iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
microRNA	RAID2
Protein-protein Interaction
IID	PINA	Mentha
Protein 3D Structure
PDB	MMDB
Post-translational Modifications (PTMs)
dbPAF	dbPTM	Phospho.ELM	UniProt
PHOSIDA
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
UBD/Alpha-Helix/UIM	UIM	11832215

Reviewed

Classification

Family	Identity	E-value	Score	Source Orthology
UBD/Alpha-Helix/UIM	43.74	4.00e-99	359.00	IUUC-Bta-012506
UBD/Alpha-Helix/DUIM	48.24	9.00e-78	289.00	IUUC-Hsa-046009
UBD/Alpha-Helix/VHS	48.24	9.00e-78	289.00	IUUC-Hsa-046009
UBD/Alpha-Helix/VHS	47.65	3.00e-77	286.00	IUUC-Rno-105125
UBD/Alpha-Helix/UIM	33.04	6.00e-29	124.00	IUUC-Sce-106192
UBD/Alpha-Helix/UIM	35.92	3.00e-36	148.00	IUUC-Spo-108220

Organism

Drosophila melanogaster

Functional Description
(View)

Essential role in endosome membrane invagination and formation of multivesicular bodies, MVBs. Required during gastrulation and appears to regulate early embryonic signaling pathways. Inhibits tyrosine kinase receptor signaling by promoting degradation of the tyrosine-phosphorylated, active receptor, potentially by sorting activated receptors into MVBs. The MVBs are then trafficked to the lysosome where their contents are degraded.

Protein Sequence
(Fasta)

MFRSSFDKNL ENATSHLRLE PDWPSILLIC DEINQKDVTP KNAFAAIKKK MNSPNPHSSC 60
YSLLVLESIV KNCGAPVHEE VFTKENCEMF SSFLESTPHE NVRQKMLELV QTWAYAFRSS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTCTTATTTG CGTTGCCCTT GCTTTTCGTC ATCTGGCAGC ACTGTAAGGG TATGTTAATT 60
TCATTGATGT GGCAGCACTA GCGCATTGCA GAAAATTTCT TTGCTTGCAA AACAATAATA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0217--Developmental protein
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR008942--ENTH_VHS
IPR024641--HRS_helical
IPR017073--Ubi-bd_Hrs_VPS27
IPR003903--UIM_dom
IPR002014--VHS_dom
IPR000306--Znf_FYVE
IPR017455--Znf_FYVE-rel
IPR011011--Znf_FYVE_PHD
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50330--UIM
PS50179--VHS
PS50178--ZF_FYVE

Pfam

PF01363--FYVE
PF12210--Hrs_helical
PF00790--VHS

SMART

SM00064--FYVE
SM00288--VHS

Gene Ontology

GO:0005938--C:cell cortex
GO:0005768--C:endosome
GO:0033565--C:ESCRT-0 complex
GO:0048471--C:perinuclear region of cytoplasm
GO:0008021--C:synaptic vesicle
GO:0046872--F:metal ion binding
GO:0043130--F:ubiquitin binding
GO:0007298--P:border follicle cell migration
GO:0006897--P:endocytosis
GO:0016197--P:endosomal transport
GO:0032509--P:endosome transport via multivesicular body sorting pathway
GO:0006887--P:exocytosis
GO:1990182--P:exosomal secretion
GO:0006886--P:intracellular protein transport
GO:0033619--P:membrane protein proteolysis
GO:0042059--P:negative regulation of epidermal growth factor receptor signaling pathway
GO:0001933--P:negative regulation of protein phosphorylation
GO:0016322--P:neuron remodeling
GO:0007269--P:neurotransmitter secretion
GO:0045743--P:positive regulation of fibroblast growth factor receptor signaling pathway
GO:0031398--P:positive regulation of protein ubiquitination
GO:0045752--P:positive regulation of Toll signaling pathway
GO:0051726--P:regulation of cell cycle
GO:0042058--P:regulation of epidermal growth factor receptor signaling pathway
GO:2000274--P:regulation of epithelial cell migration, open tracheal system
GO:0008593--P:regulation of Notch signaling pathway
GO:0016079--P:synaptic vesicle exocytosis
GO:0016082--P:synaptic vesicle priming
GO:0008293--P:torso signaling pathway
GO:0016050--P:vesicle organization

KEGG

dme:Dmel_CG2903

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001518	Ailuropoda melanoleuca	50.61	3.00e-75	275.00
IUUC-Apl-003662	Anas platyrhynchos	46.18	5.00e-96	344.00
IUUC-Aca-004940	Anolis carolinensis	46.56	6.00e-119	421.00
IUUC-Ago-007931	Ashbya gossypii	30.24	1.00e-26	114.00
IUUC-Acl-008274	Aspergillus clavatus	39.91	7.00e-40	157.00
IUUC-Afl-008521	Aspergillus flavus	38.73	3.00e-39	156.00
IUUC-Afu-008774	Aspergillus fumigatus	39.01	3.00e-39	155.00
IUUC-Ani-009445	Aspergillus nidulans	38.53	8.00e-38	151.00
IUUC-Ang-009863	Aspergillus niger	38.53	1.00e-38	153.00
IUUC-Ate-010444	Aspergillus terreus	37.89	3.00e-39	155.00
IUUC-Ame-011111	Astyanax mexicanus	48.85	2.00e-109	389.00
IUUC-Bta-012506	Bos taurus	44.84	2.00e-114	405.00
IUUC-Bci-013782	Botrytis cinerea	37.05	3.00e-38	152.00
IUUC-Cel-018493	Caenorhabditis elegans	45.50	7.00e-58	218.00
IUUC-Cja-019998	Callithrix jacchus	46.67	3.00e-67	249.00
IUUC-Cfa-020615	Canis familiaris	49.61	4.00e-77	281.00
IUUC-Cpo-022019	Cavia porcellus	43.49	1.00e-114	406.00
IUUC-Csa-023596	Chlorocebus sabaeus	47.80	2.00e-78	286.00
IUUC-Cin-025488	Ciona intestinalis	40.07	3.00e-99	355.00
IUUC-Csv-025802	Ciona savignyi	42.86	5.00e-87	314.00
IUUC-Cgl-026560	Colletotrichum gloeosporioides	39.92	5.00e-42	165.00
IUUC-Cne-026847	Cryptococcus neoformans	38.91	8.00e-41	161.00
IUUC-Dre-028353	Danio rerio	46.65	3.00e-119	421.00
IUUC-Dno-029005	Dasypus novemcinctus	43.70	3.00e-80	292.00
IUUC-Dor-030280	Dipodomys ordii	46.92	1.00e-78	286.00
IUUC-Dse-031238	Dothistroma septosporum	40.34	2.00e-45	176.00
IUUC-Ete-032235	Echinops telfairi	52.80	2.00e-71	262.00
IUUC-Eca-033873	Equus caballus	48.06	6.00e-79	288.00
IUUC-Eeu-034652	Erinaceus europaeus	50.87	7.00e-52	197.00
IUUC-Fca-036563	Felis catus	42.11	1.00e-113	402.00
IUUC-Fal-036649	Ficedula albicollis	44.79	1.00e-104	373.00
IUUC-Fox-037962	Fusarium oxysporum	39.27	6.00e-40	158.00
IUUC-Fso-038396	Fusarium solani	37.90	7.00e-39	154.00
IUUC-Gmo-039510	Gadus morhua	46.61	7.00e-116	410.00
IUUC-Ggr-039938	Gaeumannomyces graminis	37.90	1.00e-35	144.00
IUUC-Gga-040201	Gallus gallus	46.68	3.00e-117	415.00
IUUC-Gac-041459	Gasterosteus aculeatus	44.64	1.00e-125	442.00
IUUC-Ggo-044573	Gorilla gorilla	47.80	8.00e-78	284.00
IUUC-Hsa-046009	Homo sapiens	47.80	4.00e-78	285.00
IUUC-Itr-049065	Ictidomys tridecemlineatus	47.65	8.00e-79	287.00
IUUC-Kpa-049327	Komagataella pastoris	35.15	8.00e-32	131.00
IUUC-Lch-050236	Latimeria chalumnae	48.39	2.00e-54	204.00
IUUC-Loc-051850	Lepisosteus oculatus	45.45	7.00e-112	397.00
IUUC-Lma-053252	Leptosphaeria maculans	41.33	2.00e-45	176.00
IUUC-Laf-053346	Loxodonta africana	48.68	1.00e-79	290.00
IUUC-Mcc-055789	Macaca mulatta	47.80	7.00e-78	284.00
IUUC-Meu-056329	Macropus eugenii	46.26	7.00e-58	218.00
IUUC-Mor-057205	Magnaporthe oryzae	37.90	4.00e-39	155.00
IUUC-Mpo-057295	Magnaporthe poae	38.36	4.00e-39	155.00
IUUC-Mtr-057931	Medicago truncatula	41.18	4.00e-16	80.10
IUUC-Mla-058849	Melampsora laricipopulina	32.91	3.00e-31	129.00
IUUC-Mga-059361	Meleagris gallopavo	48.17	6.00e-77	281.00
IUUC-Mvi-060561	Microbotryum violaceum	36.44	1.00e-36	147.00
IUUC-Mmr-061122	Microcebus murinus	47.51	2.00e-77	282.00
IUUC-Mdo-062171	Monodelphis domestica	47.21	4.00e-82	298.00
IUUC-Mmu-063952	Mus musculus	47.51	2.00e-79	289.00
IUUC-Mpu-065852	Mustela putorius furo	42.31	2.00e-99	356.00
IUUC-Mlu-066996	Myotis lucifugus	45.79	1.00e-29	123.00
IUUC-Nfi-068539	Neosartorya fischeri	39.46	6.00e-40	158.00
IUUC-Ncr-068726	Neurospora crassa	40.18	3.00e-42	166.00
IUUC-Nle-070148	Nomascus leucogenys	44.28	6.00e-64	238.00
IUUC-Opr-070833	Ochotona princeps	51.59	3.00e-49	188.00
IUUC-Ont-071261	Oreochromis niloticus	44.41	4.00e-115	407.00
IUUC-Oan-073684	Ornithorhynchus anatinus	38.48	7.00e-52	197.00
IUUC-Ola-087570	Oryzias latipes	46.04	3.00e-75	275.00
IUUC-Oga-089087	Otolemur garnettii	47.04	5.00e-68	251.00
IUUC-Oar-089534	Ovis aries	44.52	4.00e-115	408.00
IUUC-Ptr-091654	Pan troglodytes	42.23	4.00e-59	222.00
IUUC-Pan-092652	Papio anubis	47.80	5.00e-78	285.00
IUUC-Pno-095125	Phaeosphaeria nodorum	41.63	5.00e-46	178.00
IUUC-Pfo-096757	Poecilia formosa	48.24	3.00e-79	289.00
IUUC-Pab-097788	Pongo abelii	47.94	6.00e-78	284.00
IUUC-Pca-100145	Procavia capensis	40.94	4.00e-53	202.00
IUUC-Pva-102965	Pteropus vampyrus	49.61	3.00e-78	285.00
IUUC-Pgr-103609	Puccinia graminis	31.97	5.00e-30	124.00
IUUC-Ptt-103865	Puccinia triticina	38.34	3.00e-33	136.00
IUUC-Pte-104095	Pyrenophora teres	40.00	3.00e-46	179.00
IUUC-Pyt-104668	Pyrenophora triticirepentis	40.41	3.00e-46	179.00
IUUC-Rno-105125	Rattus norvegicus	47.21	4.00e-77	282.00
IUUC-Sce-106192	Saccharomyces cerevisiae	33.04	1.00e-30	127.00
IUUC-Sha-107066	Sarcophilus harrisii	48.02	1.00e-36	147.00
IUUC-Sja-107931	Schizosaccharomyces japonicus	33.33	5.00e-24	105.00
IUUC-Spo-108220	Schizosaccharomyces pombe	35.92	2.00e-37	149.00
IUUC-Stu-112464	Solanum tuberosum	46.55	2.00e-12	67.40
IUUC-Sar-113393	Sorex araneus	51.32	3.00e-58	218.00
IUUC-Sre-114986	Sporisorium reilianum	37.56	6.00e-37	148.00
IUUC-Tgu-117505	Taeniopygia guttata	48.50	1.00e-81	296.00
IUUC-Tru-118494	Takifugu rubripes	41.86	4.00e-107	381.00
IUUC-Tsy-119626	Tarsius syrichta	50.55	1.00e-21	97.40
IUUC-Tni-120174	Tetraodon nigroviridis	45.14	2.00e-116	412.00
IUUC-Tre-122191	Trichoderma reesei	37.90	4.00e-39	155.00
IUUC-Tvi-122318	Trichoderma virens	38.81	1.00e-40	160.00
IUUC-Tme-126914	Tuber melanosporum	39.74	1.00e-42	166.00
IUUC-Ttr-129095	Tursiops truncatus	48.09	2.00e-79	290.00
IUUC-Uma-129475	Ustilago maydis	36.04	6.00e-32	132.00
IUUC-Vda-129908	Verticillium dahliae	38.33	1.00e-36	147.00
IUUC-Xtr-131900	Xenopus tropicalis	57.81	1.00e-29	124.00
IUUC-Xma-133124	Xiphophorus maculatus	44.63	1.00e-113	403.00
IUUC-Yli-134682	Yarrowia lipolytica	35.84	2.00e-30	126.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence