iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

UUCD2 ID

IUUC-Mmu-063513

UUCD1 version

UUC-MuM-00773

Ensembl Protein ID

ENSMUSP00000106145.2

UniProt Accession

Q8K4P8; D3YZ67; Q6A086; Q8BIA6; Q8BKC2; Q8BKL3; Q8BKZ8; HECW1_MOUSE

Genbank Protein ID

BAC28516.1; BAC33122.1; BAC34677.1; BAC35477.1; BAB97389.1; BAD32210.1

Protein Name

E3 ubiquitin-protein ligase HECW1; HECT, C2 and WW domain-containing protein 1; HECT-type E3 ubiquitin transferase HECW1; NEDD4-like E3 ubiquitin-protein ligase 1

Genbank Nucleotide ID

AK033922; AK047678; AK051569; AK053694; AC092710; AK172932

Gene Name

Hecw1; Kiaa0322; Nedl1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000021301.8	ENSMUST00000110516.2	ENSMUSP00000106145.2

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	miRTarBase	microRNA	TRANSFAC
RepTar	RAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
UniProt	PHOSIDA
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	5.10e-121	405.3	1272	1604

Active Site

Position(s)	Description	Evidence
1572	Glycyl thioester intermediate	{ECO:0000255\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 3    sdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlld 89
           + ++++l+++fvgEegld++G++ref++lls+el+np++glf+ys+nd++t+q++p s +  +++l++F+f Gr+lg+al ++ lld
   Q: 1272 ELQRNKLYITFVGEEGLDYSGPSREFFFLLSQELFNPYYGLFEYSANDTYTVQISPMSAFV-ENYLEWFRFSGRILGLALIHQYLLD 1357
           567899****************************************************985.5************************ PP
   S: 90   lplsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvkl 176
           ++++++fyk ll+ +++l+dle +d+e+++sl+++k+n   +i+++ ldltf+v+ee++g+++e+eLk+gG+n++Vt++Nk+eY+++
   Q: 1358 AFFTRPFYKGLLKLPCDLSDLEYLDEEFHQSLQWMKDN---NITDI-LDLTFTVNEEVFGQVTERELKSGGANTQVTEKNKKEYIER 1440
           ************************************99...9***9.**************************************** PP
   S: 177  vveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerka 263
           +v++r+++g+ +q+ea+ +Gf+ev++ +l+s+F+++elel+i G++eid++d++++t+y+ggy++ + +i+wFw ++e+f++e+r +
   Q: 1441 MVKWRVERGVVQQTEALLRGFYEVVDSRLVSVFDARELELVIAGTAEIDLNDWRNNTEYRGGYHDGHLVIRWFWAAVERFNNEQRLR 1527
           *************************************************************************************** PP
   S: 264  fLqFvTgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFels 336
           +LqFvTg+s++P +Gfa+l+     r+f+i+k+++ ++lP+++TCfn+L+LP+Y+s++ l+ekLl+A+eet+ F+l+
   Q: 1528 LLQFVTGTSSVPYEGFAALRgsngLRRFCIEKWGKITSLPRAHTCFNRLDLPPYPSYSMLYEKLLTAVEETSTFGLE 1604
           ************************999***********************************************985 PP

Organism

Mus musculus

Functional Description
(View)

E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent degradation of DVL1.

Protein Sequence
(Fasta)

MLLHLCSVKN LYQNRFLGLA AMASPSRNSQ SRRRCKEPLR YSYNPDQFHN IDIRNGAHDA 60
ITIPRSTSDT DLVTSDSRST LMVSSSYYSI GHSQDLVIHW DIKEEVDAGD WIGMYLIGEV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGAGAGCAAG CCTGGCTCCT GGTTGGTTCT CAAGTCTGGT TCCCACAGAG GAGCAGGCAG 60
GAAGGGAGGG GATGCGGGAG GAAGGATAAA GCAATAAAGT GTGCTGCGTT GCCACGCACT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR032348--HECW_N
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF16562--HECW_N
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0005829--C:cytosol
GO:0004842--F:ubiquitin-protein transferase activity

KEGG

mmu:94253

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001636	Ailuropoda melanoleuca	81.74	0.00e+00	2115.00
IUUC-Apl-003299	Anas platyrhynchos	79.17	0.00e+00	2402.00
IUUC-Aca-005024	Anolis carolinensis	77.97	0.00e+00	2361.00
IUUC-Bta-012604	Bos taurus	85.09	0.00e+00	2511.00
IUUC-Cja-019880	Callithrix jacchus	81.08	0.00e+00	2158.00
IUUC-Cfa-021216	Canis familiaris	86.90	0.00e+00	1765.00
IUUC-Cpo-021466	Cavia porcellus	94.98	0.00e+00	1700.00
IUUC-Csa-023080	Chlorocebus sabaeus	88.08	0.00e+00	2621.00
IUUC-Cho-024740	Choloepus hoffmanni	91.18	0.00e+00	1128.00
IUUC-Dre-028750	Danio rerio	72.09	0.00e+00	1533.00
IUUC-Dno-030019	Dasypus novemcinctus	86.00	0.00e+00	2559.00
IUUC-Dor-031030	Dipodomys ordii	81.15	0.00e+00	912.00
IUUC-Ete-032352	Echinops telfairi	92.97	0.00e+00	1253.00
IUUC-Eca-033948	Equus caballus	83.71	0.00e+00	2455.00
IUUC-Eeu-034474	Erinaceus europaeus	67.43	0.00e+00	1518.00
IUUC-Fca-036148	Felis catus	86.27	0.00e+00	2533.00
IUUC-Fal-036957	Ficedula albicollis	79.09	0.00e+00	2388.00
IUUC-Gmo-038714	Gadus morhua	67.79	0.00e+00	1013.00
IUUC-Gga-041194	Gallus gallus	78.85	0.00e+00	2382.00
IUUC-Gac-041366	Gasterosteus aculeatus	76.82	0.00e+00	1365.00
IUUC-Ggo-045442	Gorilla gorilla	74.10	0.00e+00	1962.00
IUUC-Hsa-045730	Homo sapiens	88.03	0.00e+00	2615.00
IUUC-Itr-048439	Ictidomys tridecemlineatus	89.25	0.00e+00	2677.00
IUUC-Lch-050185	Latimeria chalumnae	69.68	0.00e+00	1948.00
IUUC-Loc-052744	Lepisosteus oculatus	74.18	0.00e+00	2224.00
IUUC-Laf-054368	Loxodonta africana	96.13	0.00e+00	1479.00
IUUC-Mcc-055487	Macaca mulatta	87.77	0.00e+00	2623.00
IUUC-Meu-056751	Macropus eugenii	90.81	0.00e+00	726.00
IUUC-Mga-059545	Meleagris gallopavo	79.09	0.00e+00	2382.00
IUUC-Mmr-061078	Microcebus murinus	85.04	0.00e+00	2459.00
IUUC-Mdo-062176	Monodelphis domestica	83.27	0.00e+00	1696.00
IUUC-Mpu-065786	Mustela putorius furo	86.03	0.00e+00	2533.00
IUUC-Mlu-067780	Myotis lucifugus	79.72	0.00e+00	2260.00
IUUC-Nle-069213	Nomascus leucogenys	87.41	0.00e+00	2567.00
IUUC-Opr-070208	Ochotona princeps	94.49	0.00e+00	1467.00
IUUC-Ont-072132	Oreochromis niloticus	76.81	0.00e+00	1365.00
IUUC-Oan-072807	Ornithorhynchus anatinus	86.00	0.00e+00	1775.00
IUUC-Ocu-074745	Oryctolagus cuniculus	85.41	0.00e+00	2487.00
IUUC-Ola-086981	Oryzias latipes	78.60	0.00e+00	1426.00
IUUC-Oga-087965	Otolemur garnettii	85.84	0.00e+00	2439.00
IUUC-Oar-089749	Ovis aries	86.85	0.00e+00	1806.00
IUUC-Ptr-091243	Pan troglodytes	88.10	0.00e+00	2618.00
IUUC-Pan-092201	Papio anubis	87.37	0.00e+00	2596.00
IUUC-Psi-093511	Pelodiscus sinensis	79.14	0.00e+00	2331.00
IUUC-Pfo-097001	Poecilia formosa	64.31	0.00e+00	1573.00
IUUC-Pab-098728	Pongo abelii	85.57	0.00e+00	2493.00
IUUC-Pca-100129	Procavia capensis	79.90	0.00e+00	1232.00
IUUC-Pva-102250	Pteropus vampyrus	75.36	0.00e+00	2072.00
IUUC-Rno-105031	Rattus norvegicus	95.42	0.00e+00	2855.00
IUUC-Tgu-117515	Taeniopygia guttata	79.73	0.00e+00	2371.00
IUUC-Tru-117914	Takifugu rubripes	69.85	0.00e+00	1412.00
IUUC-Tsy-119379	Tarsius syrichta	77.36	0.00e+00	1335.00
IUUC-Tni-120178	Tetraodon nigroviridis	76.34	0.00e+00	1390.00
IUUC-Tbe-127762	Tupaia belangeri	79.72	0.00e+00	1877.00
IUUC-Ttr-128806	Tursiops truncatus	90.77	0.00e+00	1702.00
IUUC-Xtr-132903	Xenopus tropicalis	73.50	0.00e+00	1845.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence