDFIYTAKLSLN 160
           8*******99*****************************9.**************************987 PP
   

   E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box
   S: 1    leNclgilrfAdlydcpdLkdaaldfilkhFk 32
           l+Nc+++ r+A++y+++++ +++++f+lk+F+
   Q: 193  LDNCVEVGRIANTYNLTEVDKYVNSFVLKNFP 224
           69*****************************6 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes and thereby coordinates faithful mitotic progression and completion of cytokinesis.
 Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes and thereby coordinates faithful mitotic progression and completion of cytokinesis.
Protein Sequence
(Fasta)
MPLKWKTSSP AIWKFPVPVL KTSRSTPLSP AYISLVEEED QHMKLSLGGS EMGLSSHLQS 60
SKAGPTRIFT SNTHSSVVLQ GFDQLRLEGL LCDVTLMPGD TDDAFPVHRV MMASASDYFK 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046694|E3,BTB_3-box|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
TAGAAGAGTG ATATTTGTGT GAGAGCCTGG GTCAGGCTTA TTTTGAGACG TGGGCCCCAC 60
TGAGGTGAGG TGGCACCGCT TCCAGGGCAC ACCCTTTGCT CGGGCCCCGC CGTGACTATG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046694|E3,BTB_3-box|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0131--Cell cycle
KW-0132--Cell division
KW-0181--Complete proteome
KW-0880--Kelch repeat
KW-0498--Mitosis
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0833--Ubl conjugation pathway
Interpro

IPR011705--BACK
IPR017096--BTB-kelch_protein
IPR000210--BTB/POZ_dom
IPR015915--Kelch-typ_b-propeller
IPR006652--Kelch_1
IPR011333--SKP1/BTB/POZ
PROSITE

PS50097--BTB
Pfam

PF07707--BACK
PF00651--BTB
PF01344--Kelch_1
SMART

SM00875--BACK
SM00225--BTB
SM00612--Kelch
Gene Ontology

GO:0031463--C:Cul3-RING ubiquitin ligase complex
GO:0030496--C:midbody
GO:0000910--P:cytokinesis
GO:0007067--P:mitotic nuclear division
GO:0016567--P:protein ubiquitination
KEGG hsa:90293
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001184 Ailuropoda melanoleuca 99.54 0.00e+00 1273.00
IUUC-Aca-005013 Anolis carolinensis 92.67 0.00e+00 1258.00
IUUC-Ame-011461 Astyanax mexicanus 85.90 0.00e+00 1207.00
IUUC-Bta-012481 Bos taurus 99.69 0.00e+00 1273.00
IUUC-Cja-019972 Callithrix jacchus 99.85 0.00e+00 1276.00
IUUC-Cfa-021230 Canis familiaris 99.68 0.00e+00 1206.00
IUUC-Cpo-022428 Cavia porcellus 99.08 0.00e+00 1268.00
IUUC-Csa-023027 Chlorocebus sabaeus 100.00 0.00e+00 1276.00
IUUC-Csv-026204 Ciona savignyi 66.55 0.00e+00 798.00
IUUC-Dre-028137 Danio rerio 86.66 0.00e+00 1210.00
IUUC-Dno-029077 Dasypus novemcinctus 98.96 0.00e+00 1176.00
IUUC-Dor-030975 Dipodomys ordii 99.24 0.00e+00 1298.00
IUUC-Ete-032431 Echinops telfairi 98.43 0.00e+00 1291.00
IUUC-Eca-033771 Equus caballus 99.69 0.00e+00 1274.00
IUUC-Fca-036060 Felis catus 97.95 0.00e+00 1211.00
IUUC-Fal-037167 Ficedula albicollis 88.21 0.00e+00 1003.00
IUUC-Gac-042629 Gasterosteus aculeatus 89.26 0.00e+00 1161.00
IUUC-Ggo-045388 Gorilla gorilla 100.00 0.00e+00 1276.00
IUUC-Lch-050402 Latimeria chalumnae 91.45 0.00e+00 1251.00
IUUC-Loc-052719 Lepisosteus oculatus 90.19 0.00e+00 1207.00
IUUC-Laf-054306 Loxodonta africana 98.78 0.00e+00 1264.00
IUUC-Mcc-055150 Macaca mulatta 100.00 0.00e+00 1210.00
IUUC-Mga-060174 Meleagris gallopavo 92.98 0.00e+00 1268.00
IUUC-Mmr-061476 Microcebus murinus 99.68 0.00e+00 1207.00
IUUC-Mmu-063669 Mus musculus 95.42 0.00e+00 1315.00
IUUC-Mpu-066379 Mustela putorius furo 99.36 0.00e+00 1237.00
IUUC-Mlu-067214 Myotis lucifugus 99.54 0.00e+00 1271.00
IUUC-Nle-069858 Nomascus leucogenys 100.00 0.00e+00 1209.00
IUUC-Ocu-074431 Oryctolagus cuniculus 99.39 0.00e+00 1273.00
IUUC-Ola-086565 Oryzias latipes 89.87 0.00e+00 1169.00
IUUC-Oga-089132 Otolemur garnettii 99.54 0.00e+00 1272.00
IUUC-Oar-090227 Ovis aries 99.69 0.00e+00 1273.00
IUUC-Pan-092417 Papio anubis 100.00 0.00e+00 1276.00
IUUC-Pma-094341 Petromyzon marinus 73.37 0.00e+00 809.00
IUUC-Pfo-096698 Poecilia formosa 86.01 0.00e+00 1133.00
IUUC-Pca-100332 Procavia capensis 92.67 0.00e+00 1200.00
IUUC-Pva-102590 Pteropus vampyrus 99.08 0.00e+00 1256.00
IUUC-Rno-105802 Rattus norvegicus 95.66 0.00e+00 1253.00
IUUC-Sha-107055 Sarcophilus harrisii 89.01 0.00e+00 1215.00
IUUC-Sar-113034 Sorex araneus 94.20 0.00e+00 1217.00
IUUC-Tgu-117014 Taeniopygia guttata 92.98 0.00e+00 1268.00
IUUC-Tsy-119600 Tarsius syrichta 92.52 0.00e+00 1189.00
IUUC-Tni-119722 Tetraodon nigroviridis 86.75 0.00e+00 1132.00
IUUC-Tbe-127718 Tupaia belangeri 84.11 0.00e+00 954.00
IUUC-Ttr-128975 Tursiops truncatus 99.69 0.00e+00 1273.00
IUUC-Vpa-130756 Vicugna pacos 95.27 0.00e+00 1194.00
IUUC-Xtr-132681 Xenopus tropicalis 91.15 0.00e+00 1246.00
Created Date 25-Jun-2017

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