iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Eca-033577

UUCD1 version

UUC-EqC-00191

Ensembl Protein ID

ENSECAP00000008448.1

UniProt Accession

F6SN22; F6SN22_HORSE

Protein Name

Nitric oxide synthase-interacting protein

Gene Name

NOSIP

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSECAG00000010590.1	ENSECAT00000010888.1	ENSECAP00000008448.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/U-box	1.40e-15	57.3	40	79

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/U-box

   S: 2    vpeeflCpIslelMrdPvvlpsGitydrssIekwlasggk 41
           v ++ +C +sl++ +dPvv+p+G+ y+r++I +++ +++k
   Q: 40   VKDFDCCCLSLQPCHDPVVTPDGYLYEREAILEYILHQKK 79
           567789*****************************98887 PP

Organism

Equus caballus

Functional Description
(View)

Negatively regulates nitric oxide production by inducing NOS1 and NOS3 translocation to actin cytoskeleton and inhibiting their enzymatic activity.

Protein Sequence
(Fasta)

MTRHGKNCTA GAVYTYHEKK KDTAASGYGT QNIRLSRDAV KDFDCCCLSL QPCHDPVVTP 60
DGYLYEREAI LEYILHQKKE IARQMKAYEK QRGARREEQK ELQRAAAQDQ VRGFLEKEAS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGTTGAAGAA GCAACGAAGG AACGAGGAGT CGTTTGTAAG GTTAGTTCTA GGTGGTGAAG 60
GGCTTGTGTT GCTGGGATCG CCTTCCCGCA GGCTAGAGTC CTGGGGTCCT GAGGGAAACG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0539--Nucleus
KW-1185--Reference proteome

Interpro

IPR016818--Nitric_oxide_synth-interacting
IPR031790--Znf-NOSIP
IPR013083--Znf_RING/FYVE/PHD

Pfam

PF15906--zf-NOSIP

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0061630--F:ubiquitin protein ligase activity
GO:0016567--P:protein ubiquitination
GO:0050999--P:regulation of nitric-oxide synthase activity

KEGG

ecb:100052038

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000769	Aegilops tauschii	46.51	1.00e-16	80.90
IUUC-Aml-002069	Ailuropoda melanoleuca	92.68	8.00e-167	578.00
IUUC-Atr-002661	Amborella trichopoda	32.42	9.00e-30	123.00
IUUC-Aca-004630	Anolis carolinensis	76.08	5.00e-137	479.00
IUUC-Aly-006316	Arabidopsis lyrata	30.74	2.00e-30	125.00
IUUC-Ath-007000	Arabidopsis thaliana	30.92	1.00e-29	123.00
IUUC-Acl-008175	Aspergillus clavatus	33.62	3.00e-06	46.20
IUUC-Afl-008440	Aspergillus flavus	33.88	2.00e-06	46.60
IUUC-Afu-009012	Aspergillus fumigatus	34.75	1.00e-06	47.80
IUUC-Ani-009153	Aspergillus nidulans	32.54	1.00e-02	34.70
IUUC-Ang-009556	Aspergillus niger	34.71	4.00e-06	45.80
IUUC-Aor-009892	Aspergillus oryzae	33.88	2.00e-06	46.60
IUUC-Ate-010473	Aspergillus terreus	30.43	7.00e-05	42.70
IUUC-Ame-011874	Astyanax mexicanus	64.94	4.00e-111	394.00
IUUC-Bgr-012090	Blumeria graminis	26.04	8.00e-06	44.30
IUUC-Bta-012956	Bos taurus	97.02	7.00e-174	602.00
IUUC-Bci-013897	Botrytis cinerea	42.50	7.00e-10	58.20
IUUC-Bdi-014968	Brachypodium distachyon	30.61	5.00e-33	134.00
IUUC-Bol-015578	Brassica oleracea	30.94	8.00e-34	137.00
IUUC-Bra-017234	Brassica rapa	30.94	8.00e-34	137.00
IUUC-Cel-018637	Caenorhabditis elegans	41.49	1.00e-58	219.00
IUUC-Cja-019632	Callithrix jacchus	93.36	4.00e-169	586.00
IUUC-Cfa-020192	Canis familiaris	95.02	9.00e-171	592.00
IUUC-Cpo-021939	Cavia porcellus	91.36	2.00e-156	544.00
IUUC-Cre-023005	Chlamydomonas reinhardtii	34.32	5.00e-43	167.00
IUUC-Csa-023802	Chlorocebus sabaeus	93.69	5.00e-169	586.00
IUUC-Cho-024637	Choloepus hoffmanni	78.80	2.00e-85	307.00
IUUC-Cin-025180	Ciona intestinalis	51.99	1.00e-86	312.00
IUUC-Csv-026206	Ciona savignyi	48.40	4.00e-44	170.00
IUUC-Cgl-026696	Colletotrichum gloeosporioides	24.38	4.00e-13	68.90
IUUC-Cne-026827	Cryptococcus neoformans	36.36	1.00e-06	47.40
IUUC-Dre-028092	Danio rerio	65.13	2.00e-117	414.00
IUUC-Dno-029501	Dasypus novemcinctus	90.07	1.00e-146	512.00
IUUC-Dor-030542	Dipodomys ordii	91.09	3.00e-163	566.00
IUUC-Dse-031188	Dothistroma septosporum	24.72	1.00e-13	70.90
IUUC-Dme-031734	Drosophila melanogaster	49.35	3.00e-79	288.00
IUUC-Fca-035761	Felis catus	96.68	2.00e-173	600.00
IUUC-Fox-037703	Fusarium oxysporum	37.04	2.00e-07	50.10
IUUC-Fso-038208	Fusarium solani	27.58	2.00e-13	69.70
IUUC-Gmo-038523	Gadus morhua	61.98	1.00e-62	232.00
IUUC-Ggr-040087	Gaeumannomyces graminis	41.03	6.00e-10	58.20
IUUC-Gac-042621	Gasterosteus aculeatus	59.88	3.00e-109	387.00
IUUC-Gma-042698	Glycine max	30.48	2.00e-31	129.00
IUUC-Ggo-045357	Gorilla gorilla	93.69	3.00e-169	587.00
IUUC-Hsa-046195	Homo sapiens	93.69	3.00e-169	587.00
IUUC-Hvu-047174	Hordeum vulgare	30.43	2.00e-34	139.00
IUUC-Itr-048487	Ictidomys tridecemlineatus	94.68	6.00e-163	566.00
IUUC-Lch-050569	Latimeria chalumnae	67.95	2.00e-115	408.00
IUUC-Lpe-050992	Leersia perrieri	35.92	5.00e-23	102.00
IUUC-Loc-052522	Lepisosteus oculatus	69.77	2.00e-117	414.00
IUUC-Lma-053254	Leptosphaeria maculans	39.24	1.00e-09	57.40
IUUC-Laf-053397	Loxodonta africana	96.37	1.00e-172	598.00
IUUC-Mcc-054681	Macaca mulatta	93.69	4.00e-169	587.00
IUUC-Meu-056723	Macropus eugenii	83.83	2.00e-151	527.00
IUUC-Mor-056961	Magnaporthe oryzae	26.05	3.00e-11	62.80
IUUC-Mpo-057359	Magnaporthe poae	25.14	6.00e-07	47.80
IUUC-Mtr-058063	Medicago truncatula	32.09	2.00e-33	135.00
IUUC-Mla-059004	Melampsora laricipopulina	30.35	1.00e-24	106.00
IUUC-Mvi-060460	Microbotryum violaceum	29.17	8.00e-26	110.00
IUUC-Mmr-060847	Microcebus murinus	95.68	2.00e-172	597.00
IUUC-Mdo-062480	Monodelphis domestica	85.15	1.00e-153	535.00
IUUC-Mmu-063809	Mus musculus	93.02	4.00e-166	576.00
IUUC-Mac-064870	Musa acuminata	31.38	1.00e-32	133.00
IUUC-Mpu-066322	Mustela putorius furo	96.04	2.00e-172	597.00
IUUC-Mlu-067556	Myotis lucifugus	92.76	9.00e-159	552.00
IUUC-Nfi-068440	Neosartorya fischeri	34.75	1.00e-06	47.80
IUUC-Ncr-068898	Neurospora crassa	38.46	7.00e-08	51.20
IUUC-Nle-070049	Nomascus leucogenys	94.02	2.00e-169	587.00
IUUC-Opr-070972	Ochotona princeps	90.82	1.00e-158	551.00
IUUC-Ont-071682	Oreochromis niloticus	66.89	1.00e-117	415.00
IUUC-Oan-073296	Ornithorhynchus anatinus	98.31	1.00e-32	131.00
IUUC-Ocu-074218	Oryctolagus cuniculus	91.43	1.00e-134	471.00
IUUC-Oba-075284	Oryza barthii	32.20	8.00e-34	137.00
IUUC-Obr-076651	Oryza brachyantha	32.20	7.00e-36	144.00
IUUC-Ogl-077899	Oryza glaberrima	32.20	8.00e-34	137.00
IUUC-Ogu-078477	Oryza glumaepatula	32.88	1.00e-34	139.00
IUUC-Oin-080011	Oryza indica	32.20	9.00e-34	137.00
IUUC-Olo-080545	Oryza longistaminata	31.80	5.00e-27	115.00
IUUC-Ome-081543	Oryza meridionalis	32.20	9.00e-34	137.00
IUUC-Oni-082955	Oryza nivara	32.20	9.00e-34	137.00
IUUC-Opu-083565	Oryza punctata	32.08	4.00e-34	138.00
IUUC-Oru-084474	Oryza rufipogon	32.20	9.00e-34	137.00
IUUC-Osa-085913	Oryza sativa	32.20	9.00e-34	137.00
IUUC-Ola-086851	Oryzias latipes	67.44	6.00e-120	423.00
IUUC-Olu-087724	Ostreococcus lucimarinus	34.95	2.00e-12	66.20
IUUC-Oga-087970	Otolemur garnettii	95.03	4.00e-170	590.00
IUUC-Oar-089756	Ovis aries	93.40	3.00e-162	563.00
IUUC-Ptr-091485	Pan troglodytes	92.69	1.00e-165	575.00
IUUC-Pan-091832	Papio anubis	94.02	1.00e-169	588.00
IUUC-Pma-094551	Petromyzon marinus	62.54	6.00e-108	383.00
IUUC-Pno-094830	Phaeosphaeria nodorum	26.41	1.00e-08	53.50
IUUC-Ppa-095255	Physcomitrella patens	29.57	6.00e-31	127.00
IUUC-Pfo-096373	Poecilia formosa	65.69	1.00e-117	415.00
IUUC-Pab-098247	Pongo abelii	93.69	4.00e-169	587.00
IUUC-Pop-099186	Populus trichocarpa	30.51	4.00e-31	128.00
IUUC-Pca-100677	Procavia capensis	92.36	3.00e-141	493.00
IUUC-Ppe-101403	Prunus persica	29.79	3.00e-31	128.00
IUUC-Pva-103000	Pteropus vampyrus	96.68	7.00e-175	605.00
IUUC-Pgr-103663	Puccinia graminis	30.56	5.00e-30	125.00
IUUC-Ptt-103712	Puccinia triticina	40.00	5.00e-09	54.70
IUUC-Pte-104287	Pyrenophora teres	27.30	4.00e-17	82.40
IUUC-Pyt-104579	Pyrenophora triticirepentis	36.25	7.00e-09	54.70
IUUC-Rno-106069	Rattus norvegicus	93.36	1.00e-166	578.00
IUUC-Sha-106553	Sarcophilus harrisii	84.49	1.00e-151	528.00
IUUC-Smo-108874	Selaginella moellendorffii	31.91	3.00e-38	151.00
IUUC-Sit-110307	Setaria italica	32.54	9.00e-34	137.00
IUUC-Sly-111094	Solanum lycopersicum	31.56	2.00e-32	132.00
IUUC-Stu-112363	Solanum tuberosum	31.89	2.00e-32	132.00
IUUC-Sar-113480	Sorex araneus	94.68	2.00e-158	551.00
IUUC-Sbi-113939	Sorghum bicolor	31.74	2.00e-33	135.00
IUUC-Ssc-115644	Sus scrofa	97.67	5.00e-176	609.00
IUUC-Tru-118781	Takifugu rubripes	66.12	6.00e-121	426.00
IUUC-Tni-119672	Tetraodon nigroviridis	73.56	2.00e-34	136.00
IUUC-Tca-121795	Theobroma cacao	31.86	9.00e-35	140.00
IUUC-Tre-122037	Trichoderma reesei	36.36	3.00e-08	52.80
IUUC-Tvi-122524	Trichoderma virens	26.80	9.00e-17	80.90
IUUC-Tae-122828	Triticum aestivum	30.77	1.00e-34	140.00
IUUC-Tur-126387	Triticum urartu	30.89	5.00e-28	118.00
IUUC-Tme-127111	Tuber melanosporum	40.00	1.00e-09	57.00
IUUC-Tbe-127839	Tupaia belangeri	31.75	5.00e-03	35.00
IUUC-Ttr-128227	Tursiops truncatus	95.35	5.00e-171	592.00
IUUC-Vda-129924	Verticillium dahliae	27.27	2.00e-15	76.30
IUUC-Vpa-130802	Vicugna pacos	97.75	2.00e-45	176.00
IUUC-Vvi-131105	Vitis vinifera	32.54	6.00e-33	134.00
IUUC-Xtr-132830	Xenopus tropicalis	65.94	2.00e-123	434.00
IUUC-Xma-133618	Xiphophorus maculatus	65.46	1.00e-110	392.00
IUUC-Zma-135389	Zea mays	31.40	2.00e-32	132.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence