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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046829
Ensembl Protein ID ENSP00000426504.1
UniProt Accession P52739; B4DRL3; Q6PIF0; ZN131_HUMAN
Genbank Protein ID BAG61325.1; EAW56046.1; AAH35875.1; AAC50251.1
Protein Name Zinc finger protein 131
Genbank Nucleotide ID AK057343; AC106800; BC035875; U09410
Gene Name ZNF131
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000172262.11 ENST00000507393.1 ENSP00000427003.1
ENSG00000172262.11 ENST00000510026.5 ENSP00000425623.1
ENSG00000172262.11 ENST00000509156.5 ENSP00000426504.1
ENSG00000172262.11 ENST00000507218.5 ENSP00000425139.1
ENSG00000172262.11 ENST00000306938.8 ENSP00000305804.4
ENSG00000172262.11 ENST00000509931.5 ENSP00000425722.1
ENSG00000172262.11 ENST00000502623.1 ENSP00000423254.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
RepTarSomamiRmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Disease-associated Variation
GWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
BioGRID
DNA Methylation
TCGAICGC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/BCR/BTB_Other: BTB 2.20e-14 55.2 34 95
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/BCR/BTB_Other: BTB
   S: 1    aDvilvvggeeffahkivLaasSsvFyalflmeleesksklmveikdvqpevfrallkFlYtgkld 66
           +D++l+v+g +f+ahk+vLaa+S++Fy+ f +e+ +   ++ vei++v+  +fr+l++F Yt kl 
   Q: 34   TDITLIVDGHHFKAHKAVLAACSKFFYKFF-QEFTQ---EPLVEIEGVSKMAFRHLIEFTYTAKLM 95
           79****************************.66664...589*********************996 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Plays a role during development and organogenesis as well as in the function of the adult central nervous system (By similarity). May be involved in transcriptional regulation as a repressor of ESR1/ER-alpha signaling.
 Plays a role during development and organogenesis as well as in the function of the adult central nervous system (By similarity). May be involved in transcriptional regulation as a repressor of ESR1/ER-alpha signaling.
Protein Sequence
(Fasta)
MEAEETMECL QEFPEHHKMI LDRLNEQREQ DRFTDITLIV DGHHFKAHKA VLAACSKFFY 60
KFFQEFTQEP LVEIEGVSKM AFRHLIEFTY TAKLMIQGEE EANDVWKAAE FLQMLEAIKA 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046829|E3,BTB_Other|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GACACTGAAA ATCAGTAGAA GAAATACGCC ACATTTATTC TACCGGGGAA GACAGTGGGT 60
AAGAAAAAAA TACCGTAACA TTTAAATTAA AAAATAATTA AAAATTTAAA AGCAAATAGA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046829|E3,BTB_Other|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0238--DNA-binding
KW-1017--Isopeptide bond
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0832--Ubl conjugation
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR000210--BTB/POZ_dom
IPR027775--C2H2_Znf_fam_sub
IPR023413--GFP-like
IPR011333--SKP1/BTB/POZ
IPR027758--Zfp131
IPR013087--Znf_C2H2_type
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS50097--BTB
PS00028--ZINC_FINGER_C2H2_1
PS50157--ZINC_FINGER_C2H2_2
Pfam

PF00651--BTB
SMART

SM00225--BTB
SM00355--ZnF_C2H2
Gene Ontology

GO:0045111--C:intermediate filament cytoskeleton
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0003677--F:DNA binding
GO:0046872--F:metal ion binding
GO:0000981--F:RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0003700--F:transcription factor activity, sequence-specific DNA binding
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated
KEGG hsa:7690
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001514 Ailuropoda melanoleuca 95.87 0.00e+00 1132.00
IUUC-Apl-004058 Anas platyrhynchos 85.68 0.00e+00 691.00
IUUC-Aca-005161 Anolis carolinensis 74.96 0.00e+00 858.00
IUUC-Ame-011414 Astyanax mexicanus 55.63 2.00e-132 466.00
IUUC-Cja-018767 Callithrix jacchus 97.91 0.00e+00 1125.00
IUUC-Cfa-021094 Canis familiaris 95.85 0.00e+00 1139.00
IUUC-Cpo-022314 Cavia porcellus 87.88 0.00e+00 1030.00
IUUC-Csa-023639 Chlorocebus sabaeus 93.58 0.00e+00 1100.00
IUUC-Cho-024503 Choloepus hoffmanni 94.71 0.00e+00 1097.00
IUUC-Dre-028729 Danio rerio 62.86 5.00e-151 528.00
IUUC-Dno-029405 Dasypus novemcinctus 94.90 0.00e+00 1075.00
IUUC-Eca-033617 Equus caballus 90.39 0.00e+00 993.00
IUUC-Fca-036293 Felis catus 89.33 0.00e+00 1021.00
IUUC-Fal-037260 Ficedula albicollis 73.30 0.00e+00 820.00
IUUC-Gmo-038585 Gadus morhua 59.74 7.00e-151 527.00
IUUC-Gga-040803 Gallus gallus 79.29 0.00e+00 969.00
IUUC-Gac-041656 Gasterosteus aculeatus 55.21 6.00e-149 520.00
IUUC-Ggo-045484 Gorilla gorilla 99.52 0.00e+00 1157.00
IUUC-Itr-048719 Ictidomys tridecemlineatus 96.70 0.00e+00 1110.00
IUUC-Lch-049844 Latimeria chalumnae 66.16 0.00e+00 756.00
IUUC-Laf-053393 Loxodonta africana 92.47 0.00e+00 1065.00
IUUC-Mcc-055008 Macaca mulatta 93.58 0.00e+00 1103.00
IUUC-Meu-056284 Macropus eugenii 85.49 0.00e+00 910.00
IUUC-Mmr-060917 Microcebus murinus 85.26 0.00e+00 961.00
IUUC-Mdo-062737 Monodelphis domestica 80.91 0.00e+00 855.00
IUUC-Mmu-064068 Mus musculus 93.74 0.00e+00 1113.00
IUUC-Mpu-066880 Mustela putorius furo 96.48 0.00e+00 1143.00
IUUC-Mlu-067817 Myotis lucifugus 92.32 0.00e+00 1046.00
IUUC-Nle-069781 Nomascus leucogenys 99.68 0.00e+00 1162.00
IUUC-Ont-071713 Oreochromis niloticus 58.52 4.00e-150 525.00
IUUC-Ocu-074381 Oryctolagus cuniculus 89.57 0.00e+00 1059.00
IUUC-Ola-086936 Oryzias latipes 52.96 5.00e-152 531.00
IUUC-Oga-088696 Otolemur garnettii 65.00 1.00e-140 492.00
IUUC-Oar-090187 Ovis aries 96.96 0.00e+00 1143.00
IUUC-Ptr-091077 Pan troglodytes 94.38 0.00e+00 1076.00
IUUC-Pan-091830 Papio anubis 93.74 0.00e+00 1103.00
IUUC-Psi-093902 Pelodiscus sinensis 74.68 0.00e+00 902.00
IUUC-Pma-094410 Petromyzon marinus 43.00 3.00e-105 375.00
IUUC-Pfo-096471 Poecilia formosa 55.73 1.00e-149 523.00
IUUC-Pab-097728 Pongo abelii 94.06 0.00e+00 1046.00
IUUC-Pca-100437 Procavia capensis 96.61 2.00e-159 555.00
IUUC-Pva-102195 Pteropus vampyrus 87.64 0.00e+00 972.00
IUUC-Rno-105640 Rattus norvegicus 92.13 0.00e+00 1101.00
IUUC-Sha-107212 Sarcophilus harrisii 81.55 0.00e+00 881.00
IUUC-Ssc-115860 Sus scrofa 100.00 4.00e-45 171.00
IUUC-Tgu-116547 Taeniopygia guttata 79.74 0.00e+00 947.00
IUUC-Tru-117534 Takifugu rubripes 60.85 4.00e-154 538.00
IUUC-Tni-120102 Tetraodon nigroviridis 59.10 6.00e-150 524.00
IUUC-Ttr-128199 Tursiops truncatus 97.85 0.00e+00 1062.00
IUUC-Vpa-130705 Vicugna pacos 97.61 0.00e+00 1062.00
IUUC-Xtr-132306 Xenopus tropicalis 70.37 0.00e+00 720.00
Created Date 25-Jun-2017

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