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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-045739
UUCD1 version UUC-HoS-00289
Ensembl Protein ID ENSP00000295704.2
UniProt Accession Q96BH1; A8K0D6; Q53HQ5; Q9H874; RNF25_HUMAN
Genbank Protein ID BAB14743.1; BAF82190.1; BAD96245.1; EAW70645.1; AAH15612.1
Protein Name E3 ubiquitin-protein ligase RNF25; RING finger protein 25; RING-type E3 ubiquitin transferase RNF25
Genbank Nucleotide ID AK023968; AK289501; AK222525; AC009974; BC015612
Gene Name RNF25
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000163481.7 ENST00000295704.6 ENSP00000295704.2
ENSG00000163481.7 ENST00000423170.1 ENSP00000403582.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbcircBasecircRNADbCircNet
miRTarBasemicroRNATRANSFACTargetScan
RepTarmiRNAMapSomamiRmiRcode
RAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Information
GWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosSNPPhosphositePlus
dbPTMHPRDUniProtBioGRID
mUbiSiDa
DNA Methylation
TCGAICGC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/RING/RING RING 18757723
Classification
Family E-value Score Start End
E3 activity/RING/RING 3.00e-06 29.3 135 202
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/RING
   S: 1    CaiCledf..kdgplvlpCgHvfhadClqkw.............pglknssskefr.................CPlCr 46
           C iCl+ f  k+    +pC H fh +Cl ++                        +                 CP+Cr
   Q: 135  CVICLYGFqeKEAFTKTPCYHYFHCHCLARYiqhmeqelkaqgqE----------QeqerqhattkqkavgvqCPVCR 202
           ********65333556************99977767665554330..........134444556777777777****8 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of NKD2 (By similarity). Stimulates transcription mediated by NF-kappa-B.
 E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of NKD2 (By similarity). Stimulates transcription mediated by NF-kappa-B.
Protein Sequence
(Fasta)
MAASASAAAG EEDWVLPSEV EVLESIYLDE LQVIKGNGRT SPWEIYITLH PATAEDQDSQ 60
YVCFTLVLQV PAEYPHEVPQ ISIRNPRGLS DEQIHTILQV LGHVAKAGLG TAMLYELIEK 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-045739|E3,RING|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
AGACCCCCTG GCCCGTGCGC TTCGCAGGCC AGAGCCCCTC TCTCACCCCC AGCCTAGGAG 60
CTCCAAGCTC CTCAGGCCAA GGGACGGATT CCCTGGCGTT TAGCCCCATC TCTTCTGGCT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-045739|E3,RING|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR006575--RWD-domain
IPR016135--UBQ-conjugating_enzyme/RWD
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS50908--RWD
PS50089--ZF_RING_2
Pfam

PF05773--RWD
SMART

SM00184--RING
SM00591--RWD
Gene Ontology

GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0051059--F:NF-kappaB binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0051092--P:positive regulation of NF-kappaB transcription factor activity
GO:0016567--P:protein ubiquitination
KEGG hsa:64320
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001954 Ailuropoda melanoleuca 88.44 0.00e+00 703.00
IUUC-Atr-002830 Amborella trichopoda 28.05 6.00e-14 72.00
IUUC-Apl-003293 Anas platyrhynchos 67.45 4.00e-93 335.00
IUUC-Aca-005092 Anolis carolinensis 69.63 4.00e-101 362.00
IUUC-Aly-005434 Arabidopsis lyrata 27.65 4.00e-18 85.50
IUUC-Ath-006770 Arabidopsis thaliana 27.00 2.00e-18 86.70
IUUC-Ame-011754 Astyanax mexicanus 48.05 1.00e-58 221.00
IUUC-Bta-012592 Bos taurus 82.14 0.00e+00 670.00
IUUC-Bdi-015061 Brachypodium distachyon 24.64 3.00e-15 76.30
IUUC-Bol-015743 Brassica oleracea 26.21 2.00e-16 79.70
IUUC-Bra-018072 Brassica rapa 27.27 2.00e-15 76.30
IUUC-Cel-018515 Caenorhabditis elegans 21.88 4.00e-04 38.50
IUUC-Cja-018930 Callithrix jacchus 93.56 0.00e+00 784.00
IUUC-Cfa-020156 Canis familiaris 88.89 0.00e+00 744.00
IUUC-Cpo-021290 Cavia porcellus 82.54 0.00e+00 702.00
IUUC-Csa-023214 Chlorocebus sabaeus 96.22 0.00e+00 793.00
IUUC-Cin-025416 Ciona intestinalis 31.46 4.00e-41 162.00
IUUC-Csv-026360 Ciona savignyi 36.20 1.00e-42 167.00
IUUC-Dre-028670 Danio rerio 48.44 2.00e-54 206.00
IUUC-Dno-029970 Dasypus novemcinctus 86.49 0.00e+00 726.00
IUUC-Dor-030152 Dipodomys ordii 83.33 0.00e+00 676.00
IUUC-Dme-031914 Drosophila melanogaster 36.07 8.00e-37 147.00
IUUC-Ete-033105 Echinops telfairi 75.22 2.00e-153 535.00
IUUC-Eca-033800 Equus caballus 87.78 0.00e+00 696.00
IUUC-Eeu-034525 Erinaceus europaeus 64.89 2.00e-124 439.00
IUUC-Fca-035644 Felis catus 88.44 0.00e+00 766.00
IUUC-Fal-037121 Ficedula albicollis 50.20 7.00e-107 380.00
IUUC-Gmo-039444 Gadus morhua 49.40 6.00e-59 221.00
IUUC-Gga-041221 Gallus gallus 44.58 5.00e-71 261.00
IUUC-Gac-042354 Gasterosteus aculeatus 48.91 1.00e-66 247.00
IUUC-Gma-043721 Glycine max 27.78 4.00e-16 79.70
IUUC-Ggo-044879 Gorilla gorilla 98.44 0.00e+00 828.00
IUUC-Itr-047915 Ictidomys tridecemlineatus 88.22 0.00e+00 698.00
IUUC-Lch-050277 Latimeria chalumnae 56.15 3.00e-67 249.00
IUUC-Lpe-051139 Leersia perrieri 27.45 2.00e-17 83.60
IUUC-Loc-052367 Lepisosteus oculatus 62.67 6.00e-21 91.70
IUUC-Laf-053559 Loxodonta africana 81.56 0.00e+00 726.00
IUUC-Mcc-055367 Macaca mulatta 88.22 0.00e+00 742.00
IUUC-Meu-056730 Macropus eugenii 71.46 3.00e-146 511.00
IUUC-Mtr-058418 Medicago truncatula 26.78 2.00e-13 70.10
IUUC-Mga-060090 Meleagris gallopavo 44.74 5.00e-66 244.00
IUUC-Mmr-060618 Microcebus murinus 91.11 0.00e+00 762.00
IUUC-Mdo-063084 Monodelphis domestica 73.33 1.00e-157 549.00
IUUC-Mmu-063854 Mus musculus 81.92 0.00e+00 694.00
IUUC-Mac-064922 Musa acuminata 27.82 2.00e-19 89.70
IUUC-Mpu-066419 Mustela putorius furo 87.56 0.00e+00 721.00
IUUC-Mlu-067289 Myotis lucifugus 84.13 0.00e+00 700.00
IUUC-Nle-069090 Nomascus leucogenys 97.78 0.00e+00 843.00
IUUC-Opr-070601 Ochotona princeps 81.78 0.00e+00 652.00
IUUC-Ont-072434 Oreochromis niloticus 51.55 1.00e-67 251.00
IUUC-Ocu-074855 Oryctolagus cuniculus 84.89 0.00e+00 708.00
IUUC-Oba-075792 Oryza barthii 23.94 8.00e-17 81.60
IUUC-Obr-076917 Oryza brachyantha 26.24 1.00e-18 87.80
IUUC-Ogl-077872 Oryza glaberrima 22.88 9.00e-15 74.70
IUUC-Ogu-078151 Oryza glumaepatula 25.57 5.00e-16 79.00
IUUC-Oin-079465 Oryza indica 23.40 2.00e-16 80.10
IUUC-Olo-080907 Oryza longistaminata 22.77 5.00e-11 63.20
IUUC-Ome-081752 Oryza meridionalis 23.19 6.00e-16 78.60
IUUC-Oni-082420 Oryza nivara 25.57 5.00e-16 79.00
IUUC-Opu-083810 Oryza punctata 24.33 5.00e-17 82.00
IUUC-Oru-085177 Oryza rufipogon 23.94 8.00e-17 81.60
IUUC-Ola-087231 Oryzias latipes 51.96 3.00e-50 191.00
IUUC-Oga-088963 Otolemur garnettii 90.20 0.00e+00 764.00
IUUC-Oar-089292 Ovis aries 81.30 0.00e+00 723.00
IUUC-Ptr-091214 Pan troglodytes 98.44 0.00e+00 832.00
IUUC-Pan-092823 Papio anubis 96.44 0.00e+00 860.00
IUUC-Psi-094084 Pelodiscus sinensis 37.83 3.00e-39 155.00
IUUC-Pfo-096406 Poecilia formosa 48.45 1.00e-61 230.00
IUUC-Pab-098212 Pongo abelii 98.00 0.00e+00 822.00
IUUC-Pop-099369 Populus trichocarpa 24.43 2.00e-12 66.60
IUUC-Pca-100897 Procavia capensis 75.56 2.00e-176 611.00
IUUC-Ppe-101702 Prunus persica 22.92 6.00e-11 62.00
IUUC-Pva-102899 Pteropus vampyrus 86.89 0.00e+00 731.00
IUUC-Rno-105369 Rattus norvegicus 84.10 0.00e+00 724.00
IUUC-Sha-107344 Sarcophilus harrisii 71.24 3.00e-146 511.00
IUUC-Smo-109636 Selaginella moellendorffii 25.17 1.00e-08 52.80
IUUC-Sit-109795 Setaria italica 28.52 9.00e-18 84.30
IUUC-Sly-111014 Solanum lycopersicum 26.35 9.00e-17 82.40
IUUC-Stu-112139 Solanum tuberosum 26.94 3.00e-19 89.00
IUUC-Sar-113487 Sorex araneus 65.30 9.00e-57 214.00
IUUC-Sbi-114714 Sorghum bicolor 27.11 3.00e-17 82.80
IUUC-Ssc-115465 Sus scrofa 84.67 0.00e+00 735.00
IUUC-Tgu-117113 Taeniopygia guttata 50.12 7.00e-91 327.00
IUUC-Tsy-119186 Tarsius syrichta 84.14 1.00e-66 246.00
IUUC-Tni-120219 Tetraodon nigroviridis 53.06 2.00e-36 144.00
IUUC-Tca-121748 Theobroma cacao 23.66 2.00e-12 67.00
IUUC-Tae-123014 Triticum aestivum 27.39 1.00e-14 74.30
IUUC-Tbe-127584 Tupaia belangeri 73.87 4.00e-116 411.00
IUUC-Ttr-128244 Tursiops truncatus 84.00 0.00e+00 686.00
IUUC-Vpa-130354 Vicugna pacos 87.42 0.00e+00 729.00
IUUC-Xtr-132402 Xenopus tropicalis 50.79 6.00e-70 258.00
IUUC-Xma-133442 Xiphophorus maculatus 47.57 1.00e-61 230.00
Created Date 25-Jun-2017

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