iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Pan-092770

Ensembl Protein ID

ENSPANP00000011456.1

UniProt Accession

A0A096NEX0; A0A096NEX0_PAPAN

Genbank Protein ID

ENSPANP00000011456

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AHZZ01083552

Gene Name

FBXW11

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPANG00000006849.1	ENSPANT00000006232.1	ENSPANP00000011456.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	4.70e-58	190.6	462	496
UBD/Beta-Prp	1.90e-68	230.9	375	540

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclafsd.tllvsGsdDgtikvWDlrtgvl 35
           gH++ v+c++f d +++vsG++Dg+ikvWDl    +
   Q: 462  GHEELVRCIRF-DnKRIVSGAYDGKIKVWDLQAALD 496
           8**********.44****************977665 PP

UBD/Beta-Prp

   S: 43   kllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvlslsfspsgdklvsGshdrtirvwdletgqclee 131
           +l r l gh a+v+ v+f+++  ++v++s Drtikvw+ st++ v+tl+gh++ + +l++      +vsGs+d+tir+wd+e g cl+ 
   Q: 375  TLRRVLVGHRAAVNVVDFDDK--YIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQYRD--RLVVSGSSDNTIRLWDIECGACLR- 458
           4555679*************9..8**************************************..************************. PP
   S: 132  tlsghdgvvncvvvhpdgnllvsGslDrtvrlWdl.........ktgkllrtltgghtdsvyslsfdsngkelvsgsldgtvklwdl 209
           +l+gh+++v+c++++   + +vsG++D+++++Wdl         ++  +lrtl + h ++v  l+fd+  ++++s s+d t+ +wd+
   Q: 459  VLEGHEELVRCIRFDN--KRIVSGAYDGKIKVWDLqaaldprapASTLCLRTLVE-HSGRVFRLQFDE--FQIISSSHDDTILIWDF 540
           ***************9..***********************************99.************..99*************96 PP

Organism

Papio anubis

Protein Sequence
(Fasta)

MEPDSVIEDK TIELMCSVPR SLWLGCANLV ESMCALSCLQ SMPSVRCLQN TSVMEDQNED 60
ESPKKNTLWQ ISNGTSSVIV SRKRPSEGNY QKEKDLCIKY FDQWSESDQV EFVEHLISRM 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGAGCCCG ACTCGGTGAT TGAGGACAAG ACCATCGAGC TCATGGTGAG TGCGGCCCGC 60
TGGACCGTCT GTGCTTCCGT CCGTCCGGCC CCGGGCGGGC CTGCCCACCT CAACGTCCGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0853--WD repeat

Interpro

IPR021977--Beta-TrCP_D
IPR001810--F-box_dom
IPR020472--G-protein_beta_WD-40_rep
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50181--FBOX
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF12125--Beta-TrCP_D
PF12937--F-box-like
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM01028--Beta-TrCP_D
SM00256--FBOX
SM00320--WD40

Gene Ontology

GO:0005813--C:centrosome
GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0019005--C:SCF ubiquitin ligase complex
GO:0061630--F:ubiquitin protein ligase activity
GO:0042347--P:negative regulation of NF-kappaB import into nucleus
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0042753--P:positive regulation of circadian rhythm
GO:0045862--P:positive regulation of proteolysis
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0006470--P:protein dephosphorylation
GO:0031648--P:protein destabilization
GO:0000209--P:protein polyubiquitination
GO:0031146--P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001397	Ailuropoda melanoleuca	93.57	0.00e+00	1060.00
IUUC-Apl-003449	Anas platyrhynchos	95.82	0.00e+00	1078.00
IUUC-Ame-011174	Astyanax mexicanus	86.76	0.00e+00	977.00
IUUC-Bta-012920	Bos taurus	98.21	0.00e+00	1017.00
IUUC-Cja-018879	Callithrix jacchus	93.57	0.00e+00	1060.00
IUUC-Cfa-020021	Canis familiaris	93.57	0.00e+00	1060.00
IUUC-Cpo-022151	Cavia porcellus	96.30	0.00e+00	1009.00
IUUC-Csa-024095	Chlorocebus sabaeus	96.66	0.00e+00	1009.00
IUUC-Cho-024658	Choloepus hoffmanni	92.25	1.00e-151	529.00
IUUC-Dre-028160	Danio rerio	90.96	0.00e+00	929.00
IUUC-Dor-030498	Dipodomys ordii	92.84	0.00e+00	1023.00
IUUC-Eca-033804	Equus caballus	92.71	0.00e+00	977.00
IUUC-Fca-035887	Felis catus	93.21	0.00e+00	1030.00
IUUC-Fal-036783	Ficedula albicollis	96.23	0.00e+00	1045.00
IUUC-Gmo-038590	Gadus morhua	85.95	0.00e+00	943.00
IUUC-Gga-040628	Gallus gallus	98.64	0.00e+00	1043.00
IUUC-Gac-041305	Gasterosteus aculeatus	86.51	0.00e+00	957.00
IUUC-Ggo-044604	Gorilla gorilla	93.57	0.00e+00	1060.00
IUUC-Hsa-046139	Homo sapiens	93.57	0.00e+00	1060.00
IUUC-Lch-050460	Latimeria chalumnae	96.37	0.00e+00	988.00
IUUC-Laf-053968	Loxodonta africana	97.32	0.00e+00	1116.00
IUUC-Mcc-055822	Macaca mulatta	94.57	0.00e+00	1069.00
IUUC-Mga-059225	Meleagris gallopavo	98.59	0.00e+00	1004.00
IUUC-Mvi-060284	Microbotryum violaceum	44.95	2.00e-69	257.00
IUUC-Mmr-060746	Microcebus murinus	93.57	0.00e+00	1060.00
IUUC-Mdo-062005	Monodelphis domestica	98.78	0.00e+00	1004.00
IUUC-Mmu-063851	Mus musculus	96.61	0.00e+00	1110.00
IUUC-Mpu-065716	Mustela putorius furo	95.92	0.00e+00	1013.00
IUUC-Mlu-067001	Myotis lucifugus	96.66	0.00e+00	1009.00
IUUC-Nle-069788	Nomascus leucogenys	93.20	0.00e+00	973.00
IUUC-Opr-071229	Ochotona princeps	95.60	0.00e+00	1059.00
IUUC-Ont-071792	Oreochromis niloticus	86.92	0.00e+00	957.00
IUUC-Oan-072782	Ornithorhynchus anatinus	96.23	0.00e+00	1045.00
IUUC-Ocu-074894	Oryctolagus cuniculus	97.32	0.00e+00	1116.00
IUUC-Ola-086985	Oryzias latipes	88.79	0.00e+00	991.00
IUUC-Oga-088604	Otolemur garnettii	87.37	0.00e+00	1008.00
IUUC-Oar-090412	Ovis aries	96.79	0.00e+00	1052.00
IUUC-Ptr-091039	Pan troglodytes	93.39	0.00e+00	1058.00
IUUC-Psi-093887	Pelodiscus sinensis	97.75	0.00e+00	1076.00
IUUC-Pno-094808	Phaeosphaeria nodorum	29.50	1.00e-45	177.00
IUUC-Pfo-096783	Poecilia formosa	88.32	0.00e+00	989.00
IUUC-Pva-102547	Pteropus vampyrus	93.36	0.00e+00	1046.00
IUUC-Rno-105246	Rattus norvegicus	96.40	0.00e+00	1046.00
IUUC-Sha-107339	Sarcophilus harrisii	98.78	0.00e+00	1004.00
IUUC-Sja-107743	Schizosaccharomyces japonicus	35.38	6.00e-74	271.00
IUUC-Tgu-116541	Taeniopygia guttata	95.99	0.00e+00	1083.00
IUUC-Tru-117671	Takifugu rubripes	88.42	0.00e+00	986.00
IUUC-Tni-120359	Tetraodon nigroviridis	90.52	0.00e+00	919.00
IUUC-Tbe-127418	Tupaia belangeri	89.25	0.00e+00	946.00
IUUC-Ttr-129131	Tursiops truncatus	93.57	0.00e+00	1059.00
IUUC-Vpa-130668	Vicugna pacos	93.18	0.00e+00	1049.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence