iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Oga-087970

Ensembl Protein ID

ENSOGAP00000017136.1

UniProt Accession

H0XLZ6; H0XLZ6_OTOGA

Genbank Protein ID

ENSOGAP00000017136

Protein Name

Nitric oxide synthase-interacting protein

Genbank Nucleotide ID

AAQR03172708

Gene Name

NOSIP

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOGAG00000031136.1	ENSOGAT00000035018.1	ENSOGAP00000017136.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/U-box	1.20e-15	57.3	41	80

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/U-box

   S: 2    vpeeflCpIslelMrdPvvlpsGitydrssIekwlasggk 41
           v ++ +C +sl++ +dPvv+p+G+ y+r++I +++ +++k
   Q: 41   VKDFDCCCLSLQPCHDPVVTPDGYLYEREAILEYILHQKK 80
           567789*****************************98887 PP

Organism

Otolemur garnettii

Functional Description
(View)

Negatively regulates nitric oxide production by inducing NOS1 and NOS3 translocation to actin cytoskeleton and inhibiting their enzymatic activity.

Protein Sequence
(Fasta)

MTRHGKNCTA GAVYTYHEKK KDTAAASGYG TQNIRLSRDA VKDFDCCCLS LQPCHDPVVT 60
PDGYLYEREA ILEYILHQKK EIARQMKAYE KQRGAQRDEQ KELQKAAAQD HVRGFLEKEA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGACACGGC ATGGCAAGAA CTGCACTGCG GGAGCTGTCT ACACCTATCA CGAGAAGAAG 60
AAGGACACAG GTACAGGGTT GGTGGTGAGG TGGGGAGGGT CTGGAATGGG TCTTCAACTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0539--Nucleus
KW-1185--Reference proteome

Interpro

IPR016818--Nitric_oxide_synth-interacting
IPR031790--Znf-NOSIP
IPR013083--Znf_RING/FYVE/PHD

Pfam

PF15906--zf-NOSIP

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0003723--F:RNA binding
GO:0051001--P:negative regulation of nitric-oxide synthase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000769	Aegilops tauschii	45.98	2.00e-16	80.50
IUUC-Aml-002069	Ailuropoda melanoleuca	89.84	2.00e-160	557.00
IUUC-Atr-002661	Amborella trichopoda	31.40	5.00e-29	121.00
IUUC-Aca-004630	Anolis carolinensis	75.50	3.00e-134	470.00
IUUC-Aly-006316	Arabidopsis lyrata	30.82	7.00e-29	120.00
IUUC-Ath-007000	Arabidopsis thaliana	30.49	9.00e-29	120.00
IUUC-Acl-008175	Aspergillus clavatus	33.63	1.00e-05	44.30
IUUC-Afl-008440	Aspergillus flavus	33.33	5.00e-05	42.00
IUUC-Ani-009153	Aspergillus nidulans	32.80	1.50e-02	33.90
IUUC-Ang-009556	Aspergillus niger	34.21	2.00e-05	43.10
IUUC-Aor-009892	Aspergillus oryzae	33.33	5.00e-05	42.00
IUUC-Ate-010473	Aspergillus terreus	32.76	3.00e-05	44.30
IUUC-Ame-011874	Astyanax mexicanus	64.08	1.00e-108	385.00
IUUC-Bgr-012090	Blumeria graminis	26.78	1.00e-05	43.90
IUUC-Bta-012956	Bos taurus	95.38	5.00e-170	589.00
IUUC-Bci-013897	Botrytis cinerea	41.98	1.00e-09	57.40
IUUC-Bdi-014968	Brachypodium distachyon	29.49	1.00e-32	133.00
IUUC-Bol-015578	Brassica oleracea	31.48	3.00e-34	138.00
IUUC-Bra-017234	Brassica rapa	31.48	3.00e-34	138.00
IUUC-Cel-018637	Caenorhabditis elegans	41.54	2.00e-55	209.00
IUUC-Cja-019632	Callithrix jacchus	94.04	1.00e-169	588.00
IUUC-Cfa-020192	Canis familiaris	92.72	4.00e-166	577.00
IUUC-Cpo-021939	Cavia porcellus	89.40	8.00e-153	532.00
IUUC-Cre-023005	Chlamydomonas reinhardtii	36.01	1.00e-42	166.00
IUUC-Csa-023802	Chlorocebus sabaeus	94.70	6.00e-170	589.00
IUUC-Cho-024637	Choloepus hoffmanni	75.12	5.00e-80	290.00
IUUC-Cin-025180	Ciona intestinalis	51.82	1.00e-84	306.00
IUUC-Csv-026206	Ciona savignyi	47.87	3.00e-43	167.00
IUUC-Cgl-026696	Colletotrichum gloeosporioides	24.03	7.00e-11	61.60
IUUC-Cne-026827	Cryptococcus neoformans	35.96	1.00e-06	47.00
IUUC-Dre-028092	Danio rerio	65.25	1.00e-115	409.00
IUUC-Dno-029501	Dasypus novemcinctus	86.47	9.00e-141	493.00
IUUC-Dor-030542	Dipodomys ordii	89.47	2.00e-160	558.00
IUUC-Dse-031188	Dothistroma septosporum	24.09	8.00e-14	71.20
IUUC-Dme-031734	Drosophila melanogaster	47.40	6.00e-78	283.00
IUUC-Eca-033577	Equus caballus	95.03	4.00e-170	590.00
IUUC-Fca-035761	Felis catus	94.04	2.00e-167	581.00
IUUC-Fox-037703	Fusarium oxysporum	27.33	1.00e-07	50.80
IUUC-Fso-038208	Fusarium solani	26.33	4.00e-13	68.90
IUUC-Gmo-038523	Gadus morhua	61.66	6.00e-61	226.00
IUUC-Ggr-040087	Gaeumannomyces graminis	40.51	6.00e-10	58.20
IUUC-Gac-042621	Gasterosteus aculeatus	60.00	9.00e-108	383.00
IUUC-Gma-042698	Glycine max	30.24	3.00e-31	128.00
IUUC-Ggo-045357	Gorilla gorilla	94.70	5.00e-170	589.00
IUUC-Hsa-046195	Homo sapiens	94.70	5.00e-170	589.00
IUUC-Hvu-047174	Hordeum vulgare	29.83	9.00e-34	137.00
IUUC-Itr-048487	Ictidomys tridecemlineatus	94.04	7.00e-161	559.00
IUUC-Lch-050569	Latimeria chalumnae	69.23	7.00e-117	413.00
IUUC-Lpe-050992	Leersia perrieri	34.16	2.00e-21	97.10
IUUC-Loc-052522	Lepisosteus oculatus	69.77	4.00e-115	407.00
IUUC-Lma-053254	Leptosphaeria maculans	25.42	2.00e-12	66.60
IUUC-Laf-053397	Loxodonta africana	92.43	4.00e-164	570.00
IUUC-Mcc-054681	Macaca mulatta	94.70	4.00e-170	590.00
IUUC-Meu-056723	Macropus eugenii	82.89	6.00e-149	519.00
IUUC-Mor-056961	Magnaporthe oryzae	25.64	6.00e-12	65.10
IUUC-Mpo-057359	Magnaporthe poae	25.14	4.00e-06	45.10
IUUC-Mtr-058063	Medicago truncatula	31.16	1.00e-32	133.00
IUUC-Mla-059004	Melampsora laricipopulina	29.94	2.00e-24	106.00
IUUC-Mvi-060460	Microbotryum violaceum	30.29	8.00e-26	110.00
IUUC-Mmr-060847	Microcebus murinus	96.69	2.00e-173	601.00
IUUC-Mdo-062480	Monodelphis domestica	83.55	1.00e-149	521.00
IUUC-Mmu-063809	Mus musculus	90.40	4.00e-160	556.00
IUUC-Mac-064870	Musa acuminata	30.90	2.00e-32	132.00
IUUC-Mpu-066322	Mustela putorius furo	93.42	2.00e-166	578.00
IUUC-Mlu-067556	Myotis lucifugus	90.82	2.00e-153	535.00
IUUC-Ncr-068898	Neurospora crassa	37.97	1.00e-07	50.80
IUUC-Nle-070049	Nomascus leucogenys	95.03	2.00e-170	591.00
IUUC-Opr-070972	Ochotona princeps	89.22	7.00e-156	542.00
IUUC-Ont-071682	Oreochromis niloticus	67.00	8.00e-117	412.00
IUUC-Oan-073296	Ornithorhynchus anatinus	96.67	4.00e-31	126.00
IUUC-Ocu-074218	Oryctolagus cuniculus	90.04	1.00e-132	465.00
IUUC-Oba-075284	Oryza barthii	30.93	4.00e-32	131.00
IUUC-Obr-076651	Oryza brachyantha	31.56	3.00e-35	142.00
IUUC-Ogl-077899	Oryza glaberrima	30.93	4.00e-32	131.00
IUUC-Ogu-078477	Oryza glumaepatula	31.89	6.00e-33	134.00
IUUC-Oin-080011	Oryza indica	30.93	4.00e-32	131.00
IUUC-Olo-080545	Oryza longistaminata	30.38	3.00e-25	109.00
IUUC-Ome-081543	Oryza meridionalis	30.93	4.00e-32	131.00
IUUC-Oni-082955	Oryza nivara	30.93	4.00e-32	131.00
IUUC-Opu-083565	Oryza punctata	31.29	9.00e-33	134.00
IUUC-Oru-084474	Oryza rufipogon	30.93	4.00e-32	131.00
IUUC-Osa-085913	Oryza sativa	30.93	4.00e-32	131.00
IUUC-Ola-086851	Oryzias latipes	67.22	6.00e-119	420.00
IUUC-Olu-087724	Ostreococcus lucimarinus	33.01	6.00e-12	64.70
IUUC-Oar-089756	Ovis aries	92.11	1.00e-158	551.00
IUUC-Ptr-091485	Pan troglodytes	93.71	2.00e-166	577.00
IUUC-Pan-091832	Papio anubis	95.03	2.00e-170	591.00
IUUC-Pma-094551	Petromyzon marinus	62.01	6.00e-105	373.00
IUUC-Pno-094830	Phaeosphaeria nodorum	34.31	3.00e-08	52.40
IUUC-Ppa-095255	Physcomitrella patens	28.76	1.00e-29	123.00
IUUC-Pfo-096373	Poecilia formosa	65.47	2.00e-115	408.00
IUUC-Pab-098247	Pongo abelii	94.70	4.00e-170	590.00
IUUC-Pop-099186	Populus trichocarpa	30.24	1.00e-29	123.00
IUUC-Pca-100677	Procavia capensis	90.91	3.00e-138	483.00
IUUC-Ppe-101403	Prunus persica	30.14	1.00e-30	127.00
IUUC-Pva-103000	Pteropus vampyrus	93.38	2.00e-167	580.00
IUUC-Pgr-103663	Puccinia graminis	30.06	2.00e-30	126.00
IUUC-Ptt-103712	Puccinia triticina	40.00	5.00e-09	54.70
IUUC-Pte-104287	Pyrenophora teres	26.67	7.00e-17	81.30
IUUC-Pyt-104579	Pyrenophora triticirepentis	24.74	1.00e-09	57.00
IUUC-Rno-106069	Rattus norvegicus	90.73	1.00e-160	558.00
IUUC-Sha-106553	Sarcophilus harrisii	83.22	2.00e-148	518.00
IUUC-Smo-108874	Selaginella moellendorffii	31.94	3.00e-36	145.00
IUUC-Sit-110307	Setaria italica	30.93	9.00e-32	130.00
IUUC-Sly-111094	Solanum lycopersicum	32.20	6.00e-32	130.00
IUUC-Stu-112363	Solanum tuberosum	32.54	1.00e-31	130.00
IUUC-Sar-113480	Sorex araneus	91.39	1.00e-152	532.00
IUUC-Sbi-113939	Sorghum bicolor	30.93	3.00e-32	132.00
IUUC-Ssc-115644	Sus scrofa	94.70	1.00e-169	588.00
IUUC-Tru-118781	Takifugu rubripes	65.26	2.00e-117	414.00
IUUC-Tni-119672	Tetraodon nigroviridis	75.86	2.00e-35	139.00
IUUC-Tca-121795	Theobroma cacao	30.93	5.00e-34	138.00
IUUC-Tre-122037	Trichoderma reesei	35.90	3.00e-08	53.10
IUUC-Tvi-122524	Trichoderma virens	25.34	7.00e-16	77.80
IUUC-Tae-122828	Triticum aestivum	30.17	5.00e-34	137.00
IUUC-Tur-126387	Triticum urartu	29.96	4.00e-27	115.00
IUUC-Tme-127111	Tuber melanosporum	39.51	1.00e-09	57.40
IUUC-Ttr-128227	Tursiops truncatus	93.71	1.00e-166	578.00
IUUC-Vda-129924	Verticillium dahliae	25.87	3.00e-13	69.30
IUUC-Vpa-130802	Vicugna pacos	95.51	2.00e-44	172.00
IUUC-Vvi-131105	Vitis vinifera	31.62	6.00e-32	130.00
IUUC-Xtr-132830	Xenopus tropicalis	66.36	2.00e-122	431.00
IUUC-Xma-133618	Xiphophorus maculatus	65.90	1.00e-109	389.00
IUUC-Zma-135389	Zea mays	30.58	1.00e-31	130.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence