iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000198909.7	ENST00000579585.5	ENSP00000461988.1
ENSG00000198909.7	ENST00000584573.5	ENSP00000464130.1
ENSG00000198909.7	ENST00000361733.7	ENSP00000354485.3
ENSG00000198909.7	ENST00000577395.5	ENSP00000462086.1
ENSG00000198909.7	ENST00000577597.5	ENSP00000462917.1
ENSG00000198909.7	ENST00000585302.1	ENSP00000464532.1
ENSG00000198909.7	ENST00000581732.1	ENSP00000464482.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
miRWalk	miRecords	RepTar	miRNAMap
SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
GWASdb	OMIM
Drug and target
TTD	GRAC
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	dbPTM	HPRD
Phospho.ELM	UniProt	PHOSIDA	BioGRID
DNA Methylation
MethyCancer	TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
ULD/UDP/UFD/PB1	PB1	16949360; 17726178

Classification

Family	E-value	Score	Start	End
ULD/UDP/UFD/PB1	5.10e-16	60.3	44	119

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

ULD/UDP/UFD/PB1

   S: 1    tvrvkvsykgeirsfaldlekpgkfedLlkavrtltelknsevalkYeDedGDlvtlksDedldkavslla...skksllrll 80
           +vr+k++++ge r+  +++++p+k+ed++++v+t   ++++ ++l+Y++++ +++ lk+++dldka+++l+   s+ksl r+l
   Q: 44   DVRIKFEHNGERRI--IAFSRPVKYEDVEHKVTT---VFGQPLDLHYMNNELSIL-LKNQDDLDKAIDILDrssSMKSL-RIL 119
           59**********77..******************...******************.***************77444444.444 PP

Organism

Homo sapiens

Functional Description
(View)

Component of a protein kinase signal transduction cascade. Mediates activation of the NF-kappa-B, AP1 and DDIT3 transcriptional regulators.

Protein Sequence
(Fasta)

MDEQEALNSI MNDLVALQMN RRHRMPGYET MKNKDTGHSN RQSDVRIKFE HNGERRIIAF 60
SRPVKYEDVE HKVTTVFGQP LDLHYMNNEL SILLKNQDDL DKAIDILDRS SSMKSLRILL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTGTTTTTCG GAGCGTTCCT GAGGTGGAGA ACGGTGGCCG GACGGAGAGA CTGCGGGTCT 60
GAGGGACTGG CGGGCGGGCG GGCCGAGCGG CGCCGCCGAG GCCGGGCTGG GCCGAGCCCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0460--Magnesium
KW-0479--Metal-binding
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0723--Serine/threonine-protein kinase
KW-0808--Transferase

Interpro

IPR011009--Kinase-like_dom
IPR000270--PB1_dom
IPR000719--Prot_kinase_dom

PROSITE

PS51745--PB1
PS50011--PROTEIN_KINASE_DOM

Pfam

PF00564--PB1
PF00069--Pkinase

SMART

SM00666--PB1
SM00220--S_TKc

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005524--F:ATP binding
GO:0004709--F:MAP kinase kinase kinase activity
GO:0046872--F:metal ion binding
GO:0004672--F:protein kinase activity
GO:0004702--F:signal transducer, downstream of receptor, with serine/threonine kinase activity
GO:0030036--P:actin cytoskeleton organization
GO:0001568--P:blood vessel development
GO:0035556--P:intracellular signal transduction
GO:0000165--P:MAPK cascade
GO:0043123--P:positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:1900745--P:positive regulation of p38MAPK cascade
GO:0046777--P:protein autophosphorylation

KEGG

hsa:4215

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001464	Ailuropoda melanoleuca	93.29	0.00e+00	1259.00
IUUC-Ame-011807	Astyanax mexicanus	77.27	0.00e+00	964.00
IUUC-Bta-012717	Bos taurus	97.12	0.00e+00	1265.00
IUUC-Cja-019548	Callithrix jacchus	98.64	0.00e+00	1164.00
IUUC-Cfa-020785	Canis familiaris	97.60	0.00e+00	1274.00
IUUC-Cpo-021444	Cavia porcellus	96.96	0.00e+00	1262.00
IUUC-Csa-023898	Chlorocebus sabaeus	95.28	0.00e+00	1293.00
IUUC-Cin-025443	Ciona intestinalis	45.32	1.00e-136	480.00
IUUC-Dre-027587	Danio rerio	77.42	0.00e+00	993.00
IUUC-Dno-028984	Dasypus novemcinctus	91.17	0.00e+00	1236.00
IUUC-Eca-034089	Equus caballus	97.76	0.00e+00	1275.00
IUUC-Fca-035656	Felis catus	97.73	0.00e+00	1258.00
IUUC-Ggo-045339	Gorilla gorilla	95.28	0.00e+00	1293.00
IUUC-Itr-048091	Ictidomys tridecemlineatus	97.60	0.00e+00	1272.00
IUUC-Lpe-050706	Leersia perrieri	46.44	1.00e-68	254.00
IUUC-Loc-052751	Lepisosteus oculatus	76.75	0.00e+00	1034.00
IUUC-Laf-054342	Loxodonta africana	96.66	0.00e+00	1254.00
IUUC-Mcc-055631	Macaca mulatta	95.13	0.00e+00	1290.00
IUUC-Mga-059565	Meleagris gallopavo	86.10	0.00e+00	1108.00
IUUC-Mmr-060745	Microcebus murinus	93.29	0.00e+00	1262.00
IUUC-Mmu-063432	Mus musculus	96.65	0.00e+00	1263.00
IUUC-Mpu-066544	Mustela putorius furo	92.74	0.00e+00	1239.00
IUUC-Mlu-067655	Myotis lucifugus	96.65	0.00e+00	1263.00
IUUC-Nle-070048	Nomascus leucogenys	88.72	0.00e+00	1165.00
IUUC-Ont-071889	Oreochromis niloticus	77.16	0.00e+00	994.00
IUUC-Oan-073137	Ornithorhynchus anatinus	78.51	0.00e+00	716.00
IUUC-Ola-087055	Oryzias latipes	72.77	0.00e+00	929.00
IUUC-Oga-088913	Otolemur garnettii	92.52	0.00e+00	1196.00
IUUC-Oar-090321	Ovis aries	92.38	0.00e+00	1253.00
IUUC-Ptr-091046	Pan troglodytes	95.13	0.00e+00	1291.00
IUUC-Pan-092280	Papio anubis	94.98	0.00e+00	1290.00
IUUC-Pfo-096365	Poecilia formosa	77.24	0.00e+00	995.00
IUUC-Pab-097785	Pongo abelii	95.28	0.00e+00	1293.00
IUUC-Pva-102740	Pteropus vampyrus	92.67	0.00e+00	1251.00
IUUC-Rno-104946	Rattus norvegicus	96.33	0.00e+00	1259.00
IUUC-Ssc-115554	Sus scrofa	96.75	0.00e+00	1240.00
IUUC-Tgu-117312	Taeniopygia guttata	89.76	0.00e+00	1182.00
IUUC-Tni-120426	Tetraodon nigroviridis	75.84	0.00e+00	966.00
IUUC-Ttr-128646	Tursiops truncatus	93.15	0.00e+00	1262.00
IUUC-Xtr-132121	Xenopus tropicalis	83.87	0.00e+00	1083.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence