iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000165966.14	ENST00000402685.6	ENSP00000384197.2
ENSG00000165966.14	ENST00000539469.6	ENSP00000439990.2
ENSG00000165966.14	ENST00000298919.7	ENSP00000298919.7

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circRNADb	CircNet
miRTarBase	microRNA	TRANSFAC	RepTar
SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	PINA	HINT	Mentha
InWeb_IM
Disease-associated Variation
GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus
DNA Methylation
MethyCancer	TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/U-box	1.00e-06	30.3	14	77

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/U-box

   S: 4    eeflCpIslelMrdPvvlpsGitydrssIekwlasggktcPvtrqplteedlvPnltlrrliqaw 68
           +++ C + +++ ++P ++p+G+++ +s++  w  + ++ cP+  qpl++ +l   l lr+liq+ 
   Q: 14   PALECKLCGQVLEEPLCTPCGHVFCASCLLPWAVRRRR-CPLQCQPLAPGELYRVLPLRSLIQKL 77
           6789****************************888888.************************86 PP

Organism

Homo sapiens

Protein Sequence
(Fasta)

MGFALERFAE AVDPALECKL CGQVLEEPLC TPCGHVFCAS CLLPWAVRRR RCPLQCQPLA 60
PGELYRVLPL RSLIQKLRVQ CDYRARGCGH SVRLHELEAH VEHCDFGPAR RLRSRGGCAS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TCCCTAACAT GGGCTTTGCC CTGGAGCGCT TCGCAGAAGC CGTGGACCCG GCTCTGGAGT 60
GCAAACTGTG CGGCCAGGTG CTTGAAGAGC CCCTGTGCAC GCCGTGCGGG CACGTCTTCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001478--PDZ
IPR008974--TRAF-like
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50106--PDZ
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF00595--PDZ

SMART

SM00228--PDZ
SM00184--RING

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding

KEGG

hsa:29951

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ggo-044744	Gorilla gorilla	99.03	0.00e+00	1796.00
IUUC-Mcc-055303	Macaca mulatta	97.10	0.00e+00	1763.00
IUUC-Oar-089468	Ovis aries	85.59	4.00e-57	214.00
IUUC-Psi-093611	Pelodiscus sinensis	58.53	3.00e-85	308.00
IUUC-Pca-100982	Procavia capensis	85.88	0.00e+00	922.00
IUUC-Pva-103202	Pteropus vampyrus	81.91	0.00e+00	1493.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence