iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Kpa-049328

Ensembl Protein ID

CAY70866

UniProt Accession

C4R5N0; SLX4_KOMPG

Genbank Protein ID

CAY70866.1

Protein Name

Structure-specific endonuclease subunit SLX4

Genbank Nucleotide ID

FN392321

Gene Name

SLX4; PAS_chr3_0813

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
PAS_chr3_0813	CAY70866	CAY70866

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
UBD/ZnF/UBZ	29.41	3.30e-02	38.10	IUUC-Hsa-047035

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Komagataella pastoris

Functional Description
(View)

Regulatory subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA (By similarity).

Protein Sequence
(Fasta)

MEFVSTQIQS AYEDYEEKER HDRDIKKKLA SFKSAEFGHN FAEQTSQNSN PRKRKISEKS 60
QKERPIRSLN AQVLNMFHGN VELIKQQRAL LKVLSGKKRK VNEVLKHVEN IELENSTTHR 120

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Nucleotide Sequence
(Fasta)

ATGGAGTTTG TATCGACTCA GATACAGAGT GCCTATGAAG ACTACGAGGA AAAAGAGCGC 60
CATGATAGGG ATATCAAGAA GAAGTTAGCC AGCTTCAAGT CTGCAGAGTT TGGGCACAAC 120

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Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0227--DNA damage
KW-0233--DNA recombination
KW-0234--DNA repair
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome

Interpro

IPR018574--Structure-sp_endonuc_su_Slx4

Pfam

PF09494--Slx4

Gene Ontology

GO:0033557--C:Slx1-Slx4 complex
GO:0017108--F:5'-flap endonuclease activity
GO:0006310--P:DNA recombination
GO:0006281--P:DNA repair
GO:0006260--P:DNA replication

KEGG

ppa:PAS_chr3_0813

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Apl-003261	Anas platyrhynchos	32.43	6.00e-05	42.00
IUUC-Ame-011090	Astyanax mexicanus	36.36	2.00e-01	28.90
IUUC-Cja-019406	Callithrix jacchus	29.23	2.00e-04	40.40
IUUC-Csa-023941	Chlorocebus sabaeus	29.41	1.00e-04	39.70
IUUC-Cin-025405	Ciona intestinalis	30.30	1.00e-03	35.00
IUUC-Csv-025916	Ciona savignyi	31.91	1.00e-05	41.60
IUUC-Dre-027764	Danio rerio	29.41	3.00e-04	39.70
IUUC-Dno-030083	Dasypus novemcinctus	31.43	9.00e-05	41.60
IUUC-Eca-033407	Equus caballus	30.00	1.60e-02	33.50
IUUC-Fal-036850	Ficedula albicollis	29.41	3.00e-03	36.60
IUUC-Gga-041088	Gallus gallus	33.85	1.00e-05	44.30
IUUC-Gac-041824	Gasterosteus aculeatus	32.81	6.00e-06	42.00
IUUC-Gma-042766	Glycine max	46.15	2.00e+00	25.80
IUUC-Ggo-045642	Gorilla gorilla	29.41	9.00e-04	38.10
IUUC-Hsa-047035	Homo sapiens	29.41	1.00e-03	38.10
IUUC-Lch-050364	Latimeria chalumnae	28.57	7.00e-04	38.10
IUUC-Laf-053910	Loxodonta africana	33.33	9.00e-04	38.10
IUUC-Mcc-055883	Macaca mulatta	29.41	2.00e-04	40.40
IUUC-Meu-056224	Macropus eugenii	35.71	5.00e-03	35.40
IUUC-Mga-059880	Meleagris gallopavo	33.85	1.00e-05	43.90
IUUC-Mmr-061715	Microcebus murinus	26.47	8.00e-03	35.00
IUUC-Mdo-062426	Monodelphis domestica	27.14	3.30e-02	33.10
IUUC-Mmu-063947	Mus musculus	26.03	1.00e-03	37.70
IUUC-Mpu-066184	Mustela putorius furo	25.42	8.70e-02	31.60
IUUC-Mlu-067533	Myotis lucifugus	31.67	4.60e-02	32.30
IUUC-Nle-069204	Nomascus leucogenys	29.23	4.00e-04	39.70
IUUC-Ont-072551	Oreochromis niloticus	36.54	1.00e-03	37.70
IUUC-Ola-087360	Oryzias latipes	36.36	3.00e-05	40.00
IUUC-Olu-087747	Ostreococcus lucimarinus	20.00	5.30e+00	23.10
IUUC-Oga-089106	Otolemur garnettii	29.41	4.00e-04	38.90
IUUC-Oar-089289	Ovis aries	30.51	7.00e-03	35.40
IUUC-Ptr-091469	Pan troglodytes	29.41	9.00e-04	38.10
IUUC-Pan-091841	Papio anubis	29.41	3.00e-04	39.30
IUUC-Psi-093842	Pelodiscus sinensis	29.73	1.00e-03	37.70
IUUC-Pma-094404	Petromyzon marinus	29.09	2.00e-02	32.00
IUUC-Pab-098271	Pongo abelii	29.41	5.00e-04	38.90
IUUC-Pva-102276	Pteropus vampyrus	27.12	2.50e-02	33.50
IUUC-Sha-106722	Sarcophilus harrisii	31.43	1.00e-03	37.70
IUUC-Sre-115039	Sporisorium reilianum	27.63	1.00e-06	44.70
IUUC-Ssc-115383	Sus scrofa	25.00	7.60e-02	31.60
IUUC-Tru-118092	Takifugu rubripes	29.69	1.00e-05	41.60
IUUC-Tni-120380	Tetraodon nigroviridis	31.25	9.00e-07	45.10
IUUC-Tbe-127404	Tupaia belangeri	28.57	3.00e-03	36.60
IUUC-Uma-129640	Ustilago maydis	28.30	5.00e-05	39.70

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence