iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Csa-023910

Ensembl Protein ID

ENSCSAP00000010733.1

UniProt Accession

A0A0D9RQ44; A0A0D9RQ44_CHLSB

Genbank Protein ID

ENSCSAP00000010733

Protein Name

Ubiquitinyl hydrolase 1

Genbank Nucleotide ID

AQIB01071045

Gene Name

USP45

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCSAG00000014609.1	ENSCSAT00000012702.1	ENSCSAP00000010733.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	1.10e-74	251.6	191	753

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 2    GlkNlgNtCYmNSvLQcLsnipelrellle..kkkeklneenp..............kepkgellkslqklfeelwkskkkavsprell 74
           G++NlgNtC++N+v+Q L+++  l++ ++e  +  ++++ +                 ++ g+l+++l  +++++ +++k+  sp+ l+
   Q: 191  GITNLGNTCFFNAVMQNLAQTYTLTDRMNEikE--SSTKLK-IfpssdsqldplvveLSRPGPLTSALFLFLHSMKETEKGPLSPNVLF 276
           9*****************************542..333222.23445566666777777777*************************** PP
   S: 75   kalkkeaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsde......aeekkkkknkslisdlFqgqlksqikcl 157
           ++l+++a++f+ ++qqD+qE+l++lld++++e +k+ + ++ +++++ ++++ d+      + + k+  + ++i+++F g+l+s+++c+
   Q: 277  NQLCQKAPRFKDFQQQDSQELLHYLLDAVRTEETKRIQASILKAFNNPTTKTADDetrkkvKAYGKEGVKMNFIDRIFIGELTSTVMCE 365
           *********************************99888888888888877777773443335555555555****************** PP
   S: 158  ecdnvssreepfldlslpvpgkeetkke............................................................. 185
           ec+n+s+ ++pf+d+slp+ +++ +k++                                                             
   Q: 366  ECANISTVKDPFIDISLPIIEERVSKPLllgrmnkyrslretdhdryngnvtvenihqpraakkhssskdksqliqdrkcirklsgeav 454
           ***********************99888************************************************************* PP
   S: 186  ......................................................................................... 185
                                                                                                    
   Q: 455  vtyqtkenlemngdslmfarlmnsesplnespaddsekeasrsesnvdadseasesesaskqtelfrsssgsgvhtdgplyppsagela 543
           ***************************************************************************************** PP
   S: 186  ...........................................................................slqdcLesftkeee 199
                                                                                      s+q+cL +ft+ e 
   Q: 544  ytketdsgdkqmaeaiselrlrstvtghqdfdrenqplsisnnlcflegkhlrphspqnafqtlsqtyittskecSVQSCLYQFTSMEL 632
           ***************************************************************************************** PP
   S: 200  legenkyycekckkkqe...................aekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfctspe 269
           l g+nk+ ce+c+k+++                   a+k+l ++ +P vLilhLkRf  ++++ s +k+n++v+fpl+Ldl+pfc+ ++
   Q: 633  LMGNNKLLCENCTKNKQkyqeetsfaekkvegvytnARKQLLISAVPAVLILHLKRF--HQAGLSLRKVNRHVDFPLMLDLAPFCSATC 719
           *************88888999999999999999999*********************..9999************************88 PP
   S: 270  ekqke..kkkYeLiavvvHsGslssGHYvayvkn 301
           ++ +   k+ Y L+++v HsGs+++GHY+ayvk 
   Q: 720  KNASMgdKVLYGLYGIVEHSGSMREGHYTAYVKV 753
           77655669************************96 PP

Organism

Chlorocebus sabaeus

Protein Sequence
(Fasta)

MRVKDPSKVL PEKAKRSKRP TVPHEEDSSD DIAVGLTCQH VSHAISVNHV KRAIAENLWS 60
VCSECLKERR FYDGQPVLPS DIWLCLKCGF QGCGKNSESQ HSLKHFKNSR TEPHCIIINL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGGGCGCGCA GGCGCAGTCT CCCCAGGTTG TAGACGCTGC GGCCAGGCCG GGCAGGGTGA 60
GTTGGGGACG CGACTGTGGT CGCAGCGGCG GTGTGGTCGC CGCAGTTTCT CGGTCTTCGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00443--UCH
PF02148--zf-UBP

SMART

SM00290--ZnF_UBP

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0006281--P:DNA repair
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002331	Ailuropoda melanoleuca	72.56	0.00e+00	1003.00
IUUC-Apl-003512	Anas platyrhynchos	66.75	0.00e+00	975.00
IUUC-Aca-004284	Anolis carolinensis	60.10	0.00e+00	881.00
IUUC-Ame-010735	Astyanax mexicanus	62.32	4.00e-70	258.00
IUUC-Bta-012880	Bos taurus	80.77	0.00e+00	1172.00
IUUC-Cja-019144	Callithrix jacchus	91.19	0.00e+00	1403.00
IUUC-Cfa-020971	Canis familiaris	82.86	0.00e+00	729.00
IUUC-Cpo-022497	Cavia porcellus	68.04	0.00e+00	994.00
IUUC-Cho-024358	Choloepus hoffmanni	61.90	1.00e-110	393.00
IUUC-Dre-028106	Danio rerio	53.27	0.00e+00	737.00
IUUC-Dno-029456	Dasypus novemcinctus	77.80	0.00e+00	655.00
IUUC-Dor-030438	Dipodomys ordii	63.31	0.00e+00	863.00
IUUC-Dme-031870	Drosophila melanogaster	47.31	2.00e-35	145.00
IUUC-Ete-032736	Echinops telfairi	63.71	0.00e+00	864.00
IUUC-Eca-034211	Equus caballus	81.19	0.00e+00	1228.00
IUUC-Eeu-034797	Erinaceus europaeus	81.01	2.00e-85	310.00
IUUC-Fca-035947	Felis catus	77.15	0.00e+00	1056.00
IUUC-Fal-037199	Ficedula albicollis	66.89	0.00e+00	915.00
IUUC-Gmo-039228	Gadus morhua	60.76	1.00e-140	494.00
IUUC-Gga-040823	Gallus gallus	62.15	4.00e-143	501.00
IUUC-Gac-042406	Gasterosteus aculeatus	59.52	5.00e-136	478.00
IUUC-Ggo-045402	Gorilla gorilla	94.17	0.00e+00	1452.00
IUUC-Hsa-046430	Homo sapiens	94.16	0.00e+00	1454.00
IUUC-Itr-048855	Ictidomys tridecemlineatus	79.48	0.00e+00	650.00
IUUC-Lch-049547	Latimeria chalumnae	57.23	0.00e+00	826.00
IUUC-Loc-052842	Lepisosteus oculatus	58.13	0.00e+00	823.00
IUUC-Laf-053988	Loxodonta africana	81.47	0.00e+00	1238.00
IUUC-Mcc-055491	Macaca mulatta	92.36	0.00e+00	1416.00
IUUC-Meu-056256	Macropus eugenii	61.77	2.00e-147	516.00
IUUC-Mtr-057945	Medicago truncatula	31.79	7.00e-34	139.00
IUUC-Mga-059833	Meleagris gallopavo	58.27	1.00e-143	503.00
IUUC-Mmr-060952	Microcebus murinus	83.96	0.00e+00	1239.00
IUUC-Mdo-062642	Monodelphis domestica	68.75	0.00e+00	983.00
IUUC-Mmu-063945	Mus musculus	76.36	0.00e+00	1132.00
IUUC-Mpu-065944	Mustela putorius furo	74.06	0.00e+00	1063.00
IUUC-Mlu-067049	Myotis lucifugus	81.08	0.00e+00	1172.00
IUUC-Nle-069828	Nomascus leucogenys	93.40	0.00e+00	1439.00
IUUC-Opr-070672	Ochotona princeps	70.73	8.00e-144	504.00
IUUC-Ont-072121	Oreochromis niloticus	59.12	9.00e-133	467.00
IUUC-Oan-073656	Ornithorhynchus anatinus	62.89	0.00e+00	928.00
IUUC-Ocu-074323	Oryctolagus cuniculus	81.16	0.00e+00	1177.00
IUUC-Ola-087238	Oryzias latipes	59.08	1.00e-145	510.00
IUUC-Oga-088379	Otolemur garnettii	77.37	0.00e+00	1159.00
IUUC-Oar-089718	Ovis aries	81.19	0.00e+00	1178.00
IUUC-Ptr-091358	Pan troglodytes	94.03	0.00e+00	1453.00
IUUC-Pan-092023	Papio anubis	98.32	0.00e+00	1514.00
IUUC-Psi-093256	Pelodiscus sinensis	65.26	0.00e+00	898.00
IUUC-Pfo-097285	Poecilia formosa	52.17	2.00e-118	420.00
IUUC-Pab-098539	Pongo abelii	94.30	0.00e+00	1449.00
IUUC-Pca-100610	Procavia capensis	65.89	0.00e+00	829.00
IUUC-Pva-102985	Pteropus vampyrus	90.27	0.00e+00	694.00
IUUC-Rno-105538	Rattus norvegicus	76.17	0.00e+00	1140.00
IUUC-Sha-107022	Sarcophilus harrisii	72.85	8.00e-179	620.00
IUUC-Sar-113637	Sorex araneus	74.03	0.00e+00	988.00
IUUC-Ssc-115870	Sus scrofa	80.26	0.00e+00	1216.00
IUUC-Tgu-116907	Taeniopygia guttata	67.18	0.00e+00	981.00
IUUC-Tru-117835	Takifugu rubripes	50.86	3.00e-106	379.00
IUUC-Tsy-118869	Tarsius syrichta	82.53	0.00e+00	1088.00
IUUC-Tni-119716	Tetraodon nigroviridis	61.92	1.00e-91	330.00
IUUC-Tbe-128041	Tupaia belangeri	62.71	0.00e+00	835.00
IUUC-Ttr-128901	Tursiops truncatus	79.35	0.00e+00	1172.00
IUUC-Vpa-130331	Vicugna pacos	82.54	0.00e+00	1189.00
IUUC-Xtr-131794	Xenopus tropicalis	65.15	2.00e-143	503.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence