iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mpu-066184

Ensembl Protein ID

ENSMPUP00000014938.1

UniProt Accession

M3YUC8; M3YUC8_MUSPF

Genbank Protein ID

ENSMPUP00000014938

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AEYP01027775

Gene Name

SLX4

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMPUG00000015049.1	ENSMPUT00000015175.1	ENSMPUP00000014938.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/BCR/BTB_Other: BTB	3.20e-06	27.4	626	694
UBD/ZnF/UBZ	9.10e-08	32.2	230	255

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/BCR/BTB_Other: BTB

   S: 1    aDvilvvg.geeffahkivLaasSsvFyalflme....lees..ksklmveikdvqpevfrallkFlYtg 63
           +Dv+l+ + g +  ahk vL a+++ ++   ++e     e++  + + +v ++dv+ e+ rall++lYt 
   Q: 626  SDVQLQTDrGDVLYAHKFVLYARCPLLMQYVNSEgffvVEDGdpR-SQRVLLSDVSTEAIRALLHYLYTA 694
           69***************************9966533323344445.6788888***************96 PP

UBD/ZnF/UBZ

   S: 2    lvCPvCqkm...vdqtdfeeHlDeCl 24
           ++C++Cqk    +++t++e+H+++Cl
   Q: 230  FFCQICQKNlsaMNLTRREQHVNRCL 255
           89***********************8 PP

Organism

Mustela putorius furo

Protein Sequence
(Fasta)

MMDESDDDFK ELCASFLQRV KKNVTKEVSG ERKTQKTSSS TQISKPKRTK PTATKDKALQ 60
GPREKKTRSG SQASRTKKQG APEWQRSEPA PPENGGGSVL ASAALQEGVQ STQTEASPDS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CAGGGGCGTC TGGCTGAGTC AGTTGGTGAT GGGTCTGCGT TTGGCTCAGG TCCCGATCCC 60
AGGGTCCTGG GGTGGAGCCC CAAGTCTGGC TCCCTGCTCA GTGGGGAGTC TGCTTCTTCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR000210--BTB/POZ_dom
IPR011333--SKP1/BTB/POZ
IPR018574--Structure-sp_endonuc_su_Slx4

PROSITE

PS50097--BTB

Pfam

PF00651--BTB
PF09494--Slx4

SMART

SM00225--BTB

Gene Ontology

GO:0030054--C:cell junction
GO:0005829--C:cytosol
GO:0070522--C:ERCC4-ERCC1 complex
GO:0048476--C:Holliday junction resolvase complex
GO:0000790--C:nuclear chromatin
GO:0000784--C:nuclear chromosome, telomeric region
GO:0005654--C:nucleoplasm
GO:0033557--C:Slx1-Slx4 complex
GO:0048257--F:3'-flap endonuclease activity
GO:0017108--F:5'-flap endonuclease activity
GO:0008821--F:crossover junction endodeoxyribonuclease activity
GO:0008047--F:enzyme activator activity
GO:0010792--P:DNA double-strand break processing involved in repair via single-strand annealing
GO:0006260--P:DNA replication
GO:0000724--P:double-strand break repair via homologous recombination
GO:1904357--P:negative regulation of telomere maintenance via telomere lengthening
GO:0006289--P:nucleotide-excision repair
GO:1904431--P:positive regulation of t-circle formation
GO:0072429--P:response to intra-S DNA damage checkpoint signaling
GO:0090656--P:t-circle formation
GO:0061820--P:telomeric D-loop disassembly

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001225	Ailuropoda melanoleuca	79.67	0.00e+00	2138.00
IUUC-Apl-003261	Anas platyrhynchos	45.69	5.00e-147	516.00
IUUC-Aca-004455	Anolis carolinensis	70.18	2.00e-18	83.60
IUUC-Ame-010993	Astyanax mexicanus	30.23	3.00e-14	71.60
IUUC-Bta-013472	Bos taurus	61.16	0.00e+00	1477.00
IUUC-Cja-019406	Callithrix jacchus	61.50	0.00e+00	1519.00
IUUC-Cfa-020129	Canis familiaris	76.62	0.00e+00	2094.00
IUUC-Cpo-021944	Cavia porcellus	53.38	0.00e+00	1240.00
IUUC-Csa-023941	Chlorocebus sabaeus	57.13	0.00e+00	663.00
IUUC-Cho-024847	Choloepus hoffmanni	65.94	2.00e-150	527.00
IUUC-Cin-025405	Ciona intestinalis	42.31	2.00e-07	50.10
IUUC-Csv-025916	Ciona savignyi	35.59	4.00e-08	51.60
IUUC-Dre-027764	Danio rerio	33.16	5.00e-40	160.00
IUUC-Dno-030083	Dasypus novemcinctus	57.66	0.00e+00	1360.00
IUUC-Dor-031129	Dipodomys ordii	52.12	0.00e+00	990.00
IUUC-Dse-031510	Dothistroma septosporum	36.11	3.80e-02	34.30
IUUC-Ete-032536	Echinops telfairi	47.00	3.00e-88	320.00
IUUC-Eca-033407	Equus caballus	69.30	0.00e+00	1557.00
IUUC-Eeu-034473	Erinaceus europaeus	49.67	5.00e-57	217.00
IUUC-Fca-035730	Felis catus	71.21	0.00e+00	1888.00
IUUC-Fal-036850	Ficedula albicollis	48.01	4.00e-139	489.00
IUUC-Gmo-038677	Gadus morhua	48.21	1.00e-31	131.00
IUUC-Gga-041088	Gallus gallus	42.79	1.00e-138	488.00
IUUC-Gac-041824	Gasterosteus aculeatus	50.00	2.00e-13	68.90
IUUC-Ggo-045642	Gorilla gorilla	60.72	0.00e+00	1454.00
IUUC-Hsa-047035	Homo sapiens	62.68	0.00e+00	1578.00
IUUC-Itr-049010	Ictidomys tridecemlineatus	60.57	0.00e+00	1517.00
IUUC-Kpa-049328	Komagataella pastoris	25.37	7.60e-02	32.30
IUUC-Lch-050364	Latimeria chalumnae	41.05	7.00e-76	279.00
IUUC-Loc-052423	Lepisosteus oculatus	42.01	9.00e-40	159.00
IUUC-Laf-053910	Loxodonta africana	56.14	0.00e+00	1338.00
IUUC-Mcc-055883	Macaca mulatta	61.56	0.00e+00	1585.00
IUUC-Meu-056224	Macropus eugenii	48.59	3.00e-82	300.00
IUUC-Mga-059880	Meleagris gallopavo	46.87	1.00e-137	484.00
IUUC-Mvi-060510	Microbotryum violaceum	36.36	1.00e-04	42.70
IUUC-Mmr-061715	Microcebus murinus	64.31	0.00e+00	1667.00
IUUC-Mdo-062426	Monodelphis domestica	44.37	0.00e+00	1008.00
IUUC-Mmu-063947	Mus musculus	58.12	0.00e+00	780.00
IUUC-Mlu-067533	Myotis lucifugus	67.28	0.00e+00	1693.00
IUUC-Nle-069204	Nomascus leucogenys	64.20	0.00e+00	936.00
IUUC-Opr-070377	Ochotona princeps	61.10	0.00e+00	823.00
IUUC-Ont-072551	Oreochromis niloticus	31.09	2.00e-67	251.00
IUUC-Oan-073350	Ornithorhynchus anatinus	47.87	9.00e-105	374.00
IUUC-Ocu-074915	Oryctolagus cuniculus	62.43	0.00e+00	867.00
IUUC-Ola-087360	Oryzias latipes	55.43	1.00e-19	89.70
IUUC-Oga-089106	Otolemur garnettii	57.83	0.00e+00	1214.00
IUUC-Oar-089289	Ovis aries	62.40	0.00e+00	1025.00
IUUC-Ptr-091469	Pan troglodytes	62.84	0.00e+00	1567.00
IUUC-Pan-091841	Papio anubis	61.62	0.00e+00	1224.00
IUUC-Psi-093842	Pelodiscus sinensis	47.21	6.00e-124	439.00
IUUC-Pma-094732	Petromyzon marinus	59.62	5.00e-10	57.40
IUUC-Pfo-097299	Poecilia formosa	39.63	6.00e-32	133.00
IUUC-Pab-098271	Pongo abelii	61.83	0.00e+00	1533.00
IUUC-Pca-100721	Procavia capensis	58.90	0.00e+00	809.00
IUUC-Pva-102276	Pteropus vampyrus	70.58	0.00e+00	1872.00
IUUC-Rno-105619	Rattus norvegicus	54.68	0.00e+00	1402.00
IUUC-Sha-106722	Sarcophilus harrisii	44.70	0.00e+00	1043.00
IUUC-Sar-113673	Sorex araneus	50.70	5.00e-74	273.00
IUUC-Ssc-115383	Sus scrofa	60.83	0.00e+00	1377.00
IUUC-Tgu-117243	Taeniopygia guttata	49.88	1.00e-87	316.00
IUUC-Tru-118092	Takifugu rubripes	73.68	5.00e-20	91.30
IUUC-Tsy-119362	Tarsius syrichta	58.80	8.00e-161	561.00
IUUC-Tni-120380	Tetraodon nigroviridis	75.00	4.00e-20	91.30
IUUC-Tbe-127404	Tupaia belangeri	49.84	0.00e+00	654.00
IUUC-Ttr-128317	Tursiops truncatus	67.30	0.00e+00	1640.00
IUUC-Uma-129640	Ustilago maydis	30.51	8.00e-03	34.70
IUUC-Xtr-132533	Xenopus tropicalis	40.78	2.00e-86	314.00
IUUC-Xma-134059	Xiphophorus maculatus	31.81	5.00e-38	153.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence