iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Bta-013287

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Protein Mdm4

Genbank Nucleotide ID

DAAA02041918

Gene Name

MDM4

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSBTAG00000006255.4	ENSBTAT00000008209.4	ENSBTAP00000008209.4

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/RING/RING	90.02	0.00e+00	857.00	IUUC-Hsa-046950

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Bos taurus

Protein Sequence
(Fasta)

MTSFSTSAPC SASDSARRIS PEQTNQVRPK LPLLKILQAA GAQGEMFTVK EVMHYLGQYI 60
MVKQLYDQQE QHMVYCGGDL LGELLGRQSF SVKDPSPLYD MLRKNLVALA TAATDAAQTL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGCCCCCACA ACCCTGGGCT CGGCGGAAAG CGACTCATGG AACGGCCGTG AGGTGTGGCT 60
TTTGGGTTTT GTTGGCGAGG TGCCGGCAGG CCGGGGGCGG GGGGTGGGGG GTGGGAGAGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome

Interpro

IPR015458--MDM4
IPR016495--p53_neg-reg_MDM_2/4
IPR003121--SWIB_MDM2_domain
IPR001876--Znf_RanBP2
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS01358--ZF_RANBP2_1
PS50199--ZF_RANBP2_2
PS50089--ZF_RING_2

Pfam

PF02201--SWIB
PF00641--zf-RanBP

Gene Ontology

GO:0005634--C:nucleus
GO:0008270--F:zinc ion binding
GO:0008283--P:cell proliferation
GO:0071456--P:cellular response to hypoxia
GO:0030330--P:DNA damage response, signal transduction by p53 class mediator
GO:0045023--P:G0 to G1 transition
GO:0043066--P:negative regulation of apoptotic process
GO:0071157--P:negative regulation of cell cycle arrest
GO:0042177--P:negative regulation of protein catabolic process
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0006461--P:protein complex assembly
GO:0050821--P:protein stabilization

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001467	Ailuropoda melanoleuca	91.46	0.00e+00	807.00
IUUC-Apl-003800	Anas platyrhynchos	58.54	1.00e-150	526.00
IUUC-Aca-004608	Anolis carolinensis	55.60	2.00e-134	472.00
IUUC-Ame-010869	Astyanax mexicanus	46.25	1.00e-104	373.00
IUUC-Cja-019305	Callithrix jacchus	87.98	0.00e+00	798.00
IUUC-Cfa-020393	Canis familiaris	91.26	0.00e+00	824.00
IUUC-Cpo-022166	Cavia porcellus	86.05	0.00e+00	741.00
IUUC-Csa-023654	Chlorocebus sabaeus	90.02	0.00e+00	790.00
IUUC-Cho-024403	Choloepus hoffmanni	86.14	2.00e-124	438.00
IUUC-Dre-027754	Danio rerio	47.04	3.00e-112	398.00
IUUC-Dno-029630	Dasypus novemcinctus	85.98	0.00e+00	801.00
IUUC-Dor-031064	Dipodomys ordii	66.60	0.00e+00	630.00
IUUC-Ete-032901	Echinops telfairi	77.64	0.00e+00	756.00
IUUC-Eca-034234	Equus caballus	92.06	0.00e+00	897.00
IUUC-Eeu-035015	Erinaceus europaeus	64.43	6.00e-160	556.00
IUUC-Fca-036587	Felis catus	91.65	0.00e+00	842.00
IUUC-Fal-036906	Ficedula albicollis	50.71	1.00e-132	466.00
IUUC-Gmo-038646	Gadus morhua	43.22	4.00e-92	332.00
IUUC-Gga-040124	Gallus gallus	57.77	3.00e-114	404.00
IUUC-Gac-042397	Gasterosteus aculeatus	45.51	1.00e-103	370.00
IUUC-Ggo-045505	Gorilla gorilla	89.82	0.00e+00	810.00
IUUC-Hsa-046950	Homo sapiens	90.02	0.00e+00	813.00
IUUC-Itr-048886	Ictidomys tridecemlineatus	87.98	0.00e+00	816.00
IUUC-Lch-050141	Latimeria chalumnae	53.89	7.00e-121	427.00
IUUC-Loc-051921	Lepisosteus oculatus	49.10	6.00e-109	387.00
IUUC-Laf-054281	Loxodonta africana	84.32	0.00e+00	777.00
IUUC-Mcc-055462	Macaca mulatta	85.98	0.00e+00	737.00
IUUC-Meu-056294	Macropus eugenii	69.33	6.00e-139	487.00
IUUC-Mga-059924	Meleagris gallopavo	59.43	2.00e-161	562.00
IUUC-Mmr-061428	Microcebus murinus	88.19	0.00e+00	845.00
IUUC-Mdo-062643	Monodelphis domestica	74.45	0.00e+00	709.00
IUUC-Mmu-063229	Mus musculus	80.45	0.00e+00	749.00
IUUC-Mpu-065782	Mustela putorius furo	88.64	0.00e+00	808.00
IUUC-Mlu-068105	Myotis lucifugus	80.49	0.00e+00	762.00
IUUC-Nle-069549	Nomascus leucogenys	90.22	0.00e+00	815.00
IUUC-Opr-070568	Ochotona princeps	86.88	0.00e+00	763.00
IUUC-Ont-072276	Oreochromis niloticus	45.84	9.00e-112	397.00
IUUC-Oan-072787	Ornithorhynchus anatinus	72.86	0.00e+00	655.00
IUUC-Ocu-074912	Oryctolagus cuniculus	87.17	0.00e+00	807.00
IUUC-Ola-087037	Oryzias latipes	44.53	2.00e-94	339.00
IUUC-Oga-088953	Otolemur garnettii	83.84	0.00e+00	789.00
IUUC-Oar-089202	Ovis aries	96.33	0.00e+00	923.00
IUUC-Ptr-090964	Pan troglodytes	90.22	0.00e+00	815.00
IUUC-Pan-091975	Papio anubis	89.61	0.00e+00	802.00
IUUC-Psi-093558	Pelodiscus sinensis	59.27	8.00e-155	540.00
IUUC-Pfo-096454	Poecilia formosa	47.12	7.00e-109	387.00
IUUC-Pab-098123	Pongo abelii	90.22	0.00e+00	818.00
IUUC-Pca-101112	Procavia capensis	76.63	0.00e+00	713.00
IUUC-Pva-103098	Pteropus vampyrus	79.63	0.00e+00	751.00
IUUC-Rno-105930	Rattus norvegicus	81.10	0.00e+00	726.00
IUUC-Sha-107512	Sarcophilus harrisii	73.17	0.00e+00	632.00
IUUC-Sar-113584	Sorex araneus	81.40	0.00e+00	714.00
IUUC-Tgu-116766	Taeniopygia guttata	55.14	6.00e-98	350.00
IUUC-Tru-117829	Takifugu rubripes	46.60	3.00e-110	391.00
IUUC-Tsy-119268	Tarsius syrichta	76.17	0.00e+00	674.00
IUUC-Tni-120204	Tetraodon nigroviridis	45.59	2.00e-105	375.00
IUUC-Tbe-127840	Tupaia belangeri	81.23	1.00e-121	429.00
IUUC-Ttr-128863	Tursiops truncatus	91.24	0.00e+00	853.00
IUUC-Vpa-130718	Vicugna pacos	92.04	0.00e+00	818.00
IUUC-Xtr-132320	Xenopus tropicalis	47.50	7.00e-90	323.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence